Myeloma DCEP (Dexamethasone, Cyclophosphamide, Etoposide, and Cisplatin) Is an Effective Regimen for Peripheral Blood Stem Cell Collection in Multiple Myeloma
Bone Marrow Transplantation (2001) 28, 835–839 2001 Nature Publishing Group All rights reserved 0268–3369/01 $15.00 www.nature.com/bmt Myeloma DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin) is an effective regimen for peripheral blood stem cell collection in multiple myeloma M Lazzarino1, A Corso1, L Barbarano2, EP Alessandrino1, R Cairoli2, G Pinotti3, G Ucci4, L Uziel5, F Rodeghiero6, S Fava7, D Ferrari8, M Fiumano`9, G Frigerio10, L Isa11, A Luraschi12, S Montanara12, S Morandi13, D Perego14, A Santagostino15, M Savare`16, A Vismara17 and E Morra2 1Division of Hematology, IRCCS Policlinico S Matteo, University of Pavia, Italy; 2Division of Hematology, Ospedale Niguarda, Milano, Italy; 3Division of Oncology, Varese, Italy; 4Division of Oncology, Lecco, Italy; 5Division of Oncology, Milano S Paolo, Italy; 6Division of Hematology, Vicenza, Italy; 7Division of Internal Medicine 2, Legnano, Italy; 8Division of Internal Medicine, Abbiategrasso, Italy; 9Division of Oncology, Sondrio, Italy; 10Division of Internal Medicine, Como, Valduce, Italy; 11Division of Oncology, Gorgonzola, Italy; 12Division of Oncology, Verbania, Italy; 13Division of Hematology, Cremona, Italy; 14Division of Internal Medicine, Desio, Italy; 15Division of Oncology, Vercelli, Italy; 16Division of Internal Medicine, Magenta, Italy; and 17Division of Internal Medicine 2, Rho, Italy Summary: grams for multiple myeloma. Bone Marrow Transplan- tation (2001) 28, 835–839. DCEP (dexamethasone, cyclophosphamide, etoposide, Keywords: peripheral stem cell; mobilization; myeloma; and cisplatin) has proved to be an effective salvage ther- chemotherapy; purging in vivo apy for refractory-relapsed MM patients. Little is known, however, about its potential as mobilizing ther- apy. The aim of this study was to evaluate the efficacy of DCEP in mobilizing PBSC and to define its toxicity.
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