Summary of MDA Pesticide Bee Kill Complaint Investigations in 2016
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Chemicals Implicated in Colony Collapse Disorder
Chemicals Implicated While research is underway to determine the cause of Colony Collapse Disorder (CCD), pesticides have emerged as one of the prime suspects. Recent bans in Europe attest to the growing concerns surrounding pesticide use and honeybee decline. Neonicotinoids Neonicotinoids are a relatively new class of insecticides that share a common mode of action that affect the central nervous system of insects, resulting in paralysis and death. They include imidacloprid, acetamiprid, clothianidin, dinotefuran, nithiazine, thiacloprid and thiamethoxam. According to the EPA, uncertainties have been identified since their initial registration regarding the potential environmental fate and effects of neonicotinoid pesticides, particularly as they relate to pollinators. Studies conducted in the late 1990s suggest that neonicotinic residues can accumulate in pollen and nectar of treated plants and represent a potential risk to pollinators. There is major concern that neonicotinoid pesticides may play a role in recent pollinator declines. Neonicotinoids can also be persistent in the environment, and when used as seed treatments, translocate to residues in pollen and nectar of treated plants. The potential for these residues to affect bees and other pollinators remain uncertain. Despite these uncertainties, neonicotinoids are beginning to dominate the market place, putting pollinators at risk. The case of the neonicotinoids exemplifies two critical problems with current registration procedures and risk assessment methods for pesticides: the reliance on industry-funded science that contradicts peer-reviewed studies and the insufficiency of current risk assessment procedures to account for sublethal effects of pesticides. • Imidacloprid Used in agriculture as foliar and seed treatments, for indoor and outdoor insect control, home gardening and pet products, imidacloprid is the most popular neonicotinoid, first registered in 1994 under the trade names Merit®, Admire®, Advantage TM. -
Historical Perspectives on Apple Production: Fruit Tree Pest Management, Regulation and New Insecticidal Chemistries
Historical Perspectives on Apple Production: Fruit Tree Pest Management, Regulation and New Insecticidal Chemistries. Peter Jentsch Extension Associate Department of Entomology Cornell University's Hudson Valley Lab 3357 Rt. 9W; PO box 727 Highland, NY 12528 email: [email protected] Phone 845-691-7151 Mobile: 845-417-7465 http://www.nysaes.cornell.edu/ent/faculty/jentsch/ 2 Historical Perspectives on Fruit Production: Fruit Tree Pest Management, Regulation and New Chemistries. by Peter Jentsch I. Historical Use of Pesticides in Apple Production Overview of Apple Production and Pest Management Prior to 1940 Synthetic Pesticide Development and Use II. Influences Changing the Pest Management Profile in Apple Production Chemical Residues in Early Insect Management Historical Chemical Regulation Recent Regulation Developments Changing Pest Management Food Quality Protection Act of 1996 The Science Behind The Methodology Pesticide Revisions – Requirements For New Registrations III. Resistance of Insect Pests to Insecticides Resistance Pest Management Strategies IV. Reduced Risk Chemistries: New Modes of Action and the Insecticide Treadmill Fermentation Microbial Products Bt’s, Abamectins, Spinosads Juvenile Hormone Analogs Formamidines, Juvenile Hormone Analogs And Mimics Insect Growth Regulators Azadirachtin, Thiadiazine Neonicotinyls Major Reduced Risk Materials: Carboxamides, Carboxylic Acid Esters, Granulosis Viruses, Diphenyloxazolines, Insecticidal Soaps, Benzoyl Urea Growth Regulators, Tetronic Acids, Oxadiazenes , Particle Films, Phenoxypyrazoles, Pyridazinones, Spinosads, Tetrazines , Organotins, Quinolines. 3 I Historical Use of Pesticides in Apple Production Overview of Apple Production and Pest Management Prior to 1940 The apple has a rather ominous origin. Its inception is framed in the biblical text regarding the genesis of mankind. The backdrop appears to be the turbulent setting of what many scholars believe to be present day Iraq. -
The Impact of the Nation's Most Widely Used Insecticides on Birds
The Impact of the Nation’s Most Widely Used Insecticides on Birds Neonicotinoid Insecticides and Birds The Impact of the Nation’s Most Widely Used Insecticides on Birds American Bird Conservancy, March 2013 Grasshopper Sparrow by Luke Seitz Cover photos: Horned Lark and chicks by Middleton Evans; Corn field, stock.xchng, sxc.hu; Calico Pennant dragonfly by David Cappaert, Michigan State University, Bugwood.org 1 Neonicotinoid Insecticides and Birds American Bird Conservancy would like to thank the Turner Foundation, Wallace Genetic Foundation, Jeff and Connie Woodman, Cornell Douglas Foundation and A.W. Berry Foundation for their ongoing support for American Bird Conservancy’s Pesticides Program. Written by Dr. Pierre Mineau and Cynthia Palmer Designed by Stephanie von Blackwood About the Authors Dr. Pierre Mineau began his long and distinguished scientific career studying the effects of persistent organochlorine compounds, like DDT and PCBs, on fish-eating birds. He then became responsible for the Canadian assessment of new and existing pesticides to determine their adverse impacts on wildlife. In 1994 he transitioned from regulatory reviews to full-time research on the environmental impacts of pesticides, achieving the rank of Senior Research Scientist at Environment Canada. Working with international collaborators and graduate students, he works on assessing globally the environmental footprint of pesticides. He also studies how birds are exposed to pesticides and how bird populations respond to pesticide use and agricultural practices. His work includes defining the ecological values of birds in cropland as well as estimating the incidental take of birds from various other human activities. He has written more than 100 peer-reviewed publications and has authored some 200 presentations. -
Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects
EN58CH06-Casida ARI 5 December 2012 8:11 Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects John E. Casida1,∗ and Kathleen A. Durkin2 1Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, 2Molecular Graphics and Computational Facility, College of Chemistry, University of California, Berkeley, California 94720; email: [email protected], [email protected] Annu. Rev. Entomol. 2013. 58:99–117 Keywords The Annual Review of Entomology is online at acetylcholinesterase, calcium channels, GABAA receptor, nicotinic ento.annualreviews.org receptor, secondary targets, sodium channel This article’s doi: 10.1146/annurev-ento-120811-153645 Abstract Copyright c 2013 by Annual Reviews. Neuroactive insecticides are the principal means of protecting crops, people, All rights reserved livestock, and pets from pest insect attack and disease transmission. Cur- ∗ Corresponding author rently, the four major nerve targets are acetylcholinesterase for organophos- phates and methylcarbamates, the nicotinic acetylcholine receptor for neonicotinoids, the γ-aminobutyric acid receptor/chloride channel for by Public Health Information Access Project on 04/29/14. For personal use only. Annu. Rev. Entomol. 2013.58:99-117. Downloaded from www.annualreviews.org polychlorocyclohexanes and fiproles, and the voltage-gated sodium channel for pyrethroids and dichlorodiphenyltrichloroethane. Species selectivity and acquired resistance are attributable in part to structural differences in binding subsites, receptor subunit interfaces, or transmembrane regions. Additional targets are sites in the sodium channel (indoxacarb and metaflumizone), the glutamate-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolite), and the calcium-activated calcium channel (diamides). Secondary toxic effects in mammals from off-target serine hydrolase inhibi- tion include organophosphate-induced delayed neuropathy and disruption of the cannabinoid system. -
Genetically Modified Baculoviruses for Pest
INSECT CONTROL BIOLOGICAL AND SYNTHETIC AGENTS This page intentionally left blank INSECT CONTROL BIOLOGICAL AND SYNTHETIC AGENTS EDITED BY LAWRENCE I. GILBERT SARJEET S. GILL Amsterdam • Boston • Heidelberg • London • New York • Oxford Paris • San Diego • San Francisco • Singapore • Sydney • Tokyo Academic Press is an imprint of Elsevier Academic Press, 32 Jamestown Road, London, NW1 7BU, UK 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1800, San Diego, CA 92101-4495, USA ª 2010 Elsevier B.V. All rights reserved The chapters first appeared in Comprehensive Molecular Insect Science, edited by Lawrence I. Gilbert, Kostas Iatrou, and Sarjeet S. Gill (Elsevier, B.V. 2005). All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publishers. Permissions may be sought directly from Elsevier’s Rights Department in Oxford, UK: phone (þ44) 1865 843830, fax (þ44) 1865 853333, e-mail [email protected]. Requests may also be completed on-line via the homepage (http://www.elsevier.com/locate/permissions). Library of Congress Cataloging-in-Publication Data Insect control : biological and synthetic agents / editors-in-chief: Lawrence I. Gilbert, Sarjeet S. Gill. – 1st ed. p. cm. Includes bibliographical references and index. ISBN 978-0-12-381449-4 (alk. paper) 1. Insect pests–Control. 2. Insecticides. I. Gilbert, Lawrence I. (Lawrence Irwin), 1929- II. Gill, Sarjeet S. SB931.I42 2010 632’.7–dc22 2010010547 A catalogue record for this book is available from the British Library ISBN 978-0-12-381449-4 Cover Images: (Top Left) Important pest insect targeted by neonicotinoid insecticides: Sweet-potato whitefly, Bemisia tabaci; (Top Right) Control (bottom) and tebufenozide intoxicated by ingestion (top) larvae of the white tussock moth, from Chapter 4; (Bottom) Mode of action of Cry1A toxins, from Addendum A7. -
4-Cyano-3-Benzoylamino-N
(19) TZZ _T (11) EP 2 427 427 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C07C 255/60 (2006.01) 25.12.2013 Bulletin 2013/52 (86) International application number: (21) Application number: 10713937.0 PCT/EP2010/054862 (22) Date of filing: 14.04.2010 (87) International publication number: WO 2010/127926 (11.11.2010 Gazette 2010/45) (54) 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDE ZUR VERWENDUNG IN DER SCHÄDLINGSBEKÄMPFUNG 4-CYANO-3-BENZOYLAMINO-N-PHÉNYL-BENZAMIDES DESTINÉS À ÊTRE UTILISÉS DANS LA LUTTE ANTIPARASITAIRE (84) Designated Contracting States: • HUETER, Ottmar Franz AT BE BG CH CY CZ DE DK EE ES FI FR GB GR CH-4332 Stein (CH) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL • MAIENFISCH, Peter PT RO SE SI SK SM TR CH-4332 Stein (CH) (30) Priority: 06.05.2009 GB 0907822 (74) Representative: Herrmann, Jörg et al 18.12.2009 GB 0922234 Syngenta Crop Protection Münchwilen AG (43) Date of publication of application: Intellectual Property Department 14.03.2012 Bulletin 2012/11 Schaffhauserstrasse CH-4332 Stein (CH) (73) Proprietor: Syngenta Participations AG 4058 Basel (CH) (56) References cited: EP-A1- 1 714 958 WO-A1-2008/000438 (72) Inventors: WO-A1-2008/074427 • JUNG, Pierre Joseph Marcel CH-4332 Stein (CH) Remarks: • GODFREY, Christopher Richard Ayles Thefile contains technical information submitted after CH-4332 Stein (CH) the application was filed and not included in this specification Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. -
(12) United States Patent (10) Patent No.: US 8,900,554 B2 Tamarkin Et Al
US0089.00554B2 (12) United States Patent (10) Patent No.: US 8,900,554 B2 Tamarkin et al. (45) Date of Patent: *Dec. 2, 2014 (54) FOAMABLE COMPOSITION AND USES 3,062,715. A 1 1/1962 Reese et al. THEREOF 3,067,784 A 12/1962 Gorman 3,092.255. A 6, 1963 Hohman 3,092,555 A 6, 1963 Horn (75) Inventors: Dov Tamarkin, Maccbim (IL); Doron 3,141,821 A 7, 1964 Compeau Friedman, Karmei Yosef (IL); Meir 3,142,420 A 7/1964 Gawthrop Eini, Ness Ziona (IL) 3: A S3; sistenbackaa. (73) Assignee: Foamix Pharmaceuticals Ltd., Rehovot 3:33 A 1943: Sir (IL) 3.236,457 A 2/1966 Kennedy et al. 3,244,589 A 4, 1966 Sunnen (*) Notice: Subject to any disclaimer, the term of this 3,252,859 A 5, 1966 Silver patent is extended or adjusted under 35 3.333 A 3. Siskiewicz U.S.C. 154(b) by 0 days. 3,263,8694- W - A 8, 1966 Corsetteea spent is Subject to a terminal disis- 3,301,4443,298.919 A 1/19671, 1967 WittkeBishop et al. 3,303,970 A 2f1967 Breslau et al. 3,330,730 A 7, 1967 Hernandez (21) Appl. No.: 13/400,330 3,333,333 A 8, 1967 Noack 3,334,147 A 8, 1967 Brunelle et al. (22) Filed: Feb. 20, 2012 3,346,451 A 10, 1967 Collins et al. (Continued) (65) Prior Publication Data US 2012/0148503 A1 Jun. 14, 2012 FOREIGN PATENT DOCUMENTS AU 19878O257 9, 1986 AU 7825.15 12/2005 Related U.S. -
Acute Toxicity of Selected Insecticides and Their Safety to Honey Bee (Apis Mellifera L.) Workers Under Laboratory Conditions
Open Access Austin Environmental Sciences Special Article - Pesticides Acute Toxicity of Selected Insecticides and Their Safety to Honey Bee (Apis mellifera L.) Workers Under Laboratory Conditions Abbassy MA1*, Nasr HM1, Abo-yousef HM2 and Dawood RR1 Abstract 1 Department of Plant Protection, Damanhur University, Objectives: The honey bee, Apis mellifera L., is widely used for the Egypt production of honey, wax, pollen, propolis, royal jelly and venom and crop 2Central Laboratory of Pesticides, Ministry of Agriculture pollination. Since honey bees can be exposed to insecticides in sprayed flowering and Land Reclamation, Egypt crops, therefore, this study aimed to assess the acute toxicity and safety index *Corresponding author: Moustafa A Abbassy, of five commonly used insecticides to honey bee workers in laboratory. Department of Plant Protection, Damanhur University, Methods: Bees were exposed to the insecticides: Imidacloprid, Pesticide Chemistry and Toxicology, Egypt Thiamethoxam, Esfenvalerate, Indoxacarb and Chlorantraniliprole by two Received: May 03, 2020; Accepted: May 25, 2020; methods of exposure: topical application and feeding techniques. LD50 and LC50 Published: June 01, 2020 values for each insecticide to honey bees were determined after 24 and 48 h from treatment. Results: The LD50 values in µg per bee were 0.0018 (indoxacarb), 0.019 (esfenvalerate), 0.024 (thiamethoxam), 0.029 (imidacloprid) and 107.12 -1 (chlorantraniliprole). The LC50 values (mg L ), for each insecticide, were as follows: indoxacarb, 0.091; esfenvalerate, 0.014; thiamethoxam, 0.009; imidacloprid, 0.003 and chlorantraniliprole, 0.026, after 24 h from exposure. In general, the neonicotinoid insecticides were the most toxic to bees by feeding technique, and indoxacarb, esfenvalerate were the most toxic by contact method while chlorantraniliprole had slightly or non- toxic effect by the two methods. -
WO 2012/080415 Al 21 June 2012 (21.06.2012) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2012/080415 Al 21 June 2012 (21.06.2012) P O P C T (51) International Patent Classification: (74) Agent: THWAITE, Jonathan; Syngenta Crop Protection, A 43/36 (2006.01) A01N 47/06 (2006.01) Munchwilen AG, Schaffhauserstrasse, CH-4332 Stein A 43/40 (2006.01) A01N 51/00 (2006.01) (CH). A 43/90 (2006.01) A01P 9/00 (2006.01) (81) Designated States (unless otherwise indicated, for every A01N 57/ (2006.01) A01P 7/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A0 43/56 (2006.01) A01P 7/02 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, A0 53/00 (2006.01) A01P 7/00 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, A0 43/707 (2006.01) A01P 5/00 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (21) International Application Number: HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, PCT/EP20 11/072946 KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, 15 December 201 1 (15. 12.201 1) SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (25) Filing Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. -
FY 2009-2012 Registration Review Schedule Summary
Registration Review: Summary of Planned Schedule for Opening Registration Review Dockets by Fiscal Year 2009 to 2012 December 15, 2008 EPA Office of Pesticide Programs: Registration Review Schedule Summary 12-15-08 Update Planned Schedule for Opening Registration Review Dockets by Fiscal Year (Oct. 1 - Sept. 30) FY 2009 Dockets FY 2010 Dockets FY 2011 Dockets FY 2012 Dockets (Actuals - Reviews Initiated) CONVENTIONAL PESTICIDES Acephate OP Aldicarb CA Ethalfluralin DN Benfluralin DN Azinphos-Methyl OP Aldoxycarb CA Oryzalin DN Butralin DN Chlorethoxyfos OP Carbaryl CA Prodiamine DN Pendimethalin DN Chlorpyrifos OP Carbofuran CA Fenvalerate PPS Trifluralin DN DDVP OP Formetanate HCl CA gamma Cyhalothrin PPS Acetamiprid NN DEF OP Methiocarb CA Imiprothrin PPS Clothianidin NN Dimethoate OP Methomyl CA lambda-Cyhalothrin PPS Dinotefuran NN Disulfoton OP Oxamyl CA Permethrin PPS Nitrapyrin NN Ethoprop OP Pirimicarb CA Piperonyl butoxide PPS Thiacloprid NN Fenitrothion OP Propoxur CA Tau-fluvalinate PPS Thiamethoxam NN Fosthiazate OP Thiodicarb CA Bensulfuron SU Cypermethrin PPS Malathion OP Copper Compounds: Group 2 CU Chlorimuron SU MGK-264 PPS Methamidophos OP Copper Salts CU Metsulfuron SU Prallethrin PPS Methidathion OP Copper Sulfate CU Sulfosulfuron SU Pyrethrin and derivatives PPS Methyl-Parathion OP 1RS, cis-Permethrin PPS Thifensulfuron SU Resmethrin PPS Mevinphos OP Allethrin stereoisomers PPS Tribenuron SU Sumethrin PPS Naled OP Bifenthrin PPS 2-Hydroxyethyl octyl sulfide Tefluthrin PPS Phorate OP Cyfluthrins PPS Ancymidol Tetramethrin -
Household Insects – Homeowners ` CAUTION: All Insecticides Are Toxic to Some Degree; Therefore, Care Should Be Exercised in Their Use
Household Insects – Homeowners ` CAUTION: All insecticides are toxic to some degree; therefore, care should be exercised in their use. The manufacturer’s directions on the label in the use of the material must be followed explicitly. Insect Threats Insecticides and Treatment* Remarks Ants Feed on foods and Baits (active ingredient and Remove food and clean up the area. Place (several may damage product): bait where ants occur or congregate. May species) clothing; may also sodium tetraborate decahydrate use several different baits at the same time sting, causing severe (Amdro Kills Ants Liquid Bait, Terro to discover one that ants will consume. reaction to some Liquid Ant Baits); Care should be taken not to contaminate people. hydramethylnon (Amdro Kills Ants foodstuffs. Also treat nests in yard. Follow Bait Stations and Stakes); label. orthoboric acid (Terro Perimeter Ant Bait); fipronil (Combat Max Ant Killing Bait Stations and Gel); abamectin (Raid Max Double Control Ant Baits, Raid Ant Baits III); dinotefuran (Hot Shot Ultra Clear Roach & Ant Gel Bait, Hot Shot Ultra Liquid Ant Bait); spinosad (Ortho Home Defense Liquid Ant Bait); thiamethoxam (Raid Precision Placement Ant Bait Gel) Crack and crevices: Follow label. prallethrin, esfenvalerate, pyrethrins, pyrethrum, permethrin, tetra- methrin, phenothrin, beta-cyfluthrin, cyfluthrin Indoor space: prallethrin, esfenvalerate, pyrethrins, pyrethrum, permethrin, tetramethrin, phenothrin, cyfluthrin, bifenthrin Outdoor barrier: prallethrin, esfenvalerate, permethrin, beta-cyfluthrin, cyfluthrin, bifenthrin, malathion, carbaryl Outdoor broadcast: hydramethylnon, pyriproxyfen, beta-cyfluthrin, esfenvalerate, bifenthrin, cyfluthrin, malathion, carbaryl *Labels on insecticides should state “material may be used in the household” and should be registered by the EPA for that purpose. Household Insects – Homeowners ` CAUTION: All insecticides are toxic to some degree; therefore, care should be exercised in their use. -
Pesticides in House Dust from Urban and Farmworker Households In
Quirós-Alcalá et al. Environmental Health 2011, 10:19 http://www.ehjournal.net/content/10/1/19 RESEARCH Open Access Pesticides in house dust from urban and farmworker households in California: an observational measurement study Lesliam Quirós-Alcalá1, Asa Bradman1*, Marcia Nishioka2, Martha E Harnly3, Alan Hubbard4, Thomas E McKone1,5, Jeannette Ferber1, Brenda Eskenazi1 Abstract Background: Studies report that residential use of pesticides in low-income homes is common because of poor housing conditions and pest infestations; however, exposure data on contemporary-use pesticides in low- income households is limited. We conducted a study in low-income homes from urban and agricultural communities to: characterize and compare house dust levels of agricultural and residential-use pesticides; evaluate the correlation of pesticide concentrations in samples collected several days apart; examine whether concentrations of pesticides phased-out for residential uses, but still used in agriculture (i.e., chlorpyrifos and diazinon) have declined in homes in the agricultural community; and estimate resident children’spesticide exposures via inadvertent dust ingestion. Methods: In 2006, we collected up to two dust samples 5-8 days apart from each of 13 urban homes in Oakland, California and 15 farmworker homes in Salinas, California, an agricultural community (54 samples total). We measured 22 insecticides including organophosphates (chlorpyrifos, diazinon, diazinon-oxon, malathion, methidathion, methyl parathion, phorate, and tetrachlorvinphos) and pyrethroids (allethrin-two isomers, bifenthrin, cypermethrin-four isomers, deltamethrin, esfenvalerate, imiprothrin, permethrin-two isomers, prallethrin, and sumithrin), one phthalate herbicide (chlorthal-dimethyl), one dicarboximide fungicide (iprodione), and one pesticide synergist (piperonyl butoxide). Results: More than half of the households reported applying pesticides indoors.