A Database of Randomised Controlled Trials
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Still the Leading Antidepressant After 40
BRITISH JOURNAL OF PSYCHIATRY "2001), 178, 129^144 REVIEW ARTICLE Amitriptyline vv.therest:stilltheleading METHOD Inclusion criteria antidepressant after 40 years of randomised All RCTs comparing amitriptyline with any y other tricyclic,heterocyclic or SSRI were in- controlled trials cluded. Crossover studies were excluded. Studies adopting any criteria to define CORRADO BARBUI and MATTHEW HOTOPF patients suffering from depression were included; a concurrent diagnosis of another psychiatric disorder was not considered an exclusion criterion. Trials in patients with depression with a concomitant medical ill- Background Tricyclic antidepressants Amitriptyline is one of the first `reference' ness were not included in this review. have similar efficacy and slightly lower tricyclic antidepressants TCAs). Over the past 40 years a number of newer tricyclics, tolerability than selective serotonin Search strategy heterocyclics and selective serotonin re- Relevant studies were located by searching reuptakeinhibitorsreuptake inhibitors SSRIs).However, uptake inhibitors SSRIs) have been intro- the Cochrane Collaboration Depression, there are no systematic reviews assessing duced Garattini et aletal,1998). Despite Anxiety and Neurosis Controlled Trials several large systematic reviews comparing amitriptyline, the reference tricyclic drug, Register CCDANCTR). This specialised tricyclics and SSRIs there is no clear agree- vv. other tricyclics and SSRIs directly. register is regularly updated by electronic ment over first-line treatment of depression Medline,Embase,PsycINFO,LILACS, SongSong et aletal,1993; Anderson & Tomenson, Aims ToreviewTo review the tolerability and Psyndex,CINAHL,SIGLE) and non-electro- 1995; Montgomery & Kasper,1995; efficacy of amitriptyline inthe nicnicliterature searches. The register was HotopfHotopf et aletal,1996; Canadian Coordinating management of depression. searched using the following terms: Office for Health Technology Assessment, AMITRIPTYLIN**AMITRIPTYLIN oror AMITRILAMITRIL oror ELA-ELA- 19971997aa). -
(12) Patent Application Publication (10) Pub. No.: US 2005/0065218A1 Migeon Et Al
US 2005.0065218A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2005/0065218A1 Migeon et al. (43) Pub. Date: Mar. 24, 2005 (54) UTILIZATION OF ALVERINE, ALONE OR IN (30) Foreign Application Priority Data COMBINATION WITH TRICYCLC ANTDEPRESSANT OR A SPECIFIC Jun. 13, 2003 (FR).............................................. O307176 SEROTONIN REUPTAKE INHIBITOR FOR Apr. 30, 2004 (FR).............................................. O404639 THE TREATMENT OF DEPRESSION Publication Classification (76) Inventors: Jacques Migeon, Seattle, WA (US); Frederic Revah, Paris (FR) (51) Int. C.7 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A61K 31/137 (52) U.S. Cl. .............................................................. 514/649 Correspondence Address: SESD LARDNER (57) ABSTRACT 3000 KSTREET NW WASHINGTON, DC 20007 (US) The present invention relates to the utilization of Alverine or its metabolites, alone or in combination with a tricyclic (21) Appl. No.: 10/866,079 antidepressant or a Specific Serotonin reuptake inhibitor, for the preparation of pharmaceutical compositions for the (22) Filed: Jun. 14, 2004 treatment of depression. 80 120 OO 8 O 6 O 40 20 t Excipicnts Alverine Alverine Alverine Imiprannine (1% methylcellulose) Citate Citrate Citrate 10 mg/kg 3 mg/kg 10 mg/kg 30 mg/kg Patent Application Publication Mar. 24, 2005 Sheet 1 of 4 US 2005/0065218 A1 Excipients Alverine Alveline Alveline Inipramine (1% methylcellulose) Citrate Citrate Citrate 10 mg/kg 3 mg/kg 10 mg/kg 30 mg/kg Fi gure US 2005/0065218A1 Imipramine 30 mg/kg Figure 2 Patent Application Publication Mar. 24, 2005 Sheet 3 of 4 US 2005/0065218A1 20 Vehicle + Whicule -- Averine Alvérine Vehicule + Alverine Vehicule imipramine 3 ring/kg it 3 mg/kg t- Impramine 10 mg/kg + 3 mg/kg Wellicule imipramine 10 mg/kg Vehicule 3 mg/kg Figure 3 Patent Application Publication Mar. -
2019 Instrumentation and Consumable Catalog 2 INSTRUMENTATION and CONSUMABLE CATALOG
PRODUCT CATALOG 2019 Instrumentation and Consumable Catalog 2 INSTRUMENTATION AND CONSUMABLE CATALOG Resolvex® A200 Part Numbers: A200 96: 253-1160 Resolvex® A200 96 Resolvex A200 Standalone work station for automated sample preparation. The compact benchtop offers the one stop solution for automating sample preparation utilizing creation of multiple work flows, and programmable dispensing of up to 11 solvents. Along with its innovative positive pressure system leading to clean samples, improving accuracy, throughput and enhancing the Life time of your analytical instrument. The A200 comes with an easy to use touch screen interface allowing for easy set up of multiple work flows. In addition the light curtain safety feature will release gas pressure when manifold is activated to prevent any injuries. INSTRUMENTATION AND CONSUMABLE CATALOG 3 Resolvex® A100 Part Numbers: A100 96: 253-0019 A100 48: 253-0014 Resolvex® A100 Standalone work station for automated sample preparation. The compact benchtop offers the one stop solution for automating sample preparation utilizing creation of multiple work flows, and programmable dispensing of up to 11 solvents. Along with its innovative positive pressure system leading to clean samples, improving accuracy, throughput and enhancing the Life time of your analytical instrument. The A100 comes in 96 and 4 configuration allowing for for automated Work Flow solutions in multiple SPE formats. 4 INSTRUMENTATION AND CONSUMABLE CATALOG Resolvex® M10 96/M10 96 XT/M10 48 Part Numbers: M10 96 XT: 288-0006 M10 96: 288-0001 M10 48: 289-0004 Resolvex® M10 Standalone work station for Positive Pressure solid phase extraction. The manual Resolvex M10 48 and 96 are positive pressure manifold for 1, 3, and 6 ml cartridges, or 1ml 96 well plates. -
Still the Leading Antidepressant After 40 Years of Randomised Controlle
BRITISH JOURNAL OF PSYCHIATRY "2001), 178, 129^144 REVIEW ARTICLE Amitriptyline vv.therest:stilltheleading METHOD Inclusion criteria antidepressant after 40 years of randomised All RCTs comparing amitriptyline with any y other tricyclic,heterocyclic or SSRI were in- controlled trials cluded. Crossover studies were excluded. Studies adopting any criteria to define CORRADO BARBUI and MATTHEW HOTOPF patients suffering from depression were included; a concurrent diagnosis of another psychiatric disorder was not considered an exclusion criterion. Trials in patients with depression with a concomitant medical ill- Background Tricyclic antidepressants Amitriptyline is one of the first `reference' ness were not included in this review. have similar efficacy and slightly lower tricyclic antidepressants TCAs). Over the past 40 years a number of newer tricyclics, tolerability than selective serotonin Search strategy heterocyclics and selective serotonin re- Relevant studies were located by searching reuptakeinhibitorsreuptake inhibitors SSRIs).However, uptake inhibitors SSRIs) have been intro- the Cochrane Collaboration Depression, there are no systematic reviews assessing duced Garattini et aletal,1998). Despite Anxiety and Neurosis Controlled Trials several large systematic reviews comparing amitriptyline, the reference tricyclic drug, Register CCDANCTR). This specialised tricyclics and SSRIs there is no clear agree- vv. other tricyclics and SSRIs directly. register is regularly updated by electronic ment over first-line treatment of depression Medline,Embase,PsycINFO,LILACS, SongSong et aletal,1993; Anderson & Tomenson, Aims ToreviewTo review the tolerability and Psyndex,CINAHL,SIGLE) and non-electro- 1995; Montgomery & Kasper,1995; efficacy of amitriptyline inthe nicnicliterature searches. The register was HotopfHotopf et aletal,1996; Canadian Coordinating management of depression. searched using the following terms: Office for Health Technology Assessment, AMITRIPTYLIN**AMITRIPTYLIN oror AMITRILAMITRIL oror ELA-ELA- 19971997aa). -
Treatment Resistant Depression Clinic Clinician Referral Form
Treatment Resistant Depression Clinic Clinician Referral Form Patient Date: Name: Contact DOB: Sex: No: Ref. By: Contact: **Treating Contact: Psychiatrist: Primary Please Include Copy of Patient’s Insurance Insurance Card (Front and Back) Provider: PSYCHIATRIC NOTES How long have you known this patient? Current Diagnosis/Diagnoses: Current/Target Symptoms Past History of ECT □NO □YES If YES, # of sessions: Type: □UL □BF □BT Dates: Past response: □excellent □good □fair □poor □unknown Past History of TMS □NO □YES If YES, # of sessions: Dates: Past response: □excellent □good □fair □poor □unknown Current Medications: Current Medical Problems Emory Treatment Resistant Depression Clinic Clinician Referral Form 10/07/15 Allergies Do we have permission to contact the patient? □NO □YES ADDITIONAL NOTES Clinical Impression : Please complete the attached medication history form Include a copy of the patient’s insurance card (front and back) Fax referral form to: 404 712 7436. Attn: Emory TRD Clinic If you have any questions, please contact: Taelar Johnson at 404 712 8732 Emory Treatment Resistant Depression Clinic Clinician Referral Form 10/07/15 Generic Date drug How many weeks drug Drug Class Name was tried Min. Dose Max Dose Dosage was taken? Was it helpful?/Side Effects TCA Adapin Doxepin 150mg/d 250mg/d Anafranil Clomipramine 150mg/d 250mg/d Asendin Amoxapine 150mg/d 250mg/d Endep/Elavil Amitriptyline 150mg/d 250mg/d Ludiomil Maprotiline 150mg/d 250mg/d Norpramin Desipramine 150mg/d 250mg/d Pamelor Nortyrptiline 75mg/d 125mg/d Sinequin Doxepin -
1 Supplemental Figure 1: Illustration of Time-Varying
Supplemental Material Table of Contents Supplemental Table 1: List of classes and medications. Supplemental Table 2: Association between benzodiazepines and mortality in patients initiating hemodialysis (n=69,368) between 2013‐2014 stratified by age, sex, race, and opioid co‐dispensing. Supplemental Figure 1: Illustration of time‐varying exposure to benzodiazepine or opioid claims for one person. Several sensitivity analyses were performed wherein person‐day exposure was extended to +7 days, +14 days, and +28 days beyond the outlined periods above. 1 Supplemental Table 1: List of classes and medications. Class Medications Short‐acting benzodiazepines Alprazolam, estazolam, lorazepam, midazolam, oxazepam, temazepam, and triazolam Long‐acting benzodiazepines chlordiazepoxide, clobazam, clonazepam, clorazepate, diazepam, flurazepam Opioids alfentanil, buprenorphine, butorphanol, codeine, dihydrocodeine, fentanyl, hydrocodone, hydromorphine, meperidine, methadone, morphine, nalbuphine, nucynta, oxycodone, oxymorphone, pentazocine, propoxyphene, remifentanil, sufentanil, tapentadol, talwin, tramadol, carfentanil, pethidine, and etorphine Antidepressants citalopram, escitalopram, fluoxetine, fluvozamine, paroxetine, sertraline; desvenlafaxine, duloxetine, levomilnacipran, milnacipran, venlafaxine; vilazodone, vortioxetine; nefazodone, trazodone; atomoxetine, reboxetine, teniloxazine, viloxazine; bupropion; amitriptyline, amitriptylinoxide, clomipramine, desipramine, dibenzepin, dimetacrine, dosulepin, doxepin, imipramine, lofepramine, melitracen, -
Info on Skin Testing
Information on Skin Testing *Please review 1 week prior to testing* Your Doctor has ordered an allergy test for you. Your appointment has been made for: ___________________________________ at _______________________AM/PM at our (date) (time) _ Foulkstone / Limestone / Glasgow _ office. Skin tests are a method of testing for allergic reactions to substances, or allergens, in the environment. Our practice utilizes a test that involves no needles! We use a prick method which involves a series of small plastic applicators that carry a specific antigen which is placed on your arms. The types of allergens we test for include weeds, trees, grasses, molds, animal dander, dust mites and some foods. The testing will take 45 minutes. Please remember to wear comfortable clothing with short sleeves. Reactions can consist of itchy eyes, nose or throat, nasal congestion, runny nose, tightness in the throat or chest, wheezing, lightheadedness, hives or anaphylactic shock. Although this is very rare, our staff is fully prepared with emergency equipment and a physician is always on site. To ensure accurate testing results, certain medicines should be stopped 5 days prior to testing, although you should not stop medicines without talking to your prescribing physician. Medications that interfere with testing include but are not limited to: Antihistamines are medicines used to treat allergies, nausea, and dizziness. Many are found in over the counter cold medicines. They include, but are not limited to: ALAVERT / CLARITIN (LORATIDINE) DRAMAMINE (DIMENHYDRINATE) -
Xinyu Zhou, Bin Qin, Craig Whittington, 2 David Cohen, 3 Yiyun
Open Access Protocol Comparative efficacy and tolerability of first-generation and newer-generation antidepressant medications for depressive disorders in children and adolescents: study protocol for a systematic review and network meta-analysis Xinyu Zhou,1 Bin Qin,1 Craig Whittington,2 David Cohen,3 Yiyun Liu,1 Cinzia Del Giovane,4 Kurt D Michael,5 Yuqing Zhang,1 Peng Xie1 To cite: Zhou X, Qin B, ABSTRACT et al Strengths and limitations of this study Whittington C, . Introduction: Depressive disorders are among the Comparative efficacy and most common psychiatric disorders in children and ▪ tolerability of first-generation This Bayesian network meta-analysis can inte- adolescents, and have adverse effects on their and newer-generation grate direct evidence with indirect evidence from antidepressant medications psychosocial functioning. Questions concerning the multiple treatment comparisons to estimate the for depressive disorders in efficacy and safety of antidepressant medications in the interrelations across all treatments. children and adolescents: treatment of depression in children and adolescents, ▪ We will comprehensively assess the efficacy, study protocol for led us to integrate the direct and indirect evidence tolerability, acceptability and suicide-related out- a systematic review and using network meta-analysis to create hierarchies of comes of first-generation and newer-generation BMJ network meta-analysis. these drugs. antidepressant medications for depression in Open 2015;5:e007768. Methods and analysis: Seven databases with children and adolescents. doi:10.1136/bmjopen-2015- PubMed, EMBASE, the Cochrane Library, Web of ▪ 007768 Several subgroup and sensitivity analyses will Science, CINAHL, LiLACS and PsycINFO will be address some clinically relevant questions. searched from 1966 to December 2013 (updated to ▪ This method comprehensively synthesises data ▸ Prepublication history for May, 2015). -
Tricyclic Antidepressants Versus
Jørgensen et al. Syst Rev (2021) 10:227 https://doi.org/10.1186/s13643-021-01789-0 PROTOCOL Open Access Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis Caroline Kamp Jørgensen1* , Sophie Juul1,2,3, Faiza Siddiqui1, Marija Barbateskovic1, Klaus Munkholm4, Michael Pascal Hengartner5, Irving Kirsch6, Christian Gluud1 and Janus Christian Jakobsen1,7 Abstract Background: Major depressive disorder is a common psychiatric disorder causing great burden on patients and societies. Tricyclic antidepressants are frequently used worldwide to treat patients with major depressive disorder. It has repeatedly been shown that tricyclic antidepressants reduce depressive symptoms with a statistically signifcant efect, but the efect is small and of questionable clinical importance. Moreover, the benefcial and harmful efects of all types of tricyclic antidepressants have not previously been systematically assessed. Therefore, we aim to investigate the benefcial and harmful efects of tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder. Methods: This is a protocol for a systematic review with meta-analysis that will be reported as recommended by Pre- ferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols, bias will be assessed with the Cochrane Risk of Bias tool—version 2, our eight-step procedure will be used to assess if the thresholds for clinical signifcance are crossed, Trial Sequential Analysis will be conducted to control random errors and the certainty of the evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation approach. -
Comparative Efficacy and Acceptability of Interventions for Major Depression in Older Persons: Protocol for Bayesian Network Meta-Analysis
Open Access Protocol BMJ Open: first published as 10.1136/bmjopen-2017-019819 on 21 January 2018. Downloaded from Comparative efficacy and acceptability of interventions for major depression in older persons: protocol for Bayesian network meta-analysis Tau Ming Liew,1,2,3 Cia Sin Lee4 To cite: Liew TM, Lee CS. ABSTRACT Strengths and limitations of this study Comparative efficacy and Introduction Major depression is a leading cause of acceptability of interventions disability and has been associated with adverse effects ► This systematic review and meta-analysis will for major depression in in older persons. While many pharmacological and non- older persons: protocol provide a comprehensive summary on the efficacy pharmacological interventions have been shown to be for Bayesian network and acceptability of all available interventions for effective to address major depression in older persons, meta-analysis. BMJ Open major depression in older persons. there has not been a meta-analysis that consolidates all the 2018;8:e019819. doi:10.1136/ ► The results will provide the highest level of evidence available interventions and compare the relative benefits bmjopen-2017-019819 to inform clinicians on the best choice of treatment of these available interventions. In this study, we aim to ► Prepublication history for from among the many available pharmacological conduct a systematic review and network meta-analysis this paper is available online. and non-pharmacological interventions. to compare the efficacy and acceptability of all the known To view these files, please visit ► This protocol has been developed in accordance pharmacological and non-pharmacological interventions for the journal online (http:// dx. doi. -
Beta Blockers Herbs
Accredited Asthma, Allergy, & Food Intolerance Center • 1009B Dupont Square North • Louisville, KY • 40207 • Phone (502)895 -3330 • Fax (502)895-3356 IMPORTANT LIST OF MEDICATIONS TO AVOID - REVIEW IMMEDIATELY ANTIHISTAMINES ANTIHISTAMINES (CONT.) TRICYCLIC ANTIDEPRESSANTS **STOP 10 days PRIOR TO TESTING** **STOP 2 DAYS or 48 Hours PRIOR TO TESTING** **STOP 10 days PRIOR TO TESTING** GENERIC NAME BRAND NAME GENERIC NAME BRAND NAME **Please contact the ordering physician Azelastine Astelin Acrivastine Semprex-D before stopping these medications.** Azelastine Optivar Olopatadine Pataday Cetirizine Zyrtec GENERIC NAME BRAND NAME Chlorcyclizine HCl Ahist Amitriptyline Elavil Chlorcyclizine HCl Stahist Medications for Dizziness/Motion Amitriptyline Endep Chlorpheniramine Aller-Chlor Sickness Amitriptyline Etrafon Chlorpheniramine Chlo-Amine **STOP 10 DAYS PRIOR TO TESTING** Amitriptyline Laroxyl Chlorpheniramine Chlorphen GENERIC NAME BRAND NAME Amitriptyline Limbitrol Chlorpheniramine Chlor-Trimeton Meclizine Hydrochloride Antivert Amitriptyline Tryptizol Chlorpheniramine C.P.M. Meclizine Dramamine Amitriptyline Vanatrip Chlorpheniramine Effidac-24 Amitriptylinoxide Ambivalon Chlorpheniramine Ridraman Amitriptylinoxide Amioxid Cimetidine Tagamet Amitriptylinoxide Equilibrin Clemastine Allerhist-1 BETA BLOCKERS Amoxampine Asendin Clemastine Contac 12 Hour Allergy **DO NOT TAKE these medications the MORNING Butriptyline Evadyne Clemastine Tavist-1 OF your appointment** Clomipramine Anafranil Cyproheptadine Periactin GENERIC NAME BRAND NAME -
Resistant Depression: Effectiveness and Value
Esketamine for the Treatment of Treatment- Resistant Depression: Effectiveness and Value Draft Evidence Report March 21, 2019 Prepared for ©Institute for Clinical and Economic Review, 2019 The University of Illinois at Chicago College of ICER Staff and Consultants Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research* Steven J. Atlas, MD, MPH Daniel R. Touchette, PharmD, MA Associate Professor of Medicine Professor of Pharmacy Harvard Medical School, Boston Assistant Director, Center for Pharmacoepidemiology Director, Practice Based Research & Quality and Pharmacoeconomic Research Improvement University of Illinois at Chicago Division of General Internal Medicine Massachusetts General Hospital, Boston Nicole Boyer, PhD Research Fellow Foluso Agboola, MBBS, MPH University of Chicago Director, Evidence Synthesis Institute for Clinical and Economic Review Brian Talon, PharmD PhD Student University of Illinois at Chicago Katherine Fazioli Senior Research Assistant Bob G. Schultz, PharmD Institute for Clinical and Economic Review PhD Student and Research Fellow University of Illinois at Chicago Varun Kumar, MBBS, MPH, MSc Associate Director of Health Economics Institute for Clinical and Economic Review Ellie Adair, MPA Program Manager Institute for Clinical and Economic Review David Rind, MD Chief Medical Officer Institute for Clinical and Economic Review *The role of the University of Illinois at Chicago College of Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research is limited to the development of the Steve Pearson, MD, MSc cost-effectiveness model, and the resulting ICER reports do not President necessarily represent the views of the UIC. Institute for Clinical and Economic Review Date of Publication: March 21, 2019 Steve Atlas served as the lead author for the report.