Bhopal Disaster
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Tremprime QD Low-Odor
Version: 1.1 Revision Date: 10/12/2018 SAFETY DATA SHEET 1. Identification Material name: TREMPRIME Q.D. LOW ODOR Material: 022045 805 Recommended use and restriction on use Recommended use : Coatings Restrictions on use: Not known. Manufacturer/Importer/Supplier/Distributor Information Tremco Canadian Sealants 220 Wicksteed Ave Toronto ON M4H 1G7 CA Contact person : EH&S Department Telephone : 1-800-263-6046 Emergency telephone number : 1-800-424-9300 (US); 1-613-996-6666 (Canada) 2. Hazard(s) identification Hazard Classification Physical Hazards Flammable liquids Category 3 Health Hazards Acute toxicity (Inhalation - vapor) Category 4 Serious Eye Damage/Eye Irritation Category 2A Germ Cell Mutagenicity Category 1B Carcinogenicity Category 1B Unknown toxicity - Health Acute toxicity, oral 40.8 % Acute toxicity, dermal 43 % Acute toxicity, inhalation, vapor 97 % Acute toxicity, inhalation, dust 100 % or mist Label Elements Hazard Symbol : 1/14 800000060000 Version: 1.1 Revision Date: 10/12/2018 Signal Word: Danger Hazard Statement: Flammable liquid and vapor. Harmful if inhaled. Causes serious eye irritation. May cause genetic defects. May cause cancer. Precautionary Statements Prevention: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Keep container tightly closed. Ground and bond container and receiving equipment. Use explosion-proof [electrical/ventilating/lighting/EF e:uipment. 5se non1sparking tools. Take action to prevent static discharges. Wear protective gloves/protective clothing/eye protection/face protection. Avoid breathing dust/fume/gas/mist/vapors/spray. 5se only outdoors or in a well1ventilated area. Wash thoroughly after handling. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. -
Management of Acute Clonidine Poisoning in Adults: the Role of Resin Hemoperfusion
Management of Acute Clonidine Poisoning in Adults: The Role of Resin Hemoperfusion Shanshan Fang Department of Nephrology, 307 Hospital Bo Han Department of Nephrology, 307 Hospital Xiaoling Liu Department of Nephrology, 307 Hospital Dan Mao Department of Nephrology, 307 Hospital Chengwen Sun Laboratory of Poisonous Substance Detection, 307 Hospital Zhi Chen Department of Nephrology, 307 Hospital Ruimiao Wang Department of Nephrology, 307 Hospital Xishan Xiong ( [email protected] ) Aliated Hengsheng Hospital of the Southern Medical University https://orcid.org/0000-0002-8557- 8025 Methodology Keywords: clonidine poisoning, adrenergic alpha-agonists, bradycardia, hemoperfusion, hypotension Posted Date: September 21st, 2020 DOI: https://doi.org/10.21203/rs.3.rs-76660/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/14 Abstract Clonidine poisoning in adults is rare. An observational retrospective study including 102 adults with clonidine poisoning was conducted. 57 patients with relatively mild conditions were placed in the local emergency departments (EDs) for clinical observation, while the remaining 45 were transferred to the tertiary hospital for intensive treatment, of whom 9 were given supportive care only and 36 were given hemoperfusion (HP), as well as similar supportive treatment. The main symptoms of these cases were: sleepiness, dizziness, fatigue, headache, inarticulacy, tinnitus and dry mouth. Physical examination showed hypotension, bradycardia and shallow and slow breathing. Serum and urine clonidine concentrations were signicantly elevated24.4 ng/ml, 313.2 ng/ml, respectively. All cases slowly returned to their baseline state over 48 to 96 hours, which is co-related with the drawn of serum clonidine level. -
10 Arthropods and Corpses
Arthropods and Corpses 207 10 Arthropods and Corpses Mark Benecke, PhD CONTENTS INTRODUCTION HISTORY AND EARLY CASEWORK WOUND ARTIFACTS AND UNUSUAL FINDINGS EXEMPLARY CASES: NEGLECT OF ELDERLY PERSONS AND CHILDREN COLLECTION OF ARTHROPOD EVIDENCE DNA FORENSIC ENTOMOTOXICOLOGY FURTHER ARTIFACTS CAUSED BY ARTHROPODS REFERENCES SUMMARY The determination of the colonization interval of a corpse (“postmortem interval”) has been the major topic of forensic entomologists since the 19th century. The method is based on the link of developmental stages of arthropods, especially of blowfly larvae, to their age. The major advantage against the standard methods for the determination of the early postmortem interval (by the classical forensic pathological methods such as body temperature, post- mortem lividity and rigidity, and chemical investigations) is that arthropods can represent an accurate measure even in later stages of the postmortem in- terval when the classical forensic pathological methods fail. Apart from esti- mating the colonization interval, there are numerous other ways to use From: Forensic Pathology Reviews, Vol. 2 Edited by: M. Tsokos © Humana Press Inc., Totowa, NJ 207 208 Benecke arthropods as forensic evidence. Recently, artifacts produced by arthropods as well as the proof of neglect of elderly persons and children have become a special focus of interest. This chapter deals with the broad range of possible applications of entomology, including case examples and practical guidelines that relate to history, classical applications, DNA typing, blood-spatter arti- facts, estimation of the postmortem interval, cases of neglect, and entomotoxicology. Special reference is given to different arthropod species as an investigative and criminalistic tool. Key Words: Arthropod evidence; forensic science; blowflies; beetles; colonization interval; postmortem interval; neglect of the elderly; neglect of children; decomposition; DNA typing; entomotoxicology. -
AN INTRODUCTION to AQUATIC TOXICOLOGY This Page Intentionally Left Blank ÂÂ an INTRODUCTION to AQUATIC TOXICOLOGY
AN INTRODUCTION TO AQUATIC TOXICOLOGY This page intentionally left blank AN INTRODUCTION TO AQUATIC TOXICOLOGY MIKKO NIKINMAA Professor of Zoology, Department of Biology, Laboratory of Animal Physiology, University of Turku, Turku, Finland AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic press is an imprint of Elsevier Academic Press is an imprint of Elsevier The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, UK 225 Wyman Street, Waltham, MA 02451, USA Copyright © 2014 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangement with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. -
Victims of Seveso Disaster Face Higher Risk from Some Cancers 14 September 2009
Victims of Seveso disaster face higher risk from some cancers 14 September 2009 People living in the Seveso area of Italy, which was excess of lymphatic and hematopoietic risk. We did exposed to dioxin after an industrial accident in not identify an all-cancer excess, as seen in 1976, have experienced an increased risk of occupational cohorts which had similar, sometimes developing cancer. Researchers writing in BioMed higher, and more complex exposures". Central's open access journal Environmental Health found an increased risk of breast cancer in More information: Cancer incidence in the women from the most exposed zone and an population exposed to dioxin after the "Seveso excess of lymphatic and hematopoietic tissue accident": twenty years of follow-up; Angela Cecilia neoplasms in all but the least exposed zone. Pesatori, Dario Consonni, Maurizia Rubagotti, Paolo Grillo and Pier Alberto Bertazzi; Angela Pesatori led a team of researchers from the Environmental Health (in press); Fondazione IRCCS Ospedale Maggiore Policlinico, www.ehjournal.net/ a local hospital associated with the University of Milan, who extended a study of cancer incidence in Source: BioMed Central the area, which now covers the period 1977-96. She said, "The industrial accident that occurred in the Seveso area in 1976 exposed a large residential population to substantial amounts of TCDD [2,3,7,8-tetrachlorodibenzo-p-dioxin]. Although the International Agency for Research on Cancer and the US Environmental Protection Agency have both classified TCDD as human carcinogen, scientific debate still persists on the actual cancer risk posed to the general population. We've found that it does pose a carcinogenic hazard, although lower than anticipated from animal studies, at least at the levels experienced by this population after this accident". -
Genetic and Molecular Ecotoxicology: a Research Framework
Genetic and Molecular Ecotoxicology: A Research Framework Susan Anderson,1 Walter Sadinski,1 Lee Shugart,2 Peter Brussard,3 Michael Depledge,4 Tim Ford,5 JoEllen Hose,6 John Stegeman,7 William Suk,8 Isaac Wirgin,9 and Gerald Wogan0 1Lawrence Berkeley Laboratory, Berkeley, California; 2Oak Ridge National Laboratory, Oak Ridge, Tennessee; 3University of Nevada Reno, Reno, Nevada; 4University of Plymouth, Plymouth, UK; 5Harvard University, Cambridge, Massachusetts; 6 CCidental College, Los Angeles, California; 7Woods Hole Oceanographic Institute, Woods Hole, Massachusetts; 8National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; 9New York University Medical Center, Tuxedo, New York; 10Massachusetts Institute of Technology, Cambridge, Massachusetts Participants at the Napa Conference on Genetic and Molecular Ecotoxicology assessed the status of this field in light of heightened concerns about the genetic effects of exposure to hazardous substances and recent advancements in our capabilities to measure those effects. We present here a synthesis of the ideas discussed throughout the conference, including definitions of important concepts in the field and critical research needs and opportunities. While there were many opinions expressed on these topics, there was general agreement that there are substantive new opportuni- ties to improve the impact of genetic and molecular ecotoxicology on prediction of sublethal effects of exposure to hazardous substances. Future studies should emphasize integration of genetic ecotoxicology, ecological genetics, and molecular biology and should be directed toward improving our understanding of the ecological implications of genotoxic responses. Ecological implications may be assessed at either the population or ecosys- tem level; however, a population-level focus may be most pragmatic. -
Shortcomings of the Laboratory-Derived Median Lethal Concentration for Predicting Mortality in Field Populations: Exposure Duration and Latent Mortality
Environmental Toxicology and Chemistry, Vol. 23, No. 9, pp. 2147±2153, 2004 q 2004 SETAC Printed in the USA 0730-7268/04 $12.00 1 .00 SHORTCOMINGS OF THE LABORATORY-DERIVED MEDIAN LETHAL CONCENTRATION FOR PREDICTING MORTALITY IN FIELD POPULATIONS: EXPOSURE DURATION AND LATENT MORTALITY YUAN ZHAO* and MICHAEL C. NEWMAN Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, P.O. Box 1346, Gloucester Point, Virginia 23062-1346, USA (Received 15 October 2003; Accepted 9 February 2004) AbstractÐExposure duration and intensity (concentration or dose) determine lethal effects of toxicants. However, environmental regulators have focused on exposure intensity and have considered duration only peripherally. Conventional testing for toxicology tends to ®x exposure time and to use the median lethal concentration (LC50) at that time to quantify mortality. Fixing the exposure duration and selecting the 50% mortality level for reasons of statistical and logistical convenience result in the loss of ecologically relevant information generated at all other times and ignore latent mortality that manifests after the exposure ends. In the present study, we used survival analysis, which is widely employed in other ®elds, to include both time and concentration as covariates and to quantify latent mortality. This was done with two contrasting toxicants, copper sulfate (CuSO4) and sodium pentachlorophenol (NaPCP). Amphipods (Hyalella azteca) were exposed to different toxicant concentrations, and the percentage mortalities were noted both during and after the exposure ended. For CuSO4 at the conventional 48-h LC50 concentrations, the predicted proportions dead after including latent mortality were 65 to 85%, not 50%. -
Environmental Toxicants in Forensic Entomology
ISSN 2474-8978 TOXICOLOGY AND FORENSIC MEDICINE Open Journal Editorial Environmental Toxicants in Forensic Entomology Bashir M. Rezk, PhD1,2*; Myles S. Masters, BS Student1; Geoffroy E. Sanga Pema, BS Student1,2; Wayne J.G. Hellstrom, MD, FACS2; Asim B. Abdel-Mageed, DVM, PhD2; Suresh C. Sikka, PhD, HCLD2 1Department of Natural Sciences, Southern University at New Orleans, New Orleans, LA 70126, USA 2Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA *Corresponding author Bashir M. Rezk, PhD Associate Professor, Department of Natural Sciences, Southern University at New Orleans, 6400 Press Drive, New Orleans, LA 70126, USA; Tel. +1(504)284-5405; E-mail: [email protected] Article information Received: December 18th, 2018; Accepted: December 19th, 2018; Published: December 21st, 2018 Cite this article Rezk BM, Masters MS, Pema GES, Hellstrom WJG, Abdel-Mageed AB, Sikka SC. Environmental toxicants in forensic entomology. Toxicol Forensic Med Open J. 2018; 3(1): e1-e2. doi: 10.17140/TFMOJ-3-e008 he fundament of toxicology is the risk-benefit analysis. Cer- and Coleoptera (beetles).4 The first recorded incident in which Ttain chemical exists in the environment that if ingested, even insects were used in a criminal investigation was in 13th century in minute quantities, may alter bodily functions, induce death and China, as described in Sung Tzu's book entitled “The Washing Away interfere with the rate of decomposition of dead bodies. Ancient of Wrongs”.4,5 When a farmer was found murdered in a field with cultures discovered and reported many naturally occurring toxins a sharp weapon, all the suspects were told to place their sickles that have been used in medications, hunting, and wars. -
Chelation Therapy
Medical Policy Chelation Therapy Table of Contents • Policy: Commercial • Coding Information • Information Pertaining to All Policies • Policy: Medicare • Description • References • Authorization Information • Policy History Policy Number: 122 BCBSA Reference Number: 8.01.02 NCD/LCD: N/A Related Policies None Policy Commercial Members: Managed Care (HMO and POS), PPO, and Indemnity Medicare HMO BlueSM and Medicare PPO BlueSM Members Chelation therapy in the treatment of the following conditions is MEDICALLY NECESSARY: • Extreme conditions of metal toxicity • Treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) or due to nontransfusion-dependent thalassemia (NTDT) • Wilson's disease (hepatolenticular degeneration), or • Lead poisoning. Chelation therapy in the treatment of the following conditions is MEDICALLY NECESSARY if other modalities have failed: • Control of ventricular arrhythmias or heart block associated with digitalis toxicity • Emergency treatment of hypercalcemia. NaEDTA as chelation therapy is considered NOT MEDICALLY NECESSARY. Off-label applications of chelation therapy are considered INVESTIGATIONAL, including, but not limited to: • Alzheimer’s disease • Arthritis (includes rheumatoid arthritis) • Atherosclerosis, (e.g., coronary artery disease, secondary prevention in patients with myocardial infarction, or peripheral vascular disease) • Autism • Diabetes • Multiple sclerosis. 1 Prior Authorization Information Inpatient • For services described in this policy, precertification/preauthorization IS REQUIRED for all products if the procedure is performed inpatient. Outpatient • For services described in this policy, see below for products where prior authorization might be required if the procedure is performed outpatient. Outpatient Commercial Managed Care (HMO and POS) Prior authorization is not required. Commercial PPO and Indemnity Prior authorization is not required. Medicare HMO BlueSM Prior authorization is not required. -
European Centre for Ecotoxicology and Toxicology of Chemicals
EUROPEAN CENTRE FOR ECOTOXICOLOGY AND TOXICOLOGY OF CHEMICALS EUROPEAN CENTRE FOR ECOTOXICOLOGY AND TOXICOLOGY OF CHEMICALS ECETOC at a glance 2 Purpose 3 Values 3 Vision 3 Mission 3 Approach 3 Membership 4 ECETOC Member Companies 4 Membership benefits 5 Message from the Chairman 6 ECETOC Board of Administration 7 Report from the Secretary General 8 Science Programme 10 Foreword from the Scientific Committee Chairman 10 ECETOC revises its science strategy 11 Summary of the 2011 Science Programme 12 Highlights of 2011 15 Task forces established 16 Task forces completed 18 Workshops 21 Symposia and other meetings 24 Science Awards 28 Long-range Research Initiative 29 Communication 31 Publications 31 Online communication 32 External Representation 32 Members of the Scientific Committee 34 Members of the Secretariat 34 Finance 35 Abbreviations 36 ECETOC I European Centre for Ecotoxicology and Toxicology of Chemicals I Annual Report 2011 I page 2 Introduction Membership Message Board of Report from Science Science Long-range Communication Members of Finance Abbreviations from the Administration the Secretary Programme Awards Research the Scientific Chairman General Initiative Committee Established in 1978, ECETOC is Europe’s leading industry association for developing and promoting top quality science in human and environmental risk assessment of chemicals. Members include the main companies with interests in the manufacture and use of chemicals, biomaterials and pharmaceuticals, and organisations active in these fields. ECETOC is the scientific forum where member company experts meet and co-operate with government and academic scientists, to evaluate and assess the available data, identify gaps in knowledge and recommend research, and publish critical reviews on the ecotoxicology and toxicology of chemicals, biomaterials and pharmaceuticals. -
Effect of Hemoperfusion Using Polymyxin B-Immobilized Fiber on IL-6, HMGB-1, and IFN Gamma in a Neonatal Sepsis Model
0031-3998/05/5802-0309 PEDIATRIC RESEARCH Vol. 58, No. 2, 2005 Copyright © 2005 International Pediatric Research Foundation, Inc. Printed in U.S.A. Effect of Hemoperfusion Using Polymyxin B-Immobilized Fiber on IL-6, HMGB-1, and IFN Gamma in a Neonatal Sepsis Model MOHAMED HAMED HUSSEIN, TAKENORI KATO, TAKAHIRO SUGIURA, GHADA A. DAOUD, SATOSHI SUZUKI, SUMIO FUKUDA, HISANORI SOBAJIMA, INEKO KATO, AND HAJIME TOGARI Department of Pediatrics, Neonatology and Congenital Disorders [M.H.H., T.K., T.S., G.A.D., S.F., H.S., I.K., H.T.], Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Pediatrics [S.S.], Nagoya City Johoku Hospital, Nagoya, Japan, Neonatal Intensive Care Unit [M.H.H.], Pediatric Hospital, Cairo University, Cairo, Egypt, Maternal and Child Health Department [M.H.H., G.A.D.], VACSERA, Giza, Egypt ABSTRACT To evaluate effects of polymyxin B direct hemoperfusion at 6 h. IFN-␥ was only detected in the control group at 9 h. (PMX-DHP) on a neonatal sepsis cecal ligation and perforation Survival times in the PMX-DHP group were longer than in the (CLP) model, in 24 anesthetized and mechanically ventilated control. Thus, PMX-DHP improved septic shock in a neonatal 3-d-old piglets, 16 were assigned to CLP and an arteriovenous septic model. (Pediatr Res 58: 309–314, 2005) extracorporeal circuit from 3 h until 6 h post-CLP, with a PMX-column in PMX-DHP–treated group (8 piglets) and 8 as sham. Plasma lipopolysaccharide (LPS) was measured at before Abbreviations CLP and at 3 and 9 h. -
Chapter 4: HAZARD COMMUNICATION
Chapter 4: HAZARD COMMUNICATION The text of this chapter represents the agreement reached on a harmonised hazard communication system as part of the work on the GHS, with minor editorial changes. Additional explanatory text has been added in some sections in order to provide guidance for the reader on how to interpret the GHS agreed text. Where this is the case, the text is italicised and placed in a box to differentiate it from the agreed GHS text. OBJECTIVES AND SCOPE 1. One of the objective of the work on the GHS has been the development of a harmonised hazard communication system including labelling, safety data sheets and easily understandable symbols, based on the classification criteria developed by the focal points within the IOMC Co-ordinating Group for the Harmonisation of Chemical Classifications Systems, CG/HCCS. This work has been carried out under the auspices of the ILO, by the ILO Working Group on Hazard Communication. The specific Terms of Reference and Membership of the Working Group are provided in Annex 1. In addition the principles contained in the IOMC CG/HCCS Terms of Reference and the document “Description and Further Clarification of the Anticipated Application of the GHS (also referred to as “The Scope Document”) also applied to the work on harmonisation of hazard communication (see Chapter 2). Application of the Harmonised Hazard Communication System 2.The harmonised system for hazard communication includes the appropriate labelling tools to convey information about each of the hazard classes and categories in the GHS. The use of symbols, signal words or hazard statements other than those which have been assigned to each of the GHS hazard classes and categories would be contrary to harmonisation.