DOCSLIB.ORG

Poster Session 1: Tuesday, July 16, 4:30—6:30 PM

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Poster Session 1: Tuesday, July 16, 4:30—6:30 PM Poster Session 1: Tuesday, July 16, 4:30—6:30 PM In Vitro Buccal Membrane Absorption (IVBMA) Model for Tobacco Constituent Testing: Membrane Integrity Assays. Margaret Kraeling1, Rebecca Justiniano1, Cory Vaught1, Dana Lauterstein2, Juan Crespo-Barreto2, Robert Sprando1, Roxana P101-0073 Weil2, Raymond Yeager2, Jeffrey Yourick1. 1US FDA/CFSAN, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Laurel, MD, The United States of America. 2US FDA, Center for Tobacco Products, Office of Science, White Oak, MD, The United States of America The Interchangeability of In Vitro Key Event–Based Skin Sensitization Assays—Impact on Defined Approaches. Donna P102-0162 Macmillan1, Martyn Chilton1. 1Lhasa Limited, Granary Wharf House, Leeds, United Kingdom Transcriptional Profiling of Cytochrome P450 Genes in Adult Liver and in Whole Embryo Fry of Zebrafish in Some Developmental Stages. Hiroki Teraoka1, Natsumi Yamashita1, Yusuke Kawai2, Shuangyi Zhang1, Takio Kitazawa1, Akira P103-0219 Kubota2. 1Rakuno Gakuen University, School of Veterinary Medicine, Ebetsu, Japan. 2Obihiro University of Agriculture and Veterinary Medicine, Department of Veterinary Medicine, Obihiro, Japan Evaluation of Skin Barrier Protection Effect of Lactobacillus rhamnosus GG Using. 3D Reconstructed Skin Model. Ye-On P104-0253 Jung1, Kyung-Min Lim1, Haengdueng Jeong2, Yejin Cho2, Kitaek Nam2. 1Ewha Womans University, College of Pharmacy, Seoul, The Republic of Korea. 2Yonsei University, College of Medicine, Seodaemungu, The Republic of Korea Using C. elegans for Predictive Oral Toxicity Assessments. Piper Hunt1, Robert Sprando1. 1US FDA/CFSAN, Center for Food P105-0274 Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, Laurel, MD, The United States of America Cytotoxicity Differences of Troglitazone on HepG2 and CD133 Liver Cancer Stem Cells. Quanjun Wang1. 1Beijing Institute P106-0353 of Pharmacology and Toxicology, Beijing Institute of Pharmacology and Toxicology, Beijing, China Novel Deep Learning Methodology to Enable Drug-Induced Abnormality Detection Using Cultured Neurons on Microelectrode Arrays. Norimasa Miyamoto1, Atsuko Ojima2, Tetsuo Kitamura3, Tomoharu Osada4, Ikuro Suzuki5, Takashi Yoshinaga1. 1Eisai Co., Ltd., Global Cardiovascular Assessment, Tsukuba, Japan. 2TechnoPro R&D, Company, TechnoPro, Inc., P107-0367 Tsukuba Branch, Tsuchiura, Japan. 3LSI Medience Corporation, Safety Assessment Department, Nonclinical Research Center, Kamisu, Japan.. 4LSI Medience Corporation, Advanced Medical Business Development Department, Chiyoda, Japan. 5Tohoku Institute of Technology, Department of Electronics, Sendai, Japan Tris(1,3-Dichloro-2-Propyl) Phosphate Exposure during Early Development Alters the Normal Trajectory of Zebrafish P108-0369 Embryogenesis. Subham Dasgupta1, Vanessa Cheng1, Sara Frie Vliet1, Constance Mitchell1, David Volz1. 1University of California Riverside, Environmental Sciences, Riverside, CA, The United States of America A β-Galactosidase-Expressing E. coli Culture as an Alternative Test to Identify Skin Sensitizers and Nonsensitizers. Mahesh P109-0373 Nepal1, Dong Ho Cha1, Geon Ho Kim1, Mi Jeong Kang1, Doo Hyun Nam1, Tae Cheon Jeong1. 1Yeungnam University, Pharmacy, Gyeongsan, The Republic of Korea A Simple In Chemico Method for Testing Skin-Sensitizing Potential of Chemicals Using Small Endogenous Molecules. P110-0381 Mahesh Nepal1, Dong Ho Cha1, Geon Ho Kim1, Mi Jeong Kang1, Tae Cheon Jeong1. 1Yeungnam University, Pharmacy, Gyeongsan, The Republic of Korea 1 1 1 1 PM2.5 Induced Adverse Effect on Life Span of Caenorhabditis elegans. Guojun Li , Wenjing Zhang , Zinan Li , Nan Zhang , P111-0382 Haiming Jing1, Shan Gao1, Junyu Ning1. 1Beijing Center for Disease Prevention and Control/Beijing Research Center for Preventive Medicine/Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing, China Effects of Cyanobacterial Bloom Metabolites on NSC Survival and Differentiation In Vitro. Barbara Kubickova1, Marie Smutna1, Dasa Bohaciakova2, Klara Hilscherova1. 1Masaryk University, Research Centre for Toxic Compounds in the P112-0409 Environment, Brno, The Czech Republic. 2Masaryk University, Department of Histology and Embryology, Brno, The Czech Republic Effects of Electrical Stimulation on Human iPSC-CMs Responses to Cardiac Ion Channel Blockers. Li Pang1, Feng Wei1, Norman Stockbridge2. 1US FDA/NCTR, Division of Systems Biology, Jefferson, AR, The United States of America. 2US P113-0432 FDA/CDER, Division of Cardiovascular and Renal Products, Office of New Drugs I, Silver Spring, MD, The United States of America mRNA-Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish. Aalekhya P114-0445 Reddam1, Constance Mitchell1, Subham Dasgupta1, David Volz1. 1University of California Riverside, Department of Environmental Sciences, Riverside, CA, The United States of America Inhibitory Effect of Acremonidin E on Melanogenesis Using B16F10 Melanoma Cells and Pigmented. 3D Human Skin P115-0503 Model. Kyuri Kim1, Hanseul Park1, Kyung-Min Lim1. 1Ewha Womans University, College of Pharmacy, Seoul, The Republic of Korea Employment of Cytological Assessment of Skin Irritancy for. 3D Reconstructed Human Epidermis Model. Jee-Hyun P116-0508 Hwang1, Kyung-Min Lim1, Kitaek Nam2. 1Ewha Womans University, College of Pharmacy, Seoul, The Republic of Korea. 2Yonsei University, College of Medicine, Seodaemungu, The Republic of Korea Altered Lipid Profiles in the Skin and Liver of db/db Mice. Minjeong Kim1, Kyung-Min Lim1. 1Ewha Womans University, P117-0519 College of Pharmacy, Seoul, The Republic of Korea Establishment of a GFP Reporter THP-1 Cell Line under the Control of Endogenous Interleukin-8 Promoter. Akira Aoki1, Ryoya Kawai1, Yoshinori Okamoto1, Koji Ueda1, Takashi Isobe2, Susumu Ohkawara2, Nobumitsu Hanioka2, Toshiko Tanaka- P118-0528 Kagawa2, Hideto Jinno1. 1Meijo University, Faculty of Pharmacy, Nagoya, Japan. 2Yokohama University of Pharmacy, Department of Kampo Pharmacy and Health Pharmacy, Yokohama, Japan Predictive Capacity of Combined Methods for Tiered Approach on Evaluation of Eye Irritation. Jy Kim1, HyeLyun Jeon1, P119-0538 AhRang Cho1, Joohwan Kim1, KyungYuk Ko1, JungSun Yi1, Hak Kim1, TaeSung Kim1, KiSook Park1. 1National Institute of Food and Drug Safety Evaluation, Toxicological Screening and Testing Division, Cheongju, The Republic of Korea Multigenerational Epigenetic Effect of Deoxynivalenol in Caenorhabditis elegans. Lili Tang1, Jia-Sheng Wang1. 1University P120-0629 of Georgia, Enviornmental Health Science, Athens, GA, The United States of America Documenting International Acute Systemic Toxicity Testing Requirements to Facilitate Increased Acceptance of Nonanimal Approaches. Esther Haugabrooks 1, Kristie Sullivan2. 1Physicians Committee for Responsible Medicine, Research P121-0632 & Regulatory Affairs, Washington, DC, The United States of America. 2Physicians Committee for Responsible Medicine, Research and Regulatory Affairs, Washington, DC, The United States of America Aberrant Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Disrupts Dorsoventral Patterning during P122-0642 Early Zebrafish Embryogenesis. Vanessa Cheng1, Aalekhya Reddam1, Subham Dasgupta1, David Volz1. 1University of California Riverside, Department of Environmental Sciences, Riverside, CA, The United States of America Toxic Effects of Six Essential Oils on the Biological Model Caenorhabditis elegans. Leonor Cervantes-Ceballos1, Liset Mallarino-Miranda2, Lesly Tejeda-Benitez3, Harold Gomez Estrada4, Nayelhi Sarmiento Beleño4. 1Universidad de Cartagena, P123-0654 Facultad de Ciencias Farmacéuticas, Cartagena, Colombia. 2Universidad de Cartagena, Facultad de Ingenieria, Cartagena, Colombia. 3Universidad de Cartagena, Facultad de Ingeniería, Cartagena, Colombia. 4Universidad de Cartagena, Facultad de Ciencias Farmaceuticas, Cartagena, Colombia Modernizing Biocompatibility Testing: Replacing Animal Tests through the United States Food and Drug Administration P124-0658 (US FDA) Center for Devices and Radiological Health (CDRH) Medical Devices Development Tools (MDDT) Program. Jeffrey Brown1. 1PETA International Science Consortium Ltd., London, United Kingdom Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure: Abamectin as a Case Study. Jane LaDu1, Michelle Balik-Meisner2, Elizabeth Scholl2, Lisa Truong1, David Reif2, Robert P125-0664 Tanguay1. 1Oregon State University, Environmental and Molecular Toxicology, Corvallis, OR, The United States of America. 2NC State University, Bioinformatics Research Center and Departments of Statistics and Biological Sciences, Raleigh, NC, The United States of America Identification and Characterization of Long Non-coding RNAs in Caenorhabditis elegans Exposed to Mixture of Aflatoxin 1 1 1 1 P126-0675 B1 and Fumonisin B1. Kathy Xue , Lili Tang , Jia-Sheng Wang . University of Georgia, Environmental Health Sciences, Athens, GA, The United States of America Statistical Analysis of Me-Too Validation Study on Alternative Test Method for Eye Irritation, MCTT HCE. Song E Lim1, P127-0683 Kyung-Min Lim1, SeungJin Bae2. 1Ewha Womans University, College of Pharmacy, Seoul, The Republic of Korea. 2Ewha Womans University, College of Pharmacy, Seoul, The Republic of Korea Pioneering Better Science to Advance the. 3Rs in Acute Toxicity Testing. Nikki Gellatly1, Natalie Burden1, Helen Prior1, P128-0722
Load more

Recommended publications
  • Inventory of Toxic Plants in Morocco: an Overview of the Botanical, Biogeography, and Phytochemistry Studies
    Hindawi Journal of Toxicology Volume 2018, Article ID 4563735, 13 pages https://doi.org/10.1155/2018/4563735 Review Article Inventory of Toxic Plants in Morocco: An Overview of the Botanical, Biogeography, and Phytochemistry Studies Hanane Benzeid , Fadma Gouaz, Abba Hamadoun Touré, Mustapha Bouatia , Mohamed Oulad Bouyahya Idrissi, and Mustapha Draoui LaboratoiredeChimieAnalytiqueetdeBromatologie,FacultedeM´ edecine´ et de Pharmacie, Universite´ Mohamed V, Rabat, Morocco Correspondence should be addressed to Hanane Benzeid; [email protected] Received 10 December 2017; Revised 22 February 2018; Accepted 25 March 2018; Published 3 May 2018 Academic Editor: Orish Ebere Orisakwe Copyright © 2018 Hanane Benzeid et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Since they are natural, plants are wrongly considered nondangerous; therefore people used them in various contexts. Each plant is used alone or in mixture with others, where knowledge and the requirements of preparation and consumption are not mastered. Tus, intoxications due to the use of plants have become more and more frequent. Te reports of intoxications made at the Antipoison Center and Pharmacovigilance of Morocco (ACPM) support this fnding, since the interrogations sufered by the victimsshowthattheuseofplantsispracticedirrationally,anarchically, and uncontrollably. Faced by the increase of these cases of poisoning in Morocco, it seemed necessary to investigate the nature of poisonous plants, their monographs, and the chemicals responsible for this toxicity. 1. Introduction Tus, we thought it is necessary to study the nature of these poisonous plants and their monographs. Sinceimmemorialtime,thehumanhasusedplants,frstto feed himself and then to heal himself.
    [Show full text]
  • Veterinary Toxicology
    GINTARAS DAUNORAS VETERINARY TOXICOLOGY Lecture notes and classes works Study kit for LUHS Veterinary Faculty Foreign Students LSMU LEIDYBOS NAMAI, KAUNAS 2012 Lietuvos sveikatos moksl ų universitetas Veterinarijos akademija Neužkre čiam ųjų lig ų katedra Gintaras Daunoras VETERINARIN Ė TOKSIKOLOGIJA Paskait ų konspektai ir praktikos darb ų aprašai Mokomoji knyga LSMU Veterinarijos fakulteto užsienio studentams LSMU LEIDYBOS NAMAI, KAUNAS 2012 UDK Dau Apsvarstyta: LSMU VA Veterinarijos fakulteto Neužkre čiam ųjų lig ų katedros pos ėdyje, 2012 m. rugs ėjo 20 d., protokolo Nr. 01 LSMU VA Veterinarijos fakulteto tarybos pos ėdyje, 2012 m. rugs ėjo 28 d., protokolo Nr. 08 Recenzavo: doc. dr. Alius Pockevi čius LSMU VA Užkre čiam ųjų lig ų katedra dr. Aidas Grigonis LSMU VA Neužkre čiam ųjų lig ų katedra CONTENTS Introduction ……………………………………………………………………………………… 7 SECTION I. Lecture notes ………………………………………………………………………. 8 1. GENERAL VETERINARY TOXICOLOGY ……….……………………………………….. 8 1.1. Veterinary toxicology aims and tasks ……………………………………………………... 8 1.2. EC and Lithuanian legal documents for hazardous substances and pollution ……………. 11 1.3. Classification of poisons ……………………………………………………………………. 12 1.4. Chemicals classification and labelling ……………………………………………………… 14 2. Toxicokinetics ………………………………………………………………………...………. 15 2.2. Migration of substances through biological membranes …………………………………… 15 2.3. ADME notion ………………………………………………………………………………. 15 2.4. Possibilities of poisons entering into an animal body and methods of absorption ……… 16 2.5. Poison distribution
    [Show full text]
  • PSYCHEDELIC DRUGS (P.L) 1. Terminology “Hallucinogens
    PSYCHEDELIC DRUGS (p.l) 1. Terminology “hallucinogens” – induce hallucinations, although sensory distortions are more common “psychotomimetics” – to minic psychotic states, although truly most drugs in this class do not do so “phantasticums”or “psychedelics” – alter sensory perception (Julien uses “psychedelics”) alterations in perception, cognition, and mood, in presence of otherwise clear ability to sense” may increase sensory awareness, increase clarity, decrease control over what is sensed/experienced “self-A” may feel a passive observer of what “self-B” is experiencing often accompanied by a sense of profound meaningfulness, of divine or cosmic importance (limbic system?) these drugs can be classified by what NT they mimic: anti-ACh, agonists for NE, 5HT, or glutamate (See p. 332, Table 12.l in Julien, 9th Ed.) 2. The Anti-ACh Psychedelics e.g. scopolamine (classified as an ACh blocker) high affinity, no efficacy plant product: Belladonna or “deadly nightshade” (Atropa belladonna) Datura stramonium (jimson weed, stinkweed) Mandragora officinarum (mandrake plant) pupillary dilation (2nd to atropine) PSYCHEDELIC DRUGS (p.2) 2. Anti-ACh Psychedelics (cont.) pharmacological effects: e.g. scopolamine (Donnatal) clinically used to tx motion sickness, relax smooth muscles (gastric cramping), mild sedation/anesthetic effect PNS effects --- dry mouth relaxation of smooth muscles decreased sweating increased body temperature blurred vision dry skin pupillary dilation tachycardia, increased BP CNS effects --- drowsiness, mild euphoria profound amnesia fatigue decreased attention, focus delirium, mental confusion decreased REM sleep no increase in sensory awareness as dose increases --- restlessness, excitement, hallucinations, euphoria, disorientation at toxic dose levels --- “psychotic delirium”, confusion, stupor, coma, respiratory depression so drug is really an intoxicant, amnestic, and deliriant 3.
    [Show full text]
  • The Phytochemistry of Cherokee Aromatic Medicinal Plants
    medicines Review The Phytochemistry of Cherokee Aromatic Medicinal Plants William N. Setzer 1,2 1 Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected]; Tel.: +1-256-824-6519 2 Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA Received: 25 October 2018; Accepted: 8 November 2018; Published: 12 November 2018 Abstract: Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines. Keywords: Cherokee; Native American; traditional herbal medicine; chemical constituents; pharmacology 1. Introduction Natural products have been an important source of medicinal agents throughout history and modern medicine continues to rely on traditional knowledge for treatment of human maladies [1]. Traditional medicines such as Traditional Chinese Medicine [2], Ayurvedic [3], and medicinal plants from Latin America [4] have proven to be rich resources of biologically active compounds and potential new drugs.
    [Show full text]
  • Common Poisonous Plants in Sri Lanka
    COMMON POISONOUS PLANTS IN SRI LANKA ATHTHNA (THORN APPLE) Most poisonous flowers/ stem/ fruit/ leaves/roots Fatal dose: 50-75 seeds Botanical Name: Datura stramonium Toxin: Belladonna alkaloids (atropine, hyoscine and hyoscyamine) CIRCUMSTANCES OF DATURA POISONING Stupefying purpose Mixed with cigarettes produce state of unconsciousness to facilitate robbery & rape mixed with sweets (gingerly) robbery & rape Accidental poisoning: Children Suicidal Homicidal : very rare DATURA POISONING SIGNS & SYMPTOMS Produce characteristic manifestations of anticholinergic poisoning Dryness of mouth Autopsy findings Dysphagia Seeds in stomach & non specific Dysarthria features Diplopia Dry hot and red skin Drowsiness leading to coma Urinary retention Death : respiratory failure or cardiac arrhythmia DIVI KADURU (EVE’S APPLE) Most poisonous / latex/ fruit/ seeds Botanical Name: Pagiy antha dicotoma Botanical Name: Tabernaemanta dicotoma Toxin: alkaloids/ strychnine SIGNS & SYMPTOMS OF DIVI KADURU POISONING White latex : inflammation of eye Ingestion : dryness of mucus membranes, thirst, dilataiton of pupils, rapid pulse, psychomotor disturbances, hallucinogenic effects. Autopsy findings Accidental poisonin g: Children Seeds in stomach & non specific Suicidal poisoning features GODA KADURU (BITTER NUT) Most poisonous: Seed (although all parts toxics) Fatal dose: 1-2 seeds Botanical Name: Strychnos nux vomica Toxin: alkaloids ( strychnine/ brucine) CIRCUMSTANCES OF GODA KADURU POISONING Strychnine injections are used to kill stray dogs/
    [Show full text]
  • Technical Guidance for the Classification of Copper Metal Under the Globally Harmonized System for Classification and Labelling of Chemicals (GHS)
    Technical Guidance for the Classification of Copper Metal Under the Globally Harmonized System for Classification and Labelling of Chemicals (GHS) Prepared with International Copper Association (ICA) January 21, 2020 Table of Contents Page Executive Summary .................................................................................................................... ES-1 1 Introduction and Scope ....................................................................................................... 1 2 Physical Hazard Classifications............................................................................................ 5 2.1 Summary of Physical Hazard Classifications ........................................................... 6 2.2 Combustible Dust Considerations for Copper Metal .............................................. 7 2.2.1 Dust Particle Size ......................................................................................... 8 3 GHS Human Health Hazard Classifications ......................................................................... 9 3.1 Copper Massive ..................................................................................................... 11 3.2 Copper Powder ..................................................................................................... 15 3.3 Coated Copper Flakes ........................................................................................... 21 3.4 Summary of GHS Human Health Hazard Classifications ....................................... 26 4 GHS Environmental
    [Show full text]
  • Effects of Copper on Fish and Aquatic Resources
    Effects of Copper on Fish and Aquatic Resources Prepared for By Dr. Carol Ann Woody & Sarah Louise O’Neal Fisheries Research and Consulting Anchorage, Alaska June 2012 Effects of Copper on Fish and Aquatic Resources Introduction The Nushagak and Kvichak river watersheds in Bristol Bay Alaska (Figure 1) together produced over 650 million sockeye salmon during 1956-2011, about 40% of Bristol Bay production (ADFG 2012). Proposed mining of copper–sulfide ore in these watersheds will expose rocks with elevated metal concentrations including copper (Cu) (Figure 1; Cox 1996, NDM 2005a, Ghaffari et al. 2011). Because mining can increase metal concentrations in water by several orders of magnitude compared to uncontaminated sites (ATSDR 1990, USEPA 2000, Younger 2002), and because Cu can be highly toxic to aquatic life (Eisler 2000), this review focuses on risks to aquatic life from potential increased Cu inputs from proposed development. Figure 1. Map showing current mining claims (red) in Nushagak and Kvichak river watersheds as of 2011. Proven low- grade copper sulfide deposits are located in large lease block along Iliamna Lake. Documented salmon streams are outlined in dark blue. Note many regional streams have never been surveyed for salmon presence or absence. Sources: fish data from: www.adfg.alaska.gov/sf/SARR/AWC/index.cfm?ADFG =main.home mine data from Alaska Department of Natural Resources - http://www.asgdc.state.ak.us/ Core samples collected from Cu prospects near Iliamna Lake (Figure 1) show high potential for acid generation due to iron sulfides in the rock (NDM 2005a). When sulfides are exposed to oxygen and water sulfuric acid forms, which can dissolve metals in rock.
    [Show full text]
  • Department of the Interior U.S
    DEPARTMENT OF THE INTERIOR U.S. FISH AND WILDLIFE SERVICE REGION 2 DIVISION OF ENVIRONMENTAL CONTAMINANTS CONTAMINANTS IN BIGHORN SHEEP ON THE KOFA NATIONAL WIL DLIFE REFUGE, 2000-2001 By Carrie H. Marr, Anthony L. Velasco1, and Ron Kearns2 U.S. Fish and Wildlife Service Arizona Ecological Services Office 2321 W. Royal Palm Road, Suite 103 Phoenix, Arizona 85021 July 2004 2 ABSTRACT Soils of abandoned mines on the Kofa National Wildlife Refuge (KNWR) are contaminated with arsenic, barium, mercury, manganese, lead, and zinc. Previous studies have shown that trace element and metal concentrations in bats were elevated above threshold concentrations. High trace element and metal concentrations in bats suggested that bighorn sheep also may be exposed to these contaminants when using abandoned mines as resting areas. We found evidence of bighorn sheep use, bighorn sheep carcasses, and scat in several abandoned mines. To determine whether bighorn sheep are exposed to, and are accumulating hazardous levels of metals while using abandoned mines, we collected soil samples, as well as scat and bone samples when available. We compared mine soil concentrations to Arizona non-residential clean up levels. Hazard quotients were elevated in several mines and elevated for manganese in one Sheep Tank Mine sample. We analyzed bighorn sheep tissues for trace elements. We obtained blood, liver, and bone samples from hunter-harvested bighorn in 2000 and 2001. Arizona Game and Fish Department also collected blood from bighorn during a translocation operation in 2001. Iron and magnesium were elevated in tissues compared to reference literature concentrations in other species. Most often, domestic sheep baseline levels were used for comparison because of limited available data for bighorn sheep.
    [Show full text]
  • Toxicological Profile for Copper
    TOXICOLOGICAL PROFILE FOR COPPER U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 2004 COPPER ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. COPPER iii UPDATE STATEMENT A Toxicological Profile for Copper, Draft for Public Comment was released in September 2002. This edition supersedes any previously released draft or final profile. Toxicological profiles are revised and republished as necessary. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, Mailstop F-32 Atlanta, Georgia 30333 COPPER vii QUICK REFERENCE FOR HEALTH CARE PROVIDERS Toxicological Profiles are a unique compilation of toxicological information on a given hazardous substance. Each profile reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on a substance. Health care providers treating patients potentially exposed to hazardous substances will find the following information helpful for fast answers to often-asked questions. Primary Chapters/Sections of Interest Chapter 1: Public Health Statement: The Public Health Statement can be a useful tool for educating patients about possible exposure to a hazardous substance. It explains a substance’s relevant toxicologic properties in a nontechnical, question-and-answer format, and it includes a review of the general health effects observed following exposure. Chapter 2: Relevance to Public Health: The Relevance to Public Health Section evaluates, interprets, and assesses the significance of toxicity data to human health.
    [Show full text]
  • 12 –Dimethylbenz(Α) Anthracene (DMBA) / Croton
    TABLE OF CONTENTS I. Editorial II. Message from the PPhA President III. Pharmacy Practice a. Gender sensitivity in clinical pharmacy: a descriptive study on pharmacy students’ perspectives and gender-based patient characteristics – R. L. Salenga, A. D. Barcelona ….. b. Medication knowledge and attitudes towards professional collaboration among pharmacy assistants in Manila: a descriptive study – M.J. Bacayo, M.T. Gonzales, K. Z. Roque, R.L. Salenga ……………………………………………………………………………………………………………………………….. c. Retrospective Drug Utilization Study on NSAIDs in Osteoarthritic Elderly Patients in a Tertiary Government Hospital - K.C. Baguio, J.R. Mariano, M.B. Sagun, R.L. Salenga d. Assuring quality when sourcing pharmaceutical excipients – R.Marcuelo IV. Pharmaceutical Science a. Evaluation of 5-HT2A Receptor Agonistic Property of Elemicin – M.G. Cervantes, S.C. Co, E.B.King, M.K. Lacro, S.J.M. Lansan, K.A. Li, J.G. Apostol b. Preparation and Characterization of Chitosan/Polycaprolactone/k-Carrageenan Scaffolds – N.M.R. Ang, R.A. Guiterrez, R.M. Mendoza, J.C. Tan, J.L. Tan, F.E. Valmores, A. Bayquen c. The Efficacy of Musca Domestica (Muscidae) Larval Secretions in Debridement of Necrotic Wounds in Diabetic Rats – A.M. Abella, R.R. Balmes, M.V.C. Cambri, J. Cua, J. Del Prado, J. Apostol V. Undergraduate Research Journal (Pharmaceutical Science) a. The chemopreventive potential of crude leaf extract of Pak-Choi (Brassica rapa L. cv. Pak-choi Family Brassicaceae) in 7,12 –dimethylbenz(α) anthracene (DMBA) / croton oil-induced in vivo two-stage skin tumorigenesis in male ICR mice – S. Chua,F. Cobar, R. TABLE OF CONTENTS I. Editorial II. Message from the PPhA President III.
    [Show full text]
  • Poisonous Plants
    Plants Poisonous Plants ACMT Board Review Course September 9, 2012 Thomas C. Arnold, M.D. 1 Special Acknowledgement • Thanks to Michelle Ruha and other previous presenters for their efforts on this topic. 2 Plants • Natural Products: 5% of tox boards – Includes food and marine poisonings, herbals, plants, fungi, toxic envenomations • ~ 5% of exposures reported to PCC each year, most in children < 6 years – Often a few deaths per year, but most reported exposures minor 3 1 Plants Plant Poisoning by Organ System • GI toxins • CNS toxins • Cardiovascular toxins • Multiorgan-system toxins • Hepatotoxins • Nephrotoxins • Endocrine toxins • Dermal and mucous membrane irritants 4 Lots of calls / Little threat • Euphorbia pulcherrima – Poinsettia • Ilex spp – Holly • Phoradendron spp – Mistletoe • Lantana spp • Spathiphyllum spp – Peace lily 5 • Ingestion of this plant may produce severe vomiting and diarrhea. Purple stains on fingers and a foamy quality to the diarrhea may provide a clue to the species of plant. Pokeweed AKA Phytolacca americana Toxin: phytolaccatoxin 6 2 Plants Phytolacca americana • Edible if parboiled • Root is the most toxic part, mature berries least toxic • Contains pokeweed mitogen – May see plasmacytosis • Supportive care 7 Wikivisual.com Solanum spp wiki • 1700 species; nightshade, potato • Poisoning usually from ingestion of immature fruit • Solanine glycoalkaloids – Usually produce GI irritant effects – Hallucinations and coma reported 8 Melia azedarach Toxin: meliatoxins Chinaberry9 3 Plants Chinaberry • Tree grows
    [Show full text]
  • Modes of Action of Herbal Medicines and Plant Secondary Metabolites
    Medicines 2015, 2, 251-286; doi:10.3390/medicines2030251 OPEN ACCESS medicines ISSN 2305-6320 www.mdpi.com/journal/medicines Review Modes of Action of Herbal Medicines and Plant Secondary Metabolites Michael Wink Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, Heidelberg D-69120, Germany; E-Mail: [email protected]; Tel.: +49-6221-544-881; Fax: +49-6221-544-884 Academic Editor: Shufeng Zhou Received: 13 August 2015 / Accepted: 31 August 2015 / Published: 8 September 2015 Abstract: Plants produce a wide diversity of secondary metabolites (SM) which serve them as defense compounds against herbivores, and other plants and microbes, but also as signal compounds. In general, SM exhibit a wide array of biological and pharmacological properties. Because of this, some plants or products isolated from them have been and are still used to treat infections, health disorders or diseases. This review provides evidence that many SM have a broad spectrum of bioactivities. They often interact with the main targets in cells, such as proteins, biomembranes or nucleic acids. Whereas some SM appear to have been optimized on a few molecular targets, such as alkaloids on receptors of neurotransmitters, others (such as phenolics and terpenoids) are less specific and attack a multitude of proteins by building hydrogen, hydrophobic and ionic bonds, thus modulating their 3D structures and in consequence their bioactivities. The main modes of action are described for the major groups of common plant secondary metabolites. The multitarget activities of many SM can explain the medical application of complex extracts from medicinal plants for more health disorders which involve several targets.
    [Show full text]