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Trends Phytochem. Res. 5(2) 2021 105-109 Trends in Phytochemical Research (TPR) Journal Homepage: http://tpr.iau-shahrood.ac.ir Original Research Article Chemical composition of Leplaea mayombensis (Pellegrin) Staner CHARLIE KENMOE DJEUKEU1, HERMINE LAURE DJOMKAM MAZA1 * , ARIANE KOUAM KENMOGNE2, NORBERT SEWALD2, JEAN DUPLEX WANSI1 AND JULIETTE CATHERINE VARDAMIDES1 * 1Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon 2Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany ABSTRACT ARTICLE HISTORY One new coumarinolignan, cleomiscosin F (1) along with ten known compounds namely Received: 05 February 2021 3,4-secotirucalla-4(28),7,24-trien-21-hydroxy-21,23-epoxy-3-oic acid (2), 3,4-secotirucalla- Revised: 10 May 2021 4(28),7,24-trien-3,21-dioic acid (3), ceramid A (4), ceramid B (5), mayombensin (6), aridanin Accepted: 20 May 2021 (7), stigmasterol and β-sitosterol and their glucosides were isolated from the seeds and roots ePublished: 16 June 2021 of Leplaea mayombensis (Meliaceae). The structures of the compounds were elucidated based on the interpretation of their spectroscopic data. Some of the isolated compounds (3, 4 and 5) were tested in vitro against bacteria strains Escherichia coli, Bacillus subtilis, Pseudomonas KEYWORDS agarici, and Micrococcus luteus. Compound 3 displayed good activity against Bacillus subtilis, Micrococcus luteus, and Pseudomonas agarici with MIC values of 1.7, 2.3 and 9.8 µM, Antibacterial activity Micrococcus luteus respectively; while compound 4 showed significant activity against with MIC Coumarinolignan value of 11.9 µM. Leplaea mayombensis Minimum inhibitory concentration © 2021 Islamic Azad University, Shahrood Branch Press, All rights reserved.
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