US008969392B2

(12) United States Patent (10) Patent No.: US 8,969,392 B2 Van Den Eynde et al. (45) Date of Patent: Mar. 3, 2015

(54) PESTICIDE COMPOSITION COMPRISING (52) U.S. Cl. PROPAMOCARB-FOSETYLATE AND AN USPC ...... 514/365: 514/341; 514/383 INSECTICDALLY ACTIVE SUBSTANCE (58) Field of Classification Search USPC ...... 514/365 (75) Inventors: Koen Van Den Eynde, Merchtem (BE); See application file for complete search history. Marc Andrieux, Erkrath (DE); Heike Hungenberg, Langenfeld (DE); (56) References Cited Wolfgang Thielert, Odental (DE); Anne Suty-Heinze, Langenfeld (DE) U.S. PATENT DOCUMENTS 6,339,103 B1 1/2002 Death et al. (73) Assignee: Bayer Cropscience AG, Monheim am 2005, OO65,034 A1 3, 2005 Miele et al. Rhein (DE) 2006/0166898 A1* 7/2006 Chen ...... 514, 22 2007/0060579 A1 3/2007 Wachendorff-Neumann et al. (*) Notice: Subject to any disclaimer, the term of this 2008/005.1457 A1 2/2008 Nakaeo et al. 2008, 0221167 A1 9, 2008 Fischer et al. patent is extended or adjusted under 35 2008/0293566 A1 1 1/2008 Suty-Heinze et al. U.S.C. 154(b) by 0 days. (21) Appl. No.: 13/539,989 FOREIGN PATENT DOCUMENTS y x- - - 9 WO WO9942468 A1 * 8, 1999 (22) Filed: Jul. 2, 2012 WO 2007/10 1547 9, 2007 (65) Prior Publication Data OTHER PUBLICATIONS US 2012/O27O843 A1 Oct. 25, 2012 International Search Report for PCT/EP07/64424, mailed Apr. 1, 2008. Related U.S. Application Data * cited by examiner (62) Division of application No. 12/520.808, filed as application No. PCT/EP2007/064424 on Dec. 21, Primary Examiner - Layla Soroush 2007, now Pat. No. 8,236,830. (74) Attorney, Agent, or Firm — Miles & Stockbridge PC (30) Foreign Application Priority Data (57) ABSTRACT The present invention relates to a pesticide composition Dec. 22, 2006 (EP) ...... O6127172 intended for protecting plants, crops or seeds against phyto pathogenic fungi or damaging insects, and the corresponding (51) Int. Cl. methods of treatment using the said composition. More pre AOIN 43/78 (2006.01) cisely, the Subject of the present invention is a pesticide com A6 IK3I/425 (2006.01) position based on propamocarb-fosetylate, an AOIN 43/00 (2006.01) active Substance and optionally a further fungicide active A6 IK3I/44 (2006.01) Substance. AOIN 43/64 (2006.01) A6 IK3I/4I (2006.01) 15 Claims, No Drawings US 8,969,392 B2 1. 2 PESTICIDE COMPOSITION COMPRISING Some mixtures with other fungicide active substances are PROPAMOCARB-FOSETYLATE AND AN mentioned. However, this document is silent with regard to INSECTICDALLY ACTIVE SUBSTANCE any results or biological activity of such potential mixtures. In particular, this document does not report any activity to spe CROSS REFERENCE TO RELATED cifically control seed diseases with propamocarb-fosetylate APPLICATIONS mixtures nor this document discloses any mixture of propam ocarb-fosetylate with any insecticide active substance. There This application is a Divisional of U.S. patent application is also no mention in this document of any particular result or Ser. No. 12/520,808 filed Jun. 22, 2009, which is a S371 biological activity of any mixture of propamocarb-fosetylate National Stage Application of PCT/EP2007/064424 filed 10 with an insecticide active substance. Dec. 21, 2007, which claims priority to EP 06127172.2 filed In international patent application WO-2007/101547 there Dec. 22, 2006, the entire contents of each are herein incorpo are generically disclosed numerous mixtures of Some phtala rated by reference in their entireties. mide insecticide compounds with known fungicide Sub 15 stances. The association of these insecticide compounds with BACKGROUND OF THE INVENTION propamocarb-fosetylate has not been specifically disclosed nor has been Subject to any experimentation. Such an asso 1. Field of the Invention ciation does not form part of the present invention. The present invention relates to a pesticide composition In a main aspect, the present invention provides a compo intended for protecting plants, crops or seeds against fungal sition comprising: diseases or insect damages, and the corresponding methods of A) propamocarb-fosetylate and protection by application of the said composition. More pre B) an insecticide compound cisely, the Subject of the present invention is a pesticide com in an A/B weight ratio ranging from 1/1,000 to 1,000/1: position based on propamocarb-fosetylate and an insecticide provided that insecticide compound B differs from com active Substance or compound and optionally a further fun 25 pounds of formula (I) gicide active substance or compound. 2. Description of Related Art (I) As regards pesticide activity, in particular for the protection CH of crops, one of the problems at the heart of the research Hal Q : 30 SOCH3 studies carried out in this technical field is the improvement of N performances, in particular in terms of biological activity and H R. in particular in terms of maintaining Such an activity over CF3 H time. N F SUMMARY OF THE INVENTION 35 O CF H3C The present invention provides a pesticide composition which can be used, in particular by the farmer, for controlling the pest infesting crops and in particular for controlling wherein: insects or diseases of corn, beet, cotton, canola, beans, pea 40 Hal represents a chlorine atom, a bromine atom or a iodine nuts Vegetables, lucerne, soybean, market garden crops, turf. atom; wood, tree and horticultural plants, for example Pythium on R represents hydrogen or methyl and * may represent a corn. The pesticide compounds useful for the protection of carbon atom in R- or S-configuration. plants must be endowed with an ecotoxicity which is reduced The present invention advantageously provides a pesticide to the minimum. As far as possible, they should not be dan 45 composition which is completely high-performing in particu gerous or toxic to the operator during use. The economic lar as regards its efficacy against pests and the perenniality of factor should of course not be overlooked in the search for this efficacy so as to be able to reduce the doses of chemical novel pesticide agents. products spread in the environment for combating pest dam Propamocarb-fosetylate is a known compound having as ages or attacks of plants or crops. chemical name dimethyl-3-(propoxycarbonylamino)pro 50 The invention provides a pesticide composition capable to pylammonium-O-ethylphosphonate and which is repre be more active and active for longer, and which therefore has sented by the following formula: a lower dose, but which is also less toxic, in particular in the treatment of plants and particularly the foliar and seed treat ments of fungal diseases or the control of insects, for O 55 example, of cereals, cotton, peanut, bean, beet, canola, Solan aceae, grapevine, vegetables, lucerne, soybean, market gar den crops, turf, wood or horticultural plants. sur----- The composition according to the inventionallows control ling a broad variety of insects or fungi. For example, the 60 pesticide composition according to the invention exhibits an improved efficacy against fungus like Plasmodiophoro mycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Basidiomycetes, Deuteromycetes and Ascomycetes. This compound is described in international patent appli All these objectives or advantages, among others, were cation WO-99/42468. Some fungicide activity is reported 65 achieved by finding a pesticide composition comprising pro with regard to the straight use of this compound to control pamocarb-fosetylate; an insecticide compound and option Plasmopara viticola. ally a further fungicide compound. Such a composition Sur US 8,969,392 B2 3 4 prisingly and unexpectedly allows a very high and perennial chlovaporthrin, cis-, cis-, cis insecticide oranti-fungal efficacy againstabroad spectrum of , clocythrin, cycloprothrin, , cyha insects or fungi and in particular against those responsible for lothrin, cypermethrin (alpha, beta-, theta-, Zeta-), cyphe diseases or damages of corn for example to Oomycetes. Other nothrin, , (1R-isomer), insect pests or diseases of corn can be controlled with the , etofemprox, fenfluthrin, , pesticide composition according to the invention, in particu fenpyrithrin, , flubrocythrinate, flucythri lar the control of Ascomycetes or Basidiomycetes. nate, flufenprox, , fluvalinate, fubfenprox. The pesticide composition according to the invention may gamma-, , kadethrin, lambda-cy also be used for the treatment of bacterial or virus diseases. halothrin, , permethrin (cis-, trans-), pheno Insects or nematodes that can be controlled with the pesti 10 thrin (1r-trans isomer), , profluthrin, prot cide composition according to the invention include a broad rifenbute, pyresmethrin, resmethrin, RU15525, variety of these damaging organisms. , tau-fluvalinate, , terallethrin, tet ramethrin (-1r-isomer), , , DETAILED DESCRIPTION OF A PREFERRED ZXI8901, (); for example DDT for EMBODIMENT 15 example a compound of the type oxadiazine like indoX acarb; For the composition according to the invention, insecticide B4) a compound capable to modulate acetylcholine recep compound B is preferably selected in the list consisting of: tor, for example a compound of the type spinosyn like B1) a compound capable to act as an acetylcholine receptor ; agonist or antagonist, for example a compound of the B5) a compound capable to act as GABA-gated chloride type chloronicotinyl like , , channel antagonist, for example a compound of the type , , imidaclothiz also known as cyclodiene organochlorine like camphechlor, chlor (2E)-1-(2-chloro-1,3-thiazol-5-yl)methyl-N-nitroimi dane, , gamma-HCH, HCH, , lin dazolidin-2-imine, , nithiazine, ; dane, ; a compound of the type fiprole like , nicotine, benSultap, cartap, (2E)-1-(2- 25 acetoprole, ethiprole, , Vaniliprole; chloro-1,3-thiazol-5-yl)methyl-3,5-dimethyl-N-nitro B6) a compound capable to activate the chloride channel, 1.3.5-triaZinan-2-imine; for example a compound of the type mectin like aver B2) a compound capable to inhibit acetylcholinesterase mectin, emamectin, emamectin-benzoate, ivermectin, (ACHE), for example a compound of the type milbemycin; like alanycarb, , aldoxycarb, allyxycarb, ami 30 B7) a compound capable to mimic ajuvenile hormone like nocarb, , benfuracarb, bufencarb, butacarb, diofenolan, epolfenonane, , , , butoxycarboxim, , , kinoprene, , pyriproxifen, triprene; , cloethocarb, , ethiofencarb, B8) a compound capable to act as an ecdysone agonist or , fenothiocarb, , furathiocarb, disruptor, for example a compound of the type diacyl isoprocarb, metam-Sodium, , , 35 hydrazine like chromafenozide, halofenozide, methoxy , , , promecarb, , fenozide, ; thiodicarb, , trimethacarb. XMC, xylylcarb; B9) a compound capable to inhibit chitin biosynthesis, for triazamate; a compound of the type example a compound of the type like bis like , , azinphos (-methyl, -ethyl), trifluoron, chlofluaZuron, , fluaZuron, bromophos-ethyl, bromfenvinfos (-methyl), butathio 40 flucycloXuron, , hexaflumuron, , fos, cadusafos, , , chlo novaluron, noviflumuron, penfluoron, teflubenZuron, rfenvinphos, chlormephos, (-methyl/- triflumuron; ; ; ethyl), , cyanofenphos, , B10) a compound capable to inhibit oxidative phosphory , demeton-S-methyl, demeton-S-meth lation or to disrupt ATP, like diafenthiuron; for example ylsulphon, dialifos, , dichlofenthion, dichlor 45 a compound of the type organotin like azocyclotin, VoS/ddvp, , , dimethylvinphos, cyhexatin, fenbutatin-oxide; dioxabenzofos, , epn, , , B11) a compound capable to uncouple oxidative phospho etrimfos, famphur, , , fensul rylation via disruption of H proton gradient, for example fothion, , flupyrazofos, , , a compound of the type pyrrole like ; a foSmethilan, fosthiazate, heptenophos, iodofenphos, 50 compound of the type dinitrophenole like binapacyrl, iprobenfos, isazofos, isofenphos, isopropylo-Salicylate, dinobuton, dinocap, DNOC: , , mecarbam, methacrifos, metha B12) a compound capable to inhibit site I electron trans midophos, , , , port, for example a compound of the type METI like , , oxydemeton-methyl, (-me fenaZaquin, fenpyroximate, pyrimidifen, pyridaben, thyl/-ethyl), , , , , 55 , tolfenpyrad; ; ; , phosphocarb, , pirimiphos (-me B13) a compound capable to inhibit site II electron trans thyl/-ethyl), , propaphos, propetamphos, pro port like rotenone; thiofos, , pyraclofos, pyridaphenthion, pyri B14) a compound capable to inhibit site III electron trans dathion, quinallphos, Sebufos, Sulfotep, Sulprofos, port like acequinocyl, fluacrypyrim, , temephos, , , 60 B15) a compound capable to act as a microbial disruptor of thiometon, triaZophos, triclorfon, Vamidothion; insect midgut or intestinal membrane like stains of B3) a compound capable to modulate the Sodium channel Bacillus thuringiensis, or to block the Voltage dependant sodium channel, for B16) a compound capable to inhibit lipid synthesis, for example a compound of the type like acri example a compound of the type tetronic acid insecti nathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, 65 cide like spirodiclofen, Spiromesi?en or a compound of , , bioallethrin-s-cyclopentyl-iso the type tetramic acid insecticide like spirotetramat also mer, bioethanomethrin, biopermethrin, bioresmethrin, known as carbonic acid cis-3-(2,5-dimethylphenyl)-8- US 8,969,392 B2 5 6 methoxy-2-oxo-1-azaspiro4.5 dec-3-en-4-yl ethyl ron; propamocarb-fosetylate and : ester (CAS-reg-no 203313-25-1) and 3-(2,5-dimeth propamocarb-fosetylate and methiocarb; propamocarb-fos ylphenyl)-8-methoxy-2-oxo-1-azaspiro4.5 dec-3-en etylate and methomyl; propamocarb-fosetylate and methoxy 4-yl ethyl carbonate also known as carbonic acid 3-(2, fenozide; propamocarb-fosetylate and milbemycin; propam 5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro4.5 ocarb-fosetylate and nitenpyram; propamocarb-fosetylate dec-3-en-4-yl ethyl ester (CAS-reg-no 382608-10-8); and noValuron; propamocarb-fosetylate and profenofos; pro B17) a compound of the type carboxamide like flonicamid: pamocarb-fosetylate and pymetrozine; propamocarb-fosety B18) a compound capable to act as an octopaminergic late and rynaxapyr; propamocarb-fosetylate and spinosad; agonist like : propamocarb-fosetylate and spirodiclofen; propamocarb B19) a compound capable to inhibit magnesium-stimu 10 fosetylate and spiromesi?en; propamocarb-fosetylate and lated ATP-ase like propargite; spirotetramate; propamocarb-fosetylate and tebufenozide; B20) a compound of the type BDCA or capable to act as a propamocarb-fosetylateandtebufenozide; propamocarb-fos ryanodin receptor agonist like rynaxypyr or phthala etylate and tebufenpyrad; propamocarb-fosetylate and mides, e.g. also known as N2-1,1-dim tebufenpyrad; propamocarb-fosetylate and tebupirimphos: ethyl-2-(methylsulfonyl)ethyl-3-iodo-N1-(2-methyl 15 propamocarb-fosetylate and teflubenZuron; propamocarb 4-1.2.2.2-tetrafluoro-1-(trifluoromethyl)ethyl fosetylate and tefluthrin; propamocarb-fosetylate and thia phenyl-1,2-benzenedicarboxamide (CAS-reg-no cloprid; propamocarb-fosetylate and thiamethoxam, pro 272451-65-7); pamocarb-fosetylate and thiodicarb; propamocarb-fosetylate B21) a compound of the type analogue insec and triaZophos triflumuron; propamocarb-fosetylate and imi ticide like thiocyclam hydrogen oxalate, thiosultap-so daclothiz: propamocarb-fosetylate and (2E)-1-(2-chloro-1, dium; 3-thiazol-5-yl)methyl-3,5-dimethyl-N-nitro-1,3,5-triazi B22) a compound of the types biologica, hormones or nan-2-imine. pheromones like , Bacillus spec. Beauveria Even more preferably, the composition according to the spec., codilemone, Metarrhizium spec., Paecilomyces invention comprises propamocarb-fosetylate and abamectin; spec., thuringiensin, Verticillium spec.; 25 propamocarb-fosetylate and acetamiprid; propamocarb-fos B23) a compound of unknown or non-specific mode of etylate and aldicarb; propamocarb-fosetylate and beta-cy action, for example a compound of the type fumigant fluthrin, propamocarb-fosetylate and carbofuran, propam like , methyl bromide, sulfuryl ocarb-fosetylate and chlorpyrifos-E: propamocarb-fosetylate fluoride; a compound of the type selective feeding and clothianidin; propamocarb-fosetylate and cypermethrin; blocker like cryolite, flonicamid, pymetrozine; a com 30 propamocarb-fosetylate and cyromazine; propamocarb-fos pound of the type mite growth inhibitor like clofentez etylate and deltamethrin; propamocarb-fosetylate and ine, etoxazole, hexythiazox; amidoflumet, benclothiaz, diflubenZuron; propamocarb-fosetylate and emamectin-ben benzoximate, bifenazate, bromopropylate, buprofezin, Zoate; propamocarb-fosetylate and ethiprole; propamocarb chinomethionat, , chloro-benzilate, chlo fosetylate and fipronil; propamocarb-fosetylate and gamma ropicrin, clothiazoben, cycloprene, cyflumetofen, dicy 35 cyhalothrin; propamocarb-fosetylate and imidacloprid; clanil, fenoxacrim, fentrifanil, flubendiamide, flubenz propamocarb-fosetylate and L-cyhalothrin; propamocarb imine, flufenerim, flutenzin, gossyplure, fosetylate and lufenuron; propamocarb-fosetylate and hydramethylnone, japonilure, metoxadiaZone, petro methiocarb; propamocarb-fosetylate and methoxyfenozide; leum, piperonyl butoxide, potassium oleate, pyraflu propamocarb-fosetylate and pymetrozine; propamocarb-fos prole, pyridalyl , Sulfluramid, , tetra 40 etylate and rynaxapyr; propamocarb-fosetylate and spinosad; Sul, triarathene, verbutin. propamocarb-fosetylate and spirodiclofen; propamocarb More preferably, the composition according to the inven fosetylate and spiromesi?en; propamocarb-fosetylate and tion comprises propamocarb-fosetylate and abamectin; pro spirotetramate; propamocarb-fosetylate and tebufenozide; pamocarb-fosetylate and acephate; propamocarb-fosetylate propamocarb-fosetylate and tebufenpyrad; propamocarb and acetamiprid; propamocarb-fosetylate and ; 45 fosetylate and tefluthrin; propamocarb-fosetylate and thia propamocarb-fosetylate and aldicarb; propamocarb-fosety cloprid; propamocarb-fosetylate and thiamethoxam, pro late and alpha-cypermethrin; propamocarb-fosetylate and pamocarb-fosetylate and thiodicarb; propamocarb-fosetylate beta-cyfluthrin; propamocarb-fosetylate and bifenthrin; pro and triflumuron; propamocarb-fosetylate and imidaclothiz: pamocarb-fosetylate and carbaryl; propamocarb-fosetylate preferred composition according to the invention comprises and carbofuran; propamocarb-fosetylate and chlorfenapyr; 50 propamocarb-fosetylate and (2E)-1-(2-chloro-1,3-thiazol propamocarb-fosetylate and chlorfluaZuron; propamocarb 5-yl)methyl-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine. fosetylate and chlorpyrifos-E, propamocarb-fosetylate and Still even more preferably, the composition according to clothianidin; propamocarb-fosetylate and cyfluthrin; pro the invention comprises propamocarb-fosetylate and abam pamocarb-fosetylate and cypermethrin; propamocarb-fos ectin; propamocarb-fosetylate and aldicarb; propamocarb etylate and cyromazine; propamocarb-fosetylate and delta 55 fosetylate and beta-cyfluthrin, propamocarb-fosetylate and methrin; propamocarb-fosetylate and diflubenZuron; chlorpyrifos-E: propamocarb-fosetylate and clothianidin; propamocarb-fosetylate and dinotefuran; propamocarb-fos propamocarb-fosetylate and cyromazine; propamocarb-fos etylate and emamectin-benzoate; propamocarb-fosetylate etylate and deltamethrin; propamocarb-fosetylate and and ethiprole; propamocarb-fosetylate and fenpyroximate; diflubenZuron; propamocarb-fosetylate and emamectin-ben propamocarb-fosetylate and fipronil; propamocarb-fosety 60 Zoate; propamocarb-fosetylate and fipronil; propamocarb late and flonicamid; propamocarb-fosetylate and flubendia fosetylate and gamma-cyhalothrin; propamocarb-fosetylate mide; propamocarb-fosetylate and flufenoXuron; propam and imidacloprid; propamocarb-fosetylate and L-cyhalo ocarb-fosetylate and gamma-cyhalothrin; propamocarb thrin; propamocarb-fosetylate and methiocarb; propam fosetylate and hexaflumuron; propamocarb-fosetylate and ocarb-fosetylate and pymetrozine; propamocarb-fosetylate imidacloprid; propamocarb-fosetylate and ; pro 65 and rynaxapyr; propamocarb-fosetylate and spinosad; pro pamocarb-fosetylate and L-cyhalothrin; propamocarb-fos pamocarb-fosetylate and Spirodiclofen; propamocarb-fosety etylate and lepimectin; propamocarb-fosetylate and lufenu late and Spiromesi?en; propamocarb-fosetylate and spirotet US 8,969,392 B2 7 8 ramate; propamocarb-fosetylate and tebufenozide; C1) a compound capable to inhibit the nucleic acid synthe propamocarb-fosetylate and tebufenpyrad; propamocarb sis likebenalaxyl, benalaxyl-M, bupirimate, cloZylacon, fosetylate and tefluthrin; propamocarb-fosetylate and thia dimethirimol, ethirimol, furalaxyl, hymexaZol, methoxam, propamocarb-fosetylate and thiodicarb; propam mefenoxam, metalaxyl, metalaxyl-M, ofurace, Oxa ocarb-fosetylate and imidaclothiz: propamocarb-fosetylate 5 dixyl, oxolinic acid; and (2E)-1-(2-chloro-1,3-thiazol-5-yl)methyl-3,5-dim C2) a compound capable to inhibit the mitosis and cell ethyl-N-nitro-1,3,5-triazinan-2-imine. division like benomyl, carbendazim, diethofencarb, For the composition according to the invention the A/B ethaboxam, fuberidazole, pencycuron, thiabendazole, weight ratio preferably ranges from 1/125 to 125/1; more thiophanate-methyl, Zoxamide; 10 C3) a compound capable to inhibit the respiration for preferably from 1/25 to 25/1. example According to another aspect of the present invention, in the as CI-respiration inhibitor like diflumetorim; pesticide composition according to the invention, the com as CII-respiration inhibitor like boscalid, carboxin, fen pound ratio A/B can be advantageously selected so as to furam, flutolanil, furametpyr, furmecyclox, mepronil, produce a synergistic effect. The term synergistic effect is 15 oxycarboxin, penthiopyriad, thifluZamide; understood to mean in particular that defined by Colby in an as CIII-respiration inhibitor like amisulbrom, azox article entitled "Calculation of the synergistic and antagonis yStrobin, cyaZofamid, dimoxystrobin, enestrobin, tic responses of herbicide combinations' Weeds, (1967), 15, famoxadone, fenamidone, fluoxastrobin, kresoxim-me pages 20-22. thyl, metominostrobin, orysastrobin, picoxystrobin, The latter article mentions the formula: pyraclostrobin, trifloxystrobin: C4) a compound capable of to act as an uncoupler like dinocap, fluaZinam, meptylidinocap: E = x + y - C5) a compound capable to inhibit ATP production like = x + r -o fentin acetate, fentin chloride, fentin hydroxide, silthio 25 fam; wherein E represents the expected percentage of inhibition of C6) a compound capable to inhibit AA and protein biosyn the pest for the combination of the two compounds at defined thesis like andoprim, blasticidin-S, cyprodinil, kasuga doses (for example equal to X and y respectively), X is the mycin, kasugamycin hydrochloride hydrate, mepanipy percentage of inhibition observed for the pest by compound A rim, pyrimethanil; 30 C7) a compound capable to inhibit the signal transduction at a defined dose (equal to X), Y is the percentage of inhibition like fenpiclonil, fludioxonil, quinoxyfen; observed for the pest by compound Bata defined dose (equal C8) a compound capable to inhibit lipid and membrane to y). When the percentage of inhibition observed for the synthesis like biphenyl, chlozolinate, edifenphos, etridi combination is greater than E, there is a synergistic effect. azole, iodocarb, iprobenfos, iprodione, isoprothiolane, The term “synergistic effect” also means the effect defined 35 procymidone, propamocarb or propamocarb-hydro by application of the Tammes method, “Isoboles, a graphic chloride, pyrazophos, tolclofoS-methyl, VincloZolin; representation of synergism in pesticides'. Netherlands Jour C9) a compound capable to inhibit ergosterol biosynthesis nal of Plant Pathology, 70 (1964), pages 73-80. In a further aspect, the present invention provides a com like aldimorph, azaconazole, bitertanol, bromucona position comprising: Zole, cyproconazole, diclobutrazole, difenoconazole, 40 diniconazole, diniconazole-M, dodemorph, dodemorph A) propamocarb-fosetylate: acetate, epoxiconazole, etaconazole, fenarimol, fen B) an insecticide compound and buconazole, fenhexamid, fempropidin, fenpropimorph, C) a further fungicide compound in an A/B/C weight ratio fluguinconazole, flurprimidol, flusilazole, flutriafol, fur ranging from 1/1,000/1,000 to 1/0001/0.001: provided conazole, furconazole-cis, hexaconazole, imazalil, that insecticide compound B differs from compounds of 45 imazalil Sulfate, imibenconazole, ipconazole, metcona formula (I) Zole, myclobutanil, naftifine, nuarimol, Oxpoconazole, paclobutraZol, pefurazoate, penconazole, prochloraZ, propiconazole, prothioconazole, pyributicarb, (I) CH3 pyrifenox, simeconazole, spiroxamine, tebuconazole, Hal Q : 50 terbinafine, tetraconazole, triadimefon, triadimenol, tri SOCH3 demorph, triflumizole, triforine, triticonazole, unicona N H Zole, Viniconazole, Voriconazole; CF C10) a compound capable to inhibit cell wall synthesis like H benthiavalicarb, bialaphos, dimethomorph, flumorph, N F 55 iprovalicarb, mandipropamid, polyoxins, polyoxorim, validamycin A; O CF C11) a compound capable to inhibit melanine biosynthesis H3C like carpropamid, diclocymet, fenoxanil, phthalide, pyroquilon, tricyclazole; wherein: 60 C12) a compound capable to induce a host defence like Hal represents a chlorine atom, a bromine atom or a iodine acibenzolar-S-methyl, probenazole, tiadinil; atom; C13) a compound capable to have a multisite action like * represents a carbon atom in R- or S-configuration. Bordeaux mixture, captafol, captan, chlorothalonil, cop In addition to propamocarb-fosetylate and an insecticide per naphthenate, copper oxide, copperoxychloride, cop compound B as herein-defined, the composition according to 65 per preparations such as copper hydroxide, copper Sul the invention can comprise a further fungicide compound C phate, dichlofluanid, dithianon, dodine, dodine free preferably selected in the list consisting of: base, ferbam, fluorofolpet, folpet, guaZatine, guazatline US 8,969,392 B2 10 acetate, iminoctadine, iminoctadine albesilate, iminoc 2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-car tadine triacetate, mancopper, mancoZeb, maneb, meti boxamide, 2-(2-6-(3-chloro-2-methylphenoxy)-5- ram, metiram Zinc, oxine-copper, propineb, Sulphur and fluoropyrimidin-4-yl)oxyphenyl)-2-(methoxyimino)- Sulphur preparations including calcium polysulphide, N-methylacetamide, 1-(4-methoxyphenoxy)methyl thiram, tolylfluanid, Zineb, Ziram; 2,2-dimethylpropyl-1H-imidazole-1-carboxylic acid, C14) benthiazole, bethoxazin, capsimycin, carvone, chi O-1-(4-methoxyphenoxy)methyl-2,2-dimethylpro nomethionat, cufraneb, cyflufenamid, cymoxaniil, pyl)-1H-imidazole-1-carbothioic acid, a dipeptic mix dazomet, debacarb, dichlorophen, diclomeZine, diclo ture of methyl-IS (R.S)-3-(N-isopropoxycarbon ran, difenZoquat, difenZoquat methylsulphate, dipheny ylvalinyl)-amino-3-(4-chloro-phenyl)propanoate, lamine, ethaboxam, ferimZone, flumetover, flusulfa 10 methyl-(2-chloro-5-(1E)-N-(6-methylpyridin-2-yl) mide, fluopicolide, fluopyram also known as N-2-3- methoxy-ethanimidoyl)benzyl)carbamate, 4-chloro chloro-5-(trifluoromethyl)pyridin-2-yl)ethyl-2- alpha-methoxy-N-2-3-methoxy-4-(2-propynyloxy) (trifluoromethyl)benzamide, fluoroimide, fosetyl phenylethyl-benzeneacetamide, 3,4-dichloro-N-(2- aluminium, fosetyl-calcium, fosetyl-Sodium, 15 cyanophenyl)isothiazole-5-carboxamide, N-(2-(1,3- hexachlorobenzene, 8-hydroxyquinoline Sulfate, iruma dimethyl-butyl)-phenyl-5-fluoro-1,3-dimethyl-1H mycin, isotianil, methasulphocarb, metrafenone, methyl pyrazole-4-carboxamide. isothiocyanate, mildiomycin, natamycin, nickel dimeth Most preferred compounds C in the composition according yldithiocarbamate, nitrothal-isopropyl, octhillinone, to the invention can be selected in the list consisting of benal oxamocarb, oxyfenthiin, pentachlorophenol and salts, axyl, benalaxyl-M, benthiavalicarb, carboxin, chlorothalonil, 2-phenylphenol and salts, phosphorous acid and its salts, cyaZofamid, cymoxanil, dimetomorph, fluaZinam, fludiox piperalin, propanosine-Sodium, produinazid, pyriben onil, fluoxastrobin, fluguinconazole, flutriafol, fosetyl-Al. carb, pyrrolnitrine, quintoZene, tecloftalam, tecnaZene, hexaconazole, hymexaZol, ipconazole, mancoZeb, mandipro triazoxide, trichlamide, Valiphenal, Zarilamid and 2.3.5. pamid, maneb, mefenoxam, metalaxyl, metiram, pencona 6-tetrachloro-4-(methylsulfonyl)-pyridine, N-(4- 25 Zole, penthiopyriad, phosphorous acid, propamocarb-HCl, chloro-2-nitrophenyl)-N-ethyl-4-methyl-benzene propineb, prothioconazole, tebuconazole, thiram, triadime Sulfonamide, 2-amino-4-methyl-N-phenyl-5- nol, trifloxystrobin, triticonazole and N-2-(1,3-dimethyl-bu thiazolecarboxamide, 2-chloro-N-(2,3-dihydro-1,1,3- tyl)-phenyl-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxa trimethyl-1H-inden-4-yl)-3-pyridincarboxamide, 3-5- mide. (4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl) 30 The composition according to the invention preferably pyridine, cis-1-(4-chlorophenyl)-2-(1H-1,2,4-triazole comprises 1-yl)-cycloheptanol, methyl 1-(2,3-dihydro-2,2- A) propamocarb-fosetylate: dimethyl-1H-inden-1-yl)-1H-imidazole-5-carboxylate, B) an insecticide compound selected in the list consisting 3,4,5-trichloro-2,6-pyridinedicarbonitrile, methyl-2- of abamectin, aldicarb, beta-cyfluthrin, chlorpyrifos-E, cyclopropyl (4-methoxyphenyl)iminomethylthio 35 clothianidin, cyromazine, deltamethrin, diflubenZuron, methyl-..alpha.-(methoxymethylene)-benzeneacetate, emamectin-benzoate, fipronil, gamma-cyhalothrin, imi 4-chloro-alpha-propynyloxy-N-2-3-methoxy-4-(2- dacloprid, L-cyhalothrin, methiocarb, pymetrozine, propynyloxy)phenylethyl-benzeneacetamide, (2S)— rynaxapyr, spinosad, spirodiclofen, spiromesi?en, N-2-4-3-(4-chlorophenyl)-2-propynyloxy-3- spirotetramate, tebufenozide, tebufenpyrad, tefluthrin, methoxyphenylethyl-3-methyl-2-(methylsulfonyl) 40 thiamethoxam, thiodicarb, imidaclothiz, (2E)-1-(2- amino-butanamide, 5-chloro-7-(4-methylpiperidin-1- chloro-1,3-thiazol-5-yl)methyl-3,5-dimethyl-N-nitro yl)-6-(2,4,6-trifluorophenyl) 1,2,4-triazolo 1.5-a 1,3,5-triaZinan-2-imine and pyrimidine, 5-chloro-6-(2,4,6-trifluorophenyl)-N- C) a further fungicide compound selected in the list con (1R)-1.2.2-trimethylpropyl 12.4 triazolo 1.5-a sisting of benalaxyl, benalaxyl-M, benthiavalicarb, car pyrimidin-7-amine, 5-chloro-N-(1R)-1,2- 45 boxin, chlorothalonil, cyaZofamid, cymoxanil, dimeto dimethylpropyl-6-(2,4,6-trifluorophenyl) 1.2.4 morph, fluaZinam, fludioxonil, fluoxastrobin, triazolo 1.5-alpyrimidin-7-amine, N-1-(5-bromo-3- fluquinconazole, flutriafol, fosetyl-Al, hexaconazole, chloropyridin-2-yl)ethyl-2,4-dichloronicotinamide, hymexaZol, ipconazole, mancoZeb, mandipropamid, N-(5-bromo-3-chloropyridin-2-yl)methyl-2,4-dichlo maneb, mefenoxam, metalaxyl, metiram, penconazole, ronicotinamide, 2-butoxy-6-iodo-3-propyl-benzopyra 50 penthiopyrad, phosphorous acid, propamocarb-HCl, non-4-one, N-(Z)-(cyclopropylmethoxy)iminolo propineb, prothioconazole, tebuconazole, thiram, triadi (difluoromethoxy)-2,3-difluorophenyl)methyl-2- menol, trifloxystrobin, triticonazole and N-2-(1,3-dim phenylacetamide, N-2-1,1'-bi(cyclopropyl)-2-yl) ethyl-butyl)-phenyl-5-fluoro-1,3-dimethyl-1H-pyra phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4- Zole-4-carboxamide. carboxamide, N-ethyl-N-methyl-N'-(2-methyl-5- 55 For the composition according to the invention the A/B/C (trifluoromethyl)-4-3-(trimethylsilyl)propoxy weight ratio preferably ranges from 1/100/100 to 1/0.01/0.01; phenyl)imidoformamide, N-ethyl-N-methyl-N'-(2- more preferably from 1/80/80 to 1/0.05/0.05; even more pref methyl-5-(difluoromethyl)-4-3-(trimethylsilyl) erably from 1/50/100 to 1/1.5/2.5; still even more preferably propoxyphenyl)imidoformamide, N-(3-ethyl-3.5.5- from 1/12/25 to 1/6/12. trimethyl-cyclohexyl)-3-formylamino-2-hydroxy 60 According to another aspect of the present invention, in the benzamide, N-(4-chlorobenzyl)-3-3-methoxy-4-(prop pesticide composition according to the invention, the com 2-yn-1-yloxy)phenylpropanamide, N-(4- pound ratio A/B/C can be advantageously selected so as to chlorophenyl)(cyano)methyl-3-3-methoxy-4-(prop produce a synergistic effect. The term synergistic effect is 2-yn-1-yloxy)phenylpropanamide, 2-1-3 understood to mean in particular that defined by Colby in an (1 Fluoro-2-phenylethyl)oxyphenylethylideneamino 65 article entitled "Calculation of the synergistic and antagonis oxymethyl-alpha-(methoxyimino)-N-methyl-alpha tic responses of herbicide combinations' Weeds, (1967), 15, benzeneacetamide, N-(3',4'-dichloro-5-fluorobiphenyl pages 20-22. US 8,969,392 B2 11 12 The latter article mentions the formula: Such as silica, alumina or silicates, in particular aluminium or magnesium silicates. The solid fillers which are suitable for granules are as follows: natural, crushed or broken rocks, Such as calcite, marble, pumice, Sepiolite and dolomite; syn thetic granules of inorganic or organic flours; granules of organic material Such as sawdust, coconut shell, cornear or wherein E represents the expected percentage of inhibition of envelope, or tobacco stem, kieselguhr, tricalcium phosphate, the pest for the combination of the three compounds at powdered cork or adsorbent carbon black; water-soluble defined doses (for example equal to X, y and Z respectively), X polymers, resins, waxes; or Solid fertilizers. Such composi 10 tion may, if so desired, contain one or more compatible agents is the percentage of inhibition observed for the pest by com Such as wetting agents, dispersing agents, emulsifiers or pound A at a defined dose (equal to X), Y is the percentage of colourings which, when they are solid, may also act as dilu inhibition observed for the pest by compound B at a defined entS. dose (equal to y) and Z is the percentage of inhibition The fillers may also be liquid, for example: water, alcohols, observed for the pest by compound C at a defined dose (equal 15 in particular butanol or glycol, as well as ethers or esters to Z). When the percentage of inhibition observed for the thereof, in particular methyl glycol acetate, ketones, in par combination is greater than E, there is a synergistic effect. ticular acetone, cyclohexanone, methyl ethyl ketone, methyl The term “synergistic effect” also means the effect defined isobutyl ketone or isophorone; petroleum fractions such as by application of the Tammes method, “Isoboles, a graphic paraffinic or aromatic hydrocarbons, in particular Xylenes or representation of synergism in pesticides'. Netherlands Jour alkylnaphthalenes; mineral or plant oils; aliphatic chlorohy nal of Plant Pathology, 70 (1964), pages 73-80. drocarbons, in particular trichloroethane or methylene chlo The pesticide composition according to the invention may ride; aromatic chlorohydrocarbons, in particular chloroben comprise from 0.00001 to 100%, preferably from 0.001 to Zenes; water-soluble or highly polar solvents such as 80%, of active compounds, whether these compounds are dimethylformamide, dimethylsulphoxide, N,N-dimethyl-ac combined, or whether they are in the form of two or more 25 etamide or N-methylpyrrolidone; N-octylpyrrolidone, lique active ingredients used separately. fied gases; or the like, whether they are taken separately or as More generally, the pesticide composition according to the a mixture. invention may eventually also comprise one or more other The Surfactant can be an emulsifier, a dispersing agent or a active Substances selected from fungicide, herbicide, insecti wetting agent, of ionic or nonionic type or a mixture of these cide or plant growth regulator active compounds. 30 Surfactants. Among those Surfactants there are used, for In addition to these additional active agents, the pesticide example, polyacrylic acid salts, lignoSulphonic acid salts, composition according to the invention may also comprise phenolsulphonic or naphthalenesulphonic acid salts, poly any other adjuvants or auxiliary agent useful in plant protec condensates of ethylene oxide with fatty alcohols or fatty tion formulations such as, for example, an agriculturally Suit acids or fatty esters or fatty amines, Substituted phenols (in able inert carrier and optionally an agriculturally suitable 35 particular alkylphenols orarylphenols), ester-salts of Sulpho Surfactant. Succinic acid, taurine derivatives (in particular alkyl taurates), For its practical use, the pesticide composition according to phosphoric esters of alcohols or of polycondensates of ethyl the invention can be used alone or informulations containing ene oxide with phenols, fatty acid esters with polyols, or one or the other of the active ingredients or alternatively both Sulphate, Sulphonate or phosphate functional derivatives of of them together, in combination or association with one or 40 the compounds described above. The presence of at least one more other compatible components which are, for example, Surfactant is generally essential when the active ingredients Solid or liquid fillers or diluents, adjuvants, Surfactants or and/or the inert filler are insoluble or only sparingly soluble in equivalents, which are suitable for the desired use and which water and when the filler for the said composition to be are acceptable for uses in agriculture. The formulations can applied is water. be of any type known in the sector that is suitable for appli 45 The formulations may also contain other additives such as cation onto all types of cultures or crops. These formulations, adhesives or dyes. Adhesives such as carboxymethylcellulose which can be prepared in any manner known by the skilled or natural or synthetic polymers in the form of powders, person, also form part of the invention. granules or matrices, such as gum arabic, latex, polyvinylpyr The formulations may also contain ingredients of other rolidone, polyvinyl alcohol or polyvinyl acetate, natural types, such as protective colloids, adhesives, thickeners, 50 phospholipids, such as cephalins or lecithins, or synthetic thixotropic agents, penetrating agents, oils for spraying, sta phospholipids can be used in the formulations. It is possible to bilisers, preserving agents (in particular mould-proofing or use colourings such as inorganic pigments, such as, for biocide agents), sequestering or chelating agents or the like. example: iron oxides, titanium oxides, Prussian blue; organic More generally, the compounds used in the invention can be colouring stuffs, such as those of the alizarin, azo or metal combined with any solid or liquid additives corresponding to 55 phthalocyanin type; or of trace elements such as iron, man the usual formulation techniques. ganese, boron, copper, cobalt, molybdenum or Zinc salts. The term “filler” means an organic or inorganic, natural or The form of the pesticide composition according to the synthetic component with which the active components are invention can be selected in a large number of formulations, combined to facilitate its application, for example, onto the Such as aerosol dispenser, Suspension of capsules; cold fog plants, the seeds or the soil. This filler is consequently gen 60 ging concentrate; dustable powder, emulsifiable concentrate; erally inert and it must be acceptable (for example acceptable aqueous/aqueous type emulsion; oil/inverse type emulsion; for agronomic uses, in particular for treating plants). encapsulated granule; fine granule; Suspension concentrate The filler can be solid, for example clays, natural or syn for seed treatment; compressed gas; gas generating product; thetic silicates, silica, resins, waxes, Solid fertilizers (for granule; hot fogging concentrate; macrogranule; microgran example ammonium salts), natural soil minerals, such as 65 ule; oil-dispersible powder; oil miscible Suspension concen kaolins, clays, talc, lime, quartz, attapulgite, montmorillo trate; oil-miscible liquid; paste; plant rodlet; powder for dry nite, bentonite or diatomaceous earths, or synthetic minerals, seed treatment; seeds coated with a pesticide; Smoke maydle; US 8,969,392 B2 13 14 Smoke cartridge; Smoke generator, Smoke pellet; Smoke dients (A) or (B), optionally (C). Such a method can be rodlet; Smoke tablet; Smoke tin; soluble concentrate; soluble extended to the further application of compound (C). powder, solution for seed treatment; Suspension concen The dose of active compound usually applied in the method trate (flowable concentrate); ultra low volume liquid; ultra of treatment according to the invention is generally and low Volume Suspension; vapour releasing product; water advantageously dispersible granules or tablets; water dispersible powder for for foliar treatments: from 0.1 to 10,000 g/ha, preferably slurry treatment; water-soluble granules or tablets; water from 10 to 1,000 g/ha, more preferably from 50 to 300 soluble powder for seed treatment; wettable powder. g/ha; in case of drench or drip application, the dose can The pesticide composition according to the present inven even be reduced, especially while using inert Substrates tion covers not only the compositions which are ready to be 10 applied to the crop by means of a suitable device. Such as a like rockwool or perlite; spraying device, but also the commercial concentrated com for seed treatment: from 2 to 200 g per 100 kilogram of position which have to be diluted before application to the seed, preferably from 3 to 150 g per 100 kilogram of crop. seed; The pesticide composition herein described is used ingen 15 for soil treatment: from 0.1 to 10,000 g/ha, preferably from eral for application to growing plants, or to sites where crops 1 to 5,000 g/ha. are grown or intended to grow, or for the treatment, coating or The doses herein indicated are given as illustrative film-coating of seeds. examples of the method according to the invention. A person According to the present invention, seeds may comprise skilled in the art will know how to adapt the application doses, any propagation materials, like for example seeds, fruit, notably according to the nature of the plant or crop to be tubers, grains, roots, rhizomes, parts of plants. treated. The pesticide composition according to the invention may Under specific conditions, for example according to the also be applied to the vegetation and in particular to the leaves nature of the phytopathogenic fungus to be treated or insect to infested or capable of being infested with the phytopatho control, a lower dose may offer adequate protection. Certain genic fungi or damaged by insects. Another method of apply 25 climatic conditions, resistance or other factors like the nature ing the pesticide composition according to the invention is to of the phytopathogenic fungi or damaging insect to be elimi add a formulation containing the active ingredients to the nated or the degree of infestation, for example, of the plants irrigation water. with these fungi, may require higher doses of combined active According to another object of the present invention, there ingredients. is provided a method for controlling the phytopathogenic 30 fungi or damaging insects of plants, crops or seeds, charac The optimum dose usually depends on several factors, for terized in that an agronomically effective and substantially example on the type of phytopathogenic fungus to be treated non-phytotoxic quantity of apesticide composition according or insect to control, on the type or level of development of the to the invention is applied as seed treatment, foliar applica infested plant, on the density of vegetation, or alternatively on tion, stem application, drench or drip application or chemi 35 the method of application. gation to the seed, the plant or to the fruit of the plant or to soil Without it being limiting, the crop treated with the pesti or to inert Substrate (e.g. inorganic Substrates like sand, rock cide composition or combination according to the invention wool, glasswool; expanded minerals like perlite, Vermiculite, is, for example, grapevine, but this could be cereals, Veg Zeolite or expanded clay), Pumice, Pyroclastic materials or etables, lucerne, soybean, market garden crops, turf, wood, stuff, synthetic organic Substrates (e.g. polyurethane), 40 tree or horticultural plants. organic Substrates (e.g. peat, composts, tree waste products The method of treatment according to the invention may like coir, wood fibre or chips, tree bark) or to a liquid substrate also be useful to treat propagation material Such as tubers or (e.g. floating hydroponic systems, Nutrient Film Technique, rhizomes, but also seeds, seedlings or seedlings pricking out Aeroponics) wherein the plant is growing or in which it is and plants or plants pricking out. This method of treatment desired to grow. 45 may also be useful to treat roots. The method of treatment The expression “are applied to the plants to be treated” is according to the invention may also be useful to treat the understood to mean, for the purposes of the present invention, over-ground parts of the plant such as trunks, stems or stalks, that the pesticide composition which is the subject of the leaves, flowers and fruit of the concerned plant. invention can be applied by means of various methods of Among the plants that can be protected by the method treatment Such as: 50 according to the invention, mention can be made of cotton; spraying onto the aerial parts of the said plants a liquid flax; vine; fruit or vegetable crops such as Rosaceae sp. (for comprising one of the said compositions, instance pip fruit such as apples and pears, but also stone fruit dusting, the incorporation into the Soil of granules or pow Such as apricots, almonds and peaches), Ribesioidae sp., ders, spraying, around the said plants, and in the case of Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., trees injection or daubing, 55 Fagaceae sp., Moraceae sp., Oleaceae sp., Actimidaceae sp., coating or film-coating the seeds of the said plants with the Lauraceae sp., Musaceae sp. (for instance banana trees and aid of a plant-protection mixture comprising one of the plantins), Rubiaceae sp., Theaceae sp., Sterculiceae sp., said compositions. Rutaceae sp. (for instance lemons, oranges and grapefruit); The method according to the invention may either be a Solanaceae sp. (for instance tomatoes), Liliaceae sp., Aster curing, preventing or eradicating method. In this method, a 60 aceae sp. (for instance lettuces), Umbelliferae sp., Cruciferae composition used can be prepared beforehand by mixing the sp., Chenopodiaceae sp., Cucurbitaceae sp., Papilionaceae two or more active compounds according to the invention. sp. (for instance peas), Rosaceae sp. (for instance strawber According to an alternative of Such a method, it is also ries); major crops such as Graminae sp. (for instance maize, possible to apply simultaneously, successively or separately lawn or cereals such as wheat, rice, barley and triticale), compounds (A) and (B) and optionally (C) so as to have the 65 Asteraceae sp. (for instance Sunflower), Cruciferae sp. (for conjugated (A)/(B) (optionally (C)) effects, of distinct com instance colza), Fabacae sp. (for instance peanuts), Papilion positions each containing one of the two or three active ingre aceae sp. (for instance Soybean), Solanaceae sp. (for instance US 8,969,392 B2 15 16 potatoes), Chenopodiaceae sp. (for instance beetroots); hor Cochliobolus diseases, caused for example by Cochliobo ticultural and forest crops; as well as genetically modified lus sativus, homologues of these crops. Colletotrichum diseases, caused for example by Colletot The composition according to the invention may also be richum lindemuthanium, used in the treatment of genetically modified organisms with Cycloconium diseases, caused for example by Cycloco the compounds according to the invention or the agrochemi nium oleaginum, cal compositions according to the invention. Genetically Diaporthe diseases, caused for example by Diaporthe modified plants are plants into genome of which a heterolo Citri gous gene encoding a protein of interest has been stably Elsinoe diseases, caused for example by Elsinoe fawcettii, integrated. The expression "heterologous gene encoding a 10 protein of interest essentially means genes which give the Gloeosporium diseases, caused for example by Gloeospo transformed plant new agronomic properties, or genes for rium laeticolor, improving the agronomic quality of the modified plant. Glomerella diseases, caused for example by Glomerella The composition according to the invention may also be Cingulata, used against fungal diseases liable to grow on or inside tim 15 Guignardia diseases, caused for example by Guignardia ber. The term “timber” means all types of species of wood, bidwelli, and all types of working of this wood intended for construc Leptosphaeria diseases, caused for example by Lep tion, for example solid wood, high-density wood, laminated tosphaeria maculans, Leptosphaeria nodorum, wood, and plywood. The method for treating timber accord Magnaporthe diseases, caused for example by Mag ing to the invention mainly consists in contacting one or more naporthe grisea, compounds according to the invention, or a composition Mycosphaerella diseases, caused for example by according to the invention; this includes for example direct Mycosphaerella graminicola, Mycosphaerella application, spraying, dipping, injection or any other Suitable arachidicola, Mycosphaerella fijiensis, CaS. Phaeosphaeria diseases, caused for example by Among the diseases of plants or crops that can be con 25 Phaeosphaeria nodorum, trolled by the method according to the invention, mention can Pyrenophora diseases, caused for example by Pyreno be made of: phora teres, Powdery mildew diseases such as: Ranularia diseases, caused for example by Ranularia Blumeria diseases, caused for example by Blumeria grami collo-Cygni, nis, 30 Rhynchosporium diseases, caused for example by Rhyn Podosphaera diseases, caused for example by Podosphaera leucotricha, chosporium secalis, Sphaerotheca diseases, caused for example by Sphaeroth Septoria diseases, caused for example by Septoria apii or eCafuliginea, Septoria lycopercisi; Uncinula diseases, caused for example by Uncinula neca 35 Tiphula diseases, caused for example by Tiphula incar tor nate, Rust diseases such as: Venturia diseases, caused for example by Venturia Gymnosporangium diseases, caused for example by Gym inaequalis nosporangium Sabinae, Root and stem diseases such as: Hemileia diseases, caused for example by Hemileia vasta 40 Corticium diseases, caused for example by Corticium trix graminearum, Phakopsora diseases, caused for example by Phakopsora Fusarium diseases, caused for example by Fusarium pachyrhizi or Phakopsora meibomiae, Oxysporum, Puccinia diseases, caused for example by Puccinia recon Gaeumannomyces diseases, caused for example by Gaeu dite, 45 mannomyces graminis, Uromyces diseases, caused for example by Uromyces Rhizoctonia diseases, caused for example by Rhizoctonia appendiculatus, Solani, Oomycete diseases such as: Tapesia diseases, caused for example by Tapesia acufor Bremia diseases, caused for example by Bremia lactucae, mis, Peronospora diseases, caused for example by Peronospora 50 Thielaviopsis diseases, caused for example by Thielaviop pisi or P. brassicae, Phytophthora diseases, caused for example by Phytoph sis basicola, thora infestans, Ear and panicle diseases such as: Plasmopara diseases, caused for example by Plasmopara Alternaria diseases, caused for example by Alternaria Spp., viticola, 55 Pseudoperonospora diseases, caused for example by Aspergillus diseases, caused for example by Aspergillus Pseudoperonospora humuli or Pseudoperonospora flavus, cubensis, Cladosporium diseases, caused for example by Cladospo Pythium diseases, caused for example by Pythium rium spp.; ultimum 60 Claviceps diseases, caused for example by Claviceps pur Leafspot, leaf blotch and leaf blight diseases such as: purea, Alternaria diseases, caused for example by Alternaria Fusarium diseases, caused for example by Fusarium cul Solani; norum, Cercospora diseases, caused for example by Cercospora Gibberella diseases, caused for example by Gibberella beticola 65 Zeae, Cladiosporum diseases, caused for example by Cladiospo Monographella diseases, caused for example by rium cucunerinum, Monographella nivalis US 8,969,392 B2 17 18 Smut and bunt diseases such as: pests from the order of Orthoptera for example Acheta Sphacelotheca diseases, caused for example by Sphace domesticus, Gryllotalpa spp., Locusta migratoria lotheca reiliana, migratorioides, Melanoplus spp., Schistocerca gre Tilletia diseases, caused for example by Tilletia caries, garia, Urocystis diseases, caused for example by Urocystis 5 pests from the order of Blattaria for example Blatta Orien occulta, talis, Periplaneta americana, Leucophaea maderae, Ustilago diseases, caused for example by Ustilago nuda Blattella germanica, Fruit rot and mould diseases such as: pests from the order of Dermaptera for example Forficula Aspergillus diseases, caused for example by Aspergillus auricularia, 10 pests from the order of Isoptera for example Reticulitermes flavus, Spp., Botrytis diseases, caused for example by Botrytis cinerea, pests from the order of Phthiraptera for example Pediculus Penicillium diseases, caused for example by Penicillium humanus corporis, Haematopinus spp., Linognathus expansium, spp., Trichodectes spp., Damalinia spp.; Sclerotinia diseases, caused for example by Sclerotinia 15 pests from the order of Thysanoptera for example Herci Sclerotiorum nothrips femoralis, Thrips tabaci, Thrips palmi, Fran Verticilium diseases, caused for example by Verticilium kliniella accidentalis, alboatrum, pests from the order of Heteroptera for example Euryga Seed and Soilborne decay, mould, wilt, rot and damping-off ster spp., Dysdercus intermedius, Piesma quadrata, diseases: Cimex lectularius, Rhodnius prolixus, Triatoma spp.; Fusarium diseases, caused for example by Fusarium cul pests from the order of Homoptera for example Aleurodes norum, brassicae, Bemisia tabaci, Trialeurodes vaporariorum, Phytophthora diseases, caused for example by Phytoph Aphis gossypii, Brevicoryne brassicae, Cryptomyzus thora cactorum, ribis, Aphis fabae, Aphis pomi, Eriosoma lanigerum, Pythium diseases, caused for example by Pythium ulti 25 Hyalopterus arundinis, Phylloxera vastatrix, Pemphi nun, gus spp., Macrosiphun avenae, Myzus spp., Phorodon Rhizoctonia diseases, caused for example by Rhizoctonia humuli, Rhopa-losiphum padi, Empoasca spp., Euscelis Solani, bilobatus, Nephotettix cincticeps, Lecanium corni, Sais Sclerotium diseases, caused for example by Sclerotium setia oleae, Laodelphax striatellus, Nilaparvata lugens, rolfsii. 30 Aonidiella aurantii, Aspidiotus hederae, Pseudococcus Microdochium diseases, caused for example by Micro spp., Psylla spp.; dochium nivale, pests from the order of Lepidoptera for example Pectino Canker, broom and dieback diseases such as: phora gossypiella, Bupalus piniarius, Chematobia bru Nectria diseases, caused for example by Nectria galligena, mata, Lithocolletis blancardella, Hyponomeuta Blight diseases such as: 35 padella, Plutella xylostella, Malacosoma neustria, Monilinia diseases, caused for example by Monilinia laxa, Euproctis chrysorrhoea, Lymantria spp., Bucculatrix Leafblister or leaf curl diseases such as: thurberiella, Phyllocnistis citrella, Agrotis spp., Euxoa Taphrina diseases, caused for example by Taphrina defor spp., Feltia spp., Earias insulana, Heliothis spp., mans, Mamestra brassicae, Panolis flammea, Spodoptera spp., Decline diseases of wooden plants such as: 40 Trichoplusia ni, Carpocapsa pomonella, Pieris spp., Esca diseases, caused for example by Phaemoniella Chilo spp., Pyrausta nubilalis, Ephestia kuehniella, clamydospora, Galleria mellonella, Tineola bisselliella, Tinea pel Eutylpa dyeback, caused for example by Eutypalata, lionella, Hofmannophila pseudospretella, Cacoecia Dutch elm disease, caused for example by Ceratocystsc podana, Capua reticulana, Choristoneura filmiferana, ulmi, 45 Clysia ambiguella, Homona magnanima, Tortrix viri Diseases of flowers and Seeds such as: dana, Cnaphalocerus spp., Oulema Oryzae, Botrytis diseases, caused for example by Botrytis cinerea pests from the order of Coleoptera for example Anobium Diseases of tubers such as: punctatum, Rhizopertha dominica, Bruchidius Obtectus, Rhizoctonia diseases, caused for example by Rhizoctonia Acanthoscelides Obtectus, Hylotrupes bajulus, Agellas Solani 50 tica alni, Leptinotarsa decemlineata, Phaedon cochle Helminthosporium diseases, caused for example by Helm ariae, Diabrotica spp., Psylliodes chrysocephala, Epil inthosporium Solani. achna varivestis, Atomaria spp., Oryzaephilus The damaging insects of crops which can be controlled at surinamensis, Anthonomus spp., Sitophilus spp., Otior any development stage by using the pesticide composition rhynchus sulcatus, Cosmopolites Sordidus, Ceuthor according to the invention include: 55 rhynchus assimilis, Hypera postica, Dermestes spp., pests from the order of Isopoda for example Oniscus asel Trogoderma spp., Anthrenus spp., Attagenus spp., Lyc lus, Armadillidium vulgare, Porcellio scaber, tus spp., Melligethes aeneus, Ptinus spp., Niptus hololeu pests from the order of Diplopoda for example Blaniulus cus, Gibbium psylloides, Tribolium spp., Tenebrio moli guttulatus, tor; Agriotes spp., Conoderus spp., Melolontha pests from the order of Chilopoda for example Geophilus 60 melolontha, Amphimallon solstitialis, Costely tra Carpophagus, Scutigera spp.; Zealandica, Lissorhoptrus Oryzophilus, pests from the order of Symphyla for example Scutigerella pests from the order of Hymenoptera for example Diprion immaculata, spp., Hoplocampa spp., Lasius spp., Monomorium pests from the order of Thysanura for example Lepisma pharaonis, Vespa spp.; saccharina, 65 pests from the order of Diptera for example Aedes spp., pests from the order of Collembola for example Onychi Anopheles spp., Culex spp., Drosophila melanogaster, urus arnatus, Musca spp., Fannia spp., Caliphora erythrocephala, US 8,969,392 B2 19 20 Lucilia spp., Chrysomyia spp., Cuterebra spp., Gastro treated by being dipped into the preparation of the active philus spp., Hyppobosca spp., Stomoxys spp., Oestrus compound at the desired concentration. spp., Hypoderma spp., Tabanus spp., Tannia spp., Bibio After a period of time of 6 days, the mortality is deter hortulanus, Oscinella frit, Phorbia spp., Pegomyia hyos cyani, Ceratitis capitata, Dacus oleae, Tipulapaludosa, mined. 100% means that all the aphids have been killed: 0% Hvlemyia spp., Liriomyza spp.; means that none of the aphids have been killed. pests from the order of Siphonaptera for example Xenop According to the present application in this test e.g. the sylla cheopis, Ceratophyllus spp.; following combination shows a synergistic effect in compari pests from the class of Arachnida for example Scorpio son to the single compounds. The results are presented in maurus, Latrodectus mactans, Acarus siro, Argas spp., 10 table 1. Ornithodoros spp., Dermanyssus gallinae, Eriophyes ribis, Phyllocoptruta oleivora, Boophilus spp., Rhipi TABLE 1 cephalus spp., Amblyomma spp., Hyalomma spp., Ixodes spp., Psoroptes spp., Chorioptes spp., Sarcoptes Rate of Expected value spp., Tarsonemus spp., Bryobia praetiosa, Panonychus 15 application of according to spp., Tetranychus spp., Hemitarisonemus spp., Brevipal active Efficacy Colby formula pus spp. the plant-parasitic neaminotes such as Pratylenchus spp., compound (ppm) (%) (%) Radopholus similis, Dity lenchus dipsaci, Tilenchulus semipenetrans, Heterodera spp., Globodera spp., Propamocarb-fosetylate 2OO O f Meloidogyne spp., Aphelen.choides spp., Longidorus Clothianidin O.8 75 f spp., Xiphinema spp., Trichodorus spp., Bursaphelen Propamocarb-fosetylate + 200 - 0.8 95 81 Chus spp. Clothianidin As a further aspect, the present invention provides a prod uct comprising a compound (A) and a compound (B) and 25 optionally a compound (C), as herein defined, as a combined preparation for simultaneous, separate or sequential use in EFFICACY EXAMPLEB controlling the phytopathogenic fungi or damaging insects of plants, crops or seeds at a site. The pesticide composition according to the invention can 30 Phaedon Cochleariae Test be prepared immediately before use by using a kit-of-parts for controlling, curatively or preventively, the phytopathogenic fungi of crops, such a kit-of-parts may comprise at least one compound (A) and at least one compound (B) and optionally Solvent: 7 parts by weight of dimethylformamide compound (C) intended to be combined or used simulta 35 Emulsifier: 2 parts by weight of alkylaryl polyglycolether neously, separately or sequentially in controlling the phyto pathogenic fungi of crops at a site. To produce a suitable preparation of active compound, 1 It is therefore a pack in which the user finds all the ingre dients for preparing the fungicide formulation which they part by weight of active compound is mixed with the stated wish to apply to the crops. These ingredients, which comprise 40 amount of solvent and emulsifier, and the concentrate is in particular the active agents (A) and (B) and optionally diluted with emulsifier-containing water to the desired con compound (C) and which are packaged separately, are pro centration. vided in the form of a powder or in the form of a liquid which Cabbage leaves (Brassica oleracea) are treated by being is concentrated to a greater or lesser degree. The user simply dipped into the preparation of the active compound at the has to mix in the prescribed doses and to add the quantities of 45 desired concentration and are infested with larvae of the liquid, for example of water, necessary to obtain a formula mustard beetle Phaedon cochleariae as long as the leaves are tion which is ready to use and which can be applied to the still moist. crops. The present invention can be illustrated by the following After a period of time of 4 days, the mortality is deter and non-limitative examples. 50 mined. 100% means that all the aphids have been killed: 0% means that none of the aphids have been killed. EFFICACY EXAMPLEA According to the present application in this test e.g. the following combination shows a synergistic effect in compari Myzus persicae Test son to the single compounds. The results are presented in 55 table 2.

TABLE 2 Solvent: 7 parts by weight of dimethylformamide Emulsifier: 2 parts by weight of alkylaryl polyglycolether Rate of Expected value 60 application of according to active Efficacy Colby formula To produce a suitable preparation of active compound, 1 compound (ppm) (%) (%) part by weight of active compound is mixed with the stated Propamocarb-fosetylate 2OO 5 f amount of solvent and emulsifier, and the concentrate is Imidacloprid 2O 8O f diluted with emulsifier-containing water to the desired con Propamocarb-fosetylate + 2OO - 20 1OO 81 centration. 65 Imidacloprid Cabbage leaves (Brassica oleracea) which are heavily infested by the green peach aphid (Myzus persicae) are US 8,969,392 B2 21 22 EFFICACY EXAMPLEC fin, and Spirotetramate; wherein components A) and B) are in an A/B weight ratio ranging from 1/1,000 to 1,000/1. Plutella xylostella Test 2. A composition according to claim 1, wherein compound B is rynaxapyr. 3. A composition according to claim 1, wherein compound B is spinosad. Solvent: 7 parts by weight of dimethylformamide 4. A composition according to claim 1, wherein the A/B Emulsifier: 2 parts by weight of alkylaryl polyglycolether weight ratio ranges from 1/125 to 125/1. 5. A composition according to claim 1, wherein the A/B weight ratio ranges from 1/25 to 25/1. To produce a suitable preparation of active compound, 1 10 6. A composition according to claim 1, further comprising part by weight of active compound is mixed with the stated C) a further fungicide compound in an A/B/C weight ratio amount of solvent and emulsifier, and the concentrate is ranging from 1/1,000/1,000 to 1/0001/0.001. diluted with emulsifier-containing water to the desired con 7. A composition according to claim 6, wherein compound centration. C is selected from the group consisting of benalaxyl, benal Cabbage leaves (Brassica oleracea) are treated by being 15 axyl-M, benthiavalicarb, carboxin, chlorothalonil, cyazofa dipped into the preparation of the active compound at the mid, cymoxanil, dimetomorph, fluaZinam, fludioxonil, fluox desired concentration and are infested with larvae of the astrobin, fluquinconazole, flutriafol, fosetyl-Al. diamond black moth Plutella xylostella as long as the leaves hexaconazole, hymexaZol, ipconazole, mancoZeb, mandipro are still moist. pamid, maneb, mefenoxam, metalaxyl, metiram, pencona After a period of time of 6 days, the mortality is deter Zole, penthiopyrad, phosphorous acid, propamocarb -HC1. mined. 100% means that all the caterpillars have been killed; propineb, prothioconazole, tebuconazole, thiram, triadime 0% means that none of the caterpillars have been killed. nol, trifloxystrobin, triticonazole and N-2-(1,3-dimethyl-bu According to the present application in this test e.g. the tyl)-phenyl-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxa following combination shows a synergistic effect in compari mide. son to the single compounds. The results are presented in 25 8. A composition according to claim 6, wherein the A/B/C table 3. weight ratio ranges from 1/100/100 to 1/0.01/0.01. 9. A composition according to claim 6, wherein the A/B/C TABLE 3 weight ratio ranges from 1/80/80 to 1/0.05/0.05 Rate of Expected value 10. A composition according to claim 6, wherein the A/B/C application of according to 30 weight ratio ranges from 1/50/100 to 1/1.5/2.5. active Efficacy Colby formula 11. A composition according to claim 6, wherein the A/B/C compound (ppm) (%) (%) weight ratio ranges from 1/12/25 to 1/6/12. Propamocarb-fosetylate 2OO O f 12. A composition according to claim 1, wherein com thiacloprid 2O 2O f pound B is spirodiclofen. Propamocarb-fosetylate + 200 - 20 65 2O 35 13. A composition according to claim 1, wherein com thiacloprid pound B is spiromesifen. 14. A composition according to claim 1, wherein com What is claimed is: pound B is spirotetramate. 1. A composition comprising: A) propamocarb-fosetylate 40 15. A composition according to claim 1, which has a syn and B) an insecticide compound selected from the group ergistic effect. consisting of rynaxapyr, spinosad, Spirodiclofen, Spiromesi