Race for a Cure

Total Page:16

File Type:pdf, Size:1020Kb

Race for a Cure JUST A MINUTE AUG 13, 2020 HILITE.ORG 05 TYPES OF VACCINES See the different approaches for a COVID-19 vaccine PAST VACCINES RACE FOR A CURE Inactivated Vaccines Rabies (1885) Inactive or attenuated viruses use a form of virus that Louis Pasteur administered spinal cannot cause disease to trigger antibodies that work material from a rabies-afflicted rabbit to With pharmaceutical companies racing to RILEY TERBUSH GRAPHIC against the true virus. an infected nine-year-old boy in Paris, develop a vaccine for COVID-19, learn CENTER FOR DISEASE leading to a full recovery. about different vaccines and how CONTROL, NEW YORK TIMES, RNA Vaccines MAYO CLINIC SOURCES Influenza (1940s) they are made Directly inject the DNA messenger coding for anitviral proteins that trigger antibody development. Researchers at the University of Michigan, supported by the US Army, develop a flu HERD IMMUNITY vaccine using fertilized chicken eggs. The Adenovirus flu led to the use of mechanical ventilators. See how vaccines use herd immunity to prevent the spread of viruses, along with the A form of adenovirus enters the cells to deposit an Polio (1955) 1 vulnerabilities of vaccine technologies inactive virus that the body forms defenses against. VACCINE PROCESS Polio outbreaks caused thousands DNA Vaccines of deaths and tens of thousands of Vaccinating most paralysis cases in the United States. 1 The vaccine shot releases a of a community Inject DNA instructions to create viral proteins, which Its vaccine’s cost was covered by deactivated virus that can provides immunity the body builds and then defends against. the March of Dimes foundation. Some no longer cause illness into to the majority of of the vaccines distributed by Cutter the body. the population, thus Laboratories failed to deactivate the polio slowing the spread virus, leading to polio cases in 2 White blood cells release of the virus and vaccinated subjects. antibodies with many protecting those POTENTIAL COST varying shapes that try to who are unable to I have a lot of experience over the years dealing with Measles (1963) match with the virus in order get vaccines. pharmaceutical companies in which we’re trying to develop an John F. Enders and Thomas C. Peebles to deactivate it, the same intervention, and the one thing that is clear is that isolated the measles virus in an ill process the body uses when 3 if you try to enforce [costs] on a company that student in 1954. In 1963, they created infected and ill with a virus. “ has multiple, different opportunities to do different and distributed the vaccine created from Vaccine opposers things, they will walk away.” the isolated virus. The final version of the The body finds the correct tend to live in the vaccine, created by Maurice Hilleman, 3 - Anthony Fauci, director of the National antibody match for the virus same communities, came in 1968. It exposes the body to a Institute of Allergy and Infectious Diseases within one to three weeks. leaving people weaker version of the measles virus. The antibody latches onto the vulnerable to virus and destroys it. With disease without the Dengue (2016) the correct antibody shape buffer of those with The Coronavirus Aid, Relief and identified, the body is now immunity. These Economic Security Act would protect Prematurely released vaccines for the 2 immune to the virus. communities tend to a COVID-19 vaccine under all health mosquito-borne Dengue fever in the be disease hotspots. plans, covering it as preventive health Philippines caused risk of plasma leakage service without cost sharing. syndrome in children, a fatal disease which causes fluid leakage in the blood. VACCINE DEVELOPMENT PRECLINICAL TESTING PHASE I TESTING PHASE II TESTING PHASE III TESTING APPROVAL Factories produce Scan to see the New York Times’ Scientists test the vaccine Scientists test the Scientists test the Scientists test the Regulators look over and distributes the vaccine. The coronavirus vaccine on animals, seeking an vaccine on a small vaccine on hundreds vaccine on thousands the trials and decide development immune system reaction group of humans of people divided into of people and compare whether or not to vaccine may still COVID-19 be tested beyond tracker, which in monkeys or to evoke an groups based on age the amount infected to approve the vaccine. shows the stage other mammals. immune response. to test safety and those given a placebo. The vaccine may be distribution to screen for defects. of development for effectiveness. approved for emergency COVID-19 vaccines use during a pandemic..
Recommended publications
  • 2004 Albert B. Sabin Gold Medal Address Delivered by Award Recipient William S
    2004 Albert B. Sabin Gold Medal Address Delivered by Award Recipient William S. Jordan, Jr., M.D. With a Tribute by John R. LaMontagne, Ph.D. May 25, 2004 Arlington, Virginia INTRODUCTION by H.R. Shepherd, D.Sc. Chairman, The Albert B. Sabin Vaccine Institute he Sabin Vaccine Institute pursues Dr. Albert B. Sabin’s vision of a T world protected from disease by vaccines. The annual awarding of the Sabin Gold Medal has always been among our most meaningful traditions. The 2004 award was presented in May to an icon in vaccine research, William S. Jordan, Jr., M.D., at a ceremony in Arlington, Virginia, during the 7th Annual Conference on Vaccine Research, co-organized by the Sabin Vaccine Institute. The positive impact of vaccines on the health and well being of humanity continues to be a marvel of our modern world. Vaccine improvements, new vaccines, and vaccines in the pipeline represent an advancing field of science that brings untold preventive benefit to millions around the world. Along with his career in vaccine research, Dr. Jordan has engaged in compiling the record of scientific advancements in the field. His name is synonymous with both vaccine research and the compendium—The Jordan Report—that for 25 years has been a repository for advances in the vaccine field. The Sabin Gold Medal Advisory Committee, chaired by Maj. Gen. Philip K. Russell, M.D. (USA Ret.), selected Dr. Jordan for this honor after canvassing 300 members of the scientific community. We are pleased to recognize Dr. Jordan with this honor, noting his exemplary contributions in the vaccine field and commitment to lifesaving medical discoveries.
    [Show full text]
  • Robert Purcell: Okay
    Office of NIH History Oral History Interview with Dr. Robert H. Purcell (NIAID, LID) Conducted on December 7, 2005, by Dr. Lisa K. Walker At the National Institutes of Health, Bethesda, Maryland Abstract: Dr. Purcell describes his education and training, his early career in the Laboratory of Infectious Diseases, and his work since he has headed LID studies of hepatitis viruses. He describes how the LID broadened its work, from a focus on viruses causing respiratory diseases through the early 1960s, to include hepatitis as well as gastroenteritis viruses. He also discusses internal collaborations at NIH and extramural collaborations, and many of the chance findings and coincidences that helped to further study of hepatitis and control of infection. Dr. Purcell also comments on how advances in technology and instrumentation have influenced the study of hepatitis viruses. Lisa Walker: I would like to start out by hearing a little bit about your growing up, and your family and your decisions as you entered university and training in chemistry to begin with. Robert Purcell: Okay. I was born in Iowa and moved to Texas when I was six months old, and spent my first nine years in Dallas, Texas. Then my family moved to rural Oklahoma, and that’s where I lived until I finished college and then went off to medical school. I guess I developed an interest in science from my brother, who was in college and was taking science courses, [and] who would come home with interesting little tidbits about things, and that really kind of excited me. The school I went to, since it was in rural Oklahoma, actually was a minimal school.
    [Show full text]
  • COLLEGE of LETTERS and SCIENCE ALUMNI: KNOWLEDGE in ACTION COLLEGE of LETTERS and SCIENCE Dear Friends and Colleagues, Dean, Nicol C
    THE COLLEGE OF LETTERS AND SCIENCE • MONTANA STATE UNIVERSITY • 2016-2017 • VOLUME 13 COLLEGE OF LETTERS AND SCIENCE ALUMNI: KNOWLEDGE IN ACTION COLLEGE OF LETTERS AND SCIENCE Dear friends and colleagues, Dean, Nicol C. Rae Associate Dean, David Cherry In 2016, Montana State University Associate Dean, Bridget Kevane celebrated and honored the legacy of Director of Finance and Administration, Mindy Brown Assistant to the Dean, Sarah Miller Maurice Hilleman, the College of Letters Administrative and Student Support Coordinator, and Science’s—and arguably MSU’s— Nicol Rae. Jennifer Storment most world-changing alumnus. Communications Director, Jody Sanford Advising Coordinator, Erica Dungan Hillman graduated from MSU in 1941 with degrees in chemistry and Accounting Operations Manager, Cassandra Balent microbiology. He pursued a career as a microbiologist, specializing in vaccinology Information Technology Director, Michael Wright and developing over 40 vaccines, an unparalleled record of productivity. Of the COLLEGE OF LETTERS AND SCIENCE 14 vaccines routinely recommended in current vaccine schedules, he developed ADVISORY COUNCIL eight: those for measles, mumps, hepatitis A, hepatitis B, chickenpox, meningitis, Michael Beehler Betsy Quammen pneumonia and Haemophilus influenzae bacteria. He also played a role in the Julianne Bye Peter Roos discovery of the cold-producing adenoviruses, the hepatitis viruses and the cancer- Ingrid Degreef Peter Sadowski Marshall Gingery Bradley Snow causing virus SV40. He is credited with saving more lives than any other medical Ariana Paliobagis Gary Stoner scientist of the 20th century. Gary Popiel William Yellowtail Jr. In April of this year, MSU held the Maurice Hilleman Vaccine Symposium, DEPARTMENTS AND DEPARTMENT HEADS featuring some of the nation’s most noted experts in vaccine.
    [Show full text]
  • Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA
    GENE SILENCING BY DOUBLE STRANDED RNA Nobel Lecture, December 8, 2006 by Andrew Z. Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA. I would like to thank the Nobel Assembly of the Karolinska Institutet for the opportunity to describe some recent work on RNA-triggered gene silencing. First a few disclaimers, however. Telling the full story of gene silencing would be a mammoth enterprise that would take me many years to write and would take you well into the night to read. So we’ll need to abbreviate the story more than a little. Second (and as you will see) we are only in the dawn of our knowledge; so consider the following to be primer... the best we could do as of December 8th, 2006. And third, please understand that the story that I am telling represents the work of several generations of biologists, chemists, and many shades in between. I’m pleased and proud that work from my labo- ratory has contributed to the field, and that this has led to my being chosen as one of the messengers to relay the story in this forum. At the same time, I hope that there will be no confusion of equating our modest contributions with those of the much grander RNAi enterprise. DOUBLE STRANDED RNA AS A BIOLOGICAL ALARM SIGNAL These disclaimers in hand, the story can now start with a biography of the first main character. Double stranded RNA is probably as old (or almost as old) as life on earth.
    [Show full text]
  • Drugs That Changed the World
    Drugs That Changed the World Drugs That Changed the World How Therapeutic Agents Shaped Our Lives Irwin W. Sherman CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2017 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper Version Date: 20160922 International Standard Book Number-13: 978-1-4987-9649-1 (Hardback) This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been made to publish reliable data and information, neither the author[s] nor the publisher can accept any legal respon- sibility or liability for any errors or omissions that may be made. The publishers wish to make clear that any views or opinions expressed in this book by individual editors, authors or contributors are personal to them and do not neces- sarily reflect the views/opinions of the publishers. The information or guidance contained in this book is intended for use by medical, scientific or health-care professionals and is provided strictly as a supplement to the medical or other professional’s own judgement, their knowledge of the patient’s medical history, relevant manufacturer’s instructions and the appropriate best practice guidelines. Because of the rapid advances in medical science, any information or advice on dosages, procedures or diagnoses should be independently verified. The reader is strongly urged to consult the relevant national drug formulary and the drug companies’ and device or material manufacturers’ printed instructions, and their websites, before administering or utilizing any of the drugs, devices or materials mentioned in this book.
    [Show full text]
  • July 16-31, 2009
    Eagleville Times Also serving Arrington, College Grove, Rockvale, Triune & Unionville Volume 7, Issue 14 - 50¢ July 16 - 31, 2009 Eagleville, Tennessee Highway 99 THOMAS MAUPIN Improvement Project 2009 Uncle Dave Macon INSIDE Trailblazer Award Winner Ahead Of Schedule BY BOBBIE SUE SHELTON-LONAS BY MELISSA BUCHANAN Thomas Maupin, of Murfreesboro, was Page 2 Business The Highway 99 Improvement Project honored as the recipient of the 2009 Uncle Directory enters its final phase of construction ahead Dave Macon Trailblazer Award presented on of schedule, according to Jaime Fitzpatrick, the opening night of the 32nd annual festival TDOT’s Project Supervisor over the in Murfreesboro. This distinguished award is Murfreesboro Construction office. given to those who have been at the forefront Page 3 A Message of preserving a traditional art. Thomas, a six- The Highway 99 Improvement Project will From Your time buck dancing national champion is very provide drivers with added safety, widening deserving of this award. Considered one of Mayor the roadway, eliminating dangerous curves, the best flat-foot dancers in the country, he and adding 8-foot shoulders, as drivers has the awards to prove it. Winning more than who commute between Eagleville and the 60 first-place honors as well as the Nashville Concord area of Rockvale have already put Page 14 Health & Silver Stars Talent show for artists 60 years portions of the new state route to use. Wellness and older is quite of an accomplishment for The current phase of construction is the this self-taught dancer. This year he also was new roadbed that begins at Swamp Road, a finalist for the Tennessee Governor’s Award bypassing the downtown Eagleville area by in the Arts.
    [Show full text]
  • 25.3 Joana Final Draft Mike Format 19
    January 2016 ISAR News Vol. 25 No. 3 Editor Anthony Vere Hodge Guest editor, Joana Rocha-Pereira ©International Society for Antiviral Research La Jolla, CA, USA welcomes the 29th ICAR, 17-21 April 2016 at IN THIS ISSUE ISAR PRESIDENT’S MESSAGE ISAR President’s Message I would like to offer a warm welcome to all of our ICAR 2016 members to the 29th International Conference on Update on the 29th ICAR Antiviral Research which will be held in La Jolla, CA Invitation to La Jolla in April 2016. Our meeting this year will commence Women in Science on the afternoon of Sunday April 17th with Drug th Discovery 101 and conclude midday on Thursday 29 ICAR: Useful information April 21st. In between, Mark Prichard and the ISAR elections - Our new officers Program Committee have put together a top notch Current research scientific program which includes two Keynote New infection models for human norovirus Addresses, two mini-symposia, our annual Prusoff, drug development Elion and Holy award lectures, and a variety of Antivirals on the horizon podium presentations and posters based on submissions from our delegates. Mark has worked MERS-coronavirus: a moving target? diligently this year to also incorporate a novel session ICAR through the years on diagnostic technologies which will feature Erik De Clercq’s ISAR/ICAR memories presentations from a variety of companies that ISAR member profile provide us with the technologies necessary to more Erik De Clercq efficiently and quantitatively perform our research. News items As always the meeting will prominently feature Ebola update: So near, yet so far networking opportunities which is the hallmark of ICAR 2015 Financial summary ICAR.
    [Show full text]
  • Medical Virology of Hepatitis B: How It Began and Where We Are Now Wolfram H Gerlich
    Gerlich Virology Journal 2013, 10:239 http://www.virologyj.com/content/10/1/239 REVIEW Open Access Medical Virology of Hepatitis B: how it began and where we are now Wolfram H Gerlich Abstract Infection with hepatitis B virus (HBV) may lead to acute or chronic hepatitis. HBV infections were previously much more frequent but there are still 240 million chronic HBV carriers today and ca. 620,000 die per year from the late sequelae liver cirrhosis or hepatocellular carcinoma. Hepatitis B was recognized as a disease in ancient times, but its etiologic agent was only recently identified. The first clue in unraveling this mystery was the discovery of an enigmatic serum protein named Australia antigen 50 years ago by Baruch Blumberg. Some years later this was recognized to be the HBV surface antigen (HBsAg). Detection of HBsAg allowed for the first time screening of inapparently infected blood donors for a dangerous pathogen. The need to diagnose clinically silent HBV infections was a strong driving force in the development of modern virus diagnostics. HBsAg was the first infection marker to be assayed with a highly sensitive radio immune assay. HBV itself was among the first viruses to be detected by assay of its DNA genome and IgM antibodies against the HBV core antigen were the first to be selectively detected by the anti-μ capture assay. The cloning and sequencing of the HBV genome in 1978 paved the way to understand the viral life cycle, and allowed development of efficient vaccines and drugs. Today’s hepatitis B vaccine was the first vaccine produced by gene technology.
    [Show full text]
  • The Jordan Report 20Th Anniversary: Accelerated Development Of
    USA ES IC V R E S N A M U H & D H H E T P L A A R E T H M F F E N O T Accelerated Development of Vaccines Preface In 1982, the National Institute of Allergy and Infectious Dis­ Along with these technological advances, there has been a eases (NIAID) established the Program for the Accelerated heightened awareness of the importance of vaccines for global Development of Vaccines. For 20 years, this program has helped health and security. Acquired immunodeficiency syndrome stimulate the energy, intellect, and ability of scientists in micro­ (AIDS), malaria, and tuberculosis have demonstrated to the biology, immunology, and infectious diseases. Vaccine research world the importance of public health in economic development. has certainly benefited. The status report reflecting this Most recently, the threat of bioterrorism has reminded many progress in vaccine research has come to be known as the Jor­ Americans of the value of vaccines as public health tools. dan Report in recognition of Dr. William Jordan, past director of NIAID’s Division of Microbiology and Infectious Diseases Articles by outside experts in this edition highlight many of the (DMID) and the program’s earliest advocate. scientific advances, challenges, and issues of vaccine research during these two decades. As we look to the decade ahead, the This anniversary edition of the Jordan Report summarizes 20 payoffs from basic research will continue to invigorate vaccine years of achievements in vaccine research driven by the explo­ development, but economic, risk communication, and safety sive technological advances in genomics, immunology, and challenges are likely to influence the licensing of new vaccines.
    [Show full text]
  • U.S. Markets for Vaccines
    U.S. Markets for Vaccines U.S. Markets for Vaccines Characteristics, Case Studies, and Controversies Ernst R. Berndt, Rena N. Denoncourt, and Anjli C. Warner The AEI Press Publisher for the American Enterprise Institute WASHINGTON, D.C. Distributed to the Trade by National Book Network, 15200 NBN Way, Blue Ridge Summit, PA 17214. To order call toll free 1-800-462-6420 or 1-717-794-3800. For all other inquiries please contact the AEI Press, 1150 Seventeenth Street, N.W., Washington, D.C. 20036 or call 1-800-862-5801. Library of Congress Cataloging-in-Publication Data Berndt, Ernst R. U.S. markets for vaccines : characteristics, case studies, and controversies / Ernst R. Berndt, Rena N. Denoncourt, and Anjli C. Warner. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-0-8447-4280-9 ISBN-10: 0-8447-4280-5 1. Vaccines industry—United States. 2. Market surveys—United States. I. Denoncourt, Rena N. II. Warner, Anjli C. III. Title. [DNLM: 1. Vaccines—economics—United States. 2. Drug Discovery—economics—United States. 3. Drug Industry—economics—United States. QW 805 B524u 2009] HD9675.V333.U6 2009 381'.456153720973—dc22 2009006713 13 12 11 10 09 1 2 3 4 5 6 7 © 2009 by the American Enterprise Institute for Public Policy Research, Wash- ington, D.C. All rights reserved. No part of this publication may be used or repro- duced in any manner whatsoever without permission in writing from the American Enterprise Institute except in the case of brief quotations embodied in news articles, critical articles, or reviews. The views expressed in the publications of the American Enterprise Institute are those of the authors and do not neces- sarily reflect the views of the staff, advisory panels, officers, or trustees of AEI.
    [Show full text]
  • March 4, 2011, NIH Record, Vol. LXIII, No. 5
    MARCH 4, 2011 The Second Best Thing About Payday VOL. LXIII, NO. 5 Fought for Freedom, Respect Black History Event Honors African Americans’ ABOVE · NIH hosts visit by USAID adminis- Civil War Contributions trator Dr. Rajiv Shah. See story below. By Valerie Lambros his year’s Black History Month ob- features T servance focused on the role of Af- 1 rican Americans in the Civil War. The African-American Role in Civil War country marks the 150th anniversary of Is Topic of Black History Month Talk the start of the conflict this year. 3 The event, sponsored by the Office of Collins Names New Senior Advisor Equal Opportunity and Diversity Man- agement and the NIH Black Employ- 5 ment Program committee, provided “an AMA Honors NHGRI’s Gahl opportunity to hear more about the con- 12 tributions of African Americans to this Eight NIH’ers Named to AAAS nation,” said Dr. Lawrence Tabak, prin- Historian Royce Kinniebrew gives keynote address at cipal deputy director of NIH, in welcom- Black History Month observance. ing remarks. departments He recalled several prominent black scientists who have guided NIH, including the see black history, page 6 Briefs 2 USAID’s Shah Calls for More Science to Digest 9 Sustain Global Health Gains Milestones 10 By Steve Goldstein Paying tribute to NIH as an institution that envisions the world as it could be, not as it is today, USAID administrator Dr. Rajiv Shah extolled the role of scientific research in rais- ing health standards around the world. In a health address at NIH, Shah called for a new global health system that better con- Dr.
    [Show full text]
  • Sabin Vaccine Report
    Volume VIII, Number 1 Sabin Vaccine Spring 2005 EPORT The newsletter of the Albert B. Sabin Vaccine InstituteR — dedicated to disease prevention www.sabin.org FDA Clears Human Hookworm Vaccine for Phase I Safety Trials Sabin/GW Researchers Receive Word on Investigational New Drug Status for Vaccine Clinical trials to test the safety of a gin safety trials is a major milestone for in individuals who suffer from hook- first-of-its-kind human hookworm vac- the human hookworm vaccine project,” worm infection.” cine will begin in the Washington, DC Hotez said. “It has taken an amazing Human hookworm infection is caused area in the coming weeks after the U.S. amount of our team’s effort to get us to by parasitic worms that fasten onto the Food and Drug Administration conferred the current stage of vaccine develop- inner layers of the small intestine using investigational new drug status on the ment. Of course, our ultimate goal is to their teeth-like projections and cause vaccine this past January. No current take this research to developing coun- blood loss at the attachment site. vaccine is available to prevent hook- tries where the vaccine will be tested Hookworm disease refers to the iron worm disease, which is one of the most Continued on page 4 common chronic infections of humans with an estimated 740 million cases in The village of Americaninhas, areas of rural poverty in the tropics in a rural part of Minas Gerais and subtropics. state in Brazil, is the focus of a The Human Hookworm Vaccine Ini- field study of hookworm dis- tiative (HHVI) is sponsored by the ease burden, being conducted Albert B.
    [Show full text]