Humanized Antibody

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FOR RESEARCH USE ONLY! 07/20 Anti-RSV (Palivizumab), Humanized Antibody CATALOG NO.: A2166-100 (100 µg) BACKGROUND DESCRIPTION: The research-grade biosimilar is a humanized IgG1 kappa monoclonal antibody that is produced by recombinant DNA technology. The antibody is used to prevent RSV infections. RSV is a non-segmented, enveloped, single-stranded, negative-sense virus that is known to cause mild lower respiratory tract infections in infants. The antibody specifically targets an epitope in the antigenic A site (between amino acids 258 and 275) of the RSV fusion glycoprotein and prevents the entry of the virus inside the host cell. The antibody is composed of 95% human and 5% murine antibody sequences. It is consists of two heavy chains and two light chains and has a molecular weight of 148 kDa. The original drug received FDA approval to treat prophylaxis in children. It is also recommended to infants who are at high risk, either due to premature birth, or medical problems such as congenital heart disease and bronchopulmonary dysplasia (BPD). Human Respiratory Syncytical Virus, HRSV, MEDI 493, MEDI-493 ALTERNATE NAMES: ANTIBODY TYPE: Monoclonal CONCENTRATION: 1 mg/ml HOST/ISOTYPE: Recombinant / IgG1, kappa SOURCE: CHO cells IMMUNOGEN: Human RSV CAS NUMBER: 188039-54-5 MOLECULAR WEIGHT: 147.7 kDa PURIFICATION: Protein A purified FORM: Liquid FORMULATION: In PBS, pH 7.5 SPECIES REACTIVITY: Human STORAGE CONDITIONS: Store at -80ºC This information is only intended as a guide. The optimal dilutions must be determined by the user RELATED PRODUCTS: Anti-TNF alpha (Infliximab), Human IgG1 Antibody (A1097) Anti-RSV (Felvizumab), Human IgG1 Antibody (A1446) Anti-IgE (Omalizumab), Humanized Antibody (A2145) Anti-Flavivirus group antigen, Human IgG1 Antibody (A1102) Anti-VEGF (Bevacizumab), Humanized Antibody (A1045) FOR RESEARCH USE ONLY! Not to be used on humans. 155 S. Milpitas Blvd., Milpitas, CA 95035 USA | T: (408)493-1800 F: (408)493-1801 | www.biovision.com | [email protected] .

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Inclusion and Exclusion Criteria for Each Key Question
Supplemental Table 1: Inclusion and exclusion criteria for each key question Chronic HBV infection in adults ≥ 18 year old (detectable HBsAg in serum for >6 months) Definition of disease Q1 Q2 Q3 Q4 Q5 Q6 Q7 HBV HBV infection with infection and persistent compensated Immunoactive Immunotolerant Seroconverted HBeAg HBV mono-infected viral load cirrhosis with Population chronic HBV chronic HBV from HBeAg to negative population under low level infection infection anti-HBe entecavir or viremia tenofovir (<2000 treatment IU/ml) Adding 2nd Stopped antiviral therapy antiviral drug Interventions and Entecavir compared Antiviral Antiviral therapy compared to continued compared to comparisons to tenofovir therapy therapy continued monotherapy Q1-2: Clinical outcomes: Cirrhosis, decompensated liver disease, HCC and death Intermediate outcomes (if evidence on clinical outcomes is limited or unavailable): HBsAg loss, HBeAg seroconversion and Outcomes HBeAg loss Q3-4: Cirrhosis, decompensated liver disease, HCC, relapse (viral and clinical) and HBsAg loss Q5: Renal function, hypophosphatemia and bone density Q6: Resistance, flare/decompensation and HBeAg loss Q7: Clinical outcomes: Cirrhosis, decompensated liver disease, HCC and death Study design RCT and controlled observational studies Acute HBV infection, children and pregnant women, HIV (+), HCV (+) or HDV (+) persons or other special populations Exclusions such as hemodialysis, transplant, and treatment failure populations. Co treatment with steroids and uncontrolled studies. Supplemental Table 2: Detailed Search Strategy: Ovid Database(s): Embase 1988 to 2014 Week 37, Ovid MEDLINE(R) In-Process & Other Non- Indexed Citations and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central Register of Controlled Trials August 2014, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to July 2014 Search Strategy: # Searches Results 1 exp Hepatitis B/dt 26410 ("hepatitis B" or "serum hepatitis" or "hippie hepatitis" or "injection hepatitis" or 2 178548 "hepatitis type B").mp.
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