Polyclonal Antibody to RAD1 (Center) - Aff - Purified

OriGene Technologies, Inc. OriGene Technologies GmbH

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AP53557PU-N Polyclonal Antibody to RAD1 (Center) - Aff - Purified

Alternate names: Cell cycle checkpoint protein RAD1, DNA repair exonuclease rad1 homolog, REC1, Rad1-like DNA damage checkpoint protein Quantity: 0.4 ml Concentration: lot specific Background: This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq]. Uniprot ID: O60671 NCBI: NP_002844 GeneID: 5810 Host / Isotype: Rabbit / Ig Immunogen: KLH conjugated synthetic peptide between 118-146 amino acids from the Central region of Human RAD1. Genename: RAD1 Format: State: Liquid purified Ig fraction Purification: Affinity Chromatography on Protein A Buffer System: PBS Preservatives: 0.09% Sodium Azide Applications: ELISA: 1/1000. Western Blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This antibody recognizes Human RAD1 (Center). Add. Information: Molecular Weight: 31827 Da Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: 1. Shimada, M., et al. Hum. Genet. 128(4):433-441 (2010). 2. Takeishi, Y., et al. Genes Cells 15(7):761-771 (2010). 3. Bai, H., et al. DNA Repair (Amst.) 9(5):478-487 (2010). 4. Park, M.J., et al. DNA Repair (Amst.) 8(10):1190-1200 (2009). 5. Xu, M., et al. J. Biol. Chem. 284(31):20457-20461 (2009).

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MS/20181002 1 / 2 AP53557PU-N: Polyclonal Antibody to RAD1 (Center) - Aff - Purified

Pictures: Western blot analysis of RAD1 Antibody Cat.-No AP53557PU-N in K562 cell line lysates (35ug/lane). This demonstrates the RAD1 antibody detected the RAD1 protein (arrow).

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MS/20181002 2 / 2