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COVID 19 Review COVID 19 Review Monografia n. 5 Covid19 e i vaccini: a che punto siamo. A cura di Giorgio Banchieri, Antonio Giulio De Belvis, Maurizio Dal Maso, Stefania Mariantoni, Mario Ronchetti, Andrea Vannucci. Review realizzata in collaborazione con : 1 Nota redazionale. I materiali (articoli e dati) vengono selezionati da fonti accreditate: . Per gli articoli: The Lancet, British Medicine Journal, The New York Times, Science, Nature, Oxford Review, Cambridge Review, Quotidiano Sanità, Il Corriere della Sera, Il Sole 24Ore Sanità, La Repubblica e altri; Per le Istituzioni: . WH0/OMS, UE Centri di Prevenzione; OCDE, ONU, Protezione Civile, ISTAT, INAIL, Ministero Salute, ISS, AGENAS, CNR, Regioni, ARS, ASL, AO, AOP, IRCCS, Centri Studi e ricerche nazionali e internazionali e altri; Per i dati: . WH0/OMS, UE Centri di Prevenzione; OCDE, ONU, Protezione Civile, ISTAT, INAIL, Ministero Salute, ISS, AGENAS, CNR, Regioni, ARS, ASL, AO, AOP, IRCCS, Centri Studi e ricerche nazionali e internazionali e altri; Criteri di selezione: I materiali sono scelti in base ai seguenti criteri: Materiali di analisi recenti; Fonti accreditate; Tematiche inerenti a COVID19; Procedure internazionali e nazionali; Studi e ricerche epidemiologici; Studi su procedure per operatori sanitari e sociali; Linee Guida internazionali, nazionali e regionali; Linee Guida di società scientifiche e professionali. Le traduzioni sono fatte in automatico con il software “google” per rapidità di fruizione. Ci scusiamo se le traduzioni non sono sempre adeguate, ma riteniamo più utile la tempestività di divulgazione. Si ringraziano l’Editore COM SRL di Roma per il supporto Si ringrazia la Dr.ssa Giulia D’Allestro per il database repository. I curatori Giorgio Banchieri Segretario Nazionale del CDN ASIQUAS, Associazione Italiana per la Qualità della Assistenza Sanitaria e Sociale; Docente presso il Dipartimento di Scienze Sociali ed Economiche, Progettista e Coordinatore Didattico dei Master MIAS, MEU e MaRSS, Università “Sapienza” Roma; Già Direttore dell’Osservatorio della Qualità del SSR del Molise; Docente ai master e Direttore di progetti di ricerca e di consulenza organizzativa e gestionale in aziende sanitarie (Asl e AO) presso la LUISS Business School di Roma, presso L’Università Politecnico della Marche, presso Università del Salento; Direttore di www.osservatoriosanita.it; già Direttore FIASO, Federazione Italiana Aziende Sanitarie e Ospedaliere, membro Comitato Programma Nazionale Esiti – PNE; Membro Comitato del Tavolo Tecnico AGENAS e Regioni Re.Se.T., Reti per i Servizi Territoriali. 2 Antonio Giulio de Belvis Membro di ASIQUAS, Associazione Italiana per la Qualità dell’Assistenza Sanitaria e Sociale. Ricercatore medico e Professore incaricato in Igiene all’Università Cattolica del Sacro Cuore dal 2002. Dal 2009 al 2012, Coordinatore e Segretario Scientifico dell’Osservatorio Nazionale sulla Salute nelle Regioni Italiane e curatore del Rapporto Osservasalute, dal 2011 è referente per l’Italia dello European Observatory on Health Care Systems and Policies e co- autore del report “HIT-Italy” 2014. Dal 2012 è Direttore della UOC “Percorsi e valutazione degli outcome clinici” della Fondazione Policlinico Universitario “A. Gemelli”. Maurizio Dal Maso Membro di ASIQUAS, Associazione Italiana per la Qualità dell’Assistenza Sanitaria e Sociale. Ha svolto la sua attività professionale come medico clinico dal 1979 al 1999. Successivamente come medico di Direzione sanitaria e Project Manager aziendale, Direttore Sanitario aziendale, Direttore Generale e Commissario straordinario. Dal luglio 2019 svolge attività di consulente in Organizzazione aziendale e formatore in Project Management per Accademia Nazionale di Medicina. Lidia Goldoni Direttrice www.perlungavita.it., giornalista pubblicista, consulente servizi anziani e disabili, consulente per l'organizzazione e la gestione dei servizi sociosanitari, coordinatrice scientifica Forum sulla non autosufficienza, direttrice rivista Servizi sociali oggi, Rivista sulle politiche sociali e sanitarie e i servizi per le persone, già dirigente amministrativo del Comune di Modena, Dirigente servi sociali e assistenziali per anziani Stefania Mariantoni Membro di ASIQUAS, Associazione Italiana per la Qualità dell’Assistenza Sanitaria e Sociale. Dirigente psicologo ASL Rieti. Psicoterapeuta. Componente del Board scientifico dell’Osservatorio Psicologico in cronicità dell’Ordine degli Psicologi del Lazio. Componente Comitato Scientifico ECM di Laziocrea.. Docente Master II Livello in formazione manageriale per dirigenti di Unità Operativa Complessa Istituto “Carlo Jemolo”. Esperta in integrazione sociosanitaria. Membro di tavoli tecnici sociali e sanitari Regione Lazio. Già Coordinatore Ufficio di Piano Distretto sociosanitario Rieti 5 e referente A.T. programma inteministeriale P.I.P.P.I.. Già consulente Enti Locali per Servizi alla Persona. Mario Ronchetti Membro di ASIQUAS, Associazione Italiana per la Qualità dell’Assistenza Sanitaria e Sociale. Esperto di formazione e organizzazione dei servizi sanitari. Docente a contratto di Economia aziendale, Università di Tor Vergata. Consulente di organizzazione aziendale presso varie ASL e AO. Responsabile organizzazione percorsi di Formazione a Distanza per personale DEA e ARES 118. Membro Gruppo di lavoro regionale per la formazione del Middle Management del SSR. Docente in corsi di formazione ECM e Master. Già Direttore Sanitario aziendale. Blogger ProssimaMente.org Andrea Vannucci Membro di ASIQUAS, Associazione Italiana per la Qualità dell’Assistenza Sanitaria e Sociale. Già Direttore dell’Agenzia regionale di sanità della Toscana, Coordinatore della Commissione Qualità e Sicurezza del Consiglio sanitario regionale e Rappresentante per la Regione Toscana nel Comitato Scientifico del Programma Nazionale Esiti – PNE. Ad oggi Membro del Consiglio Direttivo di Accademia nazionale di Medicina e co-coordinatore della sezione Informazione Scientifica e Innovazione, Direttore Scientifico del Forum sistema salute 2019 e 2020; Vice Presidente di AISSMM - Associazione Italiana di Medicina e Sanità Sistemica; Professore a contratto per l’insegnamento di Organizzazione e programmazione delle aziende sanitarie del corso di laurea in Ingegneria gestionale dell’Università di Siena. Contatti. [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]. 3 Covid19 Review Newsletter pe gli operatori sanitari e sociali e per i cittadini sulla letteratura scientifica sulla pandemia Covid19 Per chi è interessato a leggere in numeri pregressi di Covid 19 Review 2020 li può trovare su: Volume 1 dal n. 1 al n. 14: htpps://issuu.com/comsrl/docs/banchieri_1-14_rev Volume 2 dal n. 14 al n. 29: https://issuu.com/comsrl/docs/covid19_review_from_prof_giorgio_banchieri_parte_2 Volume 3 dal n. 30 al n. 34 : https://issuu.com/comsrl/docs/covid19_review_from_prof_giorgio_banchieri_e_andre Volume 4 dal n. 35 al n. 60: https://issuu.com/comsrl/docs/covid19_review_parte_4_from_banchieri_e_vannucci Volume 1 dal n. 1 ad oggi https://issuu.com/comsrl/docs/weekly_series_covid19_review_2020_published … e su www.asiquas.it 4 Per leggere le monografie: www.asiquas.it 5 Indice: [Nature] Come vengono suddivisi i vaccini Covid intorno al mondo, di A Mullard; 7 [MinSalute – PCDM – ISS – Agenas – AIFA] Vaccinazioni anti SARS-Cov-2 – Piano strategico; 10 [Commissione UE] Strategia Farmaceutica per l’Europa; 18 [ECDC] Aspetti chiave riguardanti l’introduzione e la definizione delle priorità di vaccinazione Covid19 nella UE/EEA e nel Regno Unito; 23 [BMJ] Una linea guida dell'OMS sui farmaci per covid-19; 36 [ECDC] Threat Assessment Brief: rapido aumento di una variante SARS-CoV-2 con mutazioni multiple della proteina spike osservate nel Regno Unito 50 [Forbes] AstraZeneca, Oxford per creare un vaccino combinato Covid19 con lo Sputnik V russo, di R. Hart; 64 [Forbes] Moderna sottopone il vaccino Covid19 per l’approvazione di emergenza, dice che è al 100% efficace a prevenire forme gravi di malattia, di R. Hart; 65 [Nature] L’autorizzazione statunitense al primo vaccino Covid segna una nuova fase nel monitoraggio della sicurezza, di H. Ledford; 66 [Quotidiano Sanità] Vaccino Covid19. Si inizi con 1.833.975 dosi. Ecco la mappa dei destinatari regione per regione; 68 [Science] Il Panel di FDA sostiene il vaccino Covid19 di Pfizer, aprendo la strada all’uso di emergenza negli USA, J. Choen; 69 [Forbes] Vaccino Sanofi-GSK Covid19 ritardato dopo che gli studi mostrano una scarsa risposta immunitaria degli anziani, di R. Hart; 72 [NIH] Sicurezza, Tollerabilità, immunogenecità dei vaccini Covid19: una revisione sistematica e una meta analisi, di P. Yuan e altri; 73 [Science] L’Innovativo vaccino antinfluenzale universale mostra risultati promettenti nel primo test clinico, di J. Choen; 94 [La Repubblica] Vaccino contro Covid19: la paura degli italiani per il metodo Rna di Pfizer e Moderna. Gli scienziati” E’ una bufala che ci rende ong”, di Elena Dusi; 96 [The Lancet] Sicurezza e immunogenecità del vaccino ChAdOx1nCOV19 contro SAR-COV-2 un rapporto preliminare di uno studio di Fase 1 e 2, in singolo cieco, randomizzato controllato, di P. Falegatti e altri; 97 [The NEJM] Sicurezza e immunogenecità di due candidati al vaccino Covid19 a base Rna, di E. Walsh e altri; 113 [The Lancet] Aspettandosi l’inaspettato con i vaccini Covid19, di N. Bar-Zev e S. Kochher; 126 [The Lancet] Anticorpi, immunità e Covid19 di
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