1 Resume of Hyeon Ho Kim HYEON HO KIM, Ph.D. Assistant Professor 1 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University (SKKU) 2 Institute for Future Medicine, Samsung Medical Center (SMC) Room # B4-118, Comprehensive Cancer Center, Samsung Medical Center 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea Phone: 82-2-3410-1039 (Office); 82-2-2148-7222/7223 (Lab) Web page: www.saihst.skku.edu / E-mail: [email protected]; [email protected] EDUCATION 1997 - 2002 Ph.D. School of Life Sciences and Biotechnology, Korea University, Korea 1995 - 1997 MS Department of Biotechnology, Korea University, Korea 1991 - 1995 BS Department of Biotechnology, Korea University, Korea PROFESSIONAL EXPERIENCES 2015 - present Editorial Board Member of Molecules and Cells 2014 - present Editorial Board Member of Scientific Reports (Nature Publishing Group) 2010 - present Assistant Prof SAIHST, Sungkyunkwan University/Samsung Medical Center, Korea 2005 - 2010 Visiting Fellow National Institute on Aging/National Institutes of Health, USA 2004 - 2005 Senior researcher Institute of Dermatological Science, Seoul National University, Korea 2002 - 2004 Post-doc Clinical Research Institute, Seoul National University Hospital, Korea 2002 - 2002 Post-doc School of Life Sciences and Biotechnology, Korea University, Korea 1995 - 1997 Researcher Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea 2 Resume of Hyeon Ho Kim PUBLICATIONS 38. Cho SY, Ha SY, Huang SM, Kim JH, Kang MS, Yoo HY, Kim HH, Park CK, Um SH, Kim KH, Kim SH. The prognostic significance of Smad3, Smad4, Smad3 phosphoisoform expression in esophageal squamous cell carcinoma. Med Oncol. 2014 Nov;31(11):236. doi: 10.1007/s12032-014-0236-9. Epub 2014 Sep 30. 37. Shin JH, Park YM, Kim DH, Moon GJ, Bang OY, Ohn T, Kim HH. Ischemic brain extract increases SDF-1 expression in astrocytes through the CXCR2/miR-223/miR-27b pathway. Biochim Biophys Acta. 2014 Jul 3; 1839: 826-36. (Corresponding author) 36. Lee KW, Sung CO, Kim JH, Kang M, Yoo HY, Kim HH, Um SH, Kim SH. CD10 expression is enhanced by Twist1 and associated with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro and in vivo. Int J Cancer. 2014 Jun 3. doi: 10.1002/ijc.29006. [Epub ahead of print] 35. Ha SY, Shin J, Kim JH, Kang MS, Yoo HY, Kim HH, Um SH, Kim SH. Overexpression of integrin αV correlates with poor prognosis in colorectal cancer. J Clin Pathol 2014 Jul;67(7):576-81. 34. Jeon ES, Shin JH, Hwang SJ, Moon KJ, Bang OY, Kim HH. Cobalt chloride induces neuronal differentiation of human mesenchymal stem cells through upregulation of microRNA-124a. Biochem Biophys Res Commun. 2014 Feb 21; 444(4): 581-7. (Corresponding author) [Recommended by Faculty of 1000 Biology] 33. Lee HW, Park YM, Lee SJ, Cho HJ, Kim DH, Lee JI, Kang MS, Seol HJ, Shim YM, Nam DH, Kim HH, Joo KM. Alpha-smooth muscle actin (ACTA2) is required for metastatic potential of human lung adenocarcinoma. Clin Cancer Res 2013 Nov 1;19(21): 5879-89. (Co-corresponding author) [Highlighted in Pulmonary Cell News] 32. Yoon SP, Kim HH, Kim J, Park RY, and Ohn T. Regulation of cellular RNA nano-particle assembly by splicing factor SRp20. J Nanosci Nanotech 2013 Jan;13(1): 184-7. (Co-first author) 31. Park YM, Hwang SJ, Masuda K, Choi KM, Jeong MR, Nam DH, Gorospe M, and Kim HH. Heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNPC) controls the metastatic potential of glioblastoma by regulating PDCD4. Mol Cell Biol 2012 Oct;32(20):4237-44. (Corresponding author) 30. Hwang SJ, Seol HJ, Park YM, Kim KH, Gorospe M, Nam DH, and Kim HH. MicroRNA-146a suppresses metastatic activity in brain metastasis. Mol Cells 2012 Sep 3;34(3):329-34. (Corresponding author) 29. Lee KW, Lee NK, Kim JH, Kang MS, Yoo HY, Kim HH, Um SH, and Kim SH. Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer. Biochem Biophys Res Commun 2012 Jul 6;423(3):454-60. 28. Jo MY, Kim YG, Kim Y, Lee SJ, Kim MH, Joo KM, Kim HH, and Nam DH. Combined therapy of temozolomide 3 Resume of Hyeon Ho Kim and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti- proliferative mechanism. Mol Med Report 2012 Apr 11;6(1):88-92. (Co-corresponding author) 27. Srikantan S, Abdelmohsen K, Lee EK, Tominaga K, Subaran SS, Kuwano Y, Kulshrestha R, Panchakshari R, Kim HH, Yang X, Martindale JL, Marasa BS, Kim MM, Wersto RP, Indig FE, Chowdhury D, Gorospe M. Translational control of Top2A influences doxorubicin efficacay. Mol Cell Biol 2011 Sep;31(18):3790-801. 26. Masuda K, Abdelmohsen K, Kim MM, Srikantan S, Lee EK, Tominaga K, Selimyan R, Martindale JL, Yang X, Lehrmann E, Zhang Y, Becker KG, Wang JY, Kim HH, Gorospe M. Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J. 2011 Mar 6;30(6):1040-53. 25. Lee EK, Lee MJ, Abdelmohsen K, Kim W, Kim MM, Srikantan S, Martindale JL, Hutchison ER, Kim HH, Marasa BS, Selimyan R, Egan JM, Smith SR, Fried SK, Gorospe M. miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor {gamma} Expression. Mol Cell Biol. 2011 Feb;31(4):626-38. 24. Kim HH, Abdelmohsen K, and Gorospe M. Regulation of HuR by DNA damage response kinases. J Nucleic Acids 2010 Jul 25. 2010. pii: 981487. (First author) 23. Lee EK, Kim HH, Kuwano Y, Abdelmohsen K, Srikantan S, Subaran SS, Gleichmann M, Mughal MR, Martindale JL, Yang X, Worley PF, Mattson MP, Gorospe M. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol. 2010 May 16. 17:732-9. 22. Kim HH, Kuwano Y, Srikantan S, Lee EK, Martindale JL, and Gorospe M. HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev. 2009 Aug 1;23(15):1743-8. (First author & Corresponding author) 21. Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim HH, Kuwano Y, Galban S, Becker KG, Kamara D, de Cabo R, Gorospe M. Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J 2009 May 6;28(9):1271-82. 20. Kim HH, Yang X, Kuwano Y, and Gorospe M. Modification at HuR(S242) alters HuR localization and proliferative influence. Cell Cycle 2008 Nov 1;7(21):3371-77. (First author) 19. Kim HH and Gorospe M. Phosphorylated HuR shuttles in cycles. Cell Cycle 2008 Oct 15;7(20):3124-26. (First author) 18. Kim HH, Abdelmohsen K, Lal A, Pullmann R Jr., Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, and Gorospe M. Nuclear HuR accumulation through phosphorylation by cdk1. Genes Dev. 2008 Jul 1;22(13):1804-15. (First author) 17. Kuwano Y, Kim HH, Abdelmohsen K, Pullmann R Jr, Martindale JL, Yang X, Gorospe M. MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90. Mol Cell Biol. 2008 Jul;28(14):4562-75. 16. Cho S, Kim HH, Lee MJ, Lee S, Park CS, Nam SJ, Han JJ, Kim JW, Chung JH. Phosphatidylserine prevents 4 Resume of Hyeon Ho Kim UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo. J Lipid Res. 2008 Jun;49(6):1235-45. 15. Kim HH, Lee Y, Eun HC, Chung JH. Eicosapentaenoic acid inhibits TNF-alpha-induced matrix metalloproteinase-9 expression in human keratinocytes, HaCaT cells. Biochem Biophys Res Commun. 2008 Apr 4;368(2):343-9. (First author) 14. Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R Jr, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M. p16(INK4a) translation suppressed by miR-24. PLoS ONE. 2008 Mar 26;3(3):e1864. 13. Abdelmohsen K, Kuwano Y, Kim HH, Gorospe M. Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem. 2008 Mar;389(3):243-55. 12. Kim HH, Gorospe M. GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover. Mol Cell. 2008 Feb 1;29(2):151-2. (First author) 11. Galbán S, Kuwano Y, Pullmann R Jr, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M. RNA-binding proteins HuR and PTB promote the translation of hypoxia- inducible factor 1alpha. Mol Cell Biol. 2008 Jan;28(1):93-107. 10. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15069-74. 9. Pullmann R Jr, Kim HH, Abdelmohsen K, Lal A, Martindale JL, Yang X, Gorospe M. Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs. Mol Cell Biol. 2007 Sep;27(18):6265-78. 8. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle. 2007 Jun 1;6(11):1288-92. 7. Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell. 2007 Feb 23;25(4):543-57. 6. Kim HH, Cho S, Lee S, Kim KH, Cho KH, Eun HC, Chung JH.