STUDENT MANUAL Basic Principles in Occupational Hygiene July 2019 This course is offered by the Occupational Hygiene Training Association and available free of charge though the OHTA website ohtatraining.org. Copyright information This student manual is provided under the Creative Commons Attribution - NoDerivs licence agreement. It can only be reproduced in its entirety without change, unless with the prior written permission of OHTA. Occupational Hygiene Training Association, 5/6 Melbourne Business Court Millennium Way, Pride Park, Derby, DE24 8LZ Email:
[email protected] TABLE OF CONTENTS ACKNOWLEDGEMENTS i 1 INTRODUCTION 1 1.1 HISTORY 3 1.2 THE IMPORTANCE OF OCCUPATIONAL HYGIENE 6 2 HUMAN PHYSIOLOGY AND INDUSTRIAL DISEASES 8 2.1 SKIN 8 2.1.1 Dermatitis 9 2.1.2 Physical damage 10 2.1.3 Biological agents 10 2.1.4 Cancer 11 2.1.5 Other effects 11 2.2 MUSCULOSKELETAL SYSTEM 11 2.3 NERVOUS SYSTEM 12 2.4 ENDOCRINE SYSTEM 14 2.5 THE CIRCULATORY SYSTEM 15 2.5.1 The blood 17 2.6 RESPIRATORY SYSTEM 18 2.7 THE GASTROINTESTINAL TRACT 21 2.8 THE LIVER 22 2.9 URINARY SYSTEM 23 2.10 THE EYE 23 3 FUNDAMENTALS OF TOXICOLOGY 25 3.1 INTRODUCTION 25 3.2 TERMS 25 3.3 BASIC CONCEPTS 26 3.3.1 Physical form 27 3.3.2 Dose 27 3.3.3 Route of entry / absorption 28 3.3.4 Metabolism 29 3.3.5 Excretion 29 3.3.6 Response to toxins 30 3.4 STAGES OF TOXICOLOGICAL EVALUATION 30 3.4.1 What adverse effects can a chemical cause? 30 3.4.2 Are the effects seen in animals relevant to man? 31 3.5 SAFETY DATA SHEETS 31 4 EXAMPLES OF HAZARDOUS SUBSTANCES / PROCESSES 33