International Journal of Molecular Sciences Article New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-L-Galacto-β-D -Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation Justyna Rewak-Soroczynska 1 , Paulina Sobierajska 1 , Sara Targonska 1 , Agata Piecuch 2 , Lukasz Grosman 1, Jaroslaw Rachuna 3, Slawomir Wasik 4 , Michal Arabski 3 , Rafal Ogorek 2 and Rafal J. Wiglusz 1,* 1 Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland;
[email protected] (J.R.-S.);
[email protected] (P.S.);
[email protected] (S.T.);
[email protected] (L.G.) 2 Department of Mycology and Genetics, University of Wroclaw, Przybyszewskiego 63, 51-148 Wroclaw, Poland;
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[email protected] (R.O.) 3 Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland;
[email protected] (J.R.);
[email protected] (M.A.) 4 Institute of Physics, Jan Kochanowski University, Swietokrzyska 15, 25-406 Kielce, Poland;
[email protected] * Correspondence:
[email protected]; Tel.: +48-(071)-395-4159 Citation: Rewak-Soroczynska, J.; Sobierajska, P.; Targonska, S.; Piecuch, Abstract: New fluconazole-loaded, 6-Anhydro-α-L-Galacto-β-D-Galactan hydrogels incorporated A.; Grosman, L.; Rachuna, J.; Wasik, with nanohydroxyapatite were prepared and their physicochemical features (XRD, X-ray Diffrac- S.; Arabski, M.; Ogorek, R.; Wiglusz, tion; SEM-EDS, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy; ATR-FTIR, R.J. New Approach to Antifungal Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy), fluconazole release profiles Activity of Fluconazole Incorporated and enzymatic degradation were determined.