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Parinaud's Oculoglandular Syndrome
Tropical Medicine and Infectious Disease Case Report Parinaud’s Oculoglandular Syndrome: A Case in an Adult with Flea-Borne Typhus and a Review M. Kevin Dixon 1, Christopher L. Dayton 2 and Gregory M. Anstead 3,4,* 1 Baylor Scott & White Clinic, 800 Scott & White Drive, College Station, TX 77845, USA; [email protected] 2 Division of Critical Care, Department of Medicine, University of Texas Health, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA; [email protected] 3 Medical Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA 4 Division of Infectious Diseases, Department of Medicine, University of Texas Health, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA * Correspondence: [email protected]; Tel.: +1-210-567-4666; Fax: +1-210-567-4670 Received: 7 June 2020; Accepted: 24 July 2020; Published: 29 July 2020 Abstract: Parinaud’s oculoglandular syndrome (POGS) is defined as unilateral granulomatous conjunctivitis and facial lymphadenopathy. The aims of the current study are to describe a case of POGS with uveitis due to flea-borne typhus (FBT) and to present a diagnostic and therapeutic approach to POGS. The patient, a 38-year old man, presented with persistent unilateral eye pain, fever, rash, preauricular and submandibular lymphadenopathy, and laboratory findings of FBT: hyponatremia, elevated transaminase and lactate dehydrogenase levels, thrombocytopenia, and hypoalbuminemia. His condition rapidly improved after starting doxycycline. Soon after hospitalization, he was diagnosed with uveitis, which responded to topical prednisolone. To derive a diagnostic and empiric therapeutic approach to POGS, we reviewed the cases of POGS from its various causes since 1976 to discern epidemiologic clues and determine successful diagnostic techniques and therapies; we found multiple cases due to cat scratch disease (CSD; due to Bartonella henselae) (twelve), tularemia (ten), sporotrichosis (three), Rickettsia conorii (three), R. -
Melioidosis in Birds and Burkholderia Pseudomallei Dispersal, Australia
LETTERS 5. Mätz-Rensing K, Jentsch KD, Rensing S, Melioidosis in Birds However, these are mostly birds Langenhuynsen S, Verschoor E, Niphuis in captivity and often exotic to the H, et al. Fatal herpes simplex infection in and Burkholderia a group of common marmosets (Callithrix location, suggesting potential reduced jacchus). Vet Pathol. 2003;40:405–11. pseudomallei immunity. Little is known about doi:10.1354/vp.40-4-405 Dispersal, Australia melioidosis in wild birds. In Sabah, 6. Bruno SF, Liebhold M, Mätz-Rensing K, Malaysia, only 1 of 440 wild birds Romão MA, Didier A, Brandes A, et al. Herpesvirus infection in free-living black- To the Editor: Melioidosis is an admitted to a research center over 9 tufted-ear marmoset (Callithrix penicil- emerging infectious disease of humans years was found to have melioidosis lata E. Geoffroyi 1812) at the state park of and animals caused by the gram- (6). Serra da Tiririca, Niterói, Rio de Janeiro, negative bacterium Burkholderia Although birds are endotherms, Brazil. Berl Munch Tierarztl Wochenschr. 1997;110:427–30. pseudomallei, which inhabits soil and with high metabolic rates and body 7. Kalter SS, Heberling RL. Comparative surface water in the disease-endemic temperature (40°C–43°C) protecting virology of primates. Bacteriol Rev. regions of Southeast Asia and northern them from many diseases, some birds 1971;35:310–64. Australia (1). The aim of this study appear more susceptible to melioidosis. 8. Mansfi eld K. Emerging and re-emerging infectious diseases of nonhuman primates. was to assess the potential for birds Indeed, high body temperature would Proceedings of the American College to spread B. -
Anaplasmosis: an Emerging Tick-Borne Disease of Importance in Canada
IDCases 14 (2018) xxx–xxx Contents lists available at ScienceDirect IDCases journal homepage: www.elsevier.com/locate/idcr Case report Anaplasmosis: An emerging tick-borne disease of importance in Canada a, b,c d,e e,f Kelsey Uminski *, Kamran Kadkhoda , Brett L. Houston , Alison Lopez , g,h i c c Lauren J. MacKenzie , Robbin Lindsay , Andrew Walkty , John Embil , d,e Ryan Zarychanski a Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada b Cadham Provincial Laboratory, Government of Manitoba, Winnipeg, MB, Canada c Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada d Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, Section of Medical Oncology and Hematology, University of Manitoba, Winnipeg, MB, Canada e CancerCare Manitoba, Department of Medical Oncology and Hematology, Winnipeg, MB, Canada f Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Pediatrics and Child Health, Section of Infectious Diseases, Winnipeg, MB, Canada g Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, Section of Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada h Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada i Public Health Agency of Canada, National Microbiology Laboratory, Zoonotic Diseases and Special Pathogens, Winnipeg, MB, Canada A R T I C L E I N F O A B S T R A C T Article history: Human Granulocytic Anaplasmosis (HGA) is an infection caused by the intracellular bacterium Received 11 September 2018 Anaplasma phagocytophilum. -
Reportable Disease Surveillance in Virginia, 2013
Reportable Disease Surveillance in Virginia, 2013 Marissa J. Levine, MD, MPH State Health Commissioner Report Production Team: Division of Surveillance and Investigation, Division of Disease Prevention, Division of Environmental Epidemiology, and Division of Immunization Virginia Department of Health Post Office Box 2448 Richmond, Virginia 23218 www.vdh.virginia.gov ACKNOWLEDGEMENT In addition to the employees of the work units listed below, the Office of Epidemiology would like to acknowledge the contributions of all those engaged in disease surveillance and control activities across the state throughout the year. We appreciate the commitment to public health of all epidemiology staff in local and district health departments and the Regional and Central Offices, as well as the conscientious work of nurses, environmental health specialists, infection preventionists, physicians, laboratory staff, and administrators. These persons report or manage disease surveillance data on an ongoing basis and diligently strive to control morbidity in Virginia. This report would not be possible without the efforts of all those who collect and follow up on morbidity reports. Divisions in the Virginia Department of Health Office of Epidemiology Disease Prevention Telephone: 804-864-7964 Environmental Epidemiology Telephone: 804-864-8182 Immunization Telephone: 804-864-8055 Surveillance and Investigation Telephone: 804-864-8141 TABLE OF CONTENTS INTRODUCTION Introduction ......................................................................................................................................1 -
Know Your Abcs: a Quick Guide to Reportable Infectious Diseases in Ohio
Know Your ABCs: A Quick Guide to Reportable Infectious Diseases in Ohio From the Ohio Administrative Code Chapter 3701-3; Effective August 1, 2019 Class A: Diseases of major public health concern because of the severity of disease or potential for epidemic spread – report immediately via telephone upon recognition that a case, a suspected case, or a positive laboratory result exists. • Anthrax • Measles • Rubella (not congenital) • Viral hemorrhagic fever • Botulism, foodborne • Meningococcal disease • Severe acute respiratory (VHF), including Ebola virus • Cholera • Middle East Respiratory syndrome (SARS) disease, Lassa fever, Marburg • Diphtheria Syndrome (MERS) • Smallpox hemorrhagic fever, and • Influenza A – novel virus • Plague • Tularemia Crimean-Congo hemorrhagic infection • Rabies, human fever Any unexpected pattern of cases, suspected cases, deaths or increased incidence of any other disease of major public health concern, because of the severity of disease or potential for epidemic spread, which may indicate a newly recognized infectious agent, outbreak, epidemic, related public health hazard or act of bioterrorism. Class B: Disease of public health concern needing timely response because of potential for epidemic spread – report by the end of the next business day after the existence of a case, a suspected case, or a positive laboratory result is known. • Amebiasis • Carbapenemase-producing • Hepatitis B (perinatal) • Salmonellosis • Arboviral neuroinvasive and carbapenem-resistant • Hepatitis C (non-perinatal) • Shigellosis -
Leptospirosis Associated Equine Recurrent Uveitis Answers to Your Important Questions What Is Leptospirosis Associated Equine Recurrent Uveitis (LAERU)?
Lisa Dauten, DVM Tri-State Veterinary Services LLC " Leptospirosis Associated Equine Recurrent Uveitis Answers to your Important Questions! What is Leptospirosis Associated Equine Recurrent Uveitis (LAERU)? Let’s start by breaking down some terminology.! Uveitis- inflammation of the uvea. Resulting in cloudiness of the eye, pain, and potential blindness. Also know as “Moon Blindness”. Caused by trauma, infection, or corneal disease.! Uvea- part of the eye containing the iris, ciliary body, and choroid. It keeps the lens of the eye in place, maintains fluid in the eye, and keeps things in the blood from entering the inside of the eye (blood-ocular barrier). ! Recurrent Uveitis- inflammation of the uvea that sporadically reoccurs through out a horses life time. Each time there is a reoccurring episode, the damage to the eye is made worse, eventually leading to permanent damage and potential blindness. ! Leptospirosis- bacteria found in the environment shed in the urine of wildlife and livestock. Horses usually are exposed when grazing pastures or drinking from natural water sources.! LAERU- Recurrent Uveitis in horses caused by Leptospirosis.! What are the clinical signs of Uveitis? Uveitis can come on very suddenly. A lot of times horses present with severe pain in the eye, tearing, squinting, and rubbing face. The eye itself is cloudy, white or blue in color. Sometimes the signs are not as dramatic. The color change of the eye may progress slowly. In these cases, horse owners may mistake the changes for cataracts.! What do I do if I think my horse has Uveitis? Call your veterinarian to request an appointment. -
Tick-Borne Diseases in Maine a Physician’S Reference Manual Deer Tick Dog Tick Lonestar Tick (CDC Photo)
tick-borne diseases in Maine A Physician’s Reference Manual Deer Tick Dog Tick Lonestar Tick (CDC PHOTO) Nymph Nymph Nymph Adult Male Adult Male Adult Male Adult Female Adult Female Adult Female images not to scale know your ticks Ticks are generally found in brushy or wooded areas, near the DEER TICK DOG TICK LONESTAR TICK Ixodes scapularis Dermacentor variabilis Amblyomma americanum ground; they cannot jump or fly. Ticks are attracted to a variety (also called blacklegged tick) (also called wood tick) of host factors including body heat and carbon dioxide. They will Diseases Diseases Diseases transfer to a potential host when one brushes directly against Lyme disease, Rocky Mountain spotted Ehrlichiosis anaplasmosis, babesiosis fever and tularemia them and then seek a site for attachment. What bites What bites What bites Nymph and adult females Nymph and adult females Adult females When When When April through September in Anytime temperatures are April through August New England, year-round in above freezing, greatest Southern U.S. Coloring risk is spring through fall Adult females have a dark Coloring Coloring brown body with whitish Adult females have a brown Adult females have a markings on its hood body with a white spot on reddish-brown tear shaped the hood Size: body with dark brown hood Unfed Adults: Size: Size: Watermelon seed Nymphs: Poppy seed Nymphs: Poppy seed Unfed Adults: Sesame seed Unfed Adults: Sesame seed suMMer fever algorithM ALGORITHM FOR DIFFERENTIATING TICK-BORNE DISEASES IN MAINE Patient resides, works, or recreates in an area likely to have ticks and is exhibiting fever, This algorithm is intended for use as a general guide when pursuing a diagnosis. -
Melioidosis in Northern Tanzania: an Important Cause of Febrile Illness?
Melioidosis and serological evidence of exposure to Burkholderia pseudomallei among patients with fever, northern Tanzania Michael Maze Department of Medicine University of Otago, Christchurch Melioidosis Melioidosis caused by Burkholderia pseudomallei • Challenging to identify when cultured Soil reservoir, with human infection from contact with contaminated water Most infected people are asymptomatic: 1 clinical illness for 4,500 antibody producing exposures Febrile illness with a variety of presentations and bacteraemia is present in 40-60% of people with acute illness Estimated 89,000 deaths globally Gavin Koh CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=4975784 Laboratory diagnosis of febrile inpatients, northern Tanzania, 2007-8 (n=870) Malaria (1.6%) Bacteremia (9.8%) Mycobacteremia (1.6%) Fungemia (2.9%) Brucellosis (3.5%) Leptospirosis (8.8%) Q fever (5.0%) No diagnosis (50.1%) Spotted fever group rickettsiosis (8.0%) Typhus group rickettsiosis (0.4%) Chikungunya (7.9%) Crump PLoS Neglect Trop Dis 2013; 7: e2324 Predicted environmental suitability for B. pseudomallei in East Africa Large areas of Africa are predicted to be highly suitable for Burkholderia pseudomallei East Africa is less suitable but pockets of higher suitability including northern Tanzania Northern Tanzania Increasing suitability for B. pseudomallei Limmathurotsakul Nat Microbiol. 2016;1(1). Melioidosis epidemiology in Africa Paucity of empiric data • Scattered case reports • Report from Kilifi, Kenya identified 4 bacteraemic cases from 66,000 patients who had blood cultured1 • 5.9% seroprevalence among healthy adults in Uganda2 • No reports from Tanzania 1. Limmathurotsakul Nat Microbiol. 2016;1(1). 2. Frazer J R Army Med Corps. 1982;128(3):123-30. -
Murine Typhus As a Common Cause of Fever of Intermediate Duration a 17-Year Study in the South of Spain
ORIGINAL INVESTIGATION Murine Typhus as a Common Cause of Fever of Intermediate Duration A 17-Year Study in the South of Spain M. Bernabeu-Wittel, MD; J. Pacho´n, PhD; A. Alarco´n, PhD; L. F. Lo´pez-Corte´s, PhD; P. Viciana, PhD; M. E. Jime´nez-Mejı´as, PhD; J. L. Villanueva, PhD; R. Torronteras, PhD; F. J. Caballero-Granado, PhD Background: Fever of intermediate duration (FID), char- cluded, and MT was the cause in 6.7% of 926 cases of acterized by a febrile syndrome lasting from 7 to 28 days, FID. Insect bites were reported in only 3.8% of the cases is a frequent condition in clinical practice, but its epide- of MT previous to the onset of illness. Most cases (62.5%) miological and etiologic features are not well described. occurred in the summer and fall. A high frequency of rash Murine typhus (MT) is a worldwide illness; neverthe- (62.5%) was noted. Arthromyalgia (77%), headache less, to our knowledge, no studies describing its epide- (71%), and respiratory (25%) and gastrointestinal (23%) miological and clinical characteristics have been per- symptoms were also frequent. Laboratory findings were formed in the south of Spain. Also, its significance as a unspecific. Organ complications were uncommon (8.6%), cause of FID is unknown. but they were severe in 4 cases. The mean duration of fever was 12.5 days. Cure was achieved in all cases, al- Objective: To determine the epidemiological features, though only 44 patients received specific treatment. clinical characteristics, and prognosis of MT and, pro- spectively, its incidence as a cause of FID. -
Tick-Borne Disease Working Group 2020 Report to Congress
2nd Report Supported by the U.S. Department of Health and Human Services • Office of the Assistant Secretary for Health Tick-Borne Disease Working Group 2020 Report to Congress Information and opinions in this report do not necessarily reflect the opinions of each member of the Working Group, the U.S. Department of Health and Human Services, or any other component of the Federal government. Table of Contents Executive Summary . .1 Chapter 4: Clinical Manifestations, Appendices . 114 Diagnosis, and Diagnostics . 28 Chapter 1: Background . 4 Appendix A. Tick-Borne Disease Congressional Action ................. 8 Chapter 5: Causes, Pathogenesis, Working Group .....................114 and Pathophysiology . 44 The Tick-Borne Disease Working Group . 8 Appendix B. Tick-Borne Disease Working Chapter 6: Treatment . 51 Group Subcommittees ...............117 Second Report: Focus and Structure . 8 Chapter 7: Clinician and Public Appendix C. Acronyms and Abbreviations 126 Chapter 2: Methods of the Education, Patient Access Working Group . .10 to Care . 59 Appendix D. 21st Century Cures Act ...128 Topic Development Briefs ............ 10 Chapter 8: Epidemiology and Appendix E. Working Group Charter. .131 Surveillance . 84 Subcommittees ..................... 10 Chapter 9: Federal Inventory . 93 Appendix F. Federal Inventory Survey . 136 Federal Inventory ....................11 Chapter 10: Public Input . 98 Appendix G. References .............149 Minority Responses ................. 13 Chapter 11: Looking Forward . .103 Chapter 3: Tick Biology, Conclusion . 112 Ecology, and Control . .14 Contributions U.S. Department of Health and Human Services James J. Berger, MS, MT(ASCP), SBB B. Kaye Hayes, MPA Working Group Members David Hughes Walker, MD (Co-Chair) Adalbeto Pérez de León, DVM, MS, PhD Leigh Ann Soltysiak, MS (Co-Chair) Kevin R. -
IAP Guidelines on Rickettsial Diseases in Children
G U I D E L I N E S IAP Guidelines on Rickettsial Diseases in Children NARENDRA RATHI, *ATUL KULKARNI AND #VIJAY Y EWALE; FOR INDIAN A CADEMY OF PEDIATRICS GUIDELINES ON RICKETTSIAL DISEASES IN CHILDREN COMMITTEE From Smile Healthcare, Rehabilitation and Research Foundation, Smile Institute of Child Health, Ramdaspeth, Akola; *Department of Pediatrics, Ashwini Medical College, Solapur; and #Dr Yewale Multispeciality Hospital for Children, Navi Mumbai; for Indian Academy of Pediatrics “Guidelines on Rickettsial Diseases in Children” Committee. Correspondence to: Dr Narendra Rathi, Consultant Pediatrician, Smile Healthcare, Rehabilitation & Research Foundation, Smile Institute of Child Health, Ramdaspeth, Akola, Maharashtra, India. [email protected]. Objective: To formulate practice guidelines on rickettsial diseases in children for pediatricians across India. Justification: Rickettsial diseases are increasingly being reported from various parts of India. Due to low index of suspicion, nonspecific clinical features in early course of disease, and absence of easily available, sensitive and specific diagnostic tests, these infections are difficult to diagnose. With timely diagnosis, therapy is easy, affordable and often successful. On the other hand, in endemic areas, where healthcare workers have high index of suspicion for these infections, there is rampant and irrational use of doxycycline as a therapeutic trial in patients of undifferentiated fevers. Thus, there is a need to formulate practice guidelines regarding rickettsial diseases in children in Indian context. Process: A committee was formed for preparing guidelines on rickettsial diseases in children in June 2016. A meeting of consultative committee was held in IAP office, Mumbai and scientific content was discussed. Methodology and results were scrutinized by all members and consensus was reached. -
Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015
biology Article Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 Susanne Schjørring 1,2, Martin Tugwell Jepsen 1,3, Camilla Adler Sørensen 3,4, Palle Valentiner-Branth 5, Bjørn Kantsø 4, Randi Føns Petersen 1,4 , Ole Skovgaard 6,* and Karen A. Krogfelt 1,3,4,6,* 1 Department of Bacteria, Parasites and Fungi, Statens Serum Institut (SSI), 2300 Copenhagen, Denmark; [email protected] (S.S.); [email protected] (M.T.J.); [email protected] (R.F.P.) 2 European Program for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control (ECDC), 27180 Solnar, Sweden 3 Scandtick Innovation, Project Group, InterReg, 551 11 Jönköping, Sweden; [email protected] 4 Virus and Microbiological Special Diagnostics, Statens Serum Institut (SSI), 2300 Copenhagen, Denmark; [email protected] 5 Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut (SSI), 2300 Copenhagen, Denmark; [email protected] 6 Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark * Correspondence: [email protected] (O.S.); [email protected] (K.A.K.) Received: 19 May 2020; Accepted: 15 June 2020; Published: 19 June 2020 Abstract: Rickettsiosis is a vector-borne disease caused by bacterial species in the genus Rickettsia. Ticks in Scandinavia are reported to be infected with Rickettsia, yet only a few Scandinavian human cases are described, and rickettsiosis is poorly understood. The aim of this study was to determine the prevalence of rickettsiosis in Denmark based on laboratory findings. We found that in the Danish individuals who tested positive for Rickettsia by serology, the majority (86%; 484/561) of the infections belonged to the spotted fever group.