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Official Nh Dhhs Health Alert
THIS IS AN OFFICIAL NH DHHS HEALTH ALERT Distributed by the NH Health Alert Network [email protected] May 18, 2018, 1300 EDT (1:00 PM EDT) NH-HAN 20180518 Tickborne Diseases in New Hampshire Key Points and Recommendations: 1. Blacklegged ticks transmit at least five different infections in New Hampshire (NH): Lyme disease, Anaplasma, Babesia, Powassan virus, and Borrelia miyamotoi. 2. NH has one of the highest rates of Lyme disease in the nation, and 50-60% of blacklegged ticks sampled from across NH have been found to be infected with Borrelia burgdorferi, the bacterium that causes Lyme disease. 3. NH has experienced a significant increase in human cases of anaplasmosis, with cases more than doubling from 2016 to 2017. The reason for the increase is unknown at this time. 4. The number of new cases of babesiosis also increased in 2017; because Babesia can be transmitted through blood transfusions in addition to tick bites, providers should ask patients with suspected babesiosis whether they have donated blood or received a blood transfusion. 5. Powassan is a newer tickborne disease which has been identified in three NH residents during past seasons in 2013, 2016 and 2017. While uncommon, Powassan can cause a debilitating neurological illness, so providers should maintain an index of suspicion for patients presenting with an unexplained meningoencephalitis. 6. Borrelia miyamotoi infection usually presents with a nonspecific febrile illness similar to other tickborne diseases like anaplasmosis, and has recently been identified in one NH resident. Tests for Lyme disease do not reliably detect Borrelia miyamotoi, so providers should consider specific testing for Borrelia miyamotoi (see Attachment 1) and other pathogens if testing for Lyme disease is negative but a tickborne disease is still suspected. -
Ixodes Ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement
International Journal of Molecular Sciences Article Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement Jan Kotál 1,2 , Stéphanie G. I. Polderdijk 3 , Helena Langhansová 1, Monika Ederová 1, Larissa A. Martins 2 , Zuzana Beránková 1, Adéla Chlastáková 1 , OndˇrejHajdušek 4, Michail Kotsyfakis 1,2 , James A. Huntington 3 and JindˇrichChmelaˇr 1,* 1 Department of Medical Biology, Faculty of Science, University of South Bohemia in Ceskˇ é Budˇejovice, Branišovská 1760c, 37005 Ceskˇ é Budˇejovice,Czech Republic; [email protected] (J.K.); [email protected] (H.L.); [email protected] (M.E.); [email protected] (Z.B.); [email protected] (A.C.); [email protected] (M.K.) 2 Laboratory of Genomics and Proteomics of Disease Vectors, Institute of Parasitology, Biology Center CAS, Branišovská 1160/31, 37005 Ceskˇ é Budˇejovice,Czech Republic; [email protected] 3 Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK; [email protected] (S.G.I.P.); [email protected] (J.A.H.) 4 Laboratory of Vector Immunology, Institute of Parasitology, Biology Center CAS, Branišovská 1160/31, 37005 Ceskˇ é Budˇejovice,Czech Republic; [email protected] * Correspondence: [email protected] Abstract: Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the Citation: Kotál, J.; Polderdijk, S.G.I.; transmission of tick-borne pathogens. Here we present the functional and structural characterization Langhansová, H.; Ederová, M.; of Iripin-8, a salivary serpin from the tick Ixodes ricinus, a European vector of tick-borne encephalitis Martins, L.A.; Beránková, Z.; and Lyme disease. -
Vector Hazard Report: Ticks of the Continental United States
Vector Hazard Report: Ticks of the Continental United States Notes, photos and habitat suitability models gathered from The Armed Forces Pest Management Board, VectorMap and The Walter Reed Biosystematics Unit VectorMap Armed Forces Pest Management Board Table of Contents 1. Background 4. Host Densities • Tick-borne diseases - Human Density • Climate of CONUS -Agriculture • Monthly Climate Maps • Tick-borne Disease Prevalence maps 5. References 2. Notes on Medically Important Ticks • Ixodes scapularis • Amblyomma americanum • Dermacentor variabilis • Amblyomma maculatum • Dermacentor andersoni • Ixodes pacificus 3. Habitat Suitability Models: Tick Vectors • Ixodes scapularis • Amblyomma americanum • Ixodes pacificus • Amblyomma maculatum • Dermacentor andersoni • Dermacentor variabilis Background Within the United States there are several tick-borne diseases (TBD) to consider. While most are not fatal, they can be quite debilitating and many have no known treatment or cure. Within the U.S., ticks are most active in the warmer months (April to September) and are most commonly found in forest edges with ample leaf litter, tall grass and shrubs. It is important to check yourself for ticks and tick bites after exposure to such areas. Dogs can also be infected with TBD and may also bring ticks into your home where they may feed on humans and spread disease (CDC, 2014). This report contains a list of common TBD along with background information about the vectors and habitat suitability models displaying predicted geographic distributions. Many tips and other information on preventing TBD are provided by the CDC, AFPMB or USAPHC. Back to Table of Contents Tick-Borne Diseases in the U.S. Lyme Disease Lyme disease is caused by the bacteria Borrelia burgdorferi and the primary vector is Ixodes scapularis or more commonly known as the blacklegged or deer tick. -
Severe Babesiosis Caused by Babesia Divergens in a Host with Intact Spleen, Russia, 2018 T ⁎ Irina V
Ticks and Tick-borne Diseases 10 (2019) 101262 Contents lists available at ScienceDirect Ticks and Tick-borne Diseases journal homepage: www.elsevier.com/locate/ttbdis Severe babesiosis caused by Babesia divergens in a host with intact spleen, Russia, 2018 T ⁎ Irina V. Kukinaa, Olga P. Zelyaa, , Tatiana M. Guzeevaa, Ludmila S. Karanb, Irina A. Perkovskayac, Nina I. Tymoshenkod, Marina V. Guzeevad a Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation b Central Research Institute of Epidemiology, Moscow, Russian Federation c Infectious Clinical Hospital №2 of the Moscow Department of Health, Moscow, Russian Federation d Centre for Hygiene and Epidemiology in Moscow, Moscow, Russian Federation ARTICLE INFO ABSTRACT Keywords: We report a case of severe babesiosis caused by the bovine pathogen Babesia divergens with the development of Protozoan parasites multisystem failure in a splenic host. Immunosuppression other than splenectomy can also predispose people to Babesia divergens B. divergens. There was heavy multiple invasion of up to 14 parasites inside the erythrocyte, which had not been Ixodes ricinus previously observed even in asplenic hosts. The piroplasm 18S rRNA sequence from our patient was identical B. Tick-borne disease divergens EU lineage with identity 99.5–100%. Human babesiosis 1. Introduction Leucocyte left shift with immature neutrophils, signs of dysery- thropoiesis, anisocytosis, and poikilocytosis were seen on the peripheral Babesia divergens, a protozoan blood parasite (Apicomplexa: smear. Numerous intra-erythrocytic parasites were found, which were Babesiidae) is primarily specific to bovines. This parasite is widespread initially falsely identified as Plasmodium falciparum. The patient was throughout Europe within the vector Ixodes ricinus. -
Tick-Borne Diseases Primary Tick-Borne Diseases in the Southeastern U.S
Entomology Insect Information Series Providing Leadership in Environmental Entomology Department of Entomology, Soils, and Plant Sciences • 114 Long Hall • Clemson, SC 29634-0315 • Phone: 864-656-3111 email:[email protected] Tick-borne Diseases Primary tick-borne diseases in the southeastern U.S. Affecting Humans in the Southeastern United Disease (causal organism) Tick vector (Scientific name) States Lyme disease Black-legged or “deer” tick (Borrelia burgdorferi species (Ixodes scapularis) Ticks are external parasites that attach themselves complex) to an animal host to take a blood meal at each of Rocky Mountain spotted fever American dog tick their active life stages. Blood feeding by ticks may (Rickettsia rickettsii) (Dermacentor variabilis) lead to the spread of disease. Several common Southern Tick-Associated Rash Lone star tick species of ticks may vector (transmit) disease. Many Illness or STARI (Borrelia (Amblyomma americanum) tick-borne diseases are successfully treated if lonestari (suspected, not symptoms are recognized early. When the disease is confirmed)) Tick-borne Ehrlichiosis not diagnosed during the early stages of infection, HGA-Human granulocytic Black-legged or “deer” tick treatment can be difficult and chronic symptoms anaplasmosis (Anaplasma (Ixodes scapularis) may develop. The most commonly encountered formerly Ehrlichia ticks in the southeastern U.S. are the American dog phagocytophilum) tick, lone star tick, blacklegged or “deer” tick and HME-Human monocytic Lone star tick brown dog tick. While the brown dog tick is notable Ehrlichiosis (Amblyomma americanum) because of large numbers that may be found indoors (Ehrlichia chafeensis ) American dog tick when dogs are present, it only rarely feeds on (Dermacentor variabilis) humans. -
And Toxoplasmosis in Jackass Penguins in South Africa
IMMUNOLOGICAL SURVEY OF BABESIOSIS (BABESIA PEIRCEI) AND TOXOPLASMOSIS IN JACKASS PENGUINS IN SOUTH AFRICA GRACZYK T.K.', B1~OSSY J.].", SA DERS M.L. ', D UBEY J.P.···, PLOS A .. ••• & STOSKOPF M. K .. •••• Sununary : ReSlIlIle: E x-I1V\c n oN l~ lIrIUSATION D'Ar\'"TIGENE DE B ;IB£,'lA PH/Re El EN ELISA ET simoNi,cATIVlTli t'OUR 7 bxo l'l.ASMA GONIJfI DE SI'I-IENICUS was extracted from nucleated erythrocytes Babesia peircei of IJEMIiNSUS EN ArRIQUE D U SUD naturally infected Jackass penguin (Spheniscus demersus) from South Africo (SA). Babesia peircei glycoprotein·enriched fractions Babesia peircei a ele extra it d 'erythrocytes nue/fies p,ovenanl de Sphenicus demersus originoires d 'Afrique du Sud infectes were obto ined by conca navalin A-Sepharose affinity column natulellement. Des fractions de Babesia peircei enrichies en chromatogrophy and separated by sod ium dodecyl sulphate glycoproleines onl ele oblenues par chromatographie sur colonne polyacrylam ide gel electrophoresis (SDS-PAGE ). At least d 'alfinite concona valine A-Sephorose et separees par 14 protein bonds (9, 11, 13, 20, 22, 23, 24, 43, 62, 90, electrophorese en gel de polyacrylamide-dodecylsuJfale de sodium 120, 204, and 205 kDa) were observed, with the major protein (SOS'PAGE) Q uotorze bandes proleiques au minimum ont ete at 25 kDa. Blood samples of 191 adult S. demersus were tes ted observees (9, 1 I, 13, 20, 22, 23, 24, 43, 62, 90, 120, 204, by enzyme-linked immunosorbent assoy (ELISA) utilizing B. peircei et 205 Wa), 10 proleine ma;eure elant de 25 Wo. -
Francisella Spp. Infections in Farmed and Wild Fish. ICES CM 2008/D:07
ICES CM 2008/D:07 Francisella spp. infections in farmed and wild fish Duncan J. Colquhoun1, Adam Zerihun2 and Jarle Mikalsen3 National Veterinary Institute, Section for Fish Health, Ullevaalsveien 68, 0454 Oslo, Norway 1 tel: +47 23 21 61 41; fax: +47 23 21 61 01; e-mail: [email protected] 2 tel: +47 23 21 61 08; fax: +47 23 21 61 01; e-mail: [email protected] 3 tel: +47 23 21 61 55; fax: +47 23 21 61 01; e-mail: [email protected] Abstract Bacteria within the genus Francisella are non-motile, Gram-negative, strictly aerobic, facultatively intracellular cocco-bacilli. While the genus includes pathogens of warm-blooded animals including humans, and potential bioterror agents, there is also increasing evidence of a number of as yet unrecognised environmental species. Due to their nutritionally fastidious nature, bacteria of the genus Francisella are generally difficult to culture, and growth is also commonly inhibited by the presence of other bacteria within sample material. For these reasons, Francisella-related fish disease may be under-diagnosed. Following the discovery in 2004/2005 that a granulomatous disease in farmed and wild Atlantic cod (Gadus morhua) is caused by a previously undescribed member of this genus (Francisella philomiragia subsp. noatunensis), similar diseases have been identified in fish in at least seven countries around the world. These infections affect both freshwater and marine fish species and involve bacteria more or less closely related to F. philomiragia subsp. philomiragia, an opportunistic human pathogen. Recent work relating to characterisation of the disease/s, classification of fish pathogenic Francisella spp. -
Tick Borne Diseases Nebraska 2018 HAN FINAL DRAFT APRIL 19 2018
TO: Primary care providers, infectious disease, laboratories, infection control, and public health FROM Thomas J. Safranek, M.D. Jeff Hamik State Epidemiologist Vector-borne Disease Epidemiologist 402-471-2937 PHONE 402-471-1374 PHONE 402-471-3601 FAX 402-471-3601 FAX Thomas Williams, M.D. Chief Medical Officer Director, Division of Public Health Department of Health and Human Services RE: TICK-BORNE DISEASES IN NEBRASKA DATE: April 20, 2018 The arrival of spring marks the beginning of another tick season. In the interest of public health and prevention, our office seeks to inform Nebraska health care providers about the known tick- borne diseases in our state. Key messages for Nebraska clinicians: Spotted fever rickettsia including Rocky Mountain spotted fever (RMSF) Our office receives reports of from 6 to 31 patients with spotted fever rickettsia every year. Health care providers risk overlooking this diagnosis because of its rarity. RMSF NEEDS TO BE A DIAGNOSTIC CONSIDERATION IN ANY PERSON WITH A FEVER AND A HISTORY OF EXPOSURE TO ENVIRONMENTS WHERE TICKS MIGHT BE PRESENT. The skin rash is not always present when the patient first presents to a physician. This disease is frequently overlooked or misdiagnosed, with numerous reports of serious and sometimes fatal consequences. Nebraska experienced a fatal case of RMSF in 2015 where the diagnosis was missed and treatment was delayed until the disease was well advanced. Laboratory diagnosis is made by detecting a rise in antibody titer to Rickettsia rickettsii between acute and convalescent sera. Treatment requires tetracycline-class of antibiotics or chloramphenicol. Tetracycline-class treatment is recommended for persons of all ages, including children. -
Bitten Enhance.Pdf
bitten. Copyright © 2019 by Kris Newby. All rights reserved. Printed in the United States of America. No part of this book may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embodied in critical articles and reviews. For information, address HarperCollins Publishers, 195 Broadway, New York, NY 10007. HarperCollins books may be purchased for educational, business, or sales pro- motional use. For information, please email the Special Markets Department at [email protected]. first edition Frontispiece: Tick research at Rocky Mountain Laboratories, in Hamilton, Mon- tana (Courtesy of Gary Hettrick, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases [NIAID], National Institutes of Health [NIH]) Maps by Nick Springer, Springer Cartographics Designed by William Ruoto Library of Congress Cataloging- in- Publication Data Names: Newby, Kris, author. Title: Bitten: the secret history of lyme disease and biological weapons / Kris Newby. Description: New York, NY: Harper Wave, [2019] Identifiers: LCCN 2019006357 | ISBN 9780062896278 (hardback) Subjects: LCSH: Lyme disease— History. | Lyme disease— Diagnosis. | Lyme Disease— Treatment. | BISAC: HEALTH & FITNESS / Diseases / Nervous System (incl. Brain). | MEDICAL / Diseases. | MEDICAL / Infectious Diseases. Classification: LCC RC155.5.N49 2019 | DDC 616.9/246—dc23 LC record available at https://lccn.loc.gov/2019006357 19 20 21 22 23 lsc 10 9 8 7 6 5 4 3 2 1 Appendix I: Ticks and Human Disease Agents -
Zoonotic Significance and Prophylactic Measure Against Babesiosis
Int.J.Curr.Microbiol.App.Sci (2015) 4(7): 938-953 International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 4 Number 7 (2015) pp. 938-953 http://www.ijcmas.com Review Article Zoonotic significance and Prophylactic Measure against babesiosis Faryal Saad, Kalimullah Khan, Shandana Ali and Noor ul Akbar* Department of Zoology, Kohat University of Science and Technology, Kohat, Khyber Pakhtunkhwa, Pakistan *Corresponding author ABSTRACT Babesiosis is a vector borne disease by the different species of genus Babesia, affecting a large no of mammals worldwide. Babesiosis has zoonotic significance all over the world, causing huge loss to livestock industry and health hazards in human population. The primary zoonotic vector of babesia is ixodes ticks. Keywo rd s Different species have different virulence, infectivity and pathogenicity. Literature was collected from the individual researchers published papers. Table was made in Babesiosis , the MS excel. The present study review for the current knowledge about the Prophylactic, babesia species ecology, host specificity, life cycle and pathogenesis with an Tick borne, emphasis on the zoonotic significance and prophylactic measures against Vector, Babesiosis. Prophylactic measure against Babesiosis in early times was hindered Zoonosis. but due to advancement in research, the anti babesial drugs and vaccines have been developed. This review emphasizes on the awareness of public sector, rural communities, owners of animal husbandry and health department about the risk of infection in KPK and control measure should be implemented. Vaccines of less price tag should be designed to prevent the infection of cattles and human population. Introduction Babesiosis is a tick transmitted disease, At specie level there is considerable infecting a wide variety of wild and confusion about the true number of zoonotic domestic animals, as well as humans. -
Melioidosis in Birds and Burkholderia Pseudomallei Dispersal, Australia
LETTERS 5. Mätz-Rensing K, Jentsch KD, Rensing S, Melioidosis in Birds However, these are mostly birds Langenhuynsen S, Verschoor E, Niphuis in captivity and often exotic to the H, et al. Fatal herpes simplex infection in and Burkholderia a group of common marmosets (Callithrix location, suggesting potential reduced jacchus). Vet Pathol. 2003;40:405–11. pseudomallei immunity. Little is known about doi:10.1354/vp.40-4-405 Dispersal, Australia melioidosis in wild birds. In Sabah, 6. Bruno SF, Liebhold M, Mätz-Rensing K, Malaysia, only 1 of 440 wild birds Romão MA, Didier A, Brandes A, et al. Herpesvirus infection in free-living black- To the Editor: Melioidosis is an admitted to a research center over 9 tufted-ear marmoset (Callithrix penicil- emerging infectious disease of humans years was found to have melioidosis lata E. Geoffroyi 1812) at the state park of and animals caused by the gram- (6). Serra da Tiririca, Niterói, Rio de Janeiro, negative bacterium Burkholderia Although birds are endotherms, Brazil. Berl Munch Tierarztl Wochenschr. 1997;110:427–30. pseudomallei, which inhabits soil and with high metabolic rates and body 7. Kalter SS, Heberling RL. Comparative surface water in the disease-endemic temperature (40°C–43°C) protecting virology of primates. Bacteriol Rev. regions of Southeast Asia and northern them from many diseases, some birds 1971;35:310–64. Australia (1). The aim of this study appear more susceptible to melioidosis. 8. Mansfi eld K. Emerging and re-emerging infectious diseases of nonhuman primates. was to assess the potential for birds Indeed, high body temperature would Proceedings of the American College to spread B. -
Distribution, Seasonality, and Hosts of the Rocky Mountain Wood Tick in the United States Author(S): Angela M
Distribution, Seasonality, and Hosts of the Rocky Mountain Wood Tick in the United States Author(s): Angela M. James, Jerome E. Freier, James E. Keirans, Lance A. Durden, James W. Mertins, and Jack L. Schlater Source: Journal of Medical Entomology, 43(1):17-24. 2006. Published By: Entomological Society of America DOI: http://dx.doi.org/10.1603/0022-2585(2006)043[0017:DSAHOT]2.0.CO;2 URL: http://www.bioone.org/doi/ full/10.1603/0022-2585%282006%29043%5B0017%3ADSAHOT%5D2.0.CO %3B2 BioOne (www.bioone.org) is a nonprofit, online aggregation of core research in the biological, ecological, and environmental sciences. BioOne provides a sustainable online platform for over 170 journals and books published by nonprofit societies, associations, museums, institutions, and presses. Your use of this PDF, the BioOne Web site, and all posted and associated content indicates your acceptance of BioOne’s Terms of Use, available at www.bioone.org/page/ terms_of_use. Usage of BioOne content is strictly limited to personal, educational, and non-commercial use. Commercial inquiries or rights and permissions requests should be directed to the individual publisher as copyright holder. BioOne sees sustainable scholarly publishing as an inherently collaborative enterprise connecting authors, nonprofit publishers, academic institutions, research libraries, and research funders in the common goal of maximizing access to critical research. SAMPLING,DISTRIBUTION,DISPERSAL Distribution, Seasonality, and Hosts of the Rocky Mountain Wood Tick in the United States ANGELA M. JAMES, JEROME E. FREIER, JAMES E. KEIRANS,1 LANCE A. DURDEN,1 2 2 JAMES W. MERTINS, AND JACK L. SCHLATER USDAÐAPHIS, Veterinary Services, Centers of Epidemiology and Animal Health, 2150 Centre Ave., Building B, Fort Collins, CO 80526Ð8117 J.