•  •  •  These disorderswereformerlyknownas: balance andcoordinationarecalledMSA-C. are calledMSA-P. Patientswhohavemoredifficultywith muscle stiffness orshakingmayresemblepatientswithPDand , aswellsomeotherfeatures.Patientswithslowness, such asslownessofmovement,musclestiffness and/orshaking/ patient hassomeofthemainfeaturesParkinson’s disease(PD) , alsocalledParkinson-plussyndrome,iswhenthe MSA isonetypeof Atypical Parkinsonism. Atypical •  •  •  •  Patients mayexperience: function. while othersensurebloodpressure,bladder, bowelandsexual involved inthecontrolofmovement,balanceandcoordination, functioning ofmultiplesystemsinthebrain.Sometheseare (MSA)isararedisorderthataffects the W pressure changes,includingthe tabletilt-test. may includebrainMRIscan, bladdertests,andtestingforblood based onsymptomsandphysical examinationfindings. Tests A diagnosismaynotbeclearatfirst.MSA isusuallydiagnosed H MSA isnotcontagiousorspreadfromperson toperson. families, butiscurrentlynotconsideredahereditarydisease. of thisclumpingisunknown.MSA hasbeendescribedinafew different cell typesandcanbeseeninabrainautopsy. The cause protein inthebraincalledalpha-synucleinthatclumpsup in The causeisunknown.MSA isassociatedwithaccumulationofa W around threetofourpeopleinevery100,000. between theageof50and60.MSA isconsideredrareandaffects MSA affects menandwomenequally. MSA usuallybegins W MSA-C: sporadicolivopontocerebellaratrophy(OPCA) MSA-P: striatonigraldegeneration(SND) MSA: Shy-Dragersyndrome Problems controllingbladderfunctionandconstipation Feeling lightheadedordizzywhilestanding Problems withbalanceandcoordination Slowness ofmovement,musclestiffness and/orshaking/tremor o hat ho hat w I G I I s M ets s s I the t SA M ? C D SA 555 EastWell Street, Suite 1100•Milwaukee, WI53202•+1414-276-2145 •www.movementdisorders.org ause Copyright ©2016 International Parkinson andMovement Disorder Society(MDS). Allrightsreserved. i a ? g nose ? d Essential FactsforPatients Essential FactsforPatients ? Multiple System Atrophy:Multiple Multiple System Atrophy:Multiple International Parkinson andMovement Disorder Society •  •  •  •  •  help yoursymptoms. MSA. However, somemedicationsandphysicaltherapiesmay There arecurrentlynotreatmentstocure,slowdownorreverse I at thebraintissue. confirm thediagnosisofMSA isbydoingan autopsy andlooking No singletestcanconfirmthediagnosis.to Theonlydefiniteway long-term careplanningmaybeneededasthediseaseprogresses. Swallowing problemsincreasetheriskofpneumonia.Overall, infections. Bladdersymptomscanleadtourinarytract In advancedstages,MSA patientshaveincreasedriskof or bowels. swallowing solidfoodorliquids,walkingandcontrolling bladder effective. You mayexperiencedifficultiesusingutensils, Over time,symptomsincreaseandtreatmentsbecomeless W s occupational therapy, orspeechandswallowingtherapy. Overall health injections intothesalivaglands. Drooling canbetreatedwithmedicationsandbotulinumtoxin catheterization. medications, regulartoileting,bladdertraining,and For bladder andbowelproblems, optionsinclude thatcontributetofallingorbalanceproblems. pressure helpsyouavoidunsteadiness,lightheadedness,and medications mayhelpincreasebloodpressure.Stable bandages orpressurestockings.Inaddition,specific advise increasingwaterandsaltintakeorusingabdominal especially thosethatmightlowerbloodpressure.Doctorsmay You mayneedtoadjustorstopmedicationsforotherillnesses, triggers likealcohol,dehydration,andheatorhottemperatures. position (orthostatichypotension)mayimprovebyavoiding Low bloodpressure whenmovingintoasittingorstanding may improvewithmedicationstypicallyusedforPD. Parkinson-like symptomsofslowness,stiffness, andtremor

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