Basics of Radiation Radiation Safety Orientation Open Source Booklet 1 (June 1, 2018)
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NATO and NATO-Russia Nuclear Terms and Definitions
NATO/RUSSIA UNCLASSIFIED PART 1 PART 1 Nuclear Terms and Definitions in English APPENDIX 1 NATO and NATO-Russia Nuclear Terms and Definitions APPENDIX 2 Non-NATO Nuclear Terms and Definitions APPENDIX 3 Definitions of Nuclear Forces NATO/RUSSIA UNCLASSIFIED 1-1 2007 NATO/RUSSIA UNCLASSIFIED PART 1 NATO and NATO-Russia Nuclear Terms and Definitions APPENDIX 1 Source References: AAP-6 : NATO Glossary of Terms and Definitions AAP-21 : NATO Glossary of NBC Terms and Definitions CP&MT : NATO-Russia Glossary of Contemporary Political and Military Terms A active decontamination alpha particle A nuclear particle emitted by heavy radionuclides in the process of The employment of chemical, biological or mechanical processes decay. Alpha particles have a range of a few centimetres in air and to remove or neutralise chemical, biological or radioactive will not penetrate clothing or the unbroken skin but inhalation or materials. (AAP-21). ingestion will result in an enduring hazard to health (AAP-21). décontamination active активное обеззараживание particule alpha альфа-частицы active material antimissile system Material, such as plutonium and certain isotopes of uranium, The basic armament of missile defence systems, designed to which is capable of supporting a fission chain reaction (AAP-6). destroy ballistic and cruise missiles and their warheads. It includes See also fissile material. antimissile missiles, launchers, automated detection and matière fissile радиоактивное вещество identification, antimissile missile tracking and guidance, and main command posts with a range of computer and communications acute radiation dose equipment. They can be subdivided into short, medium and long- The total ionising radiation dose received at one time and over a range missile defence systems (CP&MT). -
Radiation Basics
Environmental Impact Statement for Remediation of Area IV \'- f Susana Field Laboratory .A . &at is radiation? Ra - -.. - -. - - . known as ionizing radiatios bScause it can produce charged.. particles (ions)..- in matter. .-- . 'I" . .. .. .. .- . - .- . -- . .-- - .. What is radioactivity? Radioactivity is produced by the process of radioactive atmi trying to become stable. Radiation is emitted in the process. In the United State! Radioactive radioactivity is measured in units of curies. Smaller fractions of the curie are the millicurie (111,000 curie), the microcurie (111,000,000 curie), and the picocurie (1/1,000,000 microcurie). Particle What is radioactive material? Radioactive material is any material containing unstable atoms that emit radiation. What are the four basic types of ionizing radiation? Aluminum Leadl Paper foil Concrete Adphaparticles-Alpha particles consist of two protons and two neutrons. They can travel only a few centimeters in air and can be stopped easily by a sheet of paper or by the skin's surface. Betaparticles-Beta articles are smaller and lighter than alpha particles and have the mass of a single electron. A high-energy beta particle can travel a few meters in the air. Beta particles can pass through a sheet of paper, but may be stopped by a thin sheet of aluminum foil or glass. Gamma rays-Gamma rays (and x-rays), unlike alpha or beta particles, are waves of pure energy. Gamma radiation is very penetrating and can travel several hundred feet in air. Gamma radiation requires a thick wall of concrete, lead, or steel to stop it. Neutrons-A neutron is an atomic particle that has about one-quarter the weight of an alpha particle. -
MIRD Pamphlet No. 22 - Radiobiology and Dosimetry of Alpha- Particle Emitters for Targeted Radionuclide Therapy
Alpha-Particle Emitter Dosimetry MIRD Pamphlet No. 22 - Radiobiology and Dosimetry of Alpha- Particle Emitters for Targeted Radionuclide Therapy George Sgouros1, John C. Roeske2, Michael R. McDevitt3, Stig Palm4, Barry J. Allen5, Darrell R. Fisher6, A. Bertrand Brill7, Hong Song1, Roger W. Howell8, Gamal Akabani9 1Radiology and Radiological Science, Johns Hopkins University, Baltimore MD 2Radiation Oncology, Loyola University Medical Center, Maywood IL 3Medicine and Radiology, Memorial Sloan-Kettering Cancer Center, New York NY 4International Atomic Energy Agency, Vienna, Austria 5Centre for Experimental Radiation Oncology, St. George Cancer Centre, Kagarah, Australia 6Radioisotopes Program, Pacific Northwest National Laboratory, Richland WA 7Department of Radiology, Vanderbilt University, Nashville TN 8Division of Radiation Research, Department of Radiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark NJ 9Food and Drug Administration, Rockville MD In collaboration with the SNM MIRD Committee: Wesley E. Bolch, A Bertrand Brill, Darrell R. Fisher, Roger W. Howell, Ruby F. Meredith, George Sgouros (Chairman), Barry W. Wessels, Pat B. Zanzonico Correspondence and reprint requests to: George Sgouros, Ph.D. Department of Radiology and Radiological Science CRB II 4M61 / 1550 Orleans St Johns Hopkins University, School of Medicine Baltimore MD 21231 410 614 0116 (voice); 413 487-3753 (FAX) [email protected] (e-mail) - 1 - Alpha-Particle Emitter Dosimetry INDEX A B S T R A C T......................................................................................................................... -
Interim Guidelines for Hospital Response to Mass Casualties from a Radiological Incident December 2003
Interim Guidelines for Hospital Response to Mass Casualties from a Radiological Incident December 2003 Prepared by James M. Smith, Ph.D. Marie A. Spano, M.S. Division of Environmental Hazards and Health Effects, National Center for Environmental Health Summary On September 11, 2001, U.S. symbols of economic growth and military prowess were attacked and thousands of innocent lives were lost. These tragic events exposed our nation’s vulnerability to attack and heightened our awareness of potential threats. Further examination of the capabilities of foreign nations indicate that terrorist groups worldwide have access to information on the development of radiological weapons and the potential to acquire the raw materials necessary to build such weapons. The looming threat of attack has highlighted the vital role that public health agencies play in our nation’s response to terrorist incidents. Such agencies are responsible for detecting what agent was used (chemical, biological, radiological), event surveillance, distribution of necessary medical supplies, assistance with emergency medical response, and treatment guidance. In the event of a terrorist attack involving nuclear or radiological agents, it is one of CDC’s missions to insure that our nation is well prepared to respond. In an effort to fulfill this goal, CDC, in collaboration with representatives of local and state health and radiation protection departments and many medical and radiological professional organizations, has identified practical strategies that hospitals can refer -
General Terms for Radiation Studies: Dose Reconstruction Epidemiology Risk Assessment 1999
General Terms for Radiation Studies: Dose Reconstruction Epidemiology Risk Assessment 1999 Absorbed dose (A measure of potential damage to tissue): The Bias In epidemiology, this term does not refer to an opinion or amount of energy deposited by ionizing radiation in a unit mass point of view. Bias is the result of some systematic flaw in the of tissue. Expressed in units of joule per kilogram (J/kg), which design of a study, the collection of data, or in the analysis of is given the special name Agray@ (Gy). The traditional unit of data. Bias is not a chance occurrence. absorbed dose is the rad (100 rad equal 1 Gy). Biological plausibility When study results are credible and Alpha particle (ionizing radiation): A particle emitted from the believable in terms of current scientific biological knowledge. nucleus of some radioactive atoms when they decay. An alpha Birth defect An abnormality of structure, function or body particle is essentially a helium atom nucleus. It generally carries metabolism present at birth that may result in a physical and (or) more energy than gamma or beta radiation, and deposits that mental disability or is fatal. energy very quickly while passing through tissue. Alpha particles cannot penetrate the outer, dead layer of skin. Cancer A collective term for malignant tumors. (See “tumor,” Therefore, they do not cause damage to living tissue when and “malignant”). outside the body. When inhaled or ingested, however, alpha particles are especially damaging because they transfer relatively Carcinogen An agent or substance that can cause cancer. large amounts of ionizing energy to living cells. -
Radiation Glossary
Radiation Glossary Activity The rate of disintegration (transformation) or decay of radioactive material. The units of activity are Curie (Ci) and the Becquerel (Bq). Agreement State Any state with which the U.S. Nuclear Regulatory Commission has entered into an effective agreement under subsection 274b. of the Atomic Energy Act of 1954, as amended. Under the agreement, the state regulates the use of by-product, source, and small quantities of special nuclear material within said state. Airborne Radioactive Material Radioactive material dispersed in the air in the form of dusts, fumes, particulates, mists, vapors, or gases. ALARA Acronym for "As Low As Reasonably Achievable". Making every reasonable effort to maintain exposures to ionizing radiation as far below the dose limits as practical, consistent with the purpose for which the licensed activity is undertaken. It takes into account the state of technology, the economics of improvements in relation to state of technology, the economics of improvements in relation to benefits to the public health and safety, societal and socioeconomic considerations, and in relation to utilization of radioactive materials and licensed materials in the public interest. Alpha Particle A positively charged particle ejected spontaneously from the nuclei of some radioactive elements. It is identical to a helium nucleus, with a mass number of 4 and a charge of +2. Annual Limit on Intake (ALI) Annual intake of a given radionuclide by "Reference Man" which would result in either a committed effective dose equivalent of 5 rems or a committed dose equivalent of 50 rems to an organ or tissue. Attenuation The process by which radiation is reduced in intensity when passing through some material. -
A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?
Pharmaceuticals 2015, 8, 321-336; doi:10.3390/ph8020321 OPEN ACCESS pharmaceuticals ISSN 1424-8247 www.mdpi.com/journal/pharmaceuticals Review A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters? Robin M. de Kruijff, Hubert T. Wolterbeek and Antonia G. Denkova * Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands; E-Mails: [email protected] (R.M.K.); [email protected] (H.T.W.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +31-15-27-84471. Academic Editor: Svend Borup Jensen Received: 15 April 2015 / Accepted: 1 June 2015 / Published: 10 June 2015 Abstract: This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. -
Radiological Information
RADIOLOGICAL INFORMATION Frequently Asked Questions Radiation Information A. Radiation Basics 1. What is radiation? Radiation is a form of energy. It is all around us. It is a type of energy in the form of particles or electromagnetic rays that are given off by atoms. The type of radiation we are concerned with, during radiation incidents, is “ionizing radiation”. Radiation is colorless, odorless, tasteless, and invisible. 2. What is radioactivity? It is the process of emission of radiation from a material. 3. What is ionizing radiation? It is a type of radiation that has enough energy to break chemical bonds (knocking out electrons). 4. What is non-ionizing radiation? Non-ionizing radiation is a type of radiation that has a long wavelength. Long wavelength radiations do not have enough energy to "ionize" materials (knock out electrons). Some types of non-ionizing radiation sources include radio waves, microwaves produced by cellular phones, microwaves from microwave ovens and radiation given off by television sets. 5. What types of ionizing radiation are there? Three different kinds of ionizing radiation are emitted from radioactive materials: alpha (helium nuclei); beta (usually electrons); x-rays; and gamma (high energy, short wave length light). • Alpha particles stop in a few inches of air, or a thin sheet of cloth or even paper. Alpha emitting materials pose serious health dangers primarily if they are inhaled. • Beta particles are easily stopped by aluminum foil or human skin. Unless Beta particles are ingested or inhaled they usually pose little danger to people. • Gamma photons/rays and x-rays are very penetrating. -
3. Particles Or Waves? Strange Laws at the Heart of Matter
3. Particles or waves? Strange laws at the heart of matter Television news items or films sometimes show someone using a Geiger counter… maybe a prospector is searching for uranium, or perhaps a hospital worker is accounting for vital radioactive materials used to treat cancer. Geiger counters are particle detectors that make a characteristic clicking sound every time a high energy particle enters. Click – one particle; click – another particle. It is known that X-rays are emitted by electrons in the atom, whereas gamma rays, electromagnetic radiation of an even higher energy, are emitted from within the atomic nucleus. The clicking of a Geiger counter is a sign of quantum weirdness – the gamma ray waves are behaving as particles. In the same way that particles like electrons can sometimes behave as waves (we have mentioned how the wave properties of electrons allow us to study the structure of matter), all electromagnetic waves can occasionally act as particles. Every type of particle has a name, and particles of light are called photons. All electromagnetic waves, whether they are gamma rays, X-rays, visible, ultraviolet light, or radio waves, consist of photons. Another important property of electromagnetic waves is that, unlike other forms of waves such as sound, they do not need a medium to carry them. Sound waves require air to travel through, but all forms of light can propagate through empty space. It is because photons happily travel in the near vacuum of space that the radiation emitted by the Sun can heat the Earth. J. L. Cassingham with one of his company's Geiger counters, featured in an advertisement from 1955. -
Attenuation of Radiation
Attenuation of Radiation by Dr. James E. Parks Department of Physics and Astronomy 401 Nielsen Physics Building The University of Tennessee Knoxville, Tennessee 37996-1200 Copyright © March, 2001 by James Edgar Parks* *All rights are reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage or retrieval system, without permission in writing from the author. Objectives The objectives of this experiment are: (1) to study the interaction of radiation with matter, (2) to study how charged particles interact with materials, (3) to study the 3 primary ways that gamma rays interact with matter, (4) to learn how materials are effective in shielding radiation, (5) to learn some radiation terms and parameters that affect the stopping power of radiation, and (6) to measure radiation attenuation coefficients for beta particles and gamma rays. Theory There are two primary types of radiation that originate from the nucleus of the atom, and these are charged particles and gamma rays. Charged particles from radioactive sources consist primarily of alpha particles and beta particles. Alpha particles are doubly charged helium nuclei, and beta particles are negatively charged electrons. Alpha particles are emitted with a specific kinetic energy, but beta particles have a distribution of energies. The energy available for the creation of a beta particle is shared between the beta particle and a neutrino particle created simultaneously. Neutrinos are massless particles that interact with matter with a very low probability. Alpha and beta particles interact with matter by their charges interacting with the outer electrons of atoms making up the material. -
Alpha Particle Spectroscopy
Alpha Particle Spectroscopy Week of Sept. 13, 2010 Atomic and Nuclear Physics Laboratory (Physics 4780) The University of Toledo Instructor: Randy Ellingson Alpha Particle Spectroscopy • Alpha particle source – alpha decay • Context – understanding alpha particles • Energies • Interactions between alpha particles and matter (scattering and energy loss) • Semiconductor “radiation” detectors • SfSurface bibarrier detectors • Pulse generation (energy resolution?) • Data acquisition – digitization and “binning” • Multi‐channel analyzer Brief Review of Atomic Structure • Each atom consists of a positively charged core (the nucleus, contaning protons and neutrons, held together by nuclear forces ) surrounded by negatively‐charge shells (electrons). • Electrons exist in specific energy levels (orbits) around the nucleus. • Element is determined by # of protons. I.e., atoms of the same eltlement have the same # of protons, but can differ in the number of neutrons. Atoms of the same Masses: -31 me =911= 9.11 × 10 kg element (same # or protons) wihith different −27 mn = 1.67 ×10 kg # of neutrons are isotopes. Since # of −27 mp = 1.67 ×10 kg protons identifies the element, remember that # of protons is referred to as the atomic number (Z). Brief Review of Atomic Structure (continued) • Charges: electrons (‐1e), protons (+1e), and neutrons (0). • Magnitude of the charge on an electron = 1.602 x 10‐19 Coulombs. • Electrons are bound to the atom’s nucleus through the Coulomb force, in which opposite charges attract (“electrostatic force”). • Ions: basically, an atom is uncharged if the # of electrons = # of protons, and if not, you’ve got an ion (a charged atom). • Terminology for atoms, generalized to isotopes: (what is a nuclide?) A specific nuclide can be annotated as follows: A P X where A is the atomic mass number (# of protons + # of neutrons), P is the # of protons, and X is symbol for the element. -
Alpha Emitting Radionuclides and Radiopharmaceuticals for Therapy"
Report Technical Meeting on "Alpha emitting radionuclides and radiopharmaceuticals for therapy" June, 24−28, 2013 IAEA Headquarters, Vienna, Austria 1 BACKGROUND An alpha (α)-particle is a ionised 4He nucleus with a +2 electric charge and, therefore, it is relatively heavier than other subatomic particles emitted from decaying radionuclides such as electrons, neutrons, and protons. Because of this physical properties, α-particles are more effective ionization agents with linear energy transfer (LET) of the order of magnitude of 100 keV/µm, and are highly efficient in depositing energy over a short range in tissue (50–100 µm). Actually, a α-particle deposits 1500 times more energy per unit path length than a β- particle. The high mean energy deposition in tissues gives α-radiation exquisite cytotoxicity, which commonly manifests itself within the range of cell’s dimensions. This high LET may allow for an accurately controlled therapeutic modality that can be targeted to selected malignant cells with negligible burden to normal tissues. The short path length renders α-emitters suitable for treatment of minimal disease such as micro metastases or residual tumour after surgical resection of a primary lesion, hematologic cancers, infections, and compartmental cancers. A highly desirable goal in cancer therapy is the ability to target malignant cells while sparing normal cells. If significant differential targeting is achieved by a radiolabelled vector specifically designed to hold onto cancer cells, then a toxic payload on the vector will deliver a lethal dose preferentially to those cells expressing higher concentrations of the target molecule. This could be achieved by using highly cytotoxic α-particle radiation carried to specific sites of cancer cells by appropriate vectors.