ANTICANCER RESEARCH International Journal of Cancer Research and Treatment

ISSN: 0250-7005

Volume 34, Number 2, February 2014

Contents

Reviews

‘BRCAness’ and Its Implications for Platinum Action in Gynecologic Cancer. F. MUGGIA, T. SAFRA (New York, NY, USA; Tel Aviv, Israel)...... 551

MicroRNAs in Diffuse Large B-Cell Lymphoma: Implications for Pathogenesis, Diagnosis, Prognosis and Therapy. K. TROPPAN, K. WENZL, A. DEUTSCH, H. LING, P. NEUMEISTER, M. PICHLER (Graz, Austria; Houston, TX, USA) ...... 557

Fighting Fire with Fire: The Revival of Thermotherapy for Gliomas. W.L. TITSWORTH, G.J.A. MURAD, B.L. HOH, M. RAHMAN (Gainesville, FL, USA) ...... 565

Chemoembolization in Colorectal Liver Metastases: The Rebirth. G. FIORENTINI, C. ALIBERTI, L. MULAZZANI, P. COSCHIERA, V. CATALANO, D. ROSSI, P. GIORDANI, S. RICCI (Pesaro; Padova; Ancona, Italy) ...... 575

Application of FDG-PET in Cervical Cancer and Endometrial Cancer: Utility and Future Prospects. Y. NOGAMI, M. IIDA, K. BANNO, I. KISU, M. ADACHI, K. NAKAMURA, K. UMENE, K. MASUDA, E. TOMINAGA, K. TANAKA, D. AOKI (Tokyo, Japan)...... 585

Histidine Rich Glycoprotein and Cancer: A Multi-faceted Relationship. L.D.S. JOHNSON, H.A. GOUBRAN, R.R. KOTB (Victoria; Vancouver, BC; Saskatoon, SK, Canada)...... 593

Hypoxic Condition and Prognosis in Oral Squamous Cell Carcinoma. P.O. DE LIMA, C.C. JORGE, D.T. OLIVEIRA, M.C. PEREIRA (Divinópolis, Minas Gerais; Bauru, São Paulo, Brazil)...... 605

Contents continued on the back cover ISSN (print): 0250-7005 ISSN (online): 1791-7530 Editorial Board Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, P.A. ABRAHAMSSON, Malmö, Sweden G. R. F. KRUEGER, Köln, Germany . Tel / Fax: +30-22950-53389. B. B. AGGARWAL, Houston, TX, USA D. W. KUFE, Boston, MA, USA E-mails: Editorial Office: [email protected] T. AKIMOTO, Kashiwa, Chiba, Japan Pat M. KUMAR, Manchester, UK Managing Editor: [email protected] A. ARGIRIS, San Antonio, TX, USA Shant KUMAR, Manchester, UK ANTICANCER RESEARCH supports: (a) the establishment and the Toulouse, France Fukuoka, Japan J. P. ARMAND, M. KUROKI, activities of the INTERNATIONAL INSTITUTE OF ANTICANCER V. I. AVRAMIS, Los Angeles, CA, USA O. D. LAERUM, Bergen, Norway RESEARCH (IIAR; Kapandriti, Attiki, Greece); and (b) the organization R. C. BAST, Houston, TX, USA F. J. LEJEUNE, Lausanne, Switzerland of the International Conferences of Anticancer Research. G. BAUER, Freiburg, Germany L. F. LIU, Piscataway, NJ, USA For more information about ANTICANCER RESEARCH, IIAR and the E. E. BAULIEU, Le Kremlin-Bicetre, France D. M. LOPEZ, Miami, FL, USA Conferences, please visit the IIAR website: www.iiar-anticancer.org Y. BECKER, Jerusalem, Israel E. LUNDGREN, Umea°, Sweden Publication Data: ANTICANCER RESEARCH (AR) is published monthly E. J. BENZ, Jr., Boston, MA, USA H. T. LYNCH, Omaha, NE, USA from January 2009. Each annual volume comprises 12 issues. Annual J. BERGH, Stockholm, Sweden Y. MAEHARA, Fukuoka, Japan Author and Subject Indices are included in the last issue of each volume. D. D. BIGNER, Durham, NC, USA J. MAHER, , UK ANTICANCER RESEARCH Vol. 24 (2004) and onwards appears online A. BÖCKING, Düsseldorf, Germany J. MARESCAUX, Strasbourg, France with Stanford University HighWire Press from April 2009. ö G. BONADONNA, Milan, Italy J. 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KELLOKUMPU-LEHTINEN, Tampere, J. G. DELINASIOS, Athens, Greece responsibility for the opinions expressed by the contributors or for the Finland Managing Editor content of advertisements appearing therein. B. K. KEPPLER, Vienna, Austria , D. G. KIEBACK Riesa (Dresden), Germany G. J. DELINASIOS, Athens, Greece R. KLAPDOR, Hamburg, Germany Copyright© 2014, Ιnternational Institute of Anticancer Research Assisrtant Managing Editor and (Dr. John G. Delinasios), All rights reserved. U. R. KLEEBERG, Hamburg, Germany Executive Publisher D.T.P. BY IIAR ü P. KLEIHUES, Z rich, Switzerland PRINTED BY ENTYPO, ATHENS, GREECE E. ILIADIS, Athens, Greece E. KLEIN, Stockholm, Sweden PRINTED ON ACID-FREE PAPER S. D. KOTTARIDIS, Athens, Greece Production Editor 9th INTERNATIONAL CONFERENCE OF ANTICANCER RESEARCH 6-10 October 2014, Porto Carras, Sithonia , Greece www.iiar-anticancer.org/conference Information

Under the auspices of: The Union for International Cancer Control (UICC) The Asian and Pacific Federation of Clinical Biochemistry (APFCB) The Asian Pacific Organization for Cancer Prevention (APOCP) The Austrian Society for Radiation Oncology ( ÖGRO) The European Group on Tumor Markers (EGTM) The Hungarian Society of Epidemiology The International Cancer Microenvironment Society (ICMS) The International Geriatric Radiotherapy Group (IGRG) The International Institute of Anticancer Research (IIAR) The International Society for Biological and Environmental Repositories (ISBER) The International Society of Oncology and Biomarkers (ISOBM) The Italian Society of Uro-Oncology (SIUrO) The Latinamerican and Caribbean Society of Medical Oncology (SLACOM) The Lithuanian Society of Radiation Oncology (LSRT) The North-Eastern German Society of Gynecological Oncology (NOGGO) The Polish Society of Radiation Oncology (PSTRO) The Portuguese Society of Radiotherapy - Oncology (SPRO) The Society of Biotherapeutic Approaches, Japan The Szeged Foundation for Cancer Research, Hungary The Turkish Society for Electron Microscopy (TSEM)

Supported by: The International Institute of Anticancer Research IIAR

Deadline for registration: September 26, 2014. Deadline for submission of abstracts: August 10, 2014.

Dates and Venue allowing the organization and coordination of international activities on cancer. Special sessions will be devoted to the The 9th International Conference of Anticancer Research will discussion and arrangement of international cooperation be held at the Porto Carras Grand Resort, Sithonia, Halkidiki, projects and activities, encompassing the aims of the Greece, from 6 to 10 October, 2014. International Institute of Anticancer Research. General Policy The Conference is organized and supported by the International Institute of Anticancer Research. The purpose of the Anticancer Research Conferences is to The Scientific Program will comprise of oral (10, 15, 30 or exchange scientific information worldwide and to discuss 40 minutes) and poster presentations. Both overviews and recent advances in both broad and specialized areas of original works will be presented. Each oral presentation will experimental and clinical cancer research. International be allocated a five-minute discussion-time. Six conference Scientific and Medical Societies are invited to participate in rooms will be used simultaneously. Posters will be exhibited the Conference by organizing specialized sessions. This for 1-2 days. Projection facilities for PowerPoint presentations initiative presents a forum for inter-Society communication will be provided. Organizing Committee P.A. Abrahamsson, Malmö, Sweden J.W. Greiner, Bethesda, MD, USA J. Reichrath, Homburg/Saar, Germany N. Agnantis, Ioannina, Greece F. Guadagni, Rome, Italy D.A. Ribeiro, Santos, SP, Brazil F.E. Ahmed, Greenville, NC, USA C. Hastie, Guildford, Surrey, UK M. Rigaud, Limoges, France C. Alexiou, Erlangen, Germany J. Hau, Copenhagen, Denmark F.M. Robertson, Houston, TX, USA L. Amaral, Lisbon, Portugal R. Hoffman, San Diego, CA, USA M. Roselli, Rome, Italy F.L. Ampil, Shreveport, LA, USA S. Holdenrieder, Bonn, Germany G.R. Rutteman, Utrecht, Netherlands R. Andersson, Lund, Sweden T. Isbir, , Turkey C. Sansom, London, UK S. Arbak, Istanbul, Turkey S. Jhanwar, New York, NY, USA S. Sarkar, Boston, MA, USA V. Barak, Jerusalem, Israel M. Jhanwar-Uniyal, New York, NY, USA A. Schauer, Göttingen, Germany D.-T. Bau, Taichung, Taiwan B. Kaina, Mainz, Germany D. Schiffer, Vercelli, Italy G. Bauer, Freiburg, Germany E. Kandil, New Orleans, LA, USA J. Schneider, Alcorcón (Madrid) Spain A. Bishayee, Signal Hill, CA, USA D.G. Kieback, Riesa (Dresden), Germany M. Schneider, Wuppertal, Germany R. Bjerkvig, Bergen, Norway I. Kiss, Pécs, Hungary O.J. Semmes, Norfolk, VA, USA G. Broich, Monza, Italy R. Klapdor, Hamburg, Germany A. Seth, Toronto, ON, Canada C. Carlberg, Kuopio, Finland R. Knecht, Hamburg, Germany G. Sica, Rome, Italy J. Carlsson, Uppsala, Sweden M. Kohonen-Corish, Sydney, NSW, J. Slansky, Denver, CO, USA D. Characiejus, Vilnius, Lithuania Australia K. Smetana, Prague, Czech Republic C.J. Chen, Taipei, Taiwan M. Koutsilieris, Athens, Greece S.S. Smith, Duarte, CA, USA G. Ciarimboli, Münster, Germany K. Kubota, Mibu, Tochigi, Japan R.M. Snapka, Columbus, OH, USA B.F.C. Clark, Aarhus, Denmark S. Kumar, Manchester, UK J. Sterling, Nashville, TN, USA R. Clarke, Washington, DC, USA P.M. Kumar, Manchester, UK T. Stigbrand, Umeå, Sweden P. Collery, Bastia, France O.D. Laerum, Bergen, Norway K. Syrjänen, Helsinki, Finland H. Cross, Vienna, Austria S.A. Lamprecht, Beer-Sheva, Israel R.T. Todorova, Sofia, Bulgaria M. De Braekeleer, Brest, France W. Lichtenegger, , Germany O. Topolcan, Pilsen, Czech Republic K. De Meirleir, Brussels, Belgium D. Lincoln, Chapel Hill, QLD, Australia G.C. Torre, Finale Ligure (SV), Italy A.Z. Dudek, Chicago, IL, USA B. Littlefield, Andover, MA, USA V. Treska, Pilsen, Czech Republic A. Dutour, Lyon, France F. Lumachi, Padova, Italy M. de L.G. Trigo, Porto, Portugal P. Dziegiel, Wroclaw, Poland S. Mitra, Galveston, TX, USA G. Tsangaris, Athens, Greece T. Efferth, Mainz, Germany R. Molina, Barcelona, Spain E. Vairaktaris, Athens, Greece W. Engström, Uppsala, Sweden J. Molnár, Szeged, Hungary D. Vesely, Tampa, FL, USA M. Eskelinen, Kuopio, Finland N. Motohashi, Tokyo, Japan D. Vetvicka, Prague, Czech Republic J.A. Fernandez-Pol, Chesterfield, MO, USA R.M. Nagler, Haifa, Israel J.K. Vishwanatha, Fort Worth, TX, USA A. Fields, Jacksonville, FL, USA N. Nguyen, Tucson, AZ, USA G. Vollmer, Dresden, Germany M. Friedrich, Krefeld, Germany C. Nicolini, Genova, Italy A. Wani, Columbus, OH, USA R. Friedrich, Hamburg, Germany C. Pace-Asciak, Toronto, ON, Canada I.P. Witz, Tel Aviv, Israel H.-J. Gabius, , Germany S. Pathak, Houston, TX, USA Y. Yen, Duarte, CA, USA R. Ganapathi, Charlotte, NC, USA G.J. Pilkington, Portsmouth, UK C.H. Yip, Petaling Jaya, Malaysia A.F. Gazdar, Dallas, TX, USA C.D. Platsoucas, Norfolk, VA, USA O. Zoras, , Greece V. Gebbia, Palermo, Italy A. Polliack, Jerusalem, Israel Scientific Program Experimental Research Sessions 16. Apoptosis. 31. Radiotherapy. 1. Oncogenes; tumor suppressor genes; 17. Tumor microenvironment; cell–cell 32. Hyperthermia. growth factors; signal transduction. interactions; adhesion; stroma; cancer- 33. Personalized medicine in cancer. 2. Molecular and cellular biology of cancer. associated fibroblasts. 34. Advances in breast cancer. 3. Cancer stem cells. 18. Carcinogenesis. Viral oncogenesis. 35. Advances in gynecological cancer. 4. Cancer cell differentiation. 19. New anticancer agents. 36. Advances in prostate cancer. 5. Cancer genomics. Microarray technology. 20. Natural production in cancer drug 37. Advances in neurooncology. 6. Cancer proteomics. development. 38. Advances in colorectal cancer. 7. Cancer systems biology and signaling. 21. Experimental chemotherapy. 39. Advances in head and neck cancer. 8. Cancer metabolism and autophagy. 22. Immunobiology of cancer. 40. Advances in stomach and esophageal 9. Reactive oxygen/nitrogen species and 23. Gene therapy. cancer. cancer. 24. Aging and cancer. 41. Advances in hemato-oncology. 10. MicroRNAs in cancer. 42. Melanoma: New therapies and Clinical Research Sessions 11. Invasion and metastasis. biomarkers. 12. Cytogenetics and genetics. 25. Diagnosis and prognosis of cancer. 43. Chemoprevention. Enviromental 13. Epigenetics. 26. Cancer surgery. exposure and cancer risk. 14. Tumor angiogenesis and anti- 27. Serum markers. 44. Epidemiology. angiogenesis. 28. Clinical chemotherapy. 45. Nutrition and cancer. Nutritional aspects 15. Multi-drug and drug resistance. 29. Immunotherapy; biotherapy; vaccines. of cancer prevention. Mechanisms and reversal. 30. Hormone therapy. 46. Special symposia (to be announced). Publications Airport – Hotel Transportation Abstracts of all contributed papers will be published in a special issue Shuttle buses will provide transportation from of ANTICANCER RESEARCH, which will be distributed to registrants Airport to the Hotel only on Sunday, October 5, 2014, and during the Conference, as well as to all subscribing libraries and from the Hotel to the airport only on Saturday, October 11, indexing services (print and online through the Stanford University 2014. Participants will be welcomed at the airport by a HighWire Press). After recommendation by the Organizing Committee, selected contributions will be invited as complete original papers or conference representative. Participants arriving on days other reviews to be submitted for publication in ANTICANCER RESEARCH. than October 5 or departing on days other than October 11 will Paper submissions will also be welcome during the Conference. have to hire a taxi (50 min, Euro ~120) at their own expense. Abstracts (titles and authors) will be announced in www.iiar- anticancer.org/conference upon acceptance. The final conference Weather program will be publicised on September 10, 2014. October is a very pleasant month in Sithonia, Greece. The average temperature is 24˚C (range 20-30˚C). Registration – Registration is required of all participants. Instructions for Submitting an Abstract – Registration deadline: 26 September, 2014. – Deadline for submission of abstracts: 10 August, 2014. 1. Only abstracts containing new results (original research work – Registration fee: EURO 260.00; Students, EURO 140.00; or overviews) will be accepted. Abstracts should clearly and accompanying person, EURO 100.00 (each); Children, no fee. adequately describe the objectives and results of the – The registration fee for the Conference participants partially covers: research. All abstracts must be submitted in English. attendance at the scientific sessions; all Conference material and 2. All abstracts need to be accompanied by a completed documentation (final program, list of participants, book of Abstracts, Conference folder, Certificate of attendance and registration badge) from Conference Registration Form made out in the name of the the Conference Secretariat; participation in all social events (social dinners, Author presenting the paper. guitar recital, coffee breaks, closing gala dinner), and conference gifts. a. Each abstract should include a title (in capital letters), – The registration fee for accompanying persons covers: participation names of all authors (with the name of the author who in all social events; eligibility for special accommodation fees (the will be presenting the paper underlined), as well as same offer that apply to Conference participants). complete address(es). – The registration fee for the Members of the auspicious societies is waived. – Registration will be regarded as final only after all forms and b. Two types of abstracts may be submitted: registration plus accommodation fees have been received by the l Short abstract, not exceeding 300 words. Editorial Office of Anticancer Research. l Long abstracts not exceeding 1500 words, with 1-2 Accommodation figures or tables (max size 8 cm width x 12 cm height), including abstract, introduction, materials and methods, Hotel reservation requests should be submitted directly to the Editorial results, discussion, acknowledgements, references. Office of Anticancer Research. The Porto Carras Grand Resort ( HHHHH ) is located in a beautiful, peaceful setting by the sea and will provide Color figures will be charged 180.00 EURO per page. excellent service and quality half-board accommodation for all participants. c. Careful typing and proof-reading are essential. l Accommodation fees: d. Abstract forms will not be provided. – Double room: EURO 132.00 for 2 persons, per night. – Single room: EURO 98.00 per person, per night. 3. Abstracts and a completed Conference Registration Form – Children 2-12 years old as 3rd person in double room: EURO 35.00. should be sent to: Dr. John G. Delinasios, International – Triple room: EURO 180.00 for 3 persons, per night. Institute of Anticancer Research, 1st km Kapandritiou- The fee covers: accommodation in A ( HHHHH ) type rooms (bath, Kalamou Rd, P.O. Box 22, Kapandriti 19014, Greece. balcony, radio, TV, telephone), breakfast, dinner and transportation from E-mail: [email protected]. and to the Airport of Thessaloniki on October 5 and October 11, 2014, respectively. Abstracts must arrive at our offices l Service hours: Breakfast (buffet): 7.30 – 10.00 a.m.; Dinner (formal by August 10, 2014, at the latest. club style) 19.00 – 22.30 p.m.; Self-service restaurant for lunch: 12.30 – 14.00 p.m. 4. A reply (regarding decision, acceptance or revision) will reach l Accomodation requests are valid if made through the official the author within 5-12 days from submission. conference Registration Form. For accommodation & registration to be secured all fees need to have been paid in advance. Instructions for Poster Presentations l Cancellations: Abstract and registration plus accommodation fees will be returned if participation is cancelled before August 10, 2014. No Abstracts scheduled for presentation in poster sessions will be grouped refunds will be offered past this date. by topic, numbered and listed in the program, and published in the Abstract Book, as well as in ANTICANCER RESEARCH. Posters will Travel Arrangements be exhibited for 1-2 days and program listings will specify the time for The Conference will officially commence on the morning of October 6, 2014. poster discussion. Therefore, participants should preferably arrive on October 5, 2014. The The original abstract of each poster presentation should arrive by conference will conclude with the closing gala dinner on October 10, 2014. August 10, 2014, at the latest at our offices. For the preparation of the Participants are advised to finalize their travel plans at the earliest possible abstract, please follow the Instructions for Submitting an Abstract. date. Details of date, flight number and time of arrival at Thessaloniki Airport The poster board surface area is 0.64 m 2 [0.8 m (31.5 inches) high should be given to the Editorial Office not later than September 26, 2014. and 0.8 m (31.5 inches) wide]. Poster presentations should include: : www.aegeanair.com title, authors, institutional affiliation, abstract, short introduction, Olympic Airways: www.olympicairlines.com methods, results, discussion, references and conclusion. Porto Carras, Sithonia, Greece 9th INTERNATIONAL CONFERENCE OF ANTICANCER RESEARCH 6-10 October 2014, Porto Carras, Sithonia, Greece www.iiar-anticancer/conference

CONFERENCE REGISTRATION FORM n Please reserve my place at the 9th International Conference of Anticancer Research. n I shall be accompanied by ...... adults and ...... children. (Please complete separate forms for each accompanying person.) n I plan to present ...... poster(s). Topic number ...... n I plan to present ...... oral communication(s): ...... minutes. Topic Number ...... n Abstract is attached. (Please follow the instructions for submitting an abstract). n I shall require accommodation in single n or double n room; Accommodation fees: Double room, EURO 132.00 for 2 persons per night; Single room, EURO 98.00 per person per night; Children 2-12 years old, as 3rd person in the same room, EURO 35.00 (per child). Triple room, EURO 180.00 for 3 persons per night. The fee covers accommodation in 5*-type rooms, breakfast, dinner, transportation from and to Thessaloniki Airport (5-11 October 14). Registration fee: EURO 260.00; Students, EURO 100.00; Accompanying person, EURO 100.00; Children: No fee. n Registration fee is enclosed. Accommodation fee for ...... nights is also enclosed. (Cheques should be made payable to Delinasios G.J. & CO G.P., Athens, Greece. Credit cards are NOT accepted.) n Please send an invoice for EURO ...... (and instructions for payment). Please provide VAT number and billing address for European invoices. n I am a student (certificate enclosed). n I will require transportation between Thessaloniki Airport and the Porto Carras Hotels on October 5 and 11, 2014. Time of my arrival: ...... Flight no.: ...... Time of my departure: ...... Flight no.: ...... n Please enter my personal subscription to Anticancer Research/IN VIVO/2015 (including all previous volumes online) at the special conference rate. n online (EURO 200.00); n print & online (EURO 300.00). Title: ...... Name: ...... Sex: male n or female n Institution (or Company): ...... Address: ...... Tel: ...... Fax: ...... E-mail: ......

Deadline for registration: September 26, 2014. Deadline for submission of abstracts: 10 August, 2014. Please send completed form and Registration & Accommodation fees to: Dr. John G. Delinasios, International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., P.O. Box 22, Kapandriti 19014, Greece. Tel. / Fax : +30 22950 53389; e-mail: [email protected]. Website: www.iiar-anticancer.org/conference Please photocopy for additional forms. Reviews