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XIV International Symposium on Atherosclerosis Rome, Italy, June 18-22, 2006 CONTENTS • Address from the Presidents III • Scientific Committees IV • International Advisory Board V • Sponsorship VII • Contact Information VIII • General Information XI • Registration XIII • How to reach the Symposium Venue XV • Practical Information XVI • Scientific Program Information XVII • Social Program XXI • Satellite Symposia XXIII • In Grateful Appreciation XXVI • Exhibition Floor Map XXVIII • Exhibitors XXIX • Time Table XXXI • Scientific Program XXXIII • Topic Index 199 • Author Index 217 I Address from the Presidents On behalf of the XIV International Symposium on ATHEROSCLEROSIS (ISA2006) organizing committee, the International Atherosclerosis Society (IAS), and the Italian Society for the Study of Atherosclerosis (S.I.S.A.), we wish to welcome all our participants, speakers, and presenters to Rome. We are pleased to host our participants, both established investiga- tors and young promising researchers, from more than 70 countries, and hope that your stay in Rome is exciting and re- warding. The first International Symposium on ATHEROSCLEROSIS was held in 1965, some 40 years ago. Well in the twenty-first century, it is exciting to note the dramatic changes in the perception of the field within the last decade alone and to ex- plore the explosion in the field of atherosclerosis prevention and treatment. The ISA2006 will cover the traditional in- terests of atherosclerosis specialists, such as lipid/lipoprotein, lipid lowering drugs, diets, and clotting mechanisms as related to lipids, but will also expand the focus to new and exciting areas, which may potentially affect the development of atherosclerosis and ultimately improve patient care. Themes will include obesity, metabolic syndrome, diabetes, AIDS, rheumatoid arthritis, as well as novel diagnostic technologies for arterial disease determination and biochemical traits affecting atherosclerosis development and outcomes. This very rich scientific program was developed from suggestions originating from the members of the International Advisory Board, the IAS Program Committee, and the Local Scientific Program Committee. Our heartfelt thanks go out to the 184 members from 47 countries and their collaborative efforts in making this such a successful program. We hope that you will find the format of the meeting one that will allow you to participate in as many topics and aspects as you wish through Plenary Sessions, Workshops, Master Lectures, Oral Communications, Posters, and Symposia. The se- lection of subjects of the scientific sessions has attempted to minimize overlaps and we hope that the program Time Table in the Final Program and the Programme at-a-Glance will help you easily and successfully navigate our meeting and to promote a lively interdisciplinary exchange of ideas. The scientific sessions in Rome will be enriched and complemented by the pre- and post-meeting satellites throughout Italy (Bologna, Milan, Naples, Parma, and Rome), in Madrid, Spain and Belgrade, Serbia and Montenegro. Each satellite will focus on a single topic which will be covered in great depth by internationally recognized experts in the field. Last but not the least, a heartfelt thanks is extended to all our sponsors which have supported us throughout all these months not only financially but also with timely suggestions. We hope that you will enjoy the scientific sessions and the social program and that your visit to Rome will be most re- warding. Do take advantage of all that the city has to offer during your leisure time. You will find information in your regi- stration bag and hostesses are available during the entire meeting in the registration area to help you and your guests. We would like to remind you that places for the Gala Dinner at the beautiful and ancient Complesso Monumentale S. Spirito in Saxia on Tuesday evening are limited: this is yet another opportunity to foster old friendships and forge new collaborations. Welcome to Rome! Rodolfo Paoletti, M.D., Ph.D Cesare R. Sirtori, M.D., Ph.D. Elmo Mannarino, M.D. Honorary President President Vice-President XIV INTERNATIONAL SYMPOSIUM ON ATHEROSCLEROSIS III Scientific Committees Congress President: Cesare R. Sirtori (Milan, Italy) Congress Vice-President: Elmo Mannarino (Perugia, Italy) Honorary President: Rodolfo Paoletti (Milan, Italy) ISA 2006 Local Scientific Program Committee Alberico L. Catapano (Milan, Italy) Guido Franceschini (Milan, Italy) Cesare R. Sirtori (Milan, Italy) Elena Tremoli (Milan, Italy) Laura Calabresi (Milan, Italy) - Secretary IAS Program Committee Jean-Charles Fruchart (Lille, France) Heiner Greten (Hamburg, Germany) Scott M. Grundy (Dallas, TX, USA) Steve Humphries (London, UK) Eran Leitersdorf (Jerusalem, Israel) Ernst J. Schaefer (Boston, MA, USA) International Atherosclerosis Society (IAS) President and Website Editor-in-Chief: Scott M. Grundy (Dallas, TX, USA) Past-President: Heiner Greten (Hamburg, Germany) President-Elect: Jean-Charles Fruchart (Lille, France) Treasurer: Walter F. Riesen (St. Gallen, Switzerland) Secretary: Marja-Riitta Taskinen (Helsinki, Finland) Members-at-Large: Philip Barter (Sydney, Australia), M. John Chapman (Paris, France), Emilio Moriguchi (Porto Alegre, Brazil) Senior Advisers to the Board: Antonio M. Gotto, Jr. (New York, NY, USA), Rodolfo Paoletti (Milan, Italy) President XIV ISA Congress: Cesare R. Sirtori (Milan, Italy) Regional Federation Chairs: Jean Davignon (Montreal, QC, Canada), Yuji Matsuzawa (Osaka, Japan), S. Lale Tokgözoglu (Ankara, Turkey) Italian Society for the Study of Atherosclerosis (S.I.S.A.) President: Elmo Mannarino (Perugia, Italy) Secretary: Arturo Pujia (Catanzaro, Italy) Past President: Alberto Notarbartolo (Palermo, Italy) Executive Committee: Maurizio Averna (Palermo, Italy), Stefano Bertolini (Genoa, Italy) Alberico L. Catapano (Milan, Italy), Luigi Cattin (Trieste, Italy), Davide Lauro (Rome, Italy) Andrea Mezzetti (Chieti, Italy), Paolo Rubba (Naples, Italy), Giovanni B. Vigna (Ferrara, Italy) IV International Advisory Board Abdel-Aziz O. (Egypt) Fellin R. (Italy) Adlouni A. (Morocco) Fernández-Britto J.E. (Cuba) Agabiti Rosei E. (Italy) Ferrannini E. (Italy) Angelin B. (Sweden) FitzGerald G.A. (USA) Assmann G. (Germany) Fonseca F.A.H. (Brazil) Auwerx J. (France) Forte T. (USA) Averna M. (Italy) Fruchart J.-C. (France) Aviram M. (Israel) Fuster V. (USA) Avogaro A. (Italy) Gaddi A.V. (Italy) Badimon L. (Spain) Galli C. (Italy) Ballantyne C.M. (USA) Gensini G.F. (Italy) Barter P. (Australia) Gimbrone M.A., Jr. (USA) Beisiegel U. (Germany) Ginsberg H.N. (USA) Benlian P. (France) González Santos P. (Spain) Bermúdez F. (Venezuela) Gotlieb A.I. (Canada) Bertolini S. (Italy) Gotto A.M., Jr. (USA) Betteridge D.J. (UK) Greten H. (Germany) Breslow J.L. (USA) Grundy S.M. (USA) Brewer H.B., Jr. (USA) Guyton J.R. (USA) Brown W.V. (USA) Hajjar D.P. (USA) Calandra S. (Italy) Hamsten A. (Sweden) Calvo Monfil C.E. (Chile) Hancu N. (Romania) Campbell G.R. (Australia) Hanefeld M. (Germany) Carmeliet P. (Belgium) Hansson G.K. (Sweden) Carmena R. (Spain) Havekes L.M. (The Netherlands) Carrageta M. (Portugal) Humphries S. (UK) Cattaneo M. (Italy) Iliceto S. (Italy) Cattin L. (Italy) Juhan-Vague I. (France) Ceska R. (Czech Republic) Kanjuh V. (Serbia and Montenegro) Chait A. (USA) Kastelein J.J.P. (The Netherlands) Chandrakasan G. (India) Katan M.B. (The Netherlands) Chapman M.J. (France) Kipshidze N.N. (Republic of Georgia) Chen M.-F. (Taiwan, R.O.C.) Kisyanto Y. (Indonesia) Chiariello M. (Italy) Kita T. (Japan) Corsini A. (Italy) Kovanen P. (Finland) Crea F. (Italy) Lauro D. (Italy) Crepaldi G. (Italy) Lauro R. (Italy) Cuevas A.M. (Chile) Leiter L.A. (Canada) Curtiss L.K. (USA) Leitersdorf E. (Israel) Davignon J. (Canada) Libby P. (USA) De Backer G. (Belgium) Licata G. (Italy) De Caterina R. (Italy) Lim-Abrahan M.A. (Philippines) de Gaetano G. (Italy) Lin S.-J. (Taiwan, R.O.C.) Dejana E. (Italy) Lissmann S. (Uruguay) Després J.-P. (Canada) Lüscher T.F. (Switzerland) Ding P.Y.-A. (Taiwan, R.O.C.) Mahley R.W. (USA) Djuric D.M. (Serbia and Montenegro) Mancia G. (Italy) Drexler H. (Germany) Mancini M. (Italy) Durrington P.N. (UK) Mangelsdorf D. (USA) Ersanli M. (Turkey) Manzato E. (Italy) Farese R. (USA) Marais D. (South Africa) V Marchioli R. (Italy) Staels B. (France) Marcovina S.M. (USA) Stalenhoef A.F. (The Netherlands) Maseri A. (Italy) Stein O. (Israel) Matsuzawa Y. (Japan) Stein Y. (Israel) McPherson R. (Canada) Steiner G. (Canada) Mezzetti A. (Italy) Sy R.G. (Philippines) Montagnani M. (Italy) Szollár L.G. (Hungary) Morales D.D. (Philippines) Tall A. (USA) Moriguchi E. (Brazil) Taskinen M.-R. (Finland) Naruszewicz M. (Poland) Tavassoli A. (Iran) Nestel P. (Australia) Tesone P.A. (Argentina) Newby A.C. (UK) Tikkanen M.J. (Finland) Nielsen L.B. (Denmark) Tokgözoglu L. (Turkey) Nissen S.E. (USA) Tonkin A. (Australia) Noseda G. (Switzerland) Turay J. (Slovak Republic) Notarbartolo A. (Italy) Tybjærg-Hansen A. (Denmark) Novo S. (Italy) Uauy R. (UK and Chile) O'Brien R. (Australia) Utermann G. (Austria) O'Leary D. (USA) Vella S. (Italy) Olsson A.G. (Sweden) Vigna G.B. (Italy) Packard C.J. (UK) Violi F. (Italy) Pagnan A. (Italy) Volpe M. (Italy) Park J.E. (Korea) von Eckardstein A. (Switzerland) Patrono C. (Italy) Wenger N.K. (USA) Patsch J. (Austria) Yamashita S. (Japan) Pedersen T.R. (Norway) Yang Y. (China) Pitt B. (USA) Ylä-Herttuala S. (Finland) Poledne R. (Czech Republic) Zàk A. (Czech Republic) Poli A. (Italy) Zambon A. (Italy) Pujia A. (Italy) Zannis V.I.