CS HCVG15-PTT-114 02/33/2017 DISTRIBUTED BY: health conditionssuchasasthma,diabetes, disease andheart flu vaccine,it’s forthosewithchronic especiallyimportant spread Whileallpreteens ittoothers. andteensshouldgeta healthy preteens andteenscangetvery sickfrom thefluand others.of gettingseasonalfluandspreading Even itto The annualfluvaccineisthebestway to reduce thechances Flu Vaccine doctor ornurseaboutgettingthemnow. orfinishedtheHPVvaccineseriesshouldask started Preteens andteenswhohaven’tvaccine 6-12monthsapart. All 11-and12-year-olds shouldreceive twoofHPV shots girls andboysfrom HPVinfectionandcancer HPV. causedby both vaccineshelpprotect (HPV) Human papillomavirus HPV Vaccine age16. at meningococcal shot when theyare 11or12yearsshot old.Theyneedasecond infection intheblood).Preteens needthefirstmeningococcal lining around thebrainandspinalcord) andsepticemia (an cancausemeningitis(swellingof thebacteriathat ofthe some against vaccineprotects Meningococcal conjugate Meningococcal Vaccine now.getting theshot asapreteen, ask theirdoctorornurseabout get aTdapshot Preteens age11or12.Ifyour shouldgetTdapat teendidn’t tetanus, (whoopingcough). diphtheria,andpertussis three seriousdiseases: against This vaccinehelpsprotect Tdap Vaccine What vaccines need? doesmy child your preteen illnesses. orteenfrom theseother they were babies. There are canhelpprotect vaccinesthat they may comeincontact withdifferent diseasesthan when babies getcanwear offaskidsgetolder. Andaskidsgrow up Vaccines aren’t justforbabies. Someofthevaccinesthat Why needvaccines doesmy now? child Last updatedJANUARY 2017 Vaccines forPreteens: What Parents ShouldKnow What elseshouldIknowaboutthesevaccines? yourvaccines that childmay need. good ideatoaskthedoctorornurseevery year ifthere are any a physical examrequired forsports, school,orcamp. It’s a checkup. Your preteen orteencanalsogetthesevaccinesat A goodtimetogetthesevaccinesisduringayearly health bevaccinated? When shouldmy child even in are orlater. circulating, long asfluviruses January illness inyour community, canbebeneficialas fluvaccination While it’s before besttobevaccinated flubeginscausing soon asit’s available inyour community, October. ideallyby Thebesttimetogetthefluvaccineisas to getvaccinated. www.cdc.gov/vaccines/teens vaccines onCDC’s Vaccines forPreteens andTeens website at may need.You canalsofindmore aboutthese information Talk toyour child’s vaccinesthey doctorornurseaboutwhat Where canIlearnmore? cdc.gov find outmore abouttheVFCprogramby goingonlineto Native.Medicaid-eligible, AmericanIndianorAlaska You can for children ages18years and younger, whoare uninsured, The Vaccines forChildrenprogram (VFC) provides vaccines helppayingHow canIget thesevaccines? for beforeyeast, theyreceive orchickeneggs, latex, any shots. if your childhasany seriousallergies, includingallergies to effects are rare. totellthedoctorornurse Itis important very canhelpprevent Seriousside minutes aftertheshot, fainting. andthenforabout15 or lyingdownwhengettingashot Sitting preteens andteensmightfaintaftergettingashot. wasgiven. ofthearmwherein thepart theshot Some safe. Theycancausemildsideeffects, likesoreness or redness These vaccineshave allbeenstudiedvery carefully andare |DI SEASES andthe VACCINES THAT PREVENT THEM | andtypingVFCinthesearchbox. INFORMATION FORPARENTS Control andPrevention Centers for Disease Health andHuman Services U.S. of Department .
www.
If You Choose Not to Vaccinate Your Child, | information for parents | Understand the Risks and Responsibilities.
Reviewed March 2012
If you choose to delay some vaccines or reject some vaccines entirely, there can be risks. Please follow these steps to protect your child, your family, and others.
With the decision to delay or reject Before an outbreak of a vaccine- vaccines comes an important preventable disease occurs in your responsibility that could save your community: child’s life, or the life of someone else. • Talk to your child’s doctor or nurse to be sure your child’s Any time that your child is ill and you: medical record is up to date regarding vaccination status. • call 911; Ask for a copy of the updated record.
• ride in an ambulance; • Inform your child’s school, childcare facility, and other caregivers about your child’s vaccination status. • visit a hospital emergency room; or • Be aware that your child can catch diseases from people who • visit your child’s doctor or any clinic don’t have any symptoms. For example, Hib you must tell the medical staff that your child has not meningitis can be spread from people who have the received all the vaccines recommended for his or her age. bacteria in their body but are not ill. You can’t tell who Keep a vaccination record easily accessible so that you can is contagious. report exactly which vaccines your child has received, even when you are under stress.
Telling health care professionals your child's vaccination status is essential for two reasons: • When your child is being evaluated, the doctor will need to consider the possibility that your child has a vaccine- preventable disease. Many of these diseases are now uncommon, but they still occur. • The people who help your child can take precautions, such as isolating your child, so that the disease does not spread to others. One group at high risk for contracting disease is infants who are too young to be fully vaccinated. For example, the measles vaccine is not usually recommended for babies younger than 12 months. Very young babies who get measles are likely to be seriously ill, often requiring hospitalization. Other people at high risk for contracting disease are those with weaker immune systems, such as some people with cancer and transplant recipients. CS233434S When there is vaccine-preventable If you know your child is exposed to a disease in your community: vaccine-preventable disease for which he • It may not be too late to get protection by getting vaccinated. or she has not been vaccinated: Ask your child’s doctor. • Learn the early signs and symptoms of the disease. • If there are cases (or, in some circumstances, a single case) • Seek immediate medical help if your child or any family of a vaccine-preventable disease in your community, you members develop early signs or symptoms of the disease. may be asked to take your child out of school, childcare, or organized activities (for example, playgroups or sports). IMPORTANT: Notify the doctor’s office, urgent care facility, ambulance personnel, or • Your school, childcare facility, or other institution will tell emergency room staff that your child has not been you when it is safe for an unvaccinated child to return. fully vaccinated before medical staff have contact Be prepared to keep your child home for several days up to with your child or your family members. They several weeks. need to know that your child may have a vaccine- • Learn about the disease and how it is spread. It may not preventable disease so that they can treat your child be possible to avoid exposure. For example, measles is so correctly as quickly as possible. Medical staff also contagious that hours after an infected person has left can take simple precautions to prevent diseases from the room, an unvaccinated person can get measles just by spreading to others if they know ahead of entering that room. time that their patient may have a contagious disease. • Each disease is different, and the time between when your • Follow recommendations to isolate your child from others, child might have been exposed to a disease and when he or including family members, and especially infants and people she may get sick will vary. Talk with your child’s doctor or with weakened immune systems. Most vaccine-preventable the health department to get their guidelines for determining diseases can be very dangerous to infants who are too young when your child is no longer at risk of coming down with to be fully vaccinated, or children who are not vaccinated due the disease. to certain medical conditions. • Be aware that for some vaccine-preventable diseases, there are medicines to treat infected people and medicines to keep Be aware. people they come in contact with from getting the disease. 4 Any vaccine-preventable disease can strike at any • Ask your health care professional about other ways to protect time in the U.S. because all of these diseases still your family members and anyone else who may come into circulate either in the U.S. or elsewhere in the world. contact with your child. 4 Sometimes vaccine-preventable diseases cause • Your family may be contacted by the state or local health outbreaks, that is, clusters of cases in a given area. department who track infectious disease outbreaks in the 4 Some of the vaccine-preventable diseases that community. still circulate in the U.S. include whooping cough, chickenpox, Hib (a cause of meningitis), and If you travel with your child: influenza. These diseases, as well as the other vaccine-preventable diseases, can range from mild • Review the CDC travelers’ information website to severe and life-threatening. In most cases, there (http://www.cdc.gov/travel) before traveling to learn about is no way to know beforehand if a child will get a possible disease risks and vaccines that will protect mild or serious case. your family. Diseases that vaccines prevent remain 4 For some diseases, one case is enough to cause common throughout the world, including Europe. concern in a community. An example is measles, • Don't spread disease to others. If an unimmunized person which is one of the most contagious diseases known. develops a vaccine-preventable disease while traveling, This disease spreads quickly among people who are to prevent transmission to others, he or she should not not immune. travel by a plane, train, or bus until a doctor determines the person is no longer contagious.
For more information on vaccines, ask your child's health care professional, visit www.cdc.gov/vaccines or call 800-CDC-INFO (800-232-4636) INFORMATION FOR PARENTS 2018 Recommended Immunizations for Children 7-18 Years Old
Talk to your child’s doctor or nurse about the vaccines recommended for their age. Tdap Meningococcal MMR HPV Flu Tetanus, Inactivated Measles, Chickenpox Human Pneumococcal Hepatitis B Hepatitis A Influenza diphtheria, Polio mumps, Varicella papillomavirus MenACWY MenB pertussis rubella
7-8 Years
9-10 Years
11-12 Years
13-15 Years
16-18 Years
More Preteens and teens Preteens and teens All 11-12 year olds All 11-12 year Teens, 16-18 information: should get a flu should get one should get a 2-shot olds should get years old, may be vaccine every year. shot of Tdap at age series of HPV a single shot of a vaccinated with 11 or 12 years. vaccine at least meningococcal a serogroup B 6 months apart. conjugate meningococcal A 3-shot series is (MenACWY) (MenB) vaccine. needed for those vaccine. A with weakened booster shot is immune systems recommended at and those age 15 age 16. or older.
These shaded boxes indicate when the vaccine is These shaded boxes indicate the vaccine should be recommended for all children unless your doctor tells given if a child is catching-up on missed vaccines. you that your child cannot safely receive the vaccine.
These shaded boxes indicate the vaccine is This shaded box indicates children not at increased risk recommended for children with certain health or may get the vaccine if they wish after speaking to a lifestyle conditions that put them at an increased risk for provider. serious diseases. See vaccine-specific recommendations at www.cdc.gov/vaccines/pubs/ACIP-list.htm. Vaccine-Preventable Diseases and the Vaccines that Prevent Them
Diphtheria (Can be prevented by Tdap vaccination) Measles (Can be prevented by MMR vaccination) Pneumococcal Disease (Can be prevented by pneumococcal vaccination) Diphtheria is a very contagious bacterial disease that affects Measles is one of the most contagious viral diseases. Measles Pneumonia is an infection of the lungs that can be caused by the the respiratory system, including the lungs. Diphtheria bacteria virus is spread by direct contact with the airborne respiratory bacteria called pneumococcus. These bacteria can cause other types can be spread from person to person by direct contact with droplets of an infected person. Measles is so contagious that of infections too, such as ear infections, sinus infections, meningitis droplets from an infected person’s cough or sneeze. When just being in the same room after a person who has measles has (infection of the lining of the brain and spinal cord), and bloodstream people are infected, the bacteria can produce a toxin (poison) already left can result in infection. Symptoms usually include a infections. Sinus and ear infections are usually mild and are much in the body that can cause a thick coating in the back of the rash, fever, cough, and red, watery eyes. Fever can persist, rash more common than the more serious forms of pneumococcal nose or throat that makes it hard to breathe or swallow. Effects can last for up to a week, and coughing can last about 10 days. disease. However, in some cases pneumococcal disease can be fatal from this toxin can also lead to swelling of the heart muscle Measles can also cause pneumonia, seizures, brain damage, or or result in long-term problems, like brain damage and hearing loss. and, in some cases, heart failure. In serious cases, the illness can death. The bacteria that cause pneumococcal disease spread when people cause coma, paralysis, or even death. cough or sneeze. Many people have the bacteria in their nose or Meningococcal Disease (Can be prevented by meningococcal vaccination) throat at one time or another without being ill—this is known as Hepatitis A (Can be prevented by HepA vaccination) Meningococcal disease has two common outcomes: meningitis being a carrier. Hepatitis A is an infection in the liver caused by hepatitis A virus. (infection of the lining of the brain and spinal cord) and The virus is spread primarily person-to-person through the bloodstream infections. The bacteria that cause meningococcal Polio (Can be prevented by IPV vaccination) fecal-oral route. In other words, the virus is taken in by mouth disease spread through the exchange of nose and throat Polio is caused by a virus that lives in an infected person’s throat and from contact with objects, food, or drinks contaminated by the droplets, such as when coughing, sneezing, or kissing. Symptoms intestines. It spreads through contact with the stool of an infected feces (stool) of an infected person. Symptoms can include fever, include sudden onset of fever, headache, and stiff neck. With person and through droplets from a sneeze or cough. Symptoms tiredness, poor appetite, vomiting, stomach pain, and sometimes bloodstream infection, symptoms also include a dark purple typically include sore throat, fever, tiredness, nausea, headache, jaundice (when skin and eyes turn yellow). An infected person rash. About one of every ten people who gets the disease dies or stomach pain. In about 1% of cases, polio can cause paralysis. may have no symptoms, may have mild illness for a week or from it. Survivors of meningococcal disease may lose their arms Among those who are paralyzed, About 2 to 10 children out of 100 two, may have severe illness for several months, or may rarely or legs, become deaf, have problems with their nervous systems, die because the virus affects the muscles that help them breathe. develop liver failure and die from the infection. In the U.S., about become developmentally disabled, or suffer seizures or strokes. 100 people a year die from hepatitis A. Rubella (German Measles) (Can be prevented by MMR vaccination) Mumps (Can be prevented by MMR vaccination) Rubella is caused by a virus that is spread through coughing and Hepatitis B (Can be prevented by HepB vaccination) Mumps is an infectious disease caused by the mumps virus, sneezing. In children rubella usually causes a mild illness with fever, Hepatitis B causes a flu-like illness with loss of appetite, nausea, which is spread in the air by a cough or sneeze from an infected swollen glands, and a rash that lasts about 3 days. Rubella rarely vomiting, rashes, joint pain, and jaundice. Symptoms of acute person. A child can also get infected with mumps by coming in causes serious illness or complications in children, but can be very hepatitis B include fever, fatigue, loss of appetite, nausea, contact with a contaminated object, like a toy. The mumps virus serious to a baby in the womb. If a pregnant woman is infected, the vomiting, pain in joints and stomach, dark urine, grey-colored causes swollen salivary glands under the ears or jaw, fever, muscle result to the baby can be devastating, including miscarriage, serious stools, and jaundice (when skin and eyes turn yellow). aches, tiredness, abdominal pain, and loss of appetite. Severe heart defects, mental retardation and loss of hearing and eye sight. complications for children who get mumps are uncommon, but Human Papillomavirus (Can be prevented by HPV vaccination) can include meningitis (infection of the covering of the brain and Tetanus (Lockjaw) (Can be prevented by Tdap vaccination) Human papillomavirus is a common virus. HPV is most common spinal cord), encephalitis (inflammation of the brain), permanent Tetanus mainly affects the neck and belly. When people are infected, in people in their teens and early 20s. About 14 million people, hearing loss, or swelling of the testes, which rarely results in the bacteria produce a toxin (poison) that causes muscles to become including teens, become infected with HPV each year. HPV decreased fertility. tight, which is very painful. This can lead to “locking” of the jaw so infection can cause cervical, vaginal, and vulvar cancers in a person cannot open his or her mouth, swallow, or breathe. The women and penile cancer in men. HPV can also cause anal Pertussis (Whooping Cough) (Can be prevented by Tdap vaccination) bacteria that cause tetanus are found in soil, dust, and manure. The cancer, oropharyngeal cancer (back of the throat), and genital Pertussis spreads very easily through coughing and sneezing. bacteria enter the body through a puncture, cut, or sore on the skin. warts in both men and women. It can cause a bad cough that makes someone gasp for air Complete recovery from tetanus can take months. One to two out of after coughing fits. This cough can last for many weeks, which 10 people who get tetanus die from the disease. Influenza (Can be prevented by annual flu vaccination) can make preteens and teens miss school and other activities. Influenza is a highly contagious viral infection of the nose, throat, Pertussis can be deadly for babies who are too young to receive Varicella (Chickenpox) (Can be prevented by varicella vaccination) and lungs. The virus spreads easily through droplets when an the vaccine. Often babies get whooping cough from their older Chickenpox is caused by the varicella zoster virus. Chickenpox is infected person coughs or sneezes and can cause mild to severe brothers or sisters, like preteens or teens, or other people in the very contagious and spreads very easily from infected people. The illness. Typical symptoms include a sudden high fever, chills, a family. Babies with pertussis can get pneumonia, have seizures, virus can spread from either a cough, sneeze. It can also spread from dry cough, headache, runny nose, sore throat, and muscle and become brain damaged, or even die. About half of children the blisters on the skin, either by touching them or by breathing joint pain. Extreme fatigue can last from several days to weeks. under 1 year of age who get pertussis must be hospitalized. in these viral particles. Typical symptoms of chickenpox include an Influenza may lead to hospitalization or even death, even among itchy rash with blisters, tiredness, headache and fever. Chickenpox previously healthy children. is usually mild, but it can lead to severe skin infections, pneumonia, encephalitis (brain swelling), or even death.
If you have any questions about your child’s vaccines, talk to your healthcare provider. Last updated on January 17, 2018 • CS289048-A Information for Health Care Professionals about Adolescent Vaccines
The Centers for Disease Control and Prevention (CDC) recommends four vaccines for adolescents to prevent: • Tetanus, Diphtheria, Pertussis Note: Recommendations for catch-up dose and minimum interval • Meningococcal disease Note: A booster shot for teens • Human papillomavirus Note: Added indications for Gardasil; recommendation for boys • Influenza Note: Universal recommendation for everyone 6 months and older These recommendations are supported by the American Academy of Pediatrics, the American Academy of Family Physicians, and the Society for Adolescent Health and Medicine.
What can YOU do to ensure your patients get fully vaccinated? • Strongly recommend adolescent vaccines to parents of your 11 through 18 year old patients. Parents trust your opinion more than anyone else’s when it comes to immunizations. Studies consistently show that provider recommendation is the strongest predictor of vaccination. • Use every opportunity to vaccinate your adolescent patients. Ask about vaccination status when they come in for sick visits and sports physicals. • Patient reminder and recall systems such as automated postcards, phone calls and text messages are effective tools for increasing office visits. • Educate parents about the diseases that can be prevented by adolescent vaccines. Parents may know very little about pertussis, meningococcal disease, or HPV. • Implement standing orders policies so that patients can receive vaccines without a physician examination or individual physician order. Direct parents who want more information on vaccines and vaccine-preventable diseases to visit the CDC website at http://www.cdc.gov/vaccines/teens or to call 800-CDC-INFO.
Note about syncope: For all vaccines given during adolescence, syncope has been reported in both boys and girls. To avoid serious injury related to a syncopal episode, adolescents should always be sitting or lying down ► to receive vaccines, remain so for 15 minutes, AND be observed during this time. Overview of Adolescent Vaccination Recommendations • All 11 or 12 year olds should receive a single dose of Tdap vaccine if they have completed the recommended childhood DTP/DTaP vaccination series and have not Age ► 7–10 YEARS 11-12 YEARS 13-18 YEARS received Tdap ▼ Vaccine • All 11 or 12 year olds should receive a single dose of meningococcal vaccine, with a booster dose at Tdap Childhood Recommended Catch-Up age 16 years Catch-up • All girls 11 or 12 years old should get 3 doses of either HPV Recommended Catch-Up HPV vaccine to protect against cervical cancer; All boys 11 or 12 years old should get 3 doses of quadrivalent MCV4 High-Risk Recommended Recommended HPV vaccine to protect against genital warts and anal cancer Flu Recommended • All adolescents should receive a single dose of influenza vaccine every year
National Center forU.S. Immunization Department andof Health Respitatory and Human Diseases Services Office of the DirectorCenters for Disease Control and Prevention Tdap (tetanus toxoid - reduced diphtheria toxoid - Meningococcal Conjugate Vaccine (MCV4) acellular pertussis) Vaccine Although rates of meningococcal disease are the lowest they Because immunity from childhood DTaP vaccines wanes by have ever been in the United States, about 1000 cases are adolescence, a booster dose is recommended. Of the nearly reported each year in this country. Each case is alarming and 17,000 cases of pertussis reported in the United States in 2009, potentially deadly. The incidence of meningococcal disease 4265 occurred among 10- through 19-year-olds. Increasing increases in adolescence and early adulthood. About 10-15% immunization rates among adolescents is an important strategy of adolescents who contract the disease will die, and about 20% for reducing disease among both adolescents and infants too will suffer from a long-term disability. According to the 2010 young to be fully immunized. According to the 2010 National National Immunization Survey-Teen (NIS-Teen), about 63% of Immunization Survey-Teen (NIS-Teen), about 69% of 13- through 13- through 17-year-olds received MCV4. 17-year-olds received Tdap. Recommendations: Recommendations: • All 11- or 12-year-olds should receive a single dose of me- ningococcal vaccine, with a booster dose at age 16 years. • All 11- through 18-year-olds should receive a single dose of Tdap vaccine (preferably at age 11 or 12 years) if they have • For adolescents who receive the first dose at age 13 through completed the recommended childhood DTP/DTaP vaccina- 15 years, a one-time booster dose should be administered, tion series and have not received Tdap. preferably at age 16 through 18 years. Persons who receive their f0irst dose of meningococcal conjugate vaccine at or • Children aged 7 through 10 years and adolescents aged 11 through 18 years who did not complete the childhood DTaP after age 16 years do not need a booster dose. series or with unknown vaccine history should be given one • Adolescents with persistent complement component defi- dose of Tdap as part of the catch-up regimen. Td should be ciencies (e.g., C5-C9, properidin, factor H, or factor D) and used for any other doses needed. asplenia should receive a 2-dose primary series administered 2 months apart and then receive a booster dose every • Tdap should be administered regardless of interval since the 5 years. last tetanus or diphtheria toxoid-containing vaccine. While longer intervals between Td and Tdap vaccination could • Adolescents aged 11–18 years with HIV infection should be decrease the occurrence of local reactions, the benefits of routinely vaccinated with a 2-dose primary series. protection against pertussis outweigh the potential risk for • Vaccination is also recommended for unvaccinated college adverse events. freshmen who live in dormitories, and also for unvaccinated • Tdap vaccine can be administered at the same time as other military recruits. Older adolescents, including college adolescent vaccines. students, who wish to decrease their risk for meningococcal disease, may elect to receive meningococcal vaccine. Vaccines licensed in the United States: • Boostrix® (GlaxoSmithKline) is indicated for active booster • Meningococcal vaccine can be administered at the same immunization for the prevention of tetanus, diphtheria and time as other adolescent vaccines. pertussis as a single dose in persons 10 through 64 years Vaccines licensed in the United States: of age. • Menactra® (sanofi pasteur) is indicated for active immuniza- • Adacel® (sanofi pasteur) is indicated for active booster tion of persons 9 months through 55 years of age for the immunization for the prevention of tetanus, diphtheria and prevention of invasive meningococcal disease caused by pertussis as a single dose in persons 11 through 64 years N. meningitidis serogroups A, C, Y and W-135. of age. • Menveo® (Novartis) is indicated for active immunization of persons 2 through 55 years of age to prevent invasive Possible side effects: meningococcal disease caused by N. meningitidis serogroups Pain, redness, swelling at the injection site; mild fever; head- A, C, Y, and W-135. ache; fatigue; nausea, vomiting, diarrhea, or stomach ache. Possible side effects: Contraindications and precautions: The most commonly reported side effects are redness or • Tdap is contraindicated for persons with a history of serious pain at the injection site. A small percentage of recipients allergic reaction (e.g., anaphylaxis) to any component of reported fever. the vaccine. • Tdap is contraindicated for adolescents with a history of en- Contraindications and precautions: cephalopathy (e.g., coma or prolonged seizures) not attribut- • Meningococcal vaccine is contraindicated among persons able to an identifiable cause within 7 days of administration known to have a severe allergic reaction to any component of a vaccine with pertussis components. This contraindica- of the vaccine, including diphtheria toxoid, or to dry natural tion is for the pertussis components and these adolescents rubber latex. should receive Td instead of Tdap. Human Papillomavirus (HPV) Vaccine • Individuals will get the greatest benefit from the vaccine if it is administered before they have initiated any type of sexual Cervical cancer, caused by HPV, is one of the most common can- activity with another person. cers in women—every year in the United States, about 12,000 women are diagnosed with cervical cancer, and about 4,000 • Studies demonstrate that the risk for HPV infection is high women die from this disease. HPV types 16 and 18 are the most immediately following sexual debut. It is also important to common high-risk types associated with cervical cancer, while note that 1 in 5 women who have only had one lifetime sex HPV 6 and 11 are the most common low-risk types associated partner have been infected with a high-risk HPV type. with genital and respiratory tract warts (recurrent respiratory • Vaccination is recommended for patients with HPV-related papillomatosis or RRP). High-risk HPV types have also been disease and/or apparent HPV infection because the vaccine associated with other, less common cancers and precancers in can offer protection against infection with HPV vaccine types women, such as vulvar, vaginal, anal, opharyngeal carcinomas not already acquired. However, vaccination will not have a and dysplasia. HPV-associated cancers in males include certain therapeutic effect on existing HPV infection or HPV-related anal, penile, and oropharyngeal carcinomas and dysplasia. disease.
According to the 2010 NIS-Teen, about 49% of 13- through • HPV vaccine can be administered at the same time as other 17-year-old girls have started an HPV vaccine series. However, adolescent vaccines. only about 32% received all 3 doses. Completing the 3-dose HPV vaccine series is very important to ensure protection Possible side effects: against cervical cancer and other HPV-related disease. Pain, headache, redness or swelling at the injection site are the most commonly reported side effects. Vaccines licensed in the United States: • Cervarix® is indicated for the prevention of cervical cancer Contraindications and precautions: and precancers caused by HPV types 16 and 18. • HPV vaccines are not recommended for use in pregnancy. If a patient is found to be pregnant after initiating the vaccina- • Gardasil® is indicated for the prevention of cervical, vulvar, tion series, the remainder of the 3-dose series should be vaginal and anal cancers and precancers, as well as genital delayed until completion of pregnancy. However, if a vaccine warts, caused by HPV types 6, 11, 16 and 18. dose has been administered during pregnancy, no interven- Recommendations: tion is needed. Clinicians should report exposure to Gardasil • All 11 or 12 year olds should receive 3 doses of HPV vaccine during pregnancy to Merck at 800-986-8999, and exposure to protect against HPV-related disease. to Cervarix during pregnancy to GlaxoSmithKline at 888-452- 9622. • All girls 11 or 12 years old should get 3 doses of HPV vac- cine to protect against cervical cancer. Girls and young • HPV vaccines are contraindicated for persons with a history women ages 13 through 26 should get all 3 doses of an HPV of immediate hypersensitivity to any vaccine component. vaccine if they have not yet received all doses. Both brands Gardasil is contraindicated for persons with a history of of vaccine are highly effective for preventing cervical cancer immediate hypersensitivity to yeast. Prefilled syringes of and precancer caused by HPV types 16 and 18. Gardasil also Cervarix have latex in the rubber stopper and should not protects against anal cancer and genital warts. be used in persons with anaphylactic latex allergy. Cervarix single-dose vials contain no latex. • All boys 11 or 12 years old should get 3 doses of quadriva- lent HPV vaccine (Gardasil) to protect against genital warts Influenza Vaccine and anal cancer. Boys and young men 13 through 21 years, CDC recommends universal annual flu vaccination for every- who did not get any or all of the three recommended doses one aged 6 months and older. Flu can be serious, and even when they were younger, should also get the HPV vaccine fatal, for healthy adolescents, but pre-teens and teens with cer- series. MSM and immunocompromised males should receive tain medical conditions are more likely to suffer from serious flu the vaccine through age 26 years, if they did not start or complications. Conditions that place people at high risk include complete the vaccine series when they were younger. chronic lung disease (such as asthma); heart disease; endocrine • HPV vaccines are administered in a 3-dose schedule. The disorders (such as diabetes); blood disorders; neurological and second dose should be administered 1 to 2 months after neurodevelopmental conditions; kidney, liver, and metabolic the first dose, and the third dose should be administered 6 disorders; and weakened immune systems due to disease or months after the first dose. There is no maximum interval medication. Flu seasons are unpredictable and can be severe. between doses. If the HPV vaccine schedule is interrupted, Each year in the United States, more than 200,000 people are the vaccine series does not need to be restarted. hospitalized from flu-related complications. • Whenever feasible, the same brand of HPV vaccine should Annual influenza vaccination is the most effective method for be used for the entire vaccination series. However, if the preventing influenza virus infection and its complications since vaccine provider does not know which brand of vaccine was flu viruses are constantly changing. Protective immunity gener- previously administered or have it available, either brand of ally develops in 2 weeks after being vaccinated. HPV vaccine can be used to complete the series. Vaccines Licensed in the United States: • Varicella vaccine: Complete the 2-dose series if not previ- • Trivalent Inactivated Influenza Vaccine (TIV) is given as an ously completed, with at least 3 months between doses for injection. It can be used for people 6 months of age or older, persons aged 12 months through 12 years. (If the second including healthy people, those with chronic medical condi- dose was administered at least 28 days after the first dose, tions, and pregnant women. Brands licensed in the United it can be accepted as valid.) For persons aged 13 years and States include Fluarix®, Fluvirin®, Fluzone®, FluLaval®, and older, the minimum interval between doses is 28 days. Afluria®. • Inactivated poliovirus vaccine (IPV): The childhood series • Live, Intranasal Influenza Vaccine (LAIV) is given as a nasal is 4 doses. However, only 3 doses are needed for pre-teens spray. It can be used for healthy people 2 through 49 years and teens who received their third dose after 4 years of of age who are not pregnant. FluMist® is the only brand age, as well as pre-teens and teens in your care who have licensed in the United States. not received any doses. In all cases, a minimum interval of 6 months is needed between the last two doses. Recommendations: • Adolescents should receive a single dose of influenza vac- • Measles-mumps-rubella vaccine (MMR): Complete the cine every year. 2-dose series if not previously completed, with at least 28 days between doses. • Influenza vaccine can be administered at the same time as other adolescent vaccines. A vaccine series does not need to be restarted, regardless of the Possible side effects: time that has elapsed between doses. Refer to the CDC Catch- Up Immunization Schedule for more information. TIV (injection): Soreness, redness, or swelling at the injection site; hoarseness; sore, red or itchy eyes, cough; fever, aches. If these problems occur, they begin soon after the shot and usu- Vaccine Information Statements ally last 1 to 2 days. TIV contains noninfectious killed viruses and Vaccine Information Statements (VIS) are an excellent source cannot cause influenza. of information for patients about the risks, benefits, and side effects of vaccines. Federal law requires that VIS be given out LAIV (nasal spray): Runny nose, nasal congestion, or cough; before vaccines are administered. To download any VIS, visit fever; headache and muscle aches; wheezing; abdominal pain http://www.cdc.gov/vaccines/pubs/vis/default.htm or occasional vomiting or diarrhea. LAIV contains weakened in- fluenza viruses that cannot replicate outside the nasal passages and cannot cause influenza. Vaccine Adverse Events Reporting System Doctors and other health care professionals are encouraged to Contraindications and precautions: report any adverse events following administration of vaccines • Influenza vaccines should not be administered to people to the Vaccine Adverse Event Reporting System (VAERS), which who have anaphylactic hypersensitivity to eggs, unless the is jointly administered by CDC and the U.S. Food and Drug Ad- recipient has been desensitized. ministration. Visit http://vaers.hhs.gov for more information or • Moderate or severe acute illness with or without fever is a to file a report. precaution for vaccination. People who are moderately or severely ill should not be vaccinated until they recover. Vaccines for Children • GBS within 6 weeks following a previous dose of influenza The Vaccines for Children (VFC) program provides vaccines at vaccine is a precaution for use of influenza vaccines. no cost to professionals who serve eligible children. Children • LAIV (nasal spray) should not be administered to pregnant younger than 19 years of age are eligible for VFC vaccines if they adolescents, adolescents with chronic medical conditions are Medicaid-eligible, American Indian or Alaska Native or have (including asthma, metabolic disease, or hemoglobinopathy) no health insurance. Children who have health insurance that as well as adolescents receiving aspirin or other salicylates. does not cover vaccination can receive VFC vaccines through Federally Qualified Health Centers or Rural Health Centers. VFC vaccines cannot be denied to an eligible child if a family can’t Catch-Up Vaccines for Adolescents afford the administration fee. For more information about -par ticipating in VFC, visit Pre-teens and teens should receive doses of these vaccines as indicated to complete each series: http://www.cdc.gov/vaccines/programs/vfc/ • Hepatitis B vaccine (HepB): Complete the 3-dose series if not previously completed. Note: A 2-dose series (separated by at least 4 months) of Recombivax HB® is licensed for children aged 11 through 15 years.
Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services. References to non-CDC sites on the Internet do not constitute or imply endorsement of these organizations or their programs by CDC or the U.S. Department of Health and Human Services. CDC is not responsible for the content of pages found at these sites. URL addresses listed were current as of the date of publication. ÿ ÿ ÿÿÿ ÿÿ !!ÿ "ÿ#$ÿ%!ÿÿ% "&ÿ'()012ÿ4050146ÿ789@ 0PEÿIpGiEÿGEiCwÿgPCwgÿDpuutfEÿpuBCfHrg6ÿpfFÿGBpfFÿfprEgÿsCBÿDpuutfEgÿBChItfEiHÿBEuCrrEfF EFÿsCBÿuPtiFBEfÿpfFÿpFCiEguEfIgxÿ0PEÿhgEÿCsÿIBpFEÿfprEgÿtfÿIPtgÿtrrhftpItCfÿguPEFhiEÿtgÿsCBÿ dÿeCfghiIÿBEiEDpfIÿ5e)qÿgIpIErEfIgÿsCBÿFEIptiEFÿBEuCrrEfFpItCfgÿ tFEfItupItCfÿAhBACgEgÿCfiHÿpfFÿFCEgÿfCIÿtrAiHÿEfFCBgErEfIÿGHÿIPEÿ5e)qÿCBÿe2ex vwwwxuFuxyCDDpuutfEgPuAputABEugtfFExPIrix vÿRXÿ bbQ wT!Y dÿPEfÿpÿDpuutfEÿtgÿfCIÿpFrtftgIEBEFÿpIÿIPEÿBEuCrrEfFEFÿpyE6ÿ 2tAPIPEBtp6ÿIEIpfhg6ÿpfFÿpuEiihipBÿAEBIhggtgÿDpuutfE20pq 2pAIpuEi pFrtftgIEBÿpIÿpÿghGgE hEfIÿDtgtIx )fspfBt 2tAPIPEBtp6ÿIEIpfhgÿDpuutfE20 (Cÿ0BpFEÿ(prE dÿ'gEÿuCrGtfpItCfÿDpuutfEgÿtfgIEpFÿCsÿgEApBpIEÿtfEuItCfgÿwPEfÿ xyz{|}~ÿ zyzÿIHAEÿÿDpuutfEtGÿvqq0 5uI) pAABCABtpIEx tGEBt tGÿvqqq qEFDp) dÿEACBIÿuitftupiiHÿgtyftstupfIÿpFDEBgEÿEDEfIgÿICÿIPEÿpuutfEÿ5FDEBgEÿ EApItItgÿ5ÿDpuutfEEA5 pDBt 1DEfIÿEACBItfyÿ4HgIErÿv514ÿCfitfEÿvwwwxDpEBgxPPgxyCDÿCBÿGHÿ p Ip EApItItgÿÿDpuutfEEA 1fyEBt IEiEAPCfEÿv@88@77xÿ EuCrGtDpÿ dÿEACBIÿghgAEuIEFÿupgEgÿCsÿBEACBIpGiEÿDpuutfEABEDEfIpGiEÿFtgEpgEgÿ hrpfÿApAtiiCrpDtBhgÿDpuutfEq pBFpgtiÿ ICÿHChBÿgIpIEÿCBÿiCupiÿPEpiIPÿFEApBIrEfIx )fhEfpÿDpuutfEÿvtfpuItDpIEF)) hiItAiE dÿCBÿtfsCBrpItCfÿpGChIÿABEuphItCfgÿpfFÿuCfIBptfFtupItCfg6ÿgEEÿwwwx EpgiEg6ÿrhrAg6ÿpfFÿBhGEiipÿDpuutfE ÿ)) uFuxyCDDpuutfEgPuAputABEugyEfEBpiBEuguCfIBptfFtupItCfgxPIrixÿ EftfyCuCuupiÿgEBCyBChAgÿ56ÿe6ÿ6ÿÿDpuutfEEf5e2 EfpuIBp Ef5ee EfDEC EftfyCuCuupiÿgEBCyBChAÿÿDpuutfEEfe EgEBC EfGA 0BhrEfGp 5AABCDEFÿGHÿIPEÿ qfEhrCuCuupiÿ9DpiEfIÿuCfhypIEÿDpuutfEqe9 qBEDfpBÿ9 qfEhrCuCuupiÿ7DpiEfIÿACiHgpuuPpBtFEÿDpuutfEqq47 qfEhrCDp Q!Rÿÿÿ ÿS!ÿ qCitCDtBhgÿDpuutfEÿvtfpuItDpIEF)q )q TUUUVV"QWQ!WXY CIpDtBhgÿDpuutfEg9 CIpBt CIp0E ÿ RÿÿS!ÿ 0EIpfhg6ÿFtAPIPEBtp6ÿpfFÿpuEiihipBÿAEBIhggtgÿDpuutfE0FpA 5FpuEi TUUUVXV"Y CCgIBt 0EIpfhgÿpfFÿFtAPIPEBtpÿDpuutfE0F 0EftDpu ÿ Rÿÿ`RÿSR!!ÿ (Cÿ0BpFEÿ(prE TUUUVXV"Y pBtuEiipÿDpuutfE5 pBtDp bÿv! ÿ"ÿÿab!!ÿÿcR"!! 20pq6ÿPEApItItgÿÿpfFÿtfpuItDpIEFÿACitCDtBhgÿDpuutfE20pqEA)q qEFtpBt 20pq6ÿtfpuItDpIEFÿACitCDtBhgÿpfFÿÿxyz{|}~ÿ zyzÿ 20pq)qtG qEfIpuEi TUUUV"V"Y IHAEÿÿDpuutfE 0PtgÿguPEFhiEÿtfuihFEgÿBEuCrrEfFpItCfgÿtfÿEEuIÿpgÿCsÿpfhpBHÿ96ÿ789@x 20pqÿpfFÿtfpuItDpIEFÿACitCDtBhgÿDpuutfE20pq)q tfBt hpFBpuEi EpgiEg6ÿrhrAg6ÿBhGEiip6ÿpfFÿDpBtuEiipÿDpuutfEg qBChpF
ÿdefghfÿijÿkdlfmÿdhnÿkogdhÿepqrs thfesÿjieÿqsdsÿtihfeilÿdhnÿuephfqih ÿ ÿ ÿÿ !ÿ"ÿ# !ÿÿ$!%%ÿ$ÿ&ÿ'%ÿÿ'()ÿ%0ÿ12& ÿ 3 4 ÿ5647ÿ864ÿ $99ÿ@76ABÿ4 ÿ5$ 5ÿ9$570ÿ77ÿ567ÿ#$5#6C)Dÿ#67B)97ÿE F) 7ÿ1GH ÿ IPQRQÿT QUVWWQXY`abVXRÿWcRaÿdQÿTQ`YÿebaPÿaPQÿfVVaXVaQRÿaP`aÿfVggVehÿiVTÿaPVRQÿePVÿf`ggÿdQPbXYÿVTÿRa`Taÿg`aQpÿqrTbVYQÿU`aUPscqÿr`UUbX`abVXÿ`aÿaPQÿQ`TgbQRaÿVqqVTacXbatÿ`RÿbXYbU`aQYÿdtÿaPQÿuTQQXÿd`TRÿbXÿibucTQÿvhÿ IVÿ YQaQTWbXQÿWbXbWcWÿbXaQTr`gRÿdQaeQQXÿYVRQRpÿRQQÿaPQÿU`aUPscqÿRUPQYcgQÿwibucTQÿxyhÿUPVVgÿQXaTtÿ`XYÿ`YVgQQRXUaÿr`UUbXQÿ`uQÿuTVcqRÿ`TQÿRP`YQYÿbXÿuT`th vsxÿ `UUbXQbTaPvÿWV xÿWVRÿWVRÿWVRÿWVRvxÿWVRvÿWVRvÿWVR xsÿtTRsÿtTRsvÿtTRvvsvxÿtTRvsvÿtTRvÿtTRvsvÿtTR WVR
Qq`ababRÿÿwQqy vRaÿYVRQ xXYÿYVRQ TYÿYVRQ
Va`rbTcRÿw yÿ vÿwxsYVRQÿ QQÿ vRaÿYVRQ xXYÿYVRQ RQTbQRyÿ ÿwsYVRQÿRQTbQRy fVVaXVaQÿx
dbqPaPQTb`pÿaQa`XcRpÿeÿ`UQggcg`Tÿ vRaÿYVRQ xXYÿYVRQ TYÿYVRQ aPÿYVRQ aPÿYVRQ qQTacRRbRfÿwdI`ghÿiÿtTRy
jklmnopqrstÿqvwslvxklÿatqQÿdyÿ QQÿ TYÿVTÿaPÿYVRQpÿ vRaÿYVRQ xXYÿYVRQ wbdy fVVaXVaQÿ QQÿfVVaXVaQÿ
gXQcWVUVUU`gÿUVXzcu`aQ{ÿ vRaÿYVRQ xXYÿYVRQ TYÿYVRQ aPÿYVRQ wg| vy
}X`Uabr`aQYÿqVgbVrbTcR~ÿ vRaÿYVRQ xXYÿYVRQ TYÿYVRQ aPÿYVRQ w}g hÿivÿtTRy
XXc`gÿr`UUbX`abVXÿw} yÿÿ XXc`gÿr`UUbX`abVXÿw}} yÿvÿVTÿxÿYVRQR }XcQX`ÿw}} yÿ vÿYVRQÿVXgt
Q`RgQRpÿWcWqRpÿTcdQgg`ÿwy QQÿfVVaXVaQÿ vRaÿYVRQ xXYÿYVRQ
`TbUQgg`ÿw y vRaÿYVRQ xXYÿYVRQ
Qq`ababRÿ ÿwQq yÿ xsYVRQÿRQTbQRpÿQQÿfVVaXVaQÿv
QXbXuVUVUU`gÿwQX |sdÿ QQÿfVVaXVaQÿvv vRaÿYVRQ xXYÿYVRQ ÿWVRÿQX |s|ÿxÿWVRyÿ
IQa`XcRpÿYbqPaPQTb`pÿeÿ`UQggcg`Tÿ IY`q qQTacRRbRfwÿIY`qhÿÿtTRy
y QQÿfVVaXVaQÿ cW`Xÿq`qbggVW`rbTcRÿwg y v
QQÿfVVaXVaQÿvx QXbXuVUVUU`gÿ
gXQcWVUVUU`gÿqVgtR`UUP`TbYQ{ÿ QQÿfVVaXVaQÿ wgg xy
`XuQÿVfÿTQUVWWQXYQYÿ `XuQÿVfÿTQUVWWQXYQYÿ`uQRÿ `XuQÿVfÿTQUVWWQXYQYÿ`uQRÿÿ `XuQÿVfÿTQUVWWQXYQYÿ`uQRÿfVTÿXVXsPbuPsTbRÿ VÿTQUVWWQXY`abVX `uQRÿfVTÿ`ggÿUPbgYTQX fVTÿU`aUPscqÿbWWcXb`abVX fVTÿUQTa`bXÿPbuPsTbRÿÿuTVcqR uTVcqRÿaP`aÿW`tÿTQUQbrQÿr`UUbXQpÿRcdzQUaÿaVÿ bXYbrbYc`gÿUgbXbU`gÿYQUbRbVXÿW`bXu A457ÿ5 ÿÿ%ÿ%ÿÿÿ!ÿ ÿ ÿ"%ÿ"ÿ %ÿ% ! ÿ ÿ ÿ ÿ !ÿ"#$%#ÿ&!'ÿ#'"!"ÿ(#$ÿ)ÿ!"012ÿ3#'"ÿ4!ÿ"'ÿ%#ÿ!'ÿ4!ÿ'#ÿ!'#ÿÿ1ÿ!ÿ5#$6#$ÿ7#"8ÿ912 @ABÿDEFGBÿHBIPQÿRGPSTUBVÿWXYWA`FRÿVWABUFIBVÿXaUÿbTaTbFbÿTaYBGSXIVÿHBYQBBaÿUPVBVÿcPGÿWATIUGBaÿQAPVBÿSXaWWXTYTPaVÿAXSBÿHBBaÿUBIXdBUeÿfÿSXWWTaBÿVBGTBVÿUPBVÿaPYÿaBBUÿYPÿHBÿGBVYXGYBUgÿGBEXGUIBVVÿPcÿYABÿYTbBÿYAÿAXXYVÿBIXRVBUÿHBYQBBaÿ UPVBVeÿhVBÿYABÿVBWYTPaÿXRRGPRGTXYBÿcPGÿYABÿWATIUiVÿXEBeÿfIQXdVÿFVBÿYATVÿYXHIBÿTa ÿWPapFaWYTPaÿQTYAÿqTEFGBÿrÿXaUÿYABÿcPPYaPYBVÿYAXYÿcPIIPQe %$'#ÿ(#ÿ)ÿ!"ÿ'!(ÿsÿ3#'" uTaTbFbÿ uTaTbFbÿwaYBGSXIÿxBYQBBaÿvPVBV tXWWTaB fEBÿcPGÿ vPVBÿr vPVBÿrÿYPÿvPVBÿyvPVBÿyÿYPÿvPVBÿvPVBÿÿYPÿvPVBÿvPVBÿÿYPÿvPVBÿ ÿQBB VÿÿXYÿIBXVYÿrÿQBB VÿXcYBGÿDGVYÿUPVBeÿ BRXYTYTVÿx xTGYA ÿQBB V uTaTbFbÿXEBÿcPGÿYABÿDaXIÿUPVBÿTVÿyÿQBB Ve ÿQBB V uXTbFbÿXEBÿ ÿQBB V PYXSTGFV cPGÿDGVYÿUPVBÿTVÿÿQBB V uXTbFbÿXEBÿcPGÿDaXIÿUPVBÿTVÿÿbPaYAVgÿÿUXdVe rÿQBB VgÿÿUXdV vTRAYABGTXgÿYBYXaFVgÿXaUÿ ÿQBB V ÿQBB VÿQBB V ÿbPaYAV ÿbPaYAV XWBIIFIXGÿRBGYFVVTV ÿQBB Voÿ TcÿWFGGBaYÿXEBÿTVÿdPFaEBGÿYAXaÿryÿbPaYAVÿ$ÿDGVYÿUPVBÿQXVÿXUbTaTVYBGBUÿXYÿdPFaEBGÿYAXaÿXEBÿsÿbPaYAVgÿ ÿQBB Vÿ $ÿXYÿIBXVYÿrÿRGBSTPFVÿUPVBÿQXVÿtt`@ÿpfWYTHgÿtBaYXWBIgÿTHBGTqÿPGÿFa aPQae TcÿDGVYÿUPVBÿQXVÿXUbTaTVYBGBUÿ ÿQBB VÿÿXEBÿryÿYAGPFEAÿuÿbPaYAVÿpXVÿDaXIÿUPVBqoÿ HBcPGBÿYABÿrVYÿHTGYAUXde vÿTcÿWFGGBaYÿXEBÿTVÿdPFaEBGÿYAXaÿryÿbPaYAVÿ$ÿDGVYÿUPVBÿQXVÿXUbTaTVYBGBUÿXYÿXEBÿsÿYAGPFEAÿrrÿ ÿQBB VÿpXVÿDaXIÿUPVBqÿ @ATVÿUPVBÿPaIdÿaBWBVVXGdÿcPGÿWATI` defghijÿglmilnÿ ÿQBB VÿpXVÿDaXIÿUPVBqÿ bPaYAVwÿ ÿQBB V TcÿDGVYÿUPVBÿQXVÿXUbTaTVYBGBUÿXYÿXEBÿ UGBaÿXEBÿryÿYAGPFEAÿuÿbPaYAVÿ YdRBÿHo x ryÿYAGPFEAÿrÿbPaYAVe QAPÿGBWBTSBUÿÿUPVBVÿHBcPGBÿYABÿrVYÿ vÿTcÿWFGGBaYÿXEBÿTVÿryÿYAGPFEAÿuÿbPaYAVÿ$ÿDGVYÿUPVBÿQXVÿXUbTaTVYBGBUÿHBcPGBÿYABÿrVYÿHTGYAUXdgÿ$ÿ HTGYAUXde rPÿcFGYABGÿUPVBVÿaBBUBUÿTcÿDGVYÿ VBWPaUÿUPVBÿXUbTaTVYBGBUÿXYÿdPFaEBGÿYAXaÿrÿbPaYAVwÿÿ UPVBÿQXVÿXUbTaTVYBGBUÿXYÿXEBÿrÿ x bPaYAVÿPGÿPIUBGe vÿTcÿHPYAÿUPVBVÿQBGBÿtt`xutÿptBUSXwxwÿyPbSXqÿ$ÿQBGBÿXUbTaTVYBGBUÿHBcPGBÿYABÿrVYÿHTGYAUXde rPÿcFGYABGÿUPVBVÿaBBUBUÿTcÿRGBSTPFVÿUPVBÿQXVÿXUbTaTVYBGBUÿXYÿXEBÿrÿbPaYAVÿPGÿPIUBGe ÿQBB Vÿ TcÿDGVYÿUPVBÿXUbTaTVYBGBUÿHBcPGBÿYABÿ rVYÿHTGYAUXde ÿQBB Vÿ TcÿWFGGBaYÿXEBÿTVÿdPFaEBGÿYAXaÿryÿbPaYAVÿXaUÿRGBSTPFVÿUPVBÿETSBaÿXYÿ{sÿbPaYAVÿPIUe ÿQBB VÿpXVÿDaXIÿUPVBqÿ ÿQBB VÿpXVÿDaXIÿUPVBÿcPGÿABXIYAdÿ @ATVÿUPVBÿPaIdÿaBWBVVXGdÿcPGÿWATI` taBFbPWPWWXIÿÿ WATIUGBaq ÿQBB VÿpXVÿDaXIÿUPVBÿcPGÿABXIYAdÿWATIUGBaqÿ UGBaÿXEBUÿryÿYAGPFEAÿuÿbPaYAVÿ z ÿQBB V TcÿDGVYÿUPVBÿQXVÿXUbTaTVYBGBUÿXYÿYABÿTcÿRGBSTPFVÿUPVBÿETSBaÿHBYQBBaÿs`rrÿbPaYAVÿpQXTYÿFaYTIÿXYÿIBXVYÿryÿbPaYAVÿPIUqwÿ WPapFEXYB VY QAPÿGBWBTSBUÿÿUPVBVÿHBcPGBÿXEBÿryÿ rÿHTGYAUXdÿPGÿXcYBGe x bPaYAVÿPGÿcPGÿWATIUGBaÿXYÿATEAÿGTV ÿ rPÿcFGYABGÿUPVBVÿaBBUBUÿ TcÿWFGGBaYÿXEBÿTVÿryÿbPaYAVÿPGÿPIUBGÿXaUÿXYÿIBXVYÿrÿUPVBÿQXVÿETSBaÿHBcPGBÿXEBÿryÿbPaYAVe QAPÿGBWBTSBUÿÿUPVBVÿXYÿXadÿXEBe cPGÿABXIYAdÿWATIUGBaÿTcÿDGVYÿUPVBÿQXVÿrPÿcFGYABGÿUPVBVÿaBBUBUÿcPGÿABXIYAdÿWATIUGBaÿTcÿRGBSTPFVÿUPVBÿXUbTaTVYBGBUÿXYÿXEBÿyÿbPaYAVÿPGÿPIUBGe XUbTaTVYBGBUÿXYÿXEBÿyÿbPaYAVÿPGÿ PIUBGe ÿQBB V|ÿTcÿWFGGBaYÿXEBÿTVÿ{ÿÿdBXGV ÿbPaYAV|ÿpbTaTbFbÿXEBÿÿdBXGVÿcPGÿ waXWYTSXYBUÿRPITPSTGFV| ÿQBB V ÿQBB V| ÿbPaYAVÿpXVÿDaXIÿUPVBqÿTcÿWFGGBaYÿXEBÿTVÿÿdBXGVÿPGÿPIUBG DaXIÿUPVBqe uBXVIBVgÿbFbRVgÿGFHBIIX} ryÿbPaYAV ÿQBB V tXGTWBIIX~ ryÿbPaYAV ÿbPaYAV BRXYTYTVÿf ryÿbPaYAV ÿbPaYAV uBaTaEPWPWWXI puBafy`vÿuÿbPVw ÿQBB V ÿQBB V BBÿcPPYaPYBÿrr BBÿcPPYaPYBÿrr uBafy`yuÿyÿbPVq %$'#ÿ$ÿ$!%#"#"ÿ(#ÿÿ'!(ÿ12ÿ3#'" uBaTaEPWPWWXI rPYÿfRRITWXHIBÿ puBafy`vÿuÿbPVw ÿQBB Vÿ uBafy`yuÿyÿbPVq pr fq ÿQBB Vÿ @BYXaFVgÿUTRAYABGTXwÿ TcÿDGVYÿUPVBÿPcÿv@Xt v@ÿQXVÿXUbTaTVYBGBUÿHBcPGBÿYABÿrVYÿHTGYAUXdeÿ ÿbPaYAVÿTcÿDGVYÿUPVBÿPcÿv@Xt v@ÿÿ YBYXaFVgÿUTRAYABGTXgÿXaUÿ sÿdBXGV ÿQBB Vÿ QXVÿXUbTaTVYBGBUÿHBcPGBÿYABÿrVYÿ XWBIIFIXGÿRBGYFVVTV ÿbPaYAVÿpXVÿDaXIÿUPVBqÿ HTGYAUXde TcÿDGVYÿUPVBÿPcÿv@Xt v@ÿPGÿ@UXR @UÿQXVÿXUbTaTVYBGBUÿXYÿPGÿXcYBGÿYABÿrVYÿHTGYAUXde FbXaÿRXRTIIPbXSTGFVo uÿdBXGV PFYTaBÿUPVTaEÿTaYBGSXIVÿXGBÿGBWPbbBaUBUeo BRXYTYTVÿf r f ÿbPaYAV BRXYTYTVÿx r f ÿQBB VÿQBB Vÿ$ÿXYÿIBXVYÿrÿQBB VÿXcYBGÿDGVYÿUPVBe fÿcPFGYAÿUPVBÿPcÿwttÿTVÿTaUTWXYBUÿTcÿXIIÿ ÿbPaYAV| RGBSTPFVÿUPVBVÿQBGBÿXUbTaTVYBGBUÿ waXWYTSXYBUÿRPITPSTGFV| r f ÿQBB V fÿcPFGYAÿUPVBÿTVÿaPYÿaBWBVVXGdÿTcÿYABÿYATGUÿUPVBÿQXVÿXUbTaTVYBGBUÿXYÿXEBÿÿdBXGVÿPGÿPIUBGÿXaUÿXYÿIBXVYÿÿbPaYAVÿXYÿ{ÿdBXGVÿPGÿTcÿYABÿYATGUÿUPVBÿQXVÿ XcYBGÿYABÿRGBSTPFVÿUPVBe XUbTaTVYBGBUÿ{ÿbPaYAVÿXcYBGÿYABÿ VBWPaUÿUPVBe uBXVIBVgÿbFbRVgÿGFHBIIX} r f ÿQBB V ÿbPaYAVÿTcÿdPFaEBGÿYAXaÿXEBÿrÿ tXGTWBIIX~ r f dBXGVeÿ ÿQBB VÿTcÿXEBÿrÿdBXGVÿPGÿPIUBGe ÿ#ÿ5!#ÿ'#!#$!"ÿ"ÿ5#ÿ'#$ÿ%!(ÿ4ÿ#ÿ&!!!#"ÿ!&ÿ"ÿ"#$%# ÿ |}~ÿÿ }ÿÿ}~ÿÿ}}ÿÿ}ÿÿÿ~ÿÿÿÿ~ÿÿÿ}ÿ}}} 1 ÿ$2'$" 45ÿ"! '6 HIPQÿ"ÿ UIPQÿ"ÿ !"" #" $%&ÿ '"'0ÿ 4ÿ '"'0ÿ 4ÿ 7$&ÿ2$0!8ÿ&9 ABÿ0C%Dÿ %#0$ÿ&ÿ#%$%''ÿ @"$ÿ %''!%ÿ()0!&$ÿ1 ÿ 00ÿ"!'ÿ"2ÿ00ÿ"!'ÿ"2ÿ%'ÿ0ÿ&$%%8ÿ"ÿ 1'ÿ&$%%8 "@0ÿ " #0 'ÿ" #"' 0$Fÿ ÿ ÿ $2'$"3ÿ HRSSD T URSSD T @ "&$0%$% @"$ÿ0!ÿ&$%% $ #0'% &E$$% &$%% $G'%
VWXY`a`abÿde
fg`Yhaipbqÿ
raXs`sWiaYtÿ`W`YupbtÿvÿYwWxxpxYiÿXWi`pbbabyÿ rY
ÿ ÿ`XWÿde
uWpfgwgwwYxÿwgugphY`Wi
juYw`ahY`WkÿXgxaghaipbl
jumpWunYo
pWYbxWbtÿfpfXbtÿipdWxxYq
rYiawWxxYs
VWXY`a`abÿtuvÿ
pWuauhgwgwwYxÿtwxyuuÿ
W`YupbtÿkaXs`sWiaYtÿvÿYwWxxpxYiÿXWi`pbbabuzÿ kYX
VpfYuÿXYXaxxgfYhaipbue
pWuauhgwgwwYxÿdu{
uWpfgwgwwYxÿXgxbYwwsYiakWi
rYwwauY`aguÿabÿiWwgffWukWktÿ rYwwauY`aguÿYwwgikauhÿ`gÿ`sWÿ fWwgffWukWkÿgiÿXWibgubÿ¤a`sÿ YukÿYkka`aguYxÿkgbWbÿfYÿdWÿ igp`auWÿbwsWkpxWÿiWwgffWukWk YuÿYkka`aguYxÿiab©ÿYw`giÿgiÿ¤sawsÿ uWwWbbYiÿdYbWkÿguÿfWkawYxÿ ªgÿiWwgffWukY`agu ÿwgu`iYaukawY`Wk iWwYp`aguÿgiÿhYwwauY`agu `sWÿhYwwauWÿ¤gpxkÿdWÿaukawY`Wk wguka`agu¥ÿWWÿgg`ug`Wb¥ WhWiWÿwgfdauWkÿjffpugkWwaWuw 6giÿYkka`aguYxÿaugifY`aguÿiWhYikauhÿVjrÿxYdgiY`giÿXYiYfW`WibÿYukÿpbWÿgÿxahWÿhYwwauWbÿbWWÿ`sWÿ WuWiYxÿdWb`ÿiYw`awWÿ pakWxauWbÿgiÿjffpuanY`aguÿ¡tx`WiWkÿjffpugwgfXW`WuwW¢ÿY`£ÿ¤¤¤¥wkw¥hgh¦hYwwauWb¦swX¦YwaX§iWwb¦hWuWi§ Yx§iWwb¦affpugwgfXW`WuwW¥s`fxÿYukÿYdxWÿ¨§eÿgg`ug`WÿrÿY`£ÿ¤¤¤¥wkw¥hgh¦hYwwauWb¦swX¦YwaX§iWwb¦hWuWiYx§iWwb¦wgu`iYaukawY`agub¥s`fx¥ «¬®¯ÿÿ°ÿ}ÿÿÿÿ~ÿ±}ÿÿÿÿ}ÿÿ ÿÿ ÿÿ ÿ !ÿ"!ÿÿ# ÿ#$ÿ%&ÿ'!ÿ!ÿ'$!(ÿ)0123ÿ1#12(ÿ45%&ÿ 678ÿ@A8BCD8ÿEAFGHIPDÿ7IÿBCDÿAQDÿ7@ÿBCDÿRHPPFIDQÿSDIBF7IDGÿTDU7VWÿQDDXÿVVVYPGPYE7R`RHPPFIDQ`CPa`HPFab8DPQ`FIGDcYCBSUYÿÿ 678ÿRHPPFIDÿ8DP7SSDIGHBF7IQÿ@78ÿaD8Q7IQÿdeÿfDH8Qÿ7@ÿHEDÿHIGÿ7UGD8WÿQDDÿBCDÿgGAUBÿhSSAIFiHBF7IÿpPCDGAUDY qrrstsuvwxÿsvuwtsuv ÿ678ÿFI@78SHBF7Iÿ7IÿP7IB8HFIGFPHBF7IQÿHIGÿa8DPHABF7IQÿ@78ÿBCDÿAQDÿ7@ÿHÿRHPPFIDWÿP7IQAUBÿBCDÿ ÿ ÿ ÿ ÿdÿeffgdÿHIGÿ8DUDRHIBÿghhiÿ QBHBDSDIBQWÿHBÿVVVYPGPYE7R`RHPPFIDQ`CPa`HPFab8DPQ`FIGDcYCBSUYÿ ÿ678ÿPHUPAUHBFIEÿFIBD8RHUQÿTDBVDDIÿG7QDQWÿjÿVDDkQÿlÿmnÿGHfQYÿhIBD8RHUQÿ7@ÿojÿS7IBCQÿH8DÿGDBD8SFIDGÿTfÿPHUDIGH8ÿS7IBCQY ÿpFBCFIÿHÿIASTD8ÿ8HIEDÿqDYEYWÿdmrdnsWÿHÿGHQCÿqrsÿQC7AUGÿTDÿ8DHGÿHQÿtBC87AECYu ÿvHPPFIDÿG7QDQÿHGSFIFQBD8DGÿwjÿGHfQÿTD@78DÿBCDÿSFIFSASÿHEDÿ78ÿFIBD8RHUÿH8DÿP7IQFGD8DGÿRHUFGYÿx7QDQÿ7@ÿHIfÿRHPPFIDÿHGSFIFQBD8DGÿyzÿGHfQÿDH8UFD8ÿBCHIÿBCDÿSFIFSASÿ FIBD8RHUÿ78ÿSFIFSASÿHEDÿQC7AUGÿI7BÿTDÿP7AIBDGÿHQÿRHUFGÿHIGÿQC7AUGÿTDÿ8DaDHBDGÿHQÿHEDbHaa87a8FHBDYÿ{CDÿ8DaDHBÿG7QDÿQC7AUGÿTDÿQaHPDGÿH@BD8ÿBCDÿFIRHUFGÿG7QDÿTfÿ BCDÿ8DP7SSDIGDGÿSFIFSASÿFIBD8RHUYÿ678ÿ@A8BCD8ÿGDBHFUQWÿQDDÿ{HTUDÿ|bdWÿ} dff ÿÿfffÿ~ ÿÿ ÿ ÿ ÿd ÿFIÿ ÿ ÿ ÿ ÿdÿeffgdÿHBÿVVVYPGPYE7R`RHPPFIDQ`CPa`HPFab8DPQ`EDID8HUb8DPQ`BFSFIEYCBSU ÿhI@78SHBF7Iÿ7IÿB8HRDUÿRHPPFIDÿ8DAF8DSDIBQÿHIGÿ8DP7SSDIGHBF7IQÿFQÿHRHFUHTUDÿHBÿVVVIPYPGPYE7R`B8HRDU`Y ÿ678ÿRHPPFIHBF7Iÿ7@ÿaD8Q7IQÿVFBCÿFSSAI7GD PFDIPFDQWÿQDDÿ{HTUDÿnbdWÿdÿdÿ dÿÿfÿÿ dÿffd ÿFIÿ ÿ ÿ ÿ ÿdÿeffgdÿHBÿVVVYPGPYE7R`RHPPFIDQ`CPa`HPFab8DPQ`EDID8HUb8DPQ`FSSAI7P7SaDBDIPDYCBSUÿHIGÿhSSAIFiHBF7IÿFIÿpaDPFHUÿhUFIFPHUÿhF8PASQBHIPDQYÿqhIXÿ FSTD8UFIÿxpWÿ8HGfÿ{WÿHPkQ7IÿgWÿ7IEÿppWÿDGQYÿ} ÿddÿÿ dÿdÿ ÿdff ÿdÿe dÿ ÿÿ ÿUkÿ87RDÿvFUUHEDWÿhXÿgSD8FPHIÿgPHGDSfÿ7@ÿ iDGFHB8FPQWÿmdzXnbdsY ÿ{CDÿHBF7IHUÿvHPPFIDÿhI A8fÿh7SaDIQHBF7Iÿi87E8HSÿqvhhisÿFQÿHÿI7b@HAUBÿHUBD8IHBFRDÿB7ÿBCDÿB8HGFBF7IHUÿUDEHUÿQfQBDSÿ@78ÿ8DQ7URFIEÿRHPPFIDÿFI A8fÿPUHFSQYÿgUUÿ87ABFIDÿPCFUGÿHIGÿ HG7UDQPDIBÿRHPPFIDQÿH8DÿP7RD8DGÿTfÿvhhiÿDcPDaBÿ@78ÿaIDAS7P7PPHUÿa7UfQHPPCH8FGDÿRHPPFIDÿqiipvm|sYÿ678ÿS78DÿFI@78SHBF7IÿQDDÿVVVYC8QHYE7R`RHPPFIDP7SaDIQHBF7I` FIGDcYCBSUY
%¡ÿÿ¢£ÿ¤ÿ¥¢£¤¦ÿ§ ¡ÿ¥ÿ$¨ÿ©!¦ÿ ÿhI@HIBQÿVC7ÿGFGÿI7Bÿ8DPDFRDÿHÿTF8BCÿG7QDÿQC7AUGÿ " ¬£ÿ§ ¨ ¤!ÿ3ÿ¥ª§ÿ¢£¤ÿ§ ÿ«¦¨ TDEFIÿBCDÿQD8FDQÿHQÿQ77IÿHQÿ@DHQFTUDÿqQDDÿ6FEA8DÿmsY ÿx7ÿI7BÿQBH8BÿBCDÿQD8FDQÿ7Iÿ78ÿH@BD8ÿHEDÿdzÿVDDkQWÿÿ ÿª!ÿÿ¢¤#$¬0$§¨ÿdÿG7QDÿVFBCFIÿmjÿ ÿgGSFIFQB8HBF7Iÿ7@ÿ¸ÿÿFQÿaD8SFBBDGÿVCDIÿHÿ GHfQY C7A8Qÿ7@ÿTF8BCÿ@78ÿSDGFPHUUfÿQBHTUDÿFI@HIBQÿomWÿ P7STFIHBF7IÿRHPPFIDÿP7IBHFIFIEÿ³DaÿFQÿAQDGÿH@BD8ÿ ÿ{CDÿSHcFSASÿHEDÿ@78ÿBCDÿ IHUÿG7QDÿFQÿnÿS7IBCQWÿÿ E8HSQYÿhI@HIBQÿmWÿE8HSQÿHGSFIFQBD8ÿdÿG7QDÿHBÿ BCDÿTF8BCÿG7QDY GHfQY PC87I7U7EFPHUÿHEDÿdÿS7IBCÿ78ÿC7QaFBHUÿGFQPCH8EDY ÿªÿ$ÿ@78ÿBCDÿ IHUÿq|8Gÿ78ÿjBCsÿG7QDXÿmjÿ ÿ678ÿ7BCD8ÿPHBPCbAaÿEAFGHIPDWÿQDDÿ6FEA8DÿmY ÿª!ÿÿ¢¤#$¬®§¨ÿ VDDkQYÿ ¯ÿFRDÿ¢£¤ÿ§ ÿHIGÿ5¡°ÿ±ÿ ÿ¢¤²ÿqHBÿ ÿªÿ!§¨ÿx7QDÿdÿB7ÿx7QDÿmXÿjÿVDDkQÿ`ÿ ¾¡ÿÿ3£!(ÿ(ÿÿ !ÿ£!ÿ¥31®¦ÿ QDaH8HBDÿHIHB7SFPÿQFBDQsÿVFBCFIÿdmÿC7A8Qÿ7@ÿ x7QDÿmÿB7ÿx7QDÿ|XÿnÿVDDkQÿ`ÿx7QDÿdÿB7ÿx7QDÿ|Xÿdÿ § ¡ÿ¥ÿ$¨ÿ»ÿ¶µÿ¿¸ÿ«!ÿ !ÿ TF8BCWÿ8DEH8GUDQQÿ7@ÿTF8BCÿVDFECBY VDDkQYÿqpCDIÿjÿG7QDQÿH8DÿEFRDIWÿQATQBFBABDÿtx7QDÿ À!ºÿ!ÿÁ! ¦ ¯{ÿDQBÿ@78ÿ³QgEÿHIGÿHIBFb³QÿHBÿHEDÿerdmÿ juÿ@78ÿtx7QDÿ|uÿFIÿBCDQDÿPHUPAUHBF7IQYs ÿ§ ¨ S7IBCQYÿh@ÿ³DaÿQD8FDQÿFQÿGDUHfDGWÿBDQBÿdrmÿ " ¬£ÿ§ ¨ ÿzbG7QDÿQD8FDQÿHBÿmWÿjWÿWÿHIGÿdzrdnÿS7IBCQWÿHIGÿjrÿ S7IBCQÿH@BD8ÿ IHUÿG7QDY ÿ¹IRHPPFIHBDGÿaD8Q7IQÿQC7AUGÿP7SaUDBDÿHÿ|bG7QDÿ fDH8QYÿ ÿª!´ÿ¢¤#$ÿÿÿµ¶¨ÿ QD8FDQÿHBÿWÿdrmWÿHIGÿÿS7IBCQY ¯®ÿ!£ §«¨ÿgÿjBCÿG7QDÿSHfÿTDÿEFRDIÿHQÿ ¯ÿFRDÿ¢£¤ÿ§ ÿVFBCFIÿdmÿC7A8Qÿ7@ÿTF8BCWÿ ÿgG7UDQPDIBQÿddrdzÿfDH8Qÿ7@ÿHEDÿSHfÿAQDÿHIÿ 8DEH8GUDQQÿ7@ÿTF8BCÿVDFECBYÿ DH8UfÿHQÿHEDÿdmÿS7IBCQÿF@ÿHBÿUDHQBÿÿS7IBCQÿ HUBD8IHBFRDÿmbG7QDÿQPCDGAUDWÿVFBCÿHBÿUDHQBÿjÿS7IBCQÿ CHRDÿDUHaQDGÿQFIPDÿBCDÿ|8GÿG7QDY ¯6ÿ78ÿFI@HIBQÿmWÿE8HSQWÿEFRDÿ5¡°ÿ±ÿ ÿ¢¤²ÿ TDBVDDIÿG7QDQÿqHGAUBÿ@78SAUHBF7Iÿ ©§ºÿ ¯ ÿ!£ §«¨ÿgÿjBCÿG7QDÿBCHBÿVHQÿ FIÿHGGFBF7IÿB7ÿ³DaÿRHPPFIDÿVFBCFIÿdmÿC7A8Qÿ7@ÿ ¢¤ÿ7IUfsY FIHGRD8BDIBUfÿEFRDIÿHQÿDH8UfÿHQÿdmÿS7IBCQÿSHfÿ TF8BCYÿ ÿ678ÿ7BCD8ÿPHBPCbAaÿEAFGHIPDWÿQDDÿ6FEA8DÿmY ¯xÿDBD8SFIDÿS7BCD8·Qÿ³QgEÿQBHBAQÿHQÿQ77IÿHQÿ TDÿP7AIBDGÿF@ÿHBÿUDHQBÿjÿS7IBCQÿCHRDÿDUHaQDGÿ a7QQFTUDYÿh@ÿS7BCD8ÿFQÿ³QgEba7QFBFRDWÿEFRDÿ5¡°ÿ 4¡ÿÿ §!ÿ§ ¡ÿ¥ÿ$¨ÿ»ÿ¶µ¦ QFIPDÿBCDÿ|8GÿG7QDYÿ ±ÿ ÿ¢¤²ÿB7ÿFI@HIBQÿomWÿE8HSQÿHQÿQ77IÿHQÿ ÿ§ ¨ " ¬£ÿ§ ¨ a7QQFTUDWÿTABÿI7ÿUHBD8ÿBCHIÿÿGHfQÿ7@ÿHEDY ÿ !º¨ÿmbG7QDÿQD8FDQÿHBÿmÿHIGÿjÿS7IBCQY ÿ{CDÿzBCÿG7QDÿFQÿI7BÿIDPDQQH8fÿF@ÿBCDÿjBCÿG7QDÿVHQÿ ÿ!¨ ÿ 1¼¨ÿ|bG7QDÿQD8FDQÿHBÿmWÿjWÿHIGÿÿS7IBCQY HGSFIFQBD8DGÿHBÿjÿfDH8Qÿ78ÿ7UGD8Y ÿgÿP7SaUDBDÿQD8FDQÿFQÿ|ÿG7QDQÿHBÿWÿdrmWÿHIGÿrdnÿ h@ÿHIfÿG7QDÿFIÿBCDÿQD8FDQÿFQÿDFBCD8ÿ½7BH{Dÿ78ÿ ÿ678ÿ7BCD8ÿPHBPCbAaÿEAFGHIPDWÿQDDÿ6FEA8DÿmY S7IBCQYÿq7I7RHUDIBÿ³DaÿRHPPFIDÿQC7AUGÿTDÿ AIkI7VIWÿGD@HAUBÿB7ÿ|bG7QDÿQD8FDQY AQDGÿ@78ÿG7QDQÿEFRDIÿTD@78DÿHEDÿÿVDDkQYs TWÿW`iVWÿXSYdVÿTdÿ`iVÿUVÿTÿ`iVÿYXdVUÿhVd`XTdVSÿhVTbÿUVViÿpSpT¢YXdVU¢i¢YXRWVU¢XdSV£pi`hp ÿÿ ÿÿ !ÿ"ÿ#$%"&ÿ'())%0!ÿ Aÿ$Dÿ%0!)%@0 s!G!"G@8 %0(Pÿ¤2%qÿP!(7ÿ)@)tP!(Gÿ%1 P(04 #1%0%121ÿ(3!4ÿ5ÿ6!!78&ÿ eafgÿhTd`iU C3!ÿxÿ!(G84 9@2%0!ÿ'())%0(%@04ÿ efÿdYXdY`VSÿTWÿTdgÿeÿSTUVÿhVTWVÿeaÿ AÿdgÿXdThV`VÿUiVSVUÿX`ii AÿC)$DEFÿ$%"!G%HFÿ@GÿI!0()!P4ÿQRSTUVÿUVWXVUÿY`ÿabÿQbÿ hTd`iUiÿyXVÿaÿSTUVUÿÿVVUÿYYW`p erÿÿerÿSTUVUiÿeÿSTUVÿTÿerÿY`ÿVYU`ÿÿ cbÿYdSÿeafegÿhTd`iUp eaÿÿTWÿhTWVÿSTUVUÿhVTWVÿeaÿhTd`iUiÿyXVÿeÿ VVUÿY`VWÿYdgÿWXTWÿerÿSTUVp AÿI!q'(H$DE4ÿrRSTUVÿUVWXVUÿY`ÿabÿQbÿYdSÿeafegÿhTd`iUp STUVbÿY`ÿVYU`ÿÿVVUÿY`VWÿWVXTUÿSTUVp eÿrÿerÿSTUVUiÿaÿSTUVUÿTÿerbÿÿVVUÿ s()tu2 ÿ'())%0(%@04ÿ rp~rpmxÿ}m|lkrlÿvÿzmy|l Y`VWÿ`iVÿhTU`ÿWVVd`ÿSTUVÿYdSÿXVdÿÿVVUÿ Aÿv8ÿq@8!ÿ(ÿwxvvÿ1@0t84ÿyXVÿadSÿSTUVÿY`ÿVYU`ÿQÿ eyÿXVÿeÿSTUV YYW`p VVUÿY`VWÿYdSÿrWSÿ dYÿSTUVÿY`ÿeafegÿhTd`iUÿTWÿ AÿD1120@3P@"2P%0ÿq!)%!0)Fÿ!(GPÿ)@1 @0!0ÿ AÿTÿiXU`TWgÿTÿ ariÿeÿSTUVÿTÿ arÿY`ÿVYU`ÿÿ ÿVVUÿY`VWÿadSÿSTUVÿiXiVVWÿXUÿY`VWp )@1 P!1!0ÿq!)%!0) VVUÿY`VWÿYdgÿWXTWÿerÿSTUVpÿ Aÿv8ÿq@8!ÿ(ÿvxv ÿ1@0t84ÿyXVÿadSÿ dYÿSTUVÿY`ÿ eafgÿhTd`iU C3!ÿ5xv¡ÿ!(G84 VYU`ÿÿVVUÿY`VWÿeU`ÿSTUVp efÿdYXdY`VSÿTWÿTdgÿeÿSTUVÿhVTWVÿeaÿ AÿTÿiXU`TWgÿTÿVX`iVWÿerÿTWÿ ariÿeÿSTUVÿTÿ Aÿv8ÿq@8!ÿ"!@G!ÿvÿ1@0t8ÿ(0qÿ0qÿq@8!ÿ"!@G!ÿ hTd`iUiÿyXVÿaÿSTUVUbÿÿVVUÿYYW`p erbÿeÿSTUVÿTÿ arÿY`ÿVYU`ÿÿVVUÿY`VWp vÿ1@0t84ÿyXVÿrWSÿ dYÿSTUVÿÿVVUÿY`VWÿadSÿ eaÿÿTWÿhTWVÿSTUVUÿhVTWVÿeaÿhTd`iUiÿyXVÿeÿ Aÿdgÿerÿh`ÿdTÿ ariÿeÿSTUVÿTÿ arÿY`ÿ STUVp STUVbÿY`ÿVYU`ÿÿVVUÿY`VWÿWVXTUÿSTUVp VYU`ÿÿVVUÿY`VWÿ`iVÿhTU`ÿWVVd`ÿSTUVÿTÿer Aÿÿq@8!8ÿ@ÿI!q'(H$DEÿ"!@G!ÿvÿ1@0t84ÿyXVÿrWSÿ rp~rpmxÿÿVUUÿ`iYdÿWT`XdVÿUVWXVUÿ`iWTiÿeQÿ Aÿ arÿh`ÿdTÿeriÿeÿSTUVÿTÿerÿY`ÿVYU`ÿÿ dYÿSTUVÿY`ÿeafgÿhTd`iUÿYdSÿY`ÿVYU`ÿÿVVUÿ VVUÿY`VWÿ`iVÿhTU`ÿWVVd`ÿSTUVÿTÿ arp Y`VWÿadSÿSTUVp hTd`iUÿÿdTÿSTUVUÿeQÿhTd`iUÿTWÿTSVW d%)7P!ÿ)!PPÿq%8!(8!ÿ(0qÿ@t!Gÿt!1@3P@"%0@ (t%!8ÿ Aÿ0'())%0(!qÿ(ÿvxÿ1@0t84ÿeÿSTUVp ÿÿI0!21@)@))(Pÿ'())%0!8ÿ#1%0%121ÿ(3!4ÿ5ÿ6!!78ÿ (0(@1%)ÿ@Gÿ20)%@0(Pÿ(8 P!0%(ÿ)@03!0%(Pÿ AÿTWÿT`iVWÿY`iRÿXSYdVbÿUVVÿXWVÿapÿ IsvFÿÿ!(G8ÿIId& @Gÿ()¥2%G!qÿ%1120@q!)%!0)ÿ$Dÿ%0!)%@0ÿ d !)%(Pÿd%2(%@084 )tG@0%)ÿG!0(Pÿ(%P2G!ÿ0! tG@%)ÿ80qG@1!ÿ Aÿst!1@t!G( ÿ@GÿG(q%(%@0ÿG!(1!0ÿ 9@2%0!ÿ'())%0(%@0ÿ6%tÿIsv4 AÿQRSTUVÿUVWXVUÿY`ÿabÿQbÿcbÿYdSÿeafegÿhTd`iUp 1(P%30(0ÿ0!@ P(818FÿP!27!1%(8FÿP1 t@1(8Fÿ eafgÿhTd`iUÿ $@q37%0ÿq%8!(8!Fÿ(0qÿ@t!Gÿq%8!(8!8ÿ(88@)%(!qÿ s()tu2 ÿ'())%0(%@0ÿ6%tÿIsv4 efÿdYXdY`VSÿTWÿTdgÿeÿSTUVÿhVTWVÿeaÿhTd`iUiÿ 6%tÿG!(1!0ÿ6%tÿ%1120@82 G!88%'!ÿqG238ÿ AÿeÿSTUVÿTWÿiVY`igÿiXSWVdÿYVSÿaQfgÿhTd`iUÿ yXVÿaÿSTUVUbÿÿVVUÿYYW` @GÿG(q%(%@0ÿt!G( ÿ8@P%qÿ@G3(0ÿG(08 P(0(%@0ÿ X`iÿYdgÿXdThV`VÿerÿUiVSV eaÿÿTWÿhTWVÿSTUVUÿhVTWVÿeaÿhTd`iUiÿyXVÿeÿSTUVbÿ 12P% P!ÿ1!P@1(4 AÿTWÿT`iVWÿY`iRÿXSYdVbÿUVVÿXWVÿap Y`ÿVYU`ÿÿVVUÿY`VWÿWVXTUÿSTUVp C3!ÿxÿ!(G84 d !)%(Pÿ8%2(%@084ÿ$%3tuG%87ÿ)@0q%%@084ÿ jklmlÿopqmrÿsptuprÿvwÿxyzlÿk{ÿlty|tproÿtum|y}zÿk|ÿ AÿdgÿXdThV`VÿUiVSVUÿX`ii Cq1%0%8!GÿIsvÿq@8!8ÿ"!@G!ÿIIdÿ%ÿ x~|proÿtum|y}zÿluk~xÿmÿ|m}mytmxÿytÿmyltÿÿkrtulÿ erÿÿerÿSTUVUiÿeÿSTUVÿTÿerÿY`ÿVYU`ÿÿ @88%"P! y{tm|ÿtum|y}zÿk}mtpkr VVUÿY`VWÿYdgÿWXTWÿerÿSTUVp stG@0%)ÿt!(Gÿq%8!(8!ÿ# (G%)2P(GPÿ)(0@%)ÿ Aÿ$!1(@ @%!%)ÿ8!1ÿ)!PPÿG(08 P(0ÿ#$ds & eÿrÿerÿSTUVUiÿaÿSTUVUÿTÿerbÿÿVVUÿ )@03!0%(Pÿt!(Gÿq%8!(8!ÿ(0qÿ)(Gq%()ÿ(%P2G!&ÿ AÿrRSTUVÿUVWXVUÿX`iÿSTUVUÿQÿVVUÿYYW`ÿU`YW`Xdÿcÿ`Tÿ Y`VWÿ`iVÿhTU`ÿWVVd`ÿSTUVÿYdSÿXVdÿÿVVUÿ )tG@0%)ÿP203ÿq%8!(8!ÿ#%0)P2q%03ÿ(8t1(ÿG!(!qÿ eaÿhTd`iUÿY`VWÿUVUUÿ`WYdUYd`ÿWVYWSVUUÿTÿ YYW`p XhÿYXdY`XTdÿiXU`TWgp 6%tÿt%3tuq@8!Fÿ@G(PFÿ)@G%)@8!G@%q8&ÿq%("!!8ÿ AÿTÿiXU`TWgÿTÿ ariÿeÿSTUVÿTÿ arÿY`ÿVYU`ÿÿ AÿC0(@1%)ÿ@Gÿ20)%@0(Pÿ(8 P!0%(ÿ#%0)P2q%03ÿ8%)7P!ÿ 1!PP%284 VVUÿY`VWÿYdgÿWXTWÿerÿSTUVÿYdSÿYÿadSÿSTUVÿ )!PPÿq%8!(8!& C3!ÿxÿ!(G84 Tÿ arÿgÿgVYWUÿY`VWp eafgÿhTd`iU AÿdgÿXdThV`VÿUiVSVUÿX`ii efÿdYXdY`VSÿTWÿTdgÿeÿSTUVÿhVTWVÿeaÿhTd`iUiÿ erÿÿerÿSTUVUiÿeÿSTUVÿTÿerÿY`ÿVYU`ÿÿ C3!ÿ5xv¡ÿ!(G84 yXVÿaÿSTUVUbÿÿVVUÿYYW`p VVUÿY`VWÿYdgÿWXTWÿerÿSTUVp AÿTÿiXU`TWgÿTÿVX`iVWÿerÿTWÿ ariÿeÿSTUVÿTÿ erbÿaÿSTUVUÿTÿ arÿeU`ÿSTUVÿTÿ arÿ eaÿÿTWÿhTWVÿSTUVUÿhVTWVÿeaÿhTd`iUiÿyXVÿeÿSTUVbÿ eÿrÿerÿSTUVUiÿaÿSTUVUÿTÿerbÿÿVVUÿ YShXdXU`VWVSÿÿVVUÿY`VWÿerÿYdSÿadSÿSTUVÿTÿ Y`ÿVYU`ÿÿVVUÿY`VWÿWVXTUÿSTUVp Y`VWÿ`iVÿhTU`ÿWVVd`ÿSTUVÿYdSÿXVdÿÿVVUÿ arÿYShXdXU`VWVSÿY`ÿVYU`ÿgÿgVYWUÿY`VWÿ`iVÿeU`ÿ rp~rpmxÿ}m|lkrlÿÿzmy|lÿk|ÿkxm| YYW`p STUVÿTÿ arp eyÿXVÿeÿSTUV AÿTÿiXU`TWgÿTÿ ariÿeÿSTUVÿTÿ arÿY`ÿVYU`ÿÿ Aÿdgÿerÿh`ÿdTÿ ariÿaÿSTUVUÿTÿ arÿeU`ÿ AÿP!)%'!ÿ8 P!0!)@1 VVUÿY`VWÿYdgÿWXTWÿerÿSTUVpÿ STUVÿTÿ arÿ`TÿhVÿXVdÿÿVVUÿY`VWÿÿ`iVÿhTU`ÿ fdXhhdXVSÿVWUTdUÿegÿhTd`iUÿTWÿTSVW C3!ÿ5uv¡ÿ!(G84 WVVd`ÿSTUVÿTÿerÿYdSÿadSÿSTUVÿTÿ arÿ eyÿXVÿeÿSTUVÿWVVWYhgÿY`ÿVYU`ÿeQÿSYgUÿhVTWVÿ AÿTÿiXU`TWgÿTÿ ariÿeÿSTUVÿTÿ arÿY`ÿVYU`ÿÿ YShXdXU`VWVSÿY`ÿVYU`ÿgÿgVYWUÿY`VWÿ`iVÿeU`ÿSTUVÿTÿ WTVSWVp VVUÿY`VWÿYdgÿWXTWÿerÿSTUVp arp ÿ ÿ ÿÿ ÿ ÿÿ ÿ ÿ ÿ !ÿ "ÿ ## $ $%$%& $ '## (ÿ))0123ÿÿÿ)4153"ÿ5ÿ ÿÿ)4153ÿÿ ÿ6ÿ xsÿÿtDywPDzSÿISFFEDPRsÿxUEDEUwUÿSXPVÿYÿUCDuAR @SuFAwvÿISFFEDSuECDV 7ÿ ÿ ÿÿ ÿ))0123ÿ ÿÿÿ2ÿ CwuEDPÿISFFEDSuECDV (ÿ ÿ% ÿw56ÿ9 ÿ ÿ ÿÿ ÿÿ))0123ÿÿ ÿ ÿ8ÿ9 ÿ ÿ ÿ5ÿ ÿ (ÿi ÿÿ &%%% ÿÿÿ 9ÿe ÿÿ2oow8d#ÿ& !ÿÿÿ ÿ))0123ÿÿÿ ÿ6ÿ 7ÿ ÿÿ ÿÿ)4153# ÿÿ{ |ÿ ÿ9# ## $ $%$$8o #%fÿ ÿ2ÿ @ABCDEFÿHEIPBÿQERPSRPTÿSHFCACHERUV }@ÿAEHQBPDÿYÿUCDuAR`bÿcPSBRÿ ÿÿÿ ÿÿ ÿ " WXPÿY`abÿcPSBRV ÿÿ ÿ2ÿ ÿÿ{ |ÿ ÿ }WÿXPRÿx`aVÿ ÿ ÿ3ÿÿÿ (ÿdÿ9ÿÿ))0123"ÿ5ÿ ÿÿ))0123ÿeÿ ÿ6ÿ ÿ~9ÿ5!ÿ2o5wÿÿ ÿ2ÿ ÿ eÿ "ÿ ÿ 7f# 7ÿ ÿ9ÿ%ÿ)4153ÿ f# % ÿ9ÿÿ ÿ ÿ 7#ÿ }WÿXPRÿaÿSDQÿCHQPBVÿÿ ÿ ÿ 7# gh% ÿ ÿ ÿ9ÿ ÿ ÿ }yÿPBRCDRÿÿcPSBRÿSDQÿCHQPBÿ5ÿ asÿÿPvSuEuERÿWÿxPvWÿISFFEDPsÿxUEDEUwUÿSXPVÿaÿ )4153ÿ ÿ ÿÿ ÿ% ÿ ÿÿ (ÿ ÿ ÿ{ |ÿ ÿeih1fÿÿ UCDuAR i4h)ÿ ÿ&%ÿ #ÿp ÿÿ ÿÿ ÿ2o5w56ÿ #ÿ ÿÿ ÿÿ ÿÿ% ÿ)4153ÿ (ÿ ÿÿ !ÿ ÿ ÿ2o5w56ÿi4h)ÿ CwuEDPÿISFFEDSuECDV ÿ ÿ ÿ9ÿ ÿ ÿÿqÿ#ÿ0 ÿ { |ÿ ÿ ÿeÿ (ÿ2ÿ !ÿ % ÿ9ÿ&56ÿ!ÿ ÿ ÿ p ÿ6ÿÿrÿÿ ÿi4h)ÿ% ÿ ÿ i ÿ28!ÿ2o5we2f"5&2o"ÿ ## $ $ 5ÿÿ2ÿ9#ÿeiÿ ÿ ÿ ÿ ÿ ÿe ## $ $%$$ $$$%$o2#%f#ÿ 2ÿ9ÿÿ ÿ% ÿ ÿÿ ÿÿ 8r55#%fÿÿ% ÿ ÿ # e ÿ ÿ2o565rÿ !ÿ ÿ ÿ2o565rÿi4h)ÿ ÿ2ÿ ÿ ÿ ÿ ÿÿ #f { |ÿ ÿ #f @SuFAwvÿISFFEDSuECDV YsÿÿtDSFuEISuPQÿvCHECIEBwRÿISFFEDPÿxtysÿxUEDEUwUÿ (ÿi9 ÿ2ÿ9 ÿÿ ÿÿ ÿ9ÿ ÿ %iÿ SXPVÿYÿPPR bsÿÿ PSRHPRTÿUwUvRTÿSDQÿBwPHHSÿx ÿISFFEDPsÿÿ ÿÿ #ÿÿÿ ÿ ÿ CwuEDPÿISFFEDSuECDV xUEDEUwUÿSXPVÿaÿUCDuARÿCBÿBCwuEDPÿISFFEDSuECD ÿÿÿ# (ÿ & ÿ ÿÿ ÿ2!ÿ !ÿ56ÿ!ÿÿ ÿ9 #ÿ CwuEDPÿISFFEDSuECDV vPFESHÿvCvwHSuECDRVÿÿ i ÿ ÿqÿ ÿÿÿ ÿ ÿ ÿ9ÿ (ÿ2& ÿ ÿÿ5258ÿÿÿ ÿ9 # ) 9ÿ ÿ% ÿ ÿÿ ÿ ÿÿ ÿÿÿ ÿ ÿ% ÿ # (ÿp ÿ2ÿ ÿ9ÿ ÿ ÿÿ 9ÿÿ ÿ 7ÿ ÿ "ÿ @SuFAwvÿISFFEDSuECDV ÿ5ÿ # (ÿ) ÿ ÿÿÿ 7 ÿÿ ÿ ÿ (ÿhÿ ÿqÿÿÿÿ !ÿ ÿÿ ÿÿ @SuFAwvÿISFFEDSuECDV ÿÿ ÿ 9ÿ ÿ9ÿÿ ÿÿÿ%& ÿ ÿÿ (ÿ ÿ ÿÿ "ÿ2ÿ ÿÿ (ÿ ÿ ÿ ÿ 'ÿ ÿ ÿ ÿÿ 7# ÿ ÿ 7ÿ%# (ÿ ÿÿ ÿÿ& ÿ ÿÿ (ÿ) ÿ ÿ 7ÿ ÿ %ÿiÿÿÿÿ (ÿhÿ ÿÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ9!ÿ tDuPBDSuECDSHÿuBSIPHV ÿ9ÿÿ ÿ&ÿ% ÿ ÿ5ÿ ÿ ÿÿ ÿ ÿ9 ÿÿÿ ÿÿ (ÿtDSDuRÿY`aaÿUCDuARVÿ5ÿ ÿ ÿ % #ÿ (ÿ) ÿ ÿ &ÿ ÿÿ ÿ ÿ ÿ% ÿ # ÿ ÿ2ÿ ÿÿ5258ÿÿe52ÿ (ÿ) ÿ ÿÿ ÿ (ÿiÿ ÿ ÿÿÿ 9ÿÿ ÿ3ÿ ÿ ÿ ÿ ÿÿ ÿÿ &7ÿ fÿÿ2ÿ ÿ (ÿ) ÿ ÿ% ÿ !ÿ% ÿÿ ÿÿ ÿ ÿ ÿ9ÿÿÿ ÿÿÿ ÿ 9ÿÿ ÿ 7ÿ # ÿ ÿ% ÿ # e # #!ÿ ÿÿ ÿ9 fÿ ÿÿ (ÿDISFFEDSuPQÿFAEHQBPDÿaÿUCDuARÿSDQÿCHQPBVÿÿ ÿ% ÿ ÿ ÿqÿoÿ9ÿ ÿ (ÿh)1ÿÿÿ 9ÿ ÿÿ#0#ÿ ÿ 2ÿ ÿÿ ÿ ÿ 7ÿ%ÿ ÿ % # 56ÿ9 ÿÿ # ÿÿ ÿ ÿ0 ÿÿÿ9ÿ ÿ ÿ wUvRÿCwuBPSV ÿ ÿ 9ÿe ÿ ÿ5ÿ ÿ PBEPRÿ@CDuSEDEDXÿBSHÿyCHECÿSFFEDPÿxyTÿÿ (ÿ) ÿ52ÿÿ ÿ% 9ÿ ÿ ÿÿÿ ÿ%ÿÿ% 9ÿÿ ÿ dÿefghifgÿjÿefghjklmÿnn" 2ÿ ÿÿ%& ÿ ÿÿ ÿ 2ÿ 7ÿ ÿ ÿ% ÿf# (ÿpÿ ÿÿ ÿ ÿÿ% ÿ ÿ ÿ q ÿ9ÿ%ÿ ÿ ÿÿ ÿÿ ÿ ÿ ÿÿÿ ÿÿ ÿ#0#ÿh)1ÿ ÿ7ÿ ÿÿ%ÿ 7ÿÿ aasÿÿPBCXBCwvÿWTÿ@TÿTÿÿUPDEDXCFCFFSHÿISFFEDPRsÿ #ÿ0 ÿ ## $ $ $$ $ ÿÿ ÿÿ%&ÿ ÿ #ÿ x EDEUwUÿSXPVÿÿUCDuARÿ PDIPCTÿÿUCDuARÿ o5#pqro5q #ÿ PDSFuBSs (ÿs9ÿ ÿs)1ÿes)1fÿÿ ÿ ÿ sÿÿSBEFPHHSÿxWÿISFFEDPsÿÿxUEDEUwUÿSXPVÿaÿUCDuAR CwuEDPV #0#ÿÿ t #ÿ ÿ ÿÿ CwuEDPÿISFFEDSuECDV (ÿ2& ÿ "ÿ55&52ÿ9 ÿÿ5ÿ9 # ÿ ÿ ÿÿus)1vÿ ÿ # (ÿ2& ÿ "ÿ5258ÿÿÿ ÿ9 # @SuFAvV # $ $ $$ $ow# (ÿp ÿ2ÿ ÿ9ÿ ÿ ÿÿ 9ÿÿ3ÿÿ (ÿi ÿ53&58ÿ9 "ÿ5ÿ ÿ ÿÿ ÿÿ ÿ pqrowq # ÿ ÿ5ÿ ÿeÿ ÿ ÿ ÿÿ & 7ÿ 5&56ÿ9 #ÿÿ ÿ6ÿ 7# (ÿ ÿ ÿ&%ÿ !ÿ ÿ ÿ2# ÿ9ÿ ÿ f# (ÿi ÿ5&56ÿ9 "ÿ5ÿ #ÿ ÿ ÿ ÿÿ ÿ ÿÿ ÿ ÿ ÿ !ÿ "ÿ ## $ $%$%& $ '## 6789@ABÿ7D7EBAF@DGHÿAGIÿH@FEAF@DGHPÿ lmÿÿ68SDcSDE7ÿnÿR8G@GcD9D99ABÿiA99@G8HÿbR@G@RERÿ gÿ@BIS8Gÿtvloÿa8ASHÿ ÿ ÿd%ÿ QGAFDR@9ÿDSÿTEG9F@DGABÿAH7B8G@AUÿH@9VB8ÿ98BBÿI@H8AH8Uÿ Ac8Pÿloÿa8ASHÿpn8H8SDUÿqSER8GeArm xÿÿÿ%ÿÿ ÿ&%ÿ ÿxÿ WXYÿ@GT89F@DGUÿ78SH@HF8GFÿ9DR7B8R8GFÿ9DR7DG8GFÿ B@G@9ABÿI@H9S8F@DGPÿQIDB8H98GFHÿGDFÿAFÿ@G9S8AH8Iÿ ÿ ÿ ÿd%ÿ ÿÿqquq0ÿx # I8`9@8G9aÿb@G9BEI@Gcÿ89EB@dERAeÿEH8fP S@HVÿTDSÿR8G@GcD9D99ABÿnÿ@GT89F@DGÿDÿAGFÿ gÿyqAwÿ@GAIi8SF8GFBaÿc@i8GÿATF8SÿF8ÿtFÿe@SFIAa"ÿ gÿh8Gi8D h8GnÿiA99@G8m pÿ@BIÿtvlo"ÿdÿxÿÿÿ%ÿÿ pqÿÿ ÿÿrÿ s"ÿ3& ÿ ÿÿ0!ÿ3!ÿt!ÿÿq0ÿ &%ÿ #ÿz ÿd%ÿ ÿÿqq&q0ÿ 5 sÿ ÿxÿ ÿ ÿÿÿ ÿÿ # xÿ ÿ # ÿqtu0vÿx ÿw% ÿ ÿqtuqrÿx yÿ pqÿÿ ÿÿ1u0vÿ"ÿ0ÿ ÿw0ÿ ÿÿ pQÿIDB8H98GFÿllvlx"ÿ(ÿ ÿÿdÿÿ ÿ ÿ ÿÿÿ ÿs#ÿ ÿq0ÿ sÿ ÿ ÿqÿ ÿÿ ÿ ÿqÿ ÿd%ÿ #ÿ xy# gÿn8H8SD"ÿ0ÿ ÿÿ ÿqÿÿ%# gÿ ÿ ÿ&%ÿ !ÿ ÿ ÿ0# pqÿÿ ÿÿ03ÿÿÿ "ÿ0ÿ ÿÿ ÿrÿ gÿqSER8GeA"ÿ0ÿ ÿÿ ÿtÿÿ%#ÿÿ ÿ sÿ%# 0ÿ ÿÿ ÿ ÿÿtÿ!ÿ ÿÿvÿ l{mÿÿWERAGÿ7A7@BBDRAi@SEHÿbWwYfÿiA99@G8ÿbR@G@RERÿ gÿh8GA9FSA ÿÿ ÿ3ÿÿ ÿ ÿ0#ÿ Ac8Pÿÿa8ASHf pÿ ÿ% ÿ% ÿ x"ÿ 6789@ABÿ7D7EBAF@DGHÿAGIÿH@FEAF@DGHP uDEF@G8ÿAGIÿ9AF9E7ÿiA99@GAF@DGP ÿu0vÿ"ÿ0ÿ ÿÿ ÿq0ÿ sÿ% QGAFDR@9ÿDSÿTEG9F@DGABÿAH7B8G@AUÿH@9VB8ÿ98BBÿ gÿz ÿÿÿÿ ÿÿqquq0ÿ 0ÿ3ÿÿÿ "ÿ0ÿ ÿÿ ÿrÿ sÿ I@H8AH8Uÿ78SH@HF8GFÿ9DR7B8R8GFÿ9DR7DG8GFÿ x ÿwÿÿÿ ÿyÿÿ ÿ ÿqrÿÿ % I8`9@8G9aÿb@G9BEI@Gcÿ89EB@dERAeÿEH8fUÿH8SDcSDE7ÿ ÿ% xÿ | xÿ #ÿ} ÿÿ pÿÿÿÿ% !ÿs ÿ ÿ nÿR8G@GcD9D99ABÿI@H8AH8ÿDEFeS8AV ÿ % ÿÿ ÿÿÿ"ÿ !ÿÿ ÿ "ÿ gÿn8H8SD"ÿ0& ÿ ÿÿ ÿqÿÿ%# pQÿc8ÿvl{ÿa8ASHÿAFÿ@G@F@AF@DGPÿ0& ÿ ÿ 0ÿ3ÿÿÿ "ÿ0ÿ ÿÿ ÿrÿ sÿ gÿqSER8GeA"ÿv& ÿ ÿÿ2!ÿq&0!ÿÿtÿ# ÿ2ÿÿtuq0ÿ#ÿ5ÿ "ÿ4ÿ %#ÿ DF8"ÿn8H8SDÿÿqSER8GeAÿ ÿÿ ÿw % ÿÿ ÿ ÿÿÿÿ ÿ q0ÿ sÿ ÿ ÿÿ ÿÿÿ ÿ4ÿ h8ÿ GA9FSAÿÿ ÿ ÿÿ ÿ3ÿ # sÿ ÿ% ÿÿ(qvÿ # ÿ ÿ ÿqÿ y# ÿÿ ÿÿ pQÿc8ÿl~ÿa8ASHÿDSÿDBI8SÿAFÿ@G@F@AF@DGPÿv& ÿ @BIS8GÿDÿFSAi8BÿFDÿDSÿB@i8ÿ@Gÿ9DEGFS@8Hÿ8S8ÿ !ÿ ÿ ÿiijkÿ%ÿ R8G@GcD9D99ABÿI@H8AH8ÿ@Hÿa78S8GI8R@9ÿDSÿ ÿÿ2!ÿqu0ÿ!ÿÿtÿ#ÿ "ÿ ## $ $%$%& $& 87@I8R@9Uÿ@G9BEI@Gcÿ9DEGFS@8Hÿ@GÿF8ÿQTS@9AGÿ 5ÿ "ÿ3ÿ sÿ ÿqÿÿÿ R8G@Gc@F@Hÿe8BFÿDSÿIES@GcÿF8ÿWAUÿDSÿ87DHES8ÿFDÿAGÿ % $ ## 0ÿ ÿq0ÿ sÿ ÿ0ÿÿÿvÿ DEFeS8AVÿAFFS@eEFAeB8ÿFDÿAÿiA99@G8ÿH8SDcSDE7P lmÿÿq8FAGEHUÿI@7F8S@AUÿAGIÿA98BBEBASÿ78SFEHH@Hÿ ÿ4ÿÿ ÿqÿÿvÿ ÿ gÿ( ÿ03ÿÿÿ " w % ÿ wyÿ ÿÿÿÿÿ ÿ ÿ bqIA7fÿiA99@G8mÿbR@G@RERÿAc8Pÿllÿa8ASHÿTDSÿ ph8ÿ Gi8DÿbÿRDGFHfP ÿ ÿ ÿ ÿÿ ÿ y# SDEF@G8ÿiA99@GAF@DGHUÿtÿa8ASHÿTDSÿ9AF9E7ÿ qÿÿ ÿÿrÿ s"ÿ3& ÿ ÿÿ0!ÿ3!ÿt!ÿÿ gÿ ÿ ÿ ÿ% ÿÿÿ ÿ ÿ iA99@GAF@DGf q0ÿ# xÿ ÿ ÿÿÿ ÿxÿÿ #ÿ qÿÿ ÿÿ1&0vÿ"ÿ0ÿ ÿw0ÿ ÿÿ uDEF@G8ÿiA99@GAF@DGPÿ 6789@ABÿH@FEAF@DGHP ÿq0ÿ sÿ ÿ ÿqÿ ÿÿ ÿ ÿ gÿQIDB8H98GFHÿllvlÿa8ASHÿDTÿAc8Pÿqÿ # gÿW@HFDSaÿDTÿH8EABÿAeEH8ÿDSÿAHHAEBF"ÿs ÿ ÿÿ qÿxy# gÿwS8cGAGFÿAIDB8H98GFHPÿqÿ ÿ ÿ ÿ ÿÿx # ph8ÿ GA9FSAÿbÿRDGFHfPÿ % xÿw% xÿ ÿ ÿ xÿ%ÿÿ gÿXRREGD9DR7SDR@H8Iÿb@G9BEI@GcÿWXYfÿ ÿ 0ÿÿ ÿw0ÿ ÿÿ ÿq0ÿ sÿ ÿ ÿ ÿ sÿ01uvty#ÿ u0tÿx "ÿv& ÿ ÿÿ2!ÿqu0ÿ!ÿÿtÿ qÿ #ÿ0ÿ ÿxÿ ÿ ÿÿ gÿd%ÿxÿ ÿ ÿ ÿÿ ÿ # xÿÿrÿ sÿ ÿ ÿqÿ ÿÿ y# ÿ ÿ ÿÿ &ÿÿ% & gÿwS8cGAG9aPÿÿÿ !ÿ gÿ( ÿ0ÿx ÿÿ "ÿqÿ ÿÿh8Gi8Dÿÿ '& ÿ # ÿ ÿÿÿ ÿ ÿ ÿÿ#ÿ h8GA9FSA# AF9E7ÿiA99@GAF@DGP }ÿ ÿÿ ÿÿ ÿ ÿ DF8Pÿh8GA9FSAÿÿ ÿ ÿ ÿ ÿÿÿ gÿQIDB8H98GFHÿlvlxÿDÿAi8ÿGDFÿS898@i8IÿqIA7"ÿ xÿ ÿÿ ÿÿ ÿ ÿ ÿ ÿ ÿÿd#ÿ ÿ5 (efÿ ÿ ÿ qÿ !ÿ ÿxÿÿdÿ ÿ xÿq2ÿx # ÿ% #ÿ xÿ ÿ ÿÿ ÿ ÿÿ %ÿ ÿ ÿg)% ÿ gÿw8SHDGHÿAc8Iÿtvlxÿa8ASHÿGDFÿTEBBaÿ@RREG@d8Iÿ % x#ÿ xÿ ÿÿ ÿ ÿ # %%ÿÿhÿ !ÿÿÿ @FÿyqAw"ÿÿqÿ ÿÿd%ÿÿ%ÿÿ ÿ&%ÿ ÿÿ!ÿ ÿ ) ÿ55ez!ÿ ÿqt!ÿ02qtt4w3y"q324uq32r!ÿ ÿw% xÿ ÿÿ y#ÿÿÿ ÿ ÿiijkÿ%ÿ"ÿ ## $ ÿ ## $ $ $t4$ $%$ ÿ !ÿ ÿd# $%$%& $&% $ ## t434#%# ()012341&5 Talking to Parents about HPV Vaccine Recommend HPV vaccination in the same way and on the same day as all adolescent vaccines. You can say, Now that your son is 11, he is due for vaccinations today to help protect him from meningitis, HPV“ cancers, and pertussis. Remind parents of the follow-up shots their child will need and ask them to ”make appointments before they leave.
Why does my HPV vaccine is important because Some HPV infections can What diseases are child need it prevents infections that can cause cancer—like cancer caused by HPV? HPV vaccine? cause cancer. That’s why we need of the cervix or in the back to start the shot series today. of the throat—but we can protect your child from these cancers in the future by getting Is my child really HPV is a very common infection the first HPV shot today. at risk for HPV? in women and men that can cause cancer. Starting the vaccine series today will help protect your child Studies continue to prove How do you know from the cancers and diseases HPV vaccination works the vaccine works? caused by HPV. extremely well, decreasing the number of infections and HPV precancers in young people Why do they need Like all vaccines, we want to give since it has been available. HPV vaccine at HPV vaccine earlier rather than such a young age? later. If you wait, your child may I’m worried my child need three shots instead of two. Studies tell us that getting HPV vaccine doesn’t make will think that getting kids more likely to start this vaccine makes it I’m worried about Yes, HPV vaccination is very safe. having sex. I recommend OK to have sex. the safety of Like any medication, vaccines can we give your child her first HPV vaccine. Do cause side effects, including pain, HPV shot today. swelling, or redness where the shot you think it’s safe? was given. That’s normal for HPV vaccine too and should go away in a There is no known link Can HPV vaccine day or two. between HPV vaccination cause infertility Sometimes kids faint after they get and the inability to have in my child? shots and they could be injured if children in the future. they fall from fainting. We’ll protect However, women who develop an your child by having them stay HPV precancer or cancer could seated after the shot. require treatment that would limit their ability to have children.
Would you get Yes, I gave HPV vaccine to HPV vaccine for my child (or grandchild, etc.) I strongly recommend each What vaccines are your kids? when he was 11, because it’s of these vaccines and so actually required? important for preventing cancer. do experts at the CDC and major medical organizations. School entry requirements are developed Why do boys need for public health and safety, but HPV vaccination can help prevent HPV vaccine? don’t always reflect the most future infection that can lead to current medical recommendations cancers of the penis, anus, and for your child’s health. back of the throat in men.
December, 2016 | CS269453B