XIV International Symposium on
Atherosclerosis

Rome, Italy, June 18-22, 2006

CONTENTS

• Address from the Presidents • Scientific Committees • International Advisory Board • Sponsorship
III IV VVII
• Contact Information • General Information • Registration
VIII XI XIII
• How to reach the Symposium Venue • Practical Information • Scientific Program Information • Social Program
XV XVI XVII XXI
• Satellite Symposia • In Grateful Appreciation • Exhibition Floor Map • Exhibitors • Time Table • Scientific Program • Topic Index
XXIII XXVI XXVIII XXIX XXXI XXXIII
199

• 217
• • Author Index

I

Address from the Presidents

On behalf of the XIV International Symposium on ATHEROSCLEROSIS (ISA2006) organizing committee, the International Atherosclerosis Society (IAS), and the Italian Society for the Study of Atherosclerosis (S.I.S.A.), we wish to welcome all our participants, speakers, and presenters to Rome. We are pleased to host our participants, both established investigators and young promising researchers, from more than 70 countries, and hope that your stay in Rome is exciting and rewarding.

The first International Symposium on ATHEROSCLEROSIS was held in 1965, some 40 years ago. Well in the twenty-first century, it is exciting to note the dramatic changes in the perception of the field within the last decade alone and to explore the explosion in the field of atherosclerosis prevention and treatment. The ISA2006 will cover the traditional interests of atherosclerosis specialists, such as lipid/lipoprotein, lipid lowering drugs, diets, and clotting mechanisms as related to lipids, but will also expand the focus to new and exciting areas, which may potentially affect the development of atherosclerosis and ultimately improve patient care. Themes will include obesity, metabolic syndrome, diabetes, AIDS, rheumatoid arthritis, as well as novel diagnostic technologies for arterial disease determination and biochemical traits affecting atherosclerosis development and outcomes.

This very rich scientific program was developed from suggestions originating from the members of the International Advisory Board, the IAS Program Committee, and the Local Scientific Program Committee. Our heartfelt thanks go out to the 184 members from 47 countries and their collaborative efforts in making this such a successful program. We hope that you will find the format of the meeting one that will allow you to participate in as many topics and aspects as you wish through Plenary Sessions, Workshops, Master Lectures, Oral Communications, Posters, and Symposia. The selection of subjects of the scientific sessions has attempted to minimize overlaps and we hope that the program Time Table in the Final Program and the Programme at-a-Glance will help you easily and successfully navigate our meeting and to promote a lively interdisciplinary exchange of ideas.

The scientific sessions in Rome will be enriched and complemented by the pre- and post-meeting satellites throughout Italy (Bologna, Milan, Naples, Parma, and Rome), in Madrid, Spain and Belgrade, Serbia and Montenegro. Each satellite will focus on a single topic which will be covered in great depth by internationally recognized experts in the field.

Last but not the least, a heartfelt thanks is extended to all our sponsors which have supported us throughout all these months not only financially but also with timely suggestions.

We hope that you will enjoy the scientific sessions and the social program and that your visit to Rome will be most rewarding. Do take advantage of all that the city has to offer during your leisure time. You will find information in your registration bag and hostesses are available during the entire meeting in the registration area to help you and your guests. We would like to remind you that places for the Gala Dinner at the beautiful and ancient Complesso Monumentale S. Spirito in Saxia on Tuesday evening are limited: this is yet another opportunity to foster old friendships and forge new collaborations.

Welcome to Rome!

• Cesare R. Sirtori, M.D., Ph.D.
• Elmo Mannarino, M.D.
• Rodolfo Paoletti, M.D., Ph.D

• President
• Vice-President
• Honorary President

III

XIV INTERNATIONAL SYMPOSIUM ON ATHEROSCLEROSIS

Scientific Committees

Congress President: Cesare R. Sirtori (Milan, Italy) Congress Vice-President: Elmo Mannarino (Perugia, Italy) Honorary President: Rodolfo Paoletti (Milan, Italy)

ISA 2006 Local Scientific Program Committee

Alberico L. Catapano (Milan, Italy) Guido Franceschini (Milan, Italy) Cesare R. Sirtori (Milan, Italy) Elena Tremoli (Milan, Italy) Laura Calabresi (Milan, Italy) - Secretary

IAS Program Committee

Jean-Charles Fruchart (Lille, France) Heiner Greten (Hamburg, Germany) Scott M. Grundy (Dallas, TX, USA) Steve Humphries (London, UK) Eran Leitersdorf (Jerusalem, Israel) Ernst J. Schaefer (Boston, MA, USA)

International Atherosclerosis Society (IAS)

President and Website Editor-in-Chief: Scott M. Grundy (Dallas, TX, USA) Past-President: Heiner Greten (Hamburg, Germany)

President-Elect: Jean-Charles Fruchart (Lille, France) Treasurer: Walter F. Riesen (St. Gallen, Switzerland) Secretary: Marja-Riitta Taskinen (Helsinki, Finland) Members-at-Large: Philip Barter (Sydney, Australia), M. John Chapman (Paris, France), Emilio Moriguchi (Porto Alegre, Brazil)

Senior Advisers to the Board: Antonio M. Gotto, Jr. (New York, NY, USA),

Rodolfo Paoletti (Milan, Italy)

President XIV ISA Congress: Cesare R. Sirtori (Milan, Italy)

Regional Federation Chairs: Jean Davignon (Montreal, QC, Canada), Yuji Matsuzawa (Osaka, Japan), S. Lale Tokgözoglu (Ankara, Turkey)

Italian Society for the Study of Atherosclerosis (S.I.S.A.)

President: Elmo Mannarino (Perugia, Italy) Secretary: Arturo Pujia (Catanzaro, Italy) Past President: Alberto Notarbartolo (Palermo, Italy) Executive Committee: Maurizio Averna (Palermo, Italy), Stefano Bertolini (Genoa, Italy) Alberico L. Catapano (Milan, Italy), Luigi Cattin (Trieste, Italy), Davide Lauro (Rome, Italy) Andrea Mezzetti (Chieti, Italy), Paolo Rubba (Naples, Italy), Giovanni B. Vigna (Ferrara, Italy)

IV

International Advisory Board

Abdel-Aziz O. (Egypt) Adlouni A. (Morocco) Agabiti Rosei E. (Italy) Angelin B. (Sweden) Assmann G. (Germany) Auwerx J. (France)
Fellin R. (Italy) Fernández-Britto J.E. (Cuba) Ferrannini E. (Italy) FitzGerald G.A. (USA) Fonseca F.A.H. (Brazil) Forte T. (USA) Fruchart J.-C. (France) Fuster V. (USA)
Averna M. (Italy) Aviram M. (Israel)

• Avogaro A. (Italy)
• Gaddi A.V. (Italy)

Galli C. (Italy) Gensini G.F. (Italy) Gimbrone M.A., Jr. (USA) Ginsberg H.N. (USA) González Santos P. (Spain) Gotlieb A.I. (Canada) Gotto A.M., Jr. (USA) Greten H. (Germany) Grundy S.M. (USA)
Badimon L. (Spain) Ballantyne C.M. (USA) Barter P. (Australia) Beisiegel U. (Germany) Benlian P. (France) Bermúdez F. (Venezuela) Bertolini S. (Italy) Betteridge D.J. (UK) Breslow J.L. (USA) Brewer H.B., Jr. (USA) Brown W.V. (USA)
Guyton J.R. (USA) Hajjar D.P. (USA)

• Calandra S. (Italy)
• Hamsten A. (Sweden)

Hancu N. (Romania) Hanefeld M. (Germany) Hansson G.K. (Sweden) Havekes L.M. (The Netherlands) Humphries S. (UK)
Calvo Monfil C.E. (Chile) Campbell G.R. (Australia) Carmeliet P. (Belgium) Carmena R. (Spain) Carrageta M. (Portugal)

• Cattaneo M. (Italy)
• Iliceto S. (Italy)

Cattin L. (Italy) Ceska R. (Czech Republic) Chait A. (USA) Chandrakasan G. (India) Chapman M.J. (France) Chen M.-F. (Taiwan, R.O.C.) Chiariello M. (Italy) Corsini A. (Italy)
Juhan-Vague I. (France) Kanjuh V. (Serbia and Montenegro) Kastelein J.J.P. (The Netherlands) Katan M.B. (The Netherlands) Kipshidze N.N. (Republic of Georgia) Kisyanto Y. (Indonesia) Kita T. (Japan) Kovanen P. (Finland)

• Lauro D. (Italy)
• Crea F. (Italy)

Crepaldi G. (Italy) Cuevas A.M. (Chile) Curtiss L.K. (USA)
Lauro R. (Italy) Leiter L.A. (Canada) Leitersdorf E. (Israel)

• Libby P. (USA)
• Davignon J. (Canada)

De Backer G. (Belgium) De Caterina R. (Italy) de Gaetano G. (Italy) Dejana E. (Italy) Després J.-P. (Canada) Ding P.Y.-A. (Taiwan, R.O.C.) Djuric D.M. (Serbia and Montenegro) Drexler H. (Germany) Durrington P.N. (UK) Ersanli M. (Turkey) Farese R. (USA)
Licata G. (Italy) Lim-Abrahan M.A. (Philippines) Lin S.-J. (Taiwan, R.O.C.) Lissmann S. (Uruguay) Lüscher T.F. (Switzerland) Mahley R.W. (USA) Mancia G. (Italy) Mancini M. (Italy) Mangelsdorf D. (USA) Manzato E. (Italy) Marais D. (South Africa)

V

Marchioli R. (Italy) Marcovina S.M. (USA) Maseri A. (Italy) Matsuzawa Y. (Japan) McPherson R. (Canada) Mezzetti A. (Italy) Montagnani M. (Italy) Morales D.D. (Philippines) Moriguchi E. (Brazil) Naruszewicz M. (Poland) Nestel P. (Australia) Newby A.C. (UK) Nielsen L.B. (Denmark) Nissen S.E. (USA) Noseda G. (Switzerland) Notarbartolo A. (Italy) Novo S. (Italy) O'Brien R. (Australia) O'Leary D. (USA)
Staels B. (France) Stalenhoef A.F. (The Netherlands) Stein O. (Israel) Stein Y. (Israel) Steiner G. (Canada) Sy R.G. (Philippines) Szollár L.G. (Hungary) Tall A. (USA) Taskinen M.-R. (Finland) Tavassoli A. (Iran) Tesone P.A. (Argentina) Tikkanen M.J. (Finland) Tokgözoglu L. (Turkey) Tonkin A. (Australia) Turay J. (Slovak Republic) Tybjærg-Hansen A. (Denmark) Uauy R. (UK and Chile) Utermann G. (Austria) Vella S. (Italy)
Olsson A.G. (Sweden) Packard C.J. (UK) Pagnan A. (Italy)
Vigna G.B. (Italy) Violi F. (Italy) Volpe M. (Italy)
Park J.E. (Korea) Patrono C. (Italy) Patsch J. (Austria) Pedersen T.R. (Norway) Pitt B. (USA) Poledne R. (Czech Republic) Poli A. (Italy) von Eckardstein A. (Switzerland) Wenger N.K. (USA) Yamashita S. (Japan) Yang Y. (China) Ylä-Herttuala S. (Finland) Zàk A. (Czech Republic) Zambon A. (Italy)
Pujia A. (Italy) Rader D.J. (USA)
Zannis V.I. (USA) Zhu J.-R. (China)
Reddy K.S. (India) Reiner Z. (Croatia) Ricci G. (Italy) Riesen W.F. (Switzerland) Rubba P. (Italy) Rubinstein A. (Israel) Rye K.-A. (Australia) Sacks F.M. (USA) Sansoy V. (Turkey) Santamarina-Fojo S. (USA) Sarrafzadegan N. (Iran) Schaefer E.J. (USA) Schneider W.J. (Austria) Scott J. (UK) Shepherd J. (UK) Sierra Ariza I.D. (Colombia) Smirnov V. (Russia) Smith S.C., Jr. (USA) Sniderman A. (Canada) Soltero I.F. (Venezuela)

VI

Sponsorship

•

American Heart Association: Council for High Blood Pressure Research Council on Arteriosclerosis, Thrombosis, and Vascular Biology Council on Basic Cardiovascular Sciences Council on Clinical Cardiology Council on Epidemiology and Prevention Council on the Kidney in Cardiovascular Disease Council on Nutrition, Physical Activity, and Metabolism European Association for the Study of Diabetes (EASD) European Federation for Internal Medicine (EFIM) European Renal Association, European Dialysis and Transplant Association (ERA-EDTA) European Society for Clinical Investigation (ESCI) European Society of Hypertension (ESH) European Union Geriatric Medicine Society (EUGMS) International Association of Gerontology (IAG) International Conference on the Bioscience of Lipids (ICBL) International Diabetes Federation (IDF) International Society for the Study of Fatty Acids and Lipids (ISSFAL) International Society of Hypertension (ISH) International Society on Thrombosis and Haemostasis (ISTH) International Task Force for Prevention of Coronary Heart Disease International Therapeutics Society (ITS)

••••••••••••••••••••••••••••••••••••••••

International Union of Angiology (I.U.A.) Italian Association for the Study of the Liver (A.I.S.F.) Italian Association of Hospital Cardiologists (ANMCO) Italian Diabetologists Association (AMD) Italian Federation of Cardiology (FIC) Italian Heart Foundation (FIpC) Italian Out-Patient Cardiologists Association (ANCE) Italian Society for Cardiovascular Prevention (SIPREC) Italian Society for the Study of Haemostasis and Thrombosis (SISET) Italian Society of Allergy and Clinical Immunology (SIAIC) Italian Society of Biochemistry and Molecular Biology (SIB) Italian Society of Cardiology (SIC) Italian Society of Clinical Biochemistry and Clinical Biology (SIBioC) Italian Society of Experimental and Clinical Therapy (S.I.Te.C.S.) Italian Society of Gerontology and Geriatrics (SIGG) Italian Society of Hypertension (SIIA) Italian Society of Immunology, Clinical Immunology, and Allergology (SIICA) Italian Society of Internal Medicine (SIMI) Italian Society of Nephrology (SIN) Italian Society of Neurology (SIN) Italian Society of Pharmacology (SIF) The American Society of Hypertension (ASH) The Federation of European Pharmacological Societies (EPHAR) Vascular - Independent Research and Education - European Organisation (VAS) World Federation of Neurology (WFN) World Heart Federation (WHF)

VII

Contact Information

Scientific-Organizing Secretariat

FONDAZIONE GIOVANNI LORENZINI MEDICAL SCIENCE FOUNDATION ISA 2006

Via A. Appiani 7 20121 MILAN (ITALY) Phone: (+39) 02 29006267 Fax: (+39) 02 29007018 E-mail: [email protected]

GIOVANNI LORENZINI MEDICAL FOUNDATION ISA 2006

6535 Fannin, M.S. A-601 HOUSTON, TEXAS 77030 (USA) Phone: (+1) 713 797 0401 Fax: (+1) 713 796 8853 E-mail: [email protected]

Local-Organizing Secretariat

For registrations, housing bureau, travel agency, exhibition management:

AISC & MGR-AIM GROUP Milan office

Via G. Ripamonti 129 20141 MILAN (ITALY) Phone: (+39) 02 566011 Fax: (+39) 02 70048584 E-mail: [email protected]

Rome office

Via A. Ristori 38 00197 ROME (ITALY) Phone: (+39) 06 809681 Fax: (+39) 06 8088491 E-mail: [email protected]

VIII

AstraZeneca has an established heritage in cardiovascular medicine and currently offers a comprehensive portfolio of products. In particular, these medicines aim to reduce the risk, prevalence and impact of:

• Hypertension • Heart failure • Dyslipidaemia • Diabetic complications

AstraZeneca has an extensive research pipeline of new cardiovascular products with emphasis on the treatment of:

• Thromboembolic disorders • Type 2 diabetes/the metabolic syndrome

For latest news and more information, please visit

InCirculation.net and AstraZeneca.com

AstraZeneca, Mölndal, Sweden

GROWTH ISN’T JUST ABOUT GETTING BIGGER, IT’S ABOUT WORKING TOGETHER.

General Information

Venue

The Symposium is held at:

FIERA DI ROMA

VIA C. COLOMBO, 293 00147 ROME, ITALY

Secretariat and Registration Desk

The pre-registration and on-site registration desks are open as follows: Sunday, June 18 Monday, June 19 Tuesday, June 20 Wednesday, June 21 Thursday, June 22
7.30 am – 8.30 pm 7.30 am – 7.00 pm 7.30 am – 7.00 pm 7.30 am – 7.00 pm 7.30 am – 5.00 pm

In the Registration/Secretariat Area the following services are available: • Pre-Registration • On-site Registration • Invited Speakers Desk • ISA 2006 Secretariat • ECM/CME Credits • Information • Local Agency:

-----

Hotel Booking Travel Transfers - Shuttle Bus Social Program and Rome Tours Car Rental

Mobile Phones, Beepers, and Electronic Devices

Delegates are kindly requested to turn off their mobile phones, beepers, and other electronic devices during all scientific sessions.

Slide Library

A Slide Library of key selected presentations will be available after the Symposium on www.isa2006.org, www.athero.org, and www.lorenzinifoundation.org

Internet Point

An Internet Point is offered to participants during the Symposium. The Internet Point will be equipped with computers, printers and Internet connections and is located in the Exhibition Area. Supported in part by an unrestricted educational grant from Sankyo Pharma Inc. and Sankyo Co. Ltd.

Symposium Website

Home page for the ISA 2006 Symposium is: www.isa2006.org

Message Center

A computerized and staffed Message Center is located at Booth F1. Attendees will be able to deliver and collect personal messages from fellows attendees at the Message Center. Hours of operation are from Monday, June 19 to Thursday, June 22 from 9.00 am to 5.00 pm. Supported in part by an unrestricted educational grant from Takeda Italia Farmaceutici S.p.A.

XI

Insurance

Registration for the Symposium implies that the delegate agrees that neither the IAS (International Atherosclerosis Society), ISA 2006 Committee, nor the Fondazione Giovanni Lorenzini (Milan and Houston) assume any liability or responsibility whatsoever. Symposium delegates are requested to make their own arrangements for medical, travel, and personal insurance.

Official Language

The official language of the Symposium is English. Simultaneous translation is not provided.

Press Office

A press office is available in the Symposium Venue (in the building where Room 2 and Room 5 are located). Journalists and interested participants may refer to the Press Office for more information about press material and press conferences.

Scientific Exhibition

During the Symposium an exhibition of pharmaceuticals, instruments, publishing, and suppliers of medical technology is held in the Exhibition Area. Exhibition hours will be the following:

I

I

I

I

I

Sunday, June 18: Monday, June 19: Tuesday, June 20: Wednesday, June 21: Thursday, June 22:
1.30 pm – 8.30 pm 8.30 am – 6.30 pm 8.30 am – 6.30 pm 8.30 am – 6.30 pm 8.30 am – 4.30 pm

Cloakroom

A cloakroom will be at the disposal of all participants in the Symposium Venue in the Registration Area, free of charge. Delegates will be kindly requested not to leave their personal belongings after closing-time.

XII

Registration

Only registered participants may attend the scientific sessions and the social events offered by the Symposium.

REGISTRATION FEES (all amounts given in Euros, VAT 20% included)

• Participant
• € 690,00

€ 380,00 € 150,00
Student/Nurse* Accompanying Person

* Student/Nurse registration rates will be granted only to those who document their position by presenting an official statement from the head of their Department or Institution or a copy of their license.

Participants and Students/Nurses are entitled to:

• receive Final Program and Abstract Book • attend all Scientific Sessions • attend the Opening Ceremony of the Symposium and the Welcome Reception • Box Lunches and Coffee Breaks from June 19 to June 22 included • Shuttle Bus from the ISA 2006 Symposium Hotels (booked through the Congress) to the Symposium Venue
• Shuttle Bus from Basilica S. Paolo underground station to the Symposium Venue.

Accompanying Persons are entitled to:

• attend the Welcome Reception • ticket for the Tour • Shuttle Bus from the ISA 2006 Symposium Hotels (booked through the Congress) to the Symposium Venue
• Shuttle Bus from Basilica S. Paolo underground station to the Symposium Venue.

SOCIAL PROGRAM (all amounts given in Euros, VAT 20% included)

• Date
• Place
• Fees

Welcome Reception

Concert

June 18, 2006 h. 7.30 pm

• Fiera di Roma
• Complimentary

June 19, 2006 h. 8.00 pm
Basilica Santa Maria degli Angeli e dei Martiri
€ 30,00

Gala Dinner

June 20, 2006 h. 8.00 pm
Complesso Monumentale di Santo Spirito in Saxia (Borgo S.Spirito)
€ 95,00

Tour

(for accompanying persons only)
June 19, 2006 h. 9.00 am
Tour of San Pietro in Vincoli and San Clemente Church
Complimentary

XIII

For Italian Participants Only

All the Italian participants with the VAT/IVA number must indicate this number (and the corresponding address) in the registration form (DPR 633/72).

The regular invoice for the registration will be sent only to those who have indicated the fiscal code and/or the IVA number (compulsory if available) of the actual payer.

Privacy Law

The personal data will be handled exclusively by ISA 2006 Committee according to the law 675/96 and law decree 196/2003.

Name Changes

Name changes on site are charged a handling fee of € 30,00 (VAT 20% included).

Badges

The official badge must be worn for admission to all scientific sessions and other activities of the Symposium. Accompanying persons can attend the Opening Ceremony and Welcome Reception but they are not entitled to attend the scientific sessions. Lost badges are replaced for a handling fee of € 30,00 (VAT 20% included) with proof of the original registration.

Badges will show different colours:
• Invited Speakers and Chairs • Participants

RED

TRANSPARENT

GREEN

• Students • Exhibitors • Accompanying Persons

BLUE

YELLOW

Box Lunches

On June 19, 20, 21 and 22, from 12.30 to 2.30 pm box lunches will be offered in the Catering Areas No.: 1-2-4-7 to participants. Daily box lunch tickets wil be found in the Symposium badge.