Internalized Β-Particle Emitting Radionuclides
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Glossary Derived From: Human Research Program Integrated Research Plan, Revision A, (January 2009)
Glossary derived from: Human Research Program Integrated Research Plan, Revision A, (January 2009). National Aeronautics and Space Administration, Johnson Space Center, Houston, Texas 77058, pages 232-280. Report No. 153: Information Needed to Make Radiation Protection Recommendations for Space Missions Beyond Low-Earth Orbit (2006). National Council on Radiation Protection and Measurements, pages 309-318. Reprinted with permission of the National Council on Radiation Protection and Measurements, http://NCRPonline.org . Managing Space Radiation Risk in the New Era of Space Exploration (2008). Committee on the Evaluation of Radiation Shielding for Space Exploration, National Research Council. National Academies Press, pages 111-118. -A- AAPM: American Association of Physicists in Medicine. absolute risk: Expression of excess risk due to exposure as the arithmetic difference between the risk among those exposed and that obtaining in the absence of exposure. absorbed dose (D): Average amount of energy imparted by ionizing particles to a unit mass of irradiated material in a volume sufficiently small to disregard variations in the radiation field but sufficiently large to average over statistical fluctuations in energy deposition, and where energy imparted is the difference between energy entering the volume and energy leaving the volume. The same dose has different consequences depending on the type of radiation delivered. Unit: gray (Gy), equivalent to 1 J/kg. ACE: Advanced Composition Explorer Mission, launched in 1997 and orbiting the L1 libration point to sample energetic particles arriving from the Sun and interstellar and galactic sources. It also provides continuous coverage of solar wind parameters and solar energetic particle intensities (space weather). When reporting space weather, it can provide an advance warning (about one hour) of geomagnetic storms that can overload power grids, disrupt communications on Earth, and present a hazard to astronauts. -
Basics of Radiation Radiation Safety Orientation Open Source Booklet 1 (June 1, 2018)
Basics of Radiation Radiation Safety Orientation Open Source Booklet 1 (June 1, 2018) Before working with radioactive material, it is helpful to recall… Radiation is energy released from a source. • Light is a familiar example of energy traveling some distance from its source. We understand that a light bulb can remain in one place and the light can move toward us to be detected by our eyes. • The Electromagnetic Spectrum is the entire range of wavelengths or frequencies of electromagnetic radiation extending from gamma rays to the longest radio waves and includes visible light. Radioactive materials release energy with enough power to cause ionizations and are on the high end of the electromagnetic spectrum. • Although our bodies cannot sense ionizing radiation, it is helpful to think ionizing radiation behaves similarly to light. o Travels in straight lines with decreasing intensity farther away from the source o May be reflected off certain surfaces (but not all) o Absorbed when interacting with materials You will be using radioactive material that releases energy in the form of ionizing radiation. Knowing about the basics of radiation will help you understand how to work safely with radioactive material. What is “ionizing radiation”? • Ionizing radiation is energy with enough power to remove tightly bound electrons from the orbit of an atom, causing the atom to become charged or ionized. • The charged atoms can damage the internal structures of living cells. The material near the charged atom absorbs the energy causing chemical bonds to break. Are all radioactive materials the same? No, not all radioactive materials are the same. -
Cherenkov Radiation
TheThe CherenkovCherenkov effecteffect A charged particle traveling in a dielectric medium with n>1 radiates Cherenkov radiation B Wave front if its velocity is larger than the C phase velocity of light v>c/n or > 1/n (threshold) A β Charged particle The emission is due to an asymmetric polarization of the medium in front and at the rear of the particle, giving rise to a varying electric dipole momentum. dN Some of the particle energy is convertedγ = 491into light. A coherent wave front is dx generated moving at velocity v at an angle Θc If the media is transparent the Cherenkov light can be detected. If the particle is ultra-relativistic β~1 Θc = const and has max value c t AB n 1 cosθc = = = In water Θc = 43˚, in ice 41AC˚ βct βn 37 TheThe CherenkovCherenkov effecteffect The intensity of the Cherenkov radiation (number of photons per unit length of particle path and per unit of wave length) 2 2 2 2 2 Number of photons/L and radiation d N 4π z e 1 2πz 2 = 2 1 − 2 2 = 2 α sin ΘC Wavelength depends on charge dxdλ hcλ n β λ and velocity of particle 2πe2 α = Since the intensity is proportional to hc 1/λ2 short wavelengths dominate dN Using light detectors (photomultipliers)γ = sensitive491 in 400-700 nm for an ideally 100% efficient detector in the visibledx € 2 dNγ λ2 d Nγ 2 2 λ2 dλ 2 2 11 1 22 2 d 2 z sin 2 z sin 490393 zz sinsinΘc photons / cm = ∫ λ = π α ΘC ∫ 2 = π α ΘC 2 −− 2 = α ΘC λ1 λ1 dx dxdλ λ λλ1 λ2 d 2 N d 2 N dλ λ2 d 2 N = = dxdE dxdλ dE 2πhc dxdλ Energy loss is about 104 less hc 2πhc than 2 MeV/cm in water from € -
Modelling Transport and Deposition of Caesium and Iodine from the Chernobyl Accident Using the DREAM Model J
Modelling transport and deposition of caesium and iodine from the Chernobyl accident using the DREAM model J. Brandt, J. H. Christensen, L. M. Frohn To cite this version: J. Brandt, J. H. Christensen, L. M. Frohn. Modelling transport and deposition of caesium and iodine from the Chernobyl accident using the DREAM model. Atmospheric Chemistry and Physics, European Geosciences Union, 2002, 2 (5), pp.397-417. hal-00295217 HAL Id: hal-00295217 https://hal.archives-ouvertes.fr/hal-00295217 Submitted on 17 Dec 2002 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Atmos. Chem. Phys., 2, 397–417, 2002 www.atmos-chem-phys.org/acp/2/397/ Atmospheric Chemistry and Physics Modelling transport and deposition of caesium and iodine from the Chernobyl accident using the DREAM model J. Brandt, J. H. Christensen, and L. M. Frohn National Environmental Research Institute, Department of Atmospheric Environment, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark Received: 11 April 2002 – Published in Atmos. Chem. Phys. Discuss.: 24 June 2002 Revised: 9 September 2002 – Accepted: 24 September 2002 – Published: 17 December 2002 Abstract. A tracer model, DREAM (the Danish Rimpuff and low cloud scavenging process for the submicron particles and Eulerian Accidental release Model), has been developed for that the precipitation rates are relatively uncertain in the me- modelling transport, dispersion and deposition (wet and dry) teorological model compared to the relative humidity. -
New York State Department of Health Environmental Radiation Program Environmental Radiation Surveillance Site Readings
New York State Department of Health Environmental Radiation Program Environmental Radiation Surveillance Site Readings Glossary This glossary has been added in order to define technical terms that are used in the various supporting documents for this data set. Please refer to the Data Dictionary for explanation of the meaning of the column headings in the data set. 1. Alpha particles- a positively charged particle made up of two neutrons and two protons emitted by certain radioactive nuclei. a. Gross alpha radioactivity- a measurement of all alpha activity present, regardless of specific radionuclide source. 2. Americium (chemical symbol Am) - is a man-made radioactive metal, with Atomic Number 95. The most important isotope of Americium is Am-241. 3. Background radiation- is radiation that results from natural sources such as cosmic radiation and naturally-occurring radioactive materials in the ground and the earth’s atmosphere including radon. 4. Beta particles- an electron or positron emitted by certain radioactive nuclei. Beta particles can be stopped by aluminum. a. Gross beta radioactivity- measurement of all beta activity present, regardless of specific radionuclide source. 5. Cerium (chemical symbol Ce) - an iron-gray, lustrous metal. Cerium-141, -143, and - 144 are radioisotopes of cerium. 6. Cesium (chemical symbol Cs) - is a metal that may be stable (nonradioactive) or unstable (radioactive). The most common radioactive form of cesium is cesium-137. Another fairly common radioisotope is cesium-134. 7. Cobalt (chemical symbol Co) - is a metal that may be stable (non-radioactive, as found in nature), or unstable (radioactive, man-made). The most common radioactive isotope of cobalt is cobalt-60. -
12 Natural Isotopes of Elements Other Than H, C, O
12 NATURAL ISOTOPES OF ELEMENTS OTHER THAN H, C, O In this chapter we are dealing with the less common applications of natural isotopes. Our discussions will be restricted to their origin and isotopic abundances and the main characteristics. Only brief indications are given about possible applications. More details are presented in the other volumes of this series. A few isotopes are mentioned only briefly, as they are of little relevance to water studies. Based on their half-life, the isotopes concerned can be subdivided: 1) stable isotopes of some elements (He, Li, B, N, S, Cl), of which the abundance variations point to certain geochemical and hydrogeological processes, and which can be applied as tracers in the hydrological systems, 2) radioactive isotopes with half-lives exceeding the age of the universe (232Th, 235U, 238U), 3) radioactive isotopes with shorter half-lives, mainly daughter nuclides of the previous catagory of isotopes, 4) radioactive isotopes with shorter half-lives that are of cosmogenic origin, i.e. that are being produced in the atmosphere by interactions of cosmic radiation particles with atmospheric molecules (7Be, 10Be, 26Al, 32Si, 36Cl, 36Ar, 39Ar, 81Kr, 85Kr, 129I) (Lal and Peters, 1967). The isotopes can also be distinguished by their chemical characteristics: 1) the isotopes of noble gases (He, Ar, Kr) play an important role, because of their solubility in water and because of their chemically inert and thus conservative character. Table 12.1 gives the solubility values in water (data from Benson and Krause, 1976); the table also contains the atmospheric concentrations (Andrews, 1992: error in his Eq.4, where Ti/(T1) should read (Ti/T)1); 2) another category consists of the isotopes of elements that are only slightly soluble and have very low concentrations in water under moderate conditions (Be, Al). -
Correspondence Continuing Education for Nuclear Pharmacists
THE UNIVERSITY OF NEW MEXICO COLLEGE OF PHARMACY ALBUQUERQUE, NEW MEXICO The University of New Mexico Correspondence Continuing Education Courses for Nuclear Pharmacists and Nuclear Medicine Professionals VOLUME II, NUMBER 1 Radionuclide Therapy of Painful Osseous Metastasis by: Jay A. Spicer, M.S. Co-sponsored by: mpi pharmc~ services inc an mersham company The University of New Mexico College of Phamcy is approved by the American Council on Pharmaceutical Education as a provider of continuing pharmaceutical education. Program No. 180-039-93-M6. 2.5 Contact Hours or ,25 CEU’S H m Edtior William B. Hladik III, M. S., R.Ph., University of New Mexico Director of Pharmacy Continuing Education Hugh F. Kabat, Ph. D., University of New Mexico While the advice and information in this publication are believed to be true and accurate at press time, neither the author(s) nor the editor nor the publisher ean accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implid, with res~t to the matetial contained herein. The UNMPharmacy Contittutiig Educatwn Stifl and the Edtior WOUUlike to gratefully achnowkdge Sharon I, Ramirez for her technical suppoti and assktince in the producttin of this pubtiation. Copyright 1993 University of New Mexico Pharmacy Continuing Education Albuquerque, New Mexico HIONUCLIDE THERAPY OF PAINFUL OSSEOUS METASTASIS STATEMENT OF OBJECTIVES This correspondence course is intended to increase tie reader’s knowledge of radiophmaceuticals that are used in the treatment of pain associated with bone metastasis from different types of cancer. A variety of aspects regarding the agents currently being usti or tested are discussed. -
MIRD Pamphlet No. 22 - Radiobiology and Dosimetry of Alpha- Particle Emitters for Targeted Radionuclide Therapy
Alpha-Particle Emitter Dosimetry MIRD Pamphlet No. 22 - Radiobiology and Dosimetry of Alpha- Particle Emitters for Targeted Radionuclide Therapy George Sgouros1, John C. Roeske2, Michael R. McDevitt3, Stig Palm4, Barry J. Allen5, Darrell R. Fisher6, A. Bertrand Brill7, Hong Song1, Roger W. Howell8, Gamal Akabani9 1Radiology and Radiological Science, Johns Hopkins University, Baltimore MD 2Radiation Oncology, Loyola University Medical Center, Maywood IL 3Medicine and Radiology, Memorial Sloan-Kettering Cancer Center, New York NY 4International Atomic Energy Agency, Vienna, Austria 5Centre for Experimental Radiation Oncology, St. George Cancer Centre, Kagarah, Australia 6Radioisotopes Program, Pacific Northwest National Laboratory, Richland WA 7Department of Radiology, Vanderbilt University, Nashville TN 8Division of Radiation Research, Department of Radiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark NJ 9Food and Drug Administration, Rockville MD In collaboration with the SNM MIRD Committee: Wesley E. Bolch, A Bertrand Brill, Darrell R. Fisher, Roger W. Howell, Ruby F. Meredith, George Sgouros (Chairman), Barry W. Wessels, Pat B. Zanzonico Correspondence and reprint requests to: George Sgouros, Ph.D. Department of Radiology and Radiological Science CRB II 4M61 / 1550 Orleans St Johns Hopkins University, School of Medicine Baltimore MD 21231 410 614 0116 (voice); 413 487-3753 (FAX) [email protected] (e-mail) - 1 - Alpha-Particle Emitter Dosimetry INDEX A B S T R A C T......................................................................................................................... -
Nuclear Glossary
NUCLEAR GLOSSARY A ABSORBED DOSE The amount of energy deposited in a unit weight of biological tissue. The units of absorbed dose are rad and gray. ALPHA DECAY Type of radioactive decay in which an alpha ( α) particle (two protons and two neutrons) is emitted from the nucleus of an atom. ALPHA (ααα) PARTICLE. Alpha particles consist of two protons and two neutrons bound together into a particle identical to a helium nucleus. They are a highly ionizing form of particle radiation, and have low penetration. Alpha particles are emitted by radioactive nuclei such as uranium or radium in a process known as alpha decay. Owing to their charge and large mass, alpha particles are easily absorbed by materials and can travel only a few centimetres in air. They can be absorbed by tissue paper or the outer layers of human skin (about 40 µm, equivalent to a few cells deep) and so are not generally dangerous to life unless the source is ingested or inhaled. Because of this high mass and strong absorption, however, if alpha radiation does enter the body through inhalation or ingestion, it is the most destructive form of ionizing radiation, and with large enough dosage, can cause all of the symptoms of radiation poisoning. It is estimated that chromosome damage from α particles is 100 times greater than that caused by an equivalent amount of other radiation. ANNUAL LIMIT ON The intake in to the body by inhalation, ingestion or through the skin of a INTAKE (ALI) given radionuclide in a year that would result in a committed dose equal to the relevant dose limit . -
Interim Guidelines for Hospital Response to Mass Casualties from a Radiological Incident December 2003
Interim Guidelines for Hospital Response to Mass Casualties from a Radiological Incident December 2003 Prepared by James M. Smith, Ph.D. Marie A. Spano, M.S. Division of Environmental Hazards and Health Effects, National Center for Environmental Health Summary On September 11, 2001, U.S. symbols of economic growth and military prowess were attacked and thousands of innocent lives were lost. These tragic events exposed our nation’s vulnerability to attack and heightened our awareness of potential threats. Further examination of the capabilities of foreign nations indicate that terrorist groups worldwide have access to information on the development of radiological weapons and the potential to acquire the raw materials necessary to build such weapons. The looming threat of attack has highlighted the vital role that public health agencies play in our nation’s response to terrorist incidents. Such agencies are responsible for detecting what agent was used (chemical, biological, radiological), event surveillance, distribution of necessary medical supplies, assistance with emergency medical response, and treatment guidance. In the event of a terrorist attack involving nuclear or radiological agents, it is one of CDC’s missions to insure that our nation is well prepared to respond. In an effort to fulfill this goal, CDC, in collaboration with representatives of local and state health and radiation protection departments and many medical and radiological professional organizations, has identified practical strategies that hospitals can refer -
Nuclear Reactor Realities
Page 1 of 26 Nuclear Reactor Realities NUCLEAR REACTOR REALITIES (An Australian viewpoint) PREFACE Now that steam ships are no longer common, people tend to forget that nuclear power is just a replacement of coal, oil or gas for heating water to form steam to drive turbines, or of water (hydro) to do so directly. As will be shown in this tract, it is by far the safest way of doing so to generate electricity economically in large quantities – as a marine engineer of my acquaintance is fond of saying. Recently Quantum Market Research released its latest Australian Scan (The Advertiser, Saturday April 17, 2012, p 17). It has been tracking social change by interviewing 2000 Australians annually since 1992. In the concerns in the environment category, “[a]t the top of the list is nuclear accidents and waste disposal” (44.4 per cent), while “global warming” was well down the list of priorities at No 15, with only 27.7 per cent of people surveyed rating the issue as “extremely serious.” Part of the cause of such information must be that people are slowly realising that they have been deluded by publicity about unverified computer models which indicate that man’s emissions of CO2 play a major part in global warming. They have not yet realised that the history of the dangers of civilian nuclear power generation shows the reverse of their images. The topic of nuclear waste disposal is also shrouded in reactor physics mysteries, leading to a mis-placed general fear of the unknown. In this article only nuclear reactors are considered. -
Nuclear Fusion Enhances Cancer Cell Killing Efficacy in a Protontherapy Model
Nuclear fusion enhances cancer cell killing efficacy in a protontherapy model GAP Cirrone*, L Manti, D Margarone, L Giuffrida, A. Picciotto, G. Cuttone, G. Korn, V. Marchese, G. Milluzzo, G. Petringa, F. Perozziello, F. Romano, V. Scuderi * Corresponding author Abstract Protontherapy is hadrontherapy’s fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy’s superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) 12C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper 12C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + 11Bà3a reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses 10B-enriched BSH for neutron irradiation-triggered alpha-particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy’s ballistic precision with the higher RBE promised by BNCT and 12C-ion therapy is thus demonstrated. 1 The urgent need for radical radiotherapy research to achieve improved tumour control in the context of reducing the risk of normal tissue toxicity and late-occurring sequelae, has driven the fast- growing development of cancer treatment by accelerated beams of charged particles (hadrontherapy) in recent decades (1). This appears to be particularly true for protontherapy, which has emerged as the most-rapidly expanding hadrontherapy approach, totalling over 100,000 patients treated thus far worldwide (2).