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Sarms in Dietary Supplements and Other Products

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Sarms in Dietary Supplements and Other Products SARMs in Dietary Supplements and Other Products Selective androgen receptor modulators, or SARMs, are syn- damage.” They’re also prohibited for use in sport. For exam- thetic drugs designed to mimic the effects of testosterone. Al- ple, a 2017 FDA Safety Alert describes andarine and ostarine though these drugs are still in the research and testing stages as “unapproved drugs and anabolic steroid-like substances.” of development, and they are classified as drugs, yet most are In addition, some experimental drugs that are not SARMs are readily available online both as ingredients in dietary supple- being marketed as or along with SARMs, but they are equally ment products and as chemicals available for “research only.” illegal in dietary supplements and prohibited for sport. As a Some websites marketing SARMs for “research use” include result, the most common of these are also included on the next descriptions with language clearly targeting use for bodybuild- page. In addition, there are dietary supplements marketed as ing. However, according to FDA “Body-building products that contain selective androgen receptor modulators, or SARMs, SARMs that do not contain any of the drugs listed here. The have not been approved by the FDA and are associated with following list will help you recognize these drugs, which often serious safety concerns, including potential to increase the risk go by various names, as well as currently available products of heart attack or stroke and life threatening reactions like liver that contain them. SARMs • LGD-3033 » 2-[4-chlorobutyl(methyl)amino]-N-(2,6-dimethylphe- » 9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H- nyl)acetamide pyrrolo[3,2-f]quinolin-7(6H)-one • S-22 or S22 • LGD-4033 or LGD4033 » 2-[[2-(diethylamino)acetyl]amino]-4-meth- » Ligandrol yl-5-(2-methylsulfanylethyl)-1H-pyrrole-3- » 4-((R)-2-((R)-2,2,2-Trifluoro-1-hydroxyethyl)pyrroli- carboxamide din-1-yl)-2-(trifluoromethyl)benzonitrile • S-4 or S4 • MK-2866 or MK2866 » Andarine » Enobosarm » GTX-007 » Ostarine » (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-meth- » GTX-024 yl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide » (2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoro- • YK-11 methyl)phenyl]-2-hydroxy-2-methylpropanamide » YK-11- OA » (R)-Ostarine » methyl (2E)-2-[(8R,9S,10R,13S,14S,17R)-2’-me- • (2R)-3-(4-cyanophenoxy)-N-[4-cyano-3-(tri- thoxy-2’,13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12, fluoromethyl)phenyl]-2-hydroxy-2-methylpro- 14,15,16-dodecahydrocyclopenta[a]phenanthrene- panamide 17,5’-1,3-dioxolane]-4’-ylidene]acetate • RAD-140 or RAD140 • YK-500 » Testolone » (17-α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3- » 2-chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadi- oxo-19-norpregna-4,20-diene-21-carboxylic acid azol-2-yl)-2-hydroxypropylamino)-3-methylbenzonitrile methyl ester) CREATED BY OPERATION SUPPLEMENT SAFETY FROM THE CONSORTIUM FOR HEALTH AND MILITARY PERFORMANCE (CHAMP) OPSS.ORG http://opss.org Rev 112817 Other Chemicals Sold as SARMs • GW-501516 or GW501516 * • MK-677 or MK-0677 or MK677 » Cardarine » Ibutamoren » Endurobol » L 163,191 » GSK-516 » 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonyl- » GW-1516 spiro[2H-indole-3,4’-piperidine]-1’-yl)-1-oxo-3- » {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thi- phenylmethoxypropan-2-yl]propanamide azol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic » Ibutamoren mesylate acid • Crescendo » 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]- • 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonyl- 1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid spiro[2H-indole-3,4’-piperidine]-1’-yl)-1-oxo-3- • SR-9009 phenylmethoxypropan-2-yl]propanamide;meth- » Ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen- anesulfonic acid 2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate * Note: In 2013, the original developer discontinued GW501516 due to the discovery of severe toxic effects, and the World Anti-Doping Authority (WADA) issued an alert strongly warning against its use. Nevertheless, it is still widely available online. The list below includes both dietary supplement products and “research” products currently available. The latter do not have the labeling required for dietary supplements. “Current” refers to anything that could be purchased online as of the date on this list, including some products that have apparently been discontinued by their manufacturer or distributor but that can still be obtained from other sources online. The list is a far-from-complete representation of “research” suppliers, as there are too many to include them all; some may legitimately sell only to research facilities. Ingredients on label/advertising (** denotes research Product Name Distributor or Manufacturer labeling/advertising; not labeled as a dietary supplement) 4S Invitro SARM Tech LGD-4033, S4, MK-2866 Alphamass Omega Labs 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-tri- fluoroMethyl)benzonitrile Anabol LGD4033 Pureline Nutrition LGD 4033-Anabolicum-4(( R)-2-(( R’)-2,2,2-trifluoro-1-hy- droxyethyl)pyrrolidin-1-yl_-2-trifluoroMethyl)benzonitrile Anabolicum LGD-4033 SARMSX ** Anadrine S4 Pureline Nutrition Andarine - SARM (2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2- methyl-N-(4-nitro-3-trifluoromethyl.phenyl)-propionamide) Andarin S4 Hardcore Formulations Select Androgen Receptor Modulator Andarin-S4 Andarin S4 Landmark Research (Andarin) Sr Andarine (S4) Cratus Labs S4 Andarine (2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-meth- yl-N-(4-nitro-3-trifluoromethyl.phenyl)-propionamide) Andarine Hardcore Muscle Science (2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro- 3-trifluoromethyl.phenyl)-propionamide) Andarine S-4 Medals Research ** Andarine S-4 SARMSX ** CREATED BY OPERATION SUPPLEMENT SAFETY FROM THE CONSORTIUM FOR HEALTH AND MILITARY PERFORMANCE (CHAMP) OPSS.ORG Rev 112817 Ingredients on label/advertising (** denotes research Product Name Distributor or Manufacturer labeling/advertising; not labeled as a dietary supplement) Andarine S4 Brawn Nutrition ANDARINE / S4 (2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2- methyl-N-(4-nitro-3-trifluoromethyl.phenyl)-propionamide) Andarine S4 Intel Pharma Andarine (S4) Andarine S4 Panther Sports Nutrition Andarine Behemoth Beast Biotech UK MK2866, LGD4033 Black Magic MedFit Rx RAD-140, LGD-4033, GW-501516 Brawn Kodiak Labs SARM LGD-4033 (Ligandrol) Carda Ripped Muscle Science {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl} methyl)sulfanyl]-2-methylphenoxy}acetic acid Cardar1ne Olympus UK phenyl]-2-hydroxy-2-methylpropanamide Cardarine Enhanced Athlete (GW501516) Endurobol Cardarine Mass Muscle Maker no image Cardarine Twisted Labs Cardarine (GW-501516) Cardarine GW-1516 Brain Labz Cardarine GW-1516 Cardarine GW-501516 Medals Research ** Cardarine GW-501516 SARMSX ** Cardarine GW501515 Pureline Nutrition CARDAR1NE {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3- thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid, OSTAR1NE ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoro- methyl)phenyl]-2-hydroxy-2-methylpropanamide) Cardarine GW501516 Cratus Labs Cardarine {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3- thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid, OSTAR1NE ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoro- methyl)phenyl]-2-hydroxy-2-methylpropanamide) Elite GW 501516 Focused Nutrition Europe GW 501516 Elite LGD 4033 Focused Nutrition Europe LGD 4033 Elite MK-677 Focused Nutrition Europe MK-677 (Ibutamoren) Elite RAD 140 Focused Nutrition Europe RAD 140 Elite SARM Stack Focused Nutrition Europe LDG-4033, Ostarine (MK-2866), GW-501516 Elite SR-9099 Focused Nutrition Europe SR-9099 Elite YK-11 Focused Nutrition Europe YK-11 Endura Shred Olympus UK CARDAR1NE {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3- thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid, OSTAR1NE ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoro- methyl)phenyl]-2-hydroxy-2-methylpropanamide) Endure Kodiak Labs SR9009 Endurobol Hardcore Formulations Select Androgen Receptor Modulator GW501506 Endurobol Swole Labs Cardarine (GS501516) CREATED BY OPERATION SUPPLEMENT SAFETY FROM THE OPSS.ORG CONSORTIUM FOR HEALTH AND MILITARY PERFORMANCE (CHAMP) OPSS.ORG Rev 112817 Ingredients on label/advertising (** denotes research Product Name Distributor or Manufacturer labeling/advertising; not labeled as a dietary supplement) Epi-GH Primeval Labs MK-677 (Ibutamoren) Epica Stack Legal Power LGD-4033 Expanded Beast Biotech UK LDG-4033, MK-2866, GW-501516 Femavar Platinum Nutraceuticals GW501516 Fierce Kodiak Labs RAD140 SARM Folistatin Stack Legal Power MK-2866, MK-677, YK-11 GH-Pro Platinum Nutraceuticals MK-677 (Ibutamoren) Ghar1ne Olympus UK Ibutamoren/MK-677 (R)-1’-(2-methylalanyl-O-Ben- zyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[in- dole-3,4’-piperidine] Grizzly Kodiak Labs Ibutamoren (MK-677) Growth Hormone Enhanced Athlete MK-677 (Nutrobol/Ibutamoren/(R)-1-(2-methylalanyl-O-ben- zyl-D-seryl)-1-(methylsulfonyl)-1,2dihydrospiro[in- dole-3,4-piperidine]) GW 501516 Peptides Warehouse ** GW 50516 All American Peptide ** GW Extreme Mass Genetics no image GW Stamina SARM Tech {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl} methyl)sulfanyl]-2-methylphenoxy}acetic acid GW-15 Dark Label Nutrition (DLN) GW-501516 GW-501516 Blue Sky Peptide ** GW-501516 IronMag Research ** GW-501516 Madison James Research Chem- ** icals GW-501516 Maxim Peptide ** GW-501516 SARMS1 ** GW-501516 Transformix Peptides ** GW-501516 (Cardarine) Southern Sarms ** GW-XT Chem-Tek-Labs GW-501516 IbutAGen MK-677 Pureline Nutrition Ibutamoren MK-677
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