bioRxiv preprint doi: https://doi.org/10.1101/2020.05.13.094029; this version posted May 14, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Modelling the developmental spliceosomal craniofacial disorder Burn -McKeown syndrome using induced pluripotent stem cells Short title: Modelling Burn -McKeown Syndrome using induced pluripotent stem cells Katherine A. Wood 1,2 , Charlie F. Rowlands 1,2 , Huw B. Thomas 1, Steven Woods 3, Julieta O’Flaherty 3, Sofia Dou zg ou 1,2 , Su san J. Kimbe r3, William G. Newman 1,2 *,Raymond T. O’Keefe 1* 1Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, UK 2Manchester Centre for Genomic Medicine , Manchester University NHS Foundation Trust , Manchester Academic Health Science Centre, Manc hester, UK 3Division of Cell Matrix Biology and Regenerative Medicine, School of Biology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK *To whom correspondence should be addressed. Email:
[email protected] ;
[email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.05.13.094029; this version posted May 14, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license.