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1 Resume of Hyeon Ho Kim

HYEON HO KIM, Ph.D.

Assistant Professor 1 Department of Health and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan (SKKU) 2 Institute for Future , Samsung Medical Center (SMC)

Room # B4-118, Comprehensive Cancer Center, Samsung Medical Center 81 Irwon-ro, Gangnam-gu, 135-710, Korea Phone: 82-2-3410-1039 (Office); 82-2-2148-7222/7223 (Lab) Web page: www.saihst.skku.edu / E-mail: [email protected]; [email protected]

EDUCATION

1997 - 2002 Ph.D. School of Life Sciences and , , Korea 1995 - 1997 MS Department of Biotechnology, Korea University, Korea 1991 - 1995 BS Department of Biotechnology, Korea University, Korea

PROFESSIONAL EXPERIENCES

2015 - present Editorial Board Member of Molecules and Cells 2014 - present Editorial Board Member of Scientific Reports (Nature Publishing Group) 2010 - present Assistant Prof SAIHST, /Samsung Medical Center, Korea 2005 - 2010 Visiting National Institute on Aging/National Institutes of Health, USA 2004 - 2005 Senior researcher Institute of Dermatological , Seoul National University, Korea 2002 - 2004 Post-doc Clinical Research Institute, Seoul National University , Korea 2002 - 2002 Post-doc School of Life Sciences and Biotechnology, Korea University, Korea 1995 - 1997 Researcher Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea

2 Resume of Hyeon Ho Kim

PUBLICATIONS

38. Cho SY, Ha SY, Huang SM, Kim JH, Kang MS, Yoo HY, Kim HH, Park CK, Um SH, Kim KH, Kim SH. The

prognostic significance of Smad3, Smad4, Smad3 phosphoisoform expression in esophageal squamous cell

carcinoma. Med Oncol. 2014 Nov;31(11):236. doi: 10.1007/s12032-014-0236-9. Epub 2014 Sep 30.

37. Shin JH, Park YM, Kim DH, Moon GJ, Bang OY, Ohn T, Kim HH. Ischemic brain extract increases SDF-1

expression in astrocytes through the CXCR2/miR-223/miR-27b pathway. Biochim Biophys Acta. 2014 Jul 3;

1839: 826-36. (Corresponding author)

36. Lee KW, Sung CO, Kim JH, Kang M, Yoo HY, Kim HH, Um SH, Kim SH. CD10 expression is enhanced by

Twist1 and associated with poor prognosis in esophageal squamous cell carcinoma with facilitating

tumorigenicity in vitro and in vivo. Int J Cancer. 2014 Jun 3. doi: 10.1002/ijc.29006. [Epub ahead of print]

35. Ha SY, Shin J, Kim JH, Kang MS, Yoo HY, Kim HH, Um SH, Kim SH. Overexpression of integrin αV correlates

with poor prognosis in colorectal cancer. J Clin Pathol 2014 Jul;67(7):576-81.

34. Jeon ES, Shin JH, Hwang SJ, Moon KJ, Bang OY, Kim HH. Cobalt chloride induces neuronal differentiation

of human mesenchymal stem cells through upregulation of microRNA-124a. Biochem Biophys Res Commun.

2014 Feb 21; 444(4): 581-7. (Corresponding author) [Recommended by Faculty of 1000 Biology]

33. Lee HW, Park YM, Lee SJ, Cho HJ, Kim DH, Lee JI, Kang MS, Seol HJ, Shim YM, Nam DH, Kim HH, Joo KM.

Alpha-smooth muscle actin (ACTA2) is required for metastatic potential of human lung adenocarcinoma. Clin

Cancer Res 2013 Nov 1;19(21): 5879-89. (Co-corresponding author) [Highlighted in Pulmonary Cell

News]

32. Yoon SP, Kim HH, Kim J, Park RY, and Ohn T. Regulation of cellular RNA nano-particle assembly by splicing

factor SRp20. J Nanosci Nanotech 2013 Jan;13(1): 184-7. (Co-first author)

31. Park YM, Hwang SJ, Masuda K, KM, Jeong MR, Nam DH, Gorospe M, and Kim HH. Heterogeneous

nuclear ribonucleoprotein C1/C2 (hnRNPC) controls the metastatic potential of glioblastoma by regulating

PDCD4. Mol Cell Biol 2012 Oct;32(20):4237-44. (Corresponding author)

30. Hwang SJ, Seol HJ, Park YM, Kim KH, Gorospe M, Nam DH, and Kim HH. MicroRNA-146a suppresses

metastatic activity in brain metastasis. Mol Cells 2012 Sep 3;34(3):329-34. (Corresponding author)

29. Lee KW, Lee NK, Kim JH, Kang MS, Yoo HY, Kim HH, Um SH, and Kim SH. Twist1 causes the transcriptional

repression of claudin-4 with prognostic significance in esophageal cancer. Biochem Biophys Res Commun

2012 Jul 6;423(3):454-60.

28. Jo MY, Kim YG, Kim Y, Lee SJ, Kim MH, Joo KM, Kim HH, and Nam DH. Combined therapy of temozolomide 3 Resume of Hyeon Ho Kim

and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-

proliferative mechanism. Mol Med Report 2012 Apr 11;6(1):88-92. (Co-corresponding author)

27. Srikantan S, Abdelmohsen K, Lee EK, Tominaga K, Subaran SS, Kuwano Y, Kulshrestha R, Panchakshari R,

Kim HH, Yang X, Martindale JL, Marasa BS, Kim MM, Wersto RP, Indig FE, Chowdhury D, Gorospe M.

Translational control of Top2A influences doxorubicin efficacay. Mol Cell Biol 2011 Sep;31(18):3790-801.

26. Masuda K, Abdelmohsen K, Kim MM, Srikantan S, Lee EK, Tominaga K, Selimyan R, Martindale JL, Yang X,

Lehrmann E, Zhang Y, Becker KG, Wang JY, Kim HH, Gorospe M. Global dissociation of HuR-mRNA

complexes promotes cell survival after ionizing radiation. EMBO J. 2011 Mar 6;30(6):1040-53.

25. Lee EK, Lee MJ, Abdelmohsen K, Kim W, Kim MM, Srikantan S, Martindale JL, Hutchison ER, Kim HH, Marasa

BS, Selimyan R, Egan JM, Smith SR, Fried SK, Gorospe M. miR-130 Suppresses Adipogenesis by Inhibiting

Peroxisome Proliferator-Activated Receptor {gamma} Expression. Mol Cell Biol. 2011 Feb;31(4):626-38.

24. Kim HH, Abdelmohsen K, and Gorospe M. Regulation of HuR by DNA damage response kinases. J Nucleic

Acids 2010 Jul 25. 2010. pii: 981487. (First author)

23. Lee EK, Kim HH, Kuwano Y, Abdelmohsen K, Srikantan S, Subaran SS, Gleichmann M, Mughal MR,

Martindale JL, Yang X, Worley PF, Mattson MP, Gorospe M. hnRNP C promotes APP translation by competing

with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol. 2010 May 16. 17:732-9.

22. Kim HH, Kuwano Y, Srikantan S, Lee EK, Martindale JL, and Gorospe M. HuR recruits let-7/RISC to repress

c-Myc expression. Genes Dev. 2009 Aug 1;23(15):1743-8. (First author & Corresponding author)

21. Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim HH, Kuwano Y, Galban S, Becker KG, Kamara D, de Cabo R,

Gorospe M. Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J 2009 May 6;28(9):1271-82.

20. Kim HH, Yang X, Kuwano Y, and Gorospe M. Modification at HuR(S242) alters HuR localization and

proliferative influence. Cell Cycle 2008 Nov 1;7(21):3371-77. (First author)

19. Kim HH and Gorospe M. Phosphorylated HuR shuttles in cycles. Cell Cycle 2008 Oct 15;7(20):3124-26.

(First author)

18. Kim HH, Abdelmohsen K, Lal A, Pullmann R Jr., Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J,

Shokat KM, and Gorospe M. Nuclear HuR accumulation through phosphorylation by cdk1. Genes Dev. 2008

Jul 1;22(13):1804-15. (First author)

17. Kuwano Y, Kim HH, Abdelmohsen K, Pullmann R Jr, Martindale JL, Yang X, Gorospe M. MKP-1 mRNA

Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90. Mol Cell Biol. 2008

Jul;28(14):4562-75.

16. Cho S, Kim HH, Lee MJ, Lee S, Park CS, Nam SJ, Han JJ, Kim JW, Chung JH. Phosphatidylserine prevents 4 Resume of Hyeon Ho Kim

UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo.

J Lipid Res. 2008 Jun;49(6):1235-45.

15. Kim HH, Lee Y, Eun HC, Chung JH. Eicosapentaenoic acid inhibits TNF-alpha-induced matrix

metalloproteinase-9 expression in human keratinocytes, HaCaT cells. Biochem Biophys Res Commun. 2008

Apr 4;368(2):343-9. (First author)

14. Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R Jr, Srikantan S, Subrahmanyam R, Martindale JL, Yang

X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M. p16(INK4a) translation suppressed by miR-24.

PLoS ONE. 2008 Mar 26;3(3):e1864.

13. Abdelmohsen K, Kuwano Y, Kim HH, Gorospe M. Posttranscriptional gene regulation by RNA-binding

proteins during oxidative stress: implications for cellular senescence. Biol Chem. 2008 Mar;389(3):243-55.

12. Kim HH, Gorospe M. GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover. Mol Cell.

2008 Feb 1;29(2):151-2. (First author)

11. Galbán S, Kuwano Y, Pullmann R Jr, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO,

Lewis SM, Holcik M, Gorospe M. RNA-binding proteins HuR and PTB promote the translation of hypoxia-

inducible factor 1alpha. Mol Cell Biol. 2008 Jan;28(1):93-107.

10. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M,

Bernier M, Mosinger B, Margolskee RF, Egan JM. Gut-expressed gustducin and taste receptors regulate

secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15069-74.

9. Pullmann R Jr, Kim HH, Abdelmohsen K, Lal A, Martindale JL, Yang X, Gorospe M. Analysis of turnover and

translation regulatory RNA-binding protein expression through binding to cognate mRNAs. Mol Cell Biol. 2007

Sep;27(18):6265-78.

8. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti-apoptotic program by

HuR. Cell Cycle. 2007 Jun 1;6(11):1288-92.

7. Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie

DA, Furneaux H, Gorospe M. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell. 2007

Feb 23;25(4):543-57.

6. Kim HH, Cho S, Lee S, Kim KH, Cho KH, Eun HC, Chung JH. Photoprotective and anti-skin-aging effects of

eicosapentaenoic acid in human skin in vivo. J Lipid Res. 2006 May;47(5):921-30. (First author)

5. Kim HH, Ahn KS, Han H, Choung SY, Choi SY, Kim IH. Decursin and PDBu: two PKC activators distinctively

acting in the megakaryocytic differentiation of K562 human erythroleukemia cells. Leuk Res. 2005

Dec;29(12):1407-13. (First author) 5 Resume of Hyeon Ho Kim

4. Kim HH, Lee MJ, Lee SR, Kim KH, Cho KH, Eun HC, Chung JH. Augmentation of UV-induced skin wrinkling by

infrared irradiation in hairless mice. Mech Ageing Dev. 2005 Nov;126(11):1170-7. (First author)

3. Kim HH, Shin CM, Park CH, Kim KH, Cho KH, Eun HC, Chung JH. Eicosapentaenoic acid inhibits UV-induced

MMP-1 expression in human dermal fibroblasts. J Lipid Res. 2005 Aug;46(8):1712-20. (First author)

2. Kim HH, Sik Bang S, Seok Choi J, Han H, Kim IH. Involvement of PKC and ROS in the cytotoxic mechanism

of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562

erythroleukemia and U937 myeloleukemia cells. Cancer Lett. 2005 Jun 8;223(2):191-201. (First author)

1. Park CH, Lee MJ, Ahn J, Kim S, Kim HH, Kim KH, Eun HC, Chung JH. Heat shock-induced matrix

metalloproteinase (MMP)-1 and MMP-3 are mediated through ERK and JNK activation and via an autocrine

interleukin-6 loop. J Invest Dermatol 2004 Dec;123(6):1012-9.