CLK3 Monoclonal Antibody (M04), Clone 5B2

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CLK3 monoclonal antibody (M04), clone 5B2 Catalog # : H00001198-M04 規格 : [ 100 ug ] List All Specification Application Image Product Mouse monoclonal antibody raised against a partial recombinant CLK3. Western Blot (Cell lysate) Description: Immunogen: CLK3 (AAH02555, 36 a.a. ~ 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence: YPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGED YYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSS enlarge KRSSRSV Western Blot (Recombinant protein) Host: Mouse Immunohistochemistry Reactivity: Human (Formalin/PFA-fixed paraffin- embedded sections) Isotype: IgG2b Kappa Quality Control Antibody Reactive Against Recombinant Protein. Testing: enlarge Immunofluorescence enlarge Western Blot detection against Immunogen (36.74 KDa) . ELISA Storage Buffer: In 1x PBS, pH 7.4 Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. Instruction: MSDS: Download Datasheet: Download Applications Western Blot (Cell lysate) Page 1 of 3 2016/5/20 CLK3 monoclonal antibody (M04), clone 5B2 Western Blot analysis of CLK3 expression in MCF-7 ( Cat # L046V1 ). Protocol Download Western Blot (Recombinant protein) Protocol Download Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) enlarge this image Immunoperoxidase of monoclonal antibody to CLK3 on formalin-fixed paraffin-embedded human testis. [antibody concentration 1.5 ug/ml] Protocol Download Immunofluorescence enlarge this image Immunofluorescence of monoclonal antibody to CLK3 on HeLa cell. [antibody concentration 10 ug/ml] Protocol Download ELISA Gene Information Entrez GeneID: 1198 GeneBank BC002555 Accession#: Protein AAH02555 Accession#: Page 2 of 3 2016/5/20 Gene Name: CLK3 Gene Alias: FLJ22858,PHCLK3,PHCLK3/152 Gene CDC-like kinase 3 Description: Omim ID: 602990 Gene Ontology: Hyperlink Gene Summary: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq Other dual specificity protein kinase CLK3 Designations: 服務條款 | 隱私權政策 | 著作及商標 | 網站地圖 ©2016 亞諾法生技股份有限公司 Abnova Corporation. 版權所有. Page 3 of 3 2016/5/20.

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A Genome-Wide Association Study of Bisphosphonate-Associated
Calcifed Tissue International (2019) 105:51–67 https://doi.org/10.1007/s00223-019-00546-9 ORIGINAL RESEARCH A Genome‑Wide Association Study of Bisphosphonate‑Associated Atypical Femoral Fracture Mohammad Kharazmi1 · Karl Michaëlsson1 · Jörg Schilcher2 · Niclas Eriksson3,4 · Håkan Melhus3 · Mia Wadelius3 · Pär Hallberg3 Received: 8 January 2019 / Accepted: 8 April 2019 / Published online: 20 April 2019 © The Author(s) 2019 Abstract Atypical femoral fracture is a well-documented adverse reaction to bisphosphonates. It is strongly related to duration of bisphosphonate use, and the risk declines rapidly after drug withdrawal. The mechanism behind bisphosphonate-associated atypical femoral fracture is unclear, but a genetic predisposition has been suggested. With the aim to identify common genetic variants that could be used for preemptive genetic testing, we performed a genome-wide association study. Cases were recruited mainly through reports of adverse drug reactions sent to the Swedish Medical Products Agency on a nation- wide basis. We compared atypical femoral fracture cases (n = 51) with population-based controls (n = 4891), and to reduce the possibility of confounding by indication, we also compared with bisphosphonate-treated controls without a current diagnosis of cancer (n = 324). The total number of single-nucleotide polymorphisms after imputation was 7,585,874. A genome-wide signifcance threshold of p < 5 × 10−8 was used to correct for multiple testing. In addition, we performed candidate gene analyses for a panel of 29 genes previously implicated in atypical femoral fractures (signifcance threshold of p < 5.7 × 10−6). Compared with population controls, bisphosphonate-associated atypical femoral fracture was associated with four isolated, uncommon single-nucleotide polymorphisms.
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CLK3 Antibody A
Revision 1 C 0 2 - t CLK3 Antibody a e r o t S Orders: 877-616-CELL (2355) [email protected] Support: 877-678-TECH (8324) 6 5 Web: [email protected] 2 www.cellsignal.com 3 # 3 Trask Lane Danvers Massachusetts 01923 USA For Research Use Only. Not For Use In Diagnostic Procedures. Applications: Reactivity: Sensitivity: MW (kDa): Source: UniProt ID: Entrez-Gene Id: WB, IF-IC H M R Mk Endogenous 59, 17 Rabbit P49761 1198 Product Usage Information 7. Becker, W. et al. (1996) Biochim. Biophys. Acta 1312, 63-67. 8. Duncan, P.I. et al. (1998) Exp. Cell Res. 241, 300-308. Application Dilution Western Blotting 1:1000 Immunofluorescence (Immunocytochemistry) 1:25 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. Specificity / Sensitivity CLK3 Antibody detects endogenous levels of full-length and truncated forms of CLK3 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr61 of human CLK3 (P49761-1). Antibodies were purified by protein A and peptide affinity chromatography. Background The cdc2-like kinase (CLK) family contains at least four highly conserved isoforms: CLK1, CLK2, CLK3 and CLK4 (1,2). CLKs are dual specificity kinases that autophosphorylate on serine, threonine and tyrosine residues and phosphorylate exogenous substrates on serine and threonine residues (2). CLK family members exist as both a full-length catalytically active form and an alternatively-spliced, inactive truncated form (1).
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