Standards on the Management of Certain Chemical Substances (Version 10)
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Synthesis of Polycyclic Natural Products Jianmin Shi Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1990 Synthesis of polycyclic natural products Jianmin Shi Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Organic Chemistry Commons Recommended Citation Shi, Jianmin, "Synthesis of polycyclic natural products " (1990). Retrospective Theses and Dissertations. 9891. https://lib.dr.iastate.edu/rtd/9891 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. JLÎMI MICROFILMED 1991 INFORMATION TO USERS The most advanced technology has been used to photograph and reproduce this manuscript from the microfihn master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps. -
Perfluoroalkyl-Iodo Norbornane Compounds and Their Use As
Europâisches Patentamt (g) ÛJ)) European Patent Office (0) Publication number: O 002 74 1 Office européen des brevets Bl © EUROPEAN PATENT SPECIFICATION @ Date of publication of patent spécification: 18.11.81 @© Int.lnt.CI.3: Cl.3: C 07 C 61/12, C07C 103/19, number: 78101696.9 @ Application CC07C 07 C 103/737,103/737 @ Date offiling: 15.12.78 C 07 D 209/76, C07B 29/04, C07C 69/74, C 07 D 307/77, B 01 F 17/00 (54) Perfluoroaikyl-iodo norbornane compounds and their use as surfactants. (§) Priority: 27.12.77 US 865060 @ Proprietor: CIBA-GEIGY AG Patentabteilung Postfach CH-4002 Basel (CH) (43) Date of publication of application: 11.07.79 Bulletin 79/14 (72) Inventor: Brace, Neal O. 1 022 East North Path (45) Publication of the grant of the European patent: Wheaton Illinois 60187 (US) 18.11.81 Bulletin 81/46 (84) Designated Contracting States: CH DE FR GB (56) References cited: NL - A - 68 08078 Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1 ) European patent convention). Courier Press, Leamington Spa, England. The compounds of this invention are perfluoroalkyliodo norbornane derivatives of the formula wherein Y is independently oxygen or the group >NR, R is independently hydrogen or alkyl of 1 to 24 carbon atoms or each group - YR is independently halogen with the proviso that if two halogen atoms are present these are identical and Rf is a straight or branched chain perfluoroalkyl of 1 to 18 carbon atoms or said perfluoroalkyl substituted by a perfluoroalkoxy group of 2 to 6 carbon atoms. -
Revised Group Additivity Values for Enthalpies of Formation (At 298 K) of Carbon– Hydrogen and Carbon–Hydrogen–Oxygen Compounds
Revised Group Additivity Values for Enthalpies of Formation (at 298 K) of Carbon– Hydrogen and Carbon–Hydrogen–Oxygen Compounds Cite as: Journal of Physical and Chemical Reference Data 25, 1411 (1996); https://doi.org/10.1063/1.555988 Submitted: 17 January 1996 . Published Online: 15 October 2009 N. Cohen ARTICLES YOU MAY BE INTERESTED IN Additivity Rules for the Estimation of Molecular Properties. Thermodynamic Properties The Journal of Chemical Physics 29, 546 (1958); https://doi.org/10.1063/1.1744539 Critical Evaluation of Thermochemical Properties of C1–C4 Species: Updated Group- Contributions to Estimate Thermochemical Properties Journal of Physical and Chemical Reference Data 44, 013101 (2015); https:// doi.org/10.1063/1.4902535 Estimation of the Thermodynamic Properties of Hydrocarbons at 298.15 K Journal of Physical and Chemical Reference Data 17, 1637 (1988); https:// doi.org/10.1063/1.555814 Journal of Physical and Chemical Reference Data 25, 1411 (1996); https://doi.org/10.1063/1.555988 25, 1411 © 1996 American Institute of Physics for the National Institute of Standards and Technology. Revised Group Additivity Values for Enthalpies of Formation (at 298 K) of Carbon-Hydrogen and Carbon-Hydrogen-Oxygen Compounds N. Cohen Thermochemical Kinetics Research, 6507 SE 31st Avenue, Portland, Oregon 97202-8627 Received January 17, 1996; revised manuscript received September 4, 1996 A program has been undertaken for the evaluation and revision of group additivity values (GAVs) necessary for predicting, by means of Benson's group additivity method, thermochemical properties of organic molecules. This review reports on the portion of that program dealing with GAVs for enthalpies of formation at 298.15 K (hereinafter abbreviated as 298 K) for carbon-hydrogen and carbon-hydrogen-oxygen compounds. -
NXP Semiconductors NXP List of Hazardous Substances in Products
NXP Semiconductors NX3-00119 NXP List of Hazardous Substances Sustainability 01-October-2012 in Products and Packaging Sustainability Page 1 of 7 Supersedes: NX3-00119 01-October-2010 Table of contents 1 Objectives ............................................................................................................................. 2 2 Scope ................................................................................................................................... 2 3 Responsibilities, Records & Risks......................................................................................... 2 3.1 Roles and Responsibilities .................................................................................................... 2 3.2 Records ................................................................................................................................ 2 3.3 Risks .................................................................................................................................... 3 4 References ........................................................................................................................... 3 5 Definitions/Abbreviations ...................................................................................................... 3 5.1 Definitions ............................................................................................................................. 3 5.2 Abbreviations ....................................................................................................................... -
The Photochemistry of Some Substituted 2-Cyclohexenones and the Excited States Involved
PHOTOCHEMISTRY OF SUBSTITUTi':D 2... CYCLOHE:XE;NONES THE PHOTOCHEMISTRY OF S0~1E SUBSTITUTED 2~CYCLOHEXENONES AND THE EXCITED STATES INVOLVED By FLOlTI FP~ERICK SNYDER, B.Sce .A Thesis Submitted to the Faculty of Graduate Studies in Partial Fulfilment of the Requirements for the Degree Master of Science McMaster University October 1969 To MOM and DAD on Your 25th Anniversary MASTER OF SCIENCE (1969) McMASTER UNIVERSITY (Ghemi stry) Hamilton, Ontario. TITLE: The Photochemistry of some Substituted 2-Cyclohexenones and the Excited States Involved AUTHOR: Floyd Frederick Snyder, B.Sc. '(University of Alberta) SUPERVISOR: Dr. J. J. McCullough NUMBER OF PAGES: viii, 87 SCOPE AND CONTENTS: The photoadditions of 3~phenyl-2-cyclohexenone to bicyclo [2.2.1] hepta-2,5-diene, bicyclo [2.2.1] hept-2mene and cyclopentene have been studied. In all cases £.!1! fused cyclobutane products were obtained. Quenching and sensitization experiments indicated a singlet excited state to be active in photocycloaddition. Phosphorescence and fluorescence emission were observed from 3-phenyl-2-cyclohexenoneo Energy transfer to the lo~.rest triplet of 3-phenyl-2-cyclohexenone was evident from the quenching of Michler's ketone phosphorescence. Two norbornene dimers were detected in the photolysis of 3-phenyl-2-cyclo hexenone and norbornene giving evidence for a higher triplet excited state of the enone. The photoaddition of 3-methyl-2-cyclohexenone to cyclopentene l.ras studied for comparison and both .£!..! and !.r..!.U! fused adducts l-Tere obtained. In photolyses with bicyclo [2e2el] hepta-2,5 diene or cyclopentene, 2-phenyl... 2-cyclohexenone lvas unreactive. iii ACKNOWLEDGEMENTS It is a pleasure to express my gratitude to Dr. -
The Synthesis and Chemistry of Strained Bicyclic Systems
AN ABSTRACT OF THE THESIS OF LOUIS SCERBO for the Ph. D. (Name) (Degree) in CHEMISTRY presented on S.41_0C 6 1 (Date) (Major) Title: THE SYNTHESIS AND CHEMISTRY OF STRAINED BICYCLIC SYSTEMS Abstract approved Dr. F. Thomas Bond A facile route to bicyclo(2. 1. 1)hexanes was developed involving the intramolecular photocyclization of 1, 5- hexadien -3 -one to bicyclo(2. 1. 1)hexan- 2 -one. A study of the chemistry of bicyclo- (2. 1. 1)hexan -2 -one was undertaken. Deuterium exchange and boro- hydride reduction demonstrated the strain present in the ketone. Further evidence was obtained from the failure to introduce substi- tuents alpha to the carbonyl group, a usually facile reaction and a necessary step in desired ring contraction studies. After numerous unsuccessful attempts to introduce a double bond into the bicyclo(2. 1. 1) hexane system, a successful route to the parent bicyclo(2. 1. 1) hexene was achieved. The key step involved dehydrohalogenation of 2- bromobicyclo(2. 1. 1)hexane. Some prelimi- nary studies of the olefin have been carried out and its thermolysis studied. The Synthesis and Chemistry of Strained Bicyclic Systems by Louis Scerbo A THESIS submitted to Oregon State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy June 1968 APPROVED: Assistant Professor of Chemistry in charge of major Chairman of the Department of Chemistry Dean of Graduate School Date thesis is presented VA, (\rah .ClI le g Typed by Marion F. Palmateer for Louis Scerbo ACKNOWLEDGEMENT The author wishes to express appreciation to Dr. -
Process for Producing Phenyl-Substituted Heterocyclic Derivative Through Coupling Using Transition Metal Catalyst
(19) TZZ _T (11) EP 2 754 658 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 16.07.2014 Bulletin 2014/29 C07D 277/20 (2006.01) C07D 277/56 (2006.01) (21) Application number: 14163761.1 (22) Date of filing: 26.02.2010 (84) Designated Contracting States: (72) Inventors: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR • Komiyama, Masato HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL Tokyo, 191-0065 (JP) PT RO SE SI SK SM TR • Yajima, Naoki Designated Extension States: Tokyo, 191-0065 (JP) AL BA RS • Kurokawa, Masayuki Tokyo, 191-0065 (JP) (30) Priority: 27.02.2009 JP 2009046003 29.06.2009 JP 2009153770 (74) Representative: Carpmaels & Ransford LLP One Southampton Row (62) Document number(s) of the earlier application(s) in London WC1B 5HA (GB) accordance with Art. 76 EPC: 10746307.7 / 2 404 908 Remarks: This application was filed on 07-04-2014 as a (71) Applicant: Teijin Pharma Limited divisional application to the application mentioned Chiyoda-ku, under INID code 62. Tokyo 100-0013 (JP) (54) Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst (57) A process for efficiently producing, through few steps either a xanthine oxidase inhibitor, which is a therapeutic agentfor hyperuricemia, or an intermediatetherefore. The processis anovel coupling processwhich comprises subjecting a compound represented by formula (1) to coupling reaction with a compound represented by formula (2) in the presence of a transition metal compound to thereby obtain a compound represented by formula (3). -
Petroleum Reference Standards
petroleum Chiron was established in 1983 by Dr. Jon Eigill Johansen in Trondheim, Norway and started with the development and production of biomarkers for use in the search for oil in the North Sea. Chiron has therefore been involved in the preparation of steroid and triterpanoid (hopane) reference materials used in the petroleum industry for over 30 years, and possess a unique experience in this field. These compounds are found in petroleum and sediments. Hopanes are in fact the second largest group of natural products on earth, surpassed only by cellulose. This type of compound changes its chemical structure over time and maturation. They have traditionally been used in petroleum exploration, but in recent years have been increasingly used for forensic analysis, for example in the investigation of oil spills. Chiron works with major oil companies, institutions, private laboratories, universities and hospitals in this area, and is currently the only producer of a large range of oil exploration reference materials. Join our PETROLEUM BIOMARKER group on LinkedIn! The Petroleum Biomarker Group Chiron AS Stiklestadvn. 1 N-7041 Trondheim Norway Phone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA CONTENTS Aliphatic alkanes (paraffins) 1 Diterpenoid compounds 16 Deuterated n-alkanes (internal standards) 1-2 C25 Terpanes 16 Fluoro-n-alkanes (internal standard) 2 Steranes (Tetracyclic compounds) 16 n-Alkanes 2-3 Sterane internal standards 16-17 2-Methylalkanes (isoalkanes) -
Chemical Substances Control List Ver.2.8-B May 2021
PTPD-T-N01-S01-0015 Chemical Substances Control List Ver.2.8-b May 2021 The Chemical Substances Control List (The substance list) is aimed at the control of the chemical substances contained in all products of Yokogawa group. The substances listed in this list are chosen based on the main product-related regulations and industrial standards, but don’t cover all of the regulations and industrial standards. In case that the product contains any substances regulated by specific convention, law, ordinance, it must comply with these specific regulations. The detailed substances (typical example) with CAS Registry Number® are described in Appendix. We ask you for reporting those substances which are not listed in the detailed substance list, but if they are targeted substances. Prohibited-substances 1: Table 1 Control No. A1-* Global common Prohibited substances Prohibited-substances 2: Table 2 Control No. A2-* 10 substances banned under RoHS Table 3 Control No. A3-* Prohibited substances by concentration/ threshold, etc. Prohibited-substances 3: Table 4 Control No. A4-* Prohibited substances by applications Controlled substances: Table 5 Control No. B1-* REACH SVHC Table 6 Control No. B2-* Substances whose contents must be identified * If you must delivered parts that contain substance controlled by this list, you contact us. We will respond individually. 1 Table 1 Global common Prohibited substances Regulations or industrial rules A-1: CSCL (Japan) Class I Specified Chemical Substances G: REACH Annex XVII restricted substances J-A: Stockholm Convention Annex A substances (EU POPs Regulation) K: Montreal Protocol L: Ship recycling convention M: EU ship recycling regulation T: Prohibition of Certain Toxic Substances Regulations, 2012 Regulations or Control CAS Registry Substances industrial rules No. -
Prioritisation of Flame Retardants for Environmental Risk Assessment
PRIORITISATION OF FLAME RETARDANTS FOR ENVIRONMENTAL RISK ASSESSMENT P R Fisk, A E Girling and R J Wildey Research Contractor: Peter Fisk Associates © Environment Agency 2003 All rights reserved. No part of this document may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without prior permission of the Environment Agency. It is not the intention of this report to imply that any particular substance should or should not be used for any particular purpose. It is the aim of this report to evaluate concerns in respect of a wide range of different substances. This report should only be used as a tool to assist in identifying priorities for environmental risk assessment. It should not be used in isolation to assess whether any particular substance should be used for any particular purpose. The Agency has used all reasonable skill and expertise to ensure that the findings of this report are factually correct. The Agency accepts no liability for: - any losses that arise from any subsequent interpretation or application of the findings of this report by a third party; or - indirect or consequential loss (including loss of business, profit, reputation or goodwill). The Agency does not intend to exclude any liability that cannot be excluded at law. ISBN: 978-1-84432-956-4 Product Code: SCHO1008BOTE-E-P Dissemination Status Internal: Release to Chemicals Policy External: Publicly available Statement of Use This report summarises the environmental issues surrounding the use of flame retardant chemicals. It prioritises these on the basis of tonnage, hazardous properties and approximate risk ‘ranking’. -
Cyclohexene Oxide 286-20-4 NTP NOMINATION HISTORY and REVIEW
Cyclohexene oxide 286-20-4 NTP NOMINATION HISTORY AND REVIEW A. Nomination History 1. Source: National cancer Institute 2. Recommendations: -Mechanistic carcinogencity studies -Synergism studies or two-stage studies - Test with benzene or other chemicals deemed appropriate by NTP 3. Rationale/Remarks: -High annual production volume -Potential for human exposure based on its use as a research and industrial chemical -Environmental contaminant -Representative cycloalkene monoepoxide; suspicion of carcinogenicity as a member of the epoxides· chemical class 4. Priority: High 5. Date of Nomination: 4/93 B. Interagency Committee for Chemical Evaluation and Coordination Review \ 1. Date of Review: 2. Recommendations: 3. Priority: 4. NTP Chemical Selection Principles: 5. Rationale/Remarks: "' 286-20-4 Cyclohexene oxide SUMMARY OF DATA FOR CHEMICAL SELECTION CHEMICAL IDENTIFICATION CAS Registry Name: 286-20-4 Chemical Abstracts Name: 7-oxabicyclo[ 4.1.0]heptane(9CI,8CI) Synonyms and Trade Names: Cyclohexene oxide; cyclohexene epoxide; 1,2 epoxycyclohexane; cyclohexane oxide tetramethyleneoxirane; CO; CHO Structure. Molecular Formula and Molecular Weight Mol. wt.: 98.15 Chemical and Physical Properties Description: Colorless liquid with strong (pungent, offensive) odor (Sax & Lewis, 1987;Uniroyal, 1990) Boiling Point 129-131°C; 266°F (Sax & Lewis, 1987; Uniroyal, 1990; Weast, 1989) Melting Point <-10°C (Weast, 1989) Solubilitv: Very soluble in benzene; soluble in alcohol, ether, acetone, chloroform; low water solubility (-0.5 g/L) (Sax & Lewis, 1987; BASF, 1990; Weast, 1989) DensitY: 0.967 g/cc@ 25°/4°C (Sax & Lewis, 1987; Uniroyal, 1990) Prepared for NCI by Technical Resources, Inc. under Contract No. N01-CP-56019 (9/91; rev. 2/93) 6'( II 286-20-4 Cyclohexene oxide Vapor Pressure: 12 mbar (BASF, 1990) Flash Point 27oC; 81 oF (Sax & Lewis, 1989; Uniroyal, 1990.) Stabiiitv: Stable at ambient temperatures and pressures. -
WCB Dissertation Title Page Dec 3 2012
UC Berkeley UC Berkeley Electronic Theses and Dissertations Title Cobalt-Mediated Vinylic C-H Functionalization of Alkenes Permalink https://escholarship.org/uc/item/7fd5j6m2 Author Boyd, Warren Christopher Publication Date 2012 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California Cobalt-Mediated Vinylic C–H Functionalization of Alkenes By Warren Christopher Boyd A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Chemistry in the Graduate Division of the University of California, Berkeley Committee in charge: Professor Robert G. Bergman, Co-chair Professor F. Dean Toste, Co-Chair Professor K. Peter C. Vollhardt Professor Benito O. de Lumen Fall 2012 Abstract Cobalt-Mediated Vinylic C–H Functionalization of Alkenes by Warren Christopher Boyd Doctor of Philosophy in Chemistry University of California, Berkeley Professors Robert G. Bergman and F. Dean Toste, Co-Chairs Many organic reactions promoted or catalyzed by transition metals proceed via mechanisms in which bonds are formed and broken directly between the organic substrate and the metal center. Less common are reactions exhibiting ligand-based reactivity, in which the key bond formation and cleavage steps occur between the substrate and ligands attached to the active metal center. This dissertation describes the use of ligand-based reactivity of cobalt dinitrosyl complexes with alkenes to form vicinal dinitrosoalkane complexes of cobalt. In these complexes, the C–H bonds located α to the nitroso groups are significantly acidified relative to vinylic C–H bonds, allowing for these complexes to be deprotonated and functionalized with conjugate acceptors in Michael reactions.