Hossain R et al . (2020) Notulae Botanicae Horti Agrobotanici Cluj-Napoca 48(3):1155-1175 DOI:10.15835/nbha48311986 Notulae Botanicae Horti AcademicPres Research Article Agrobotanici Cluj-Napoca Pharmacological and ADMET -based pharmacokinetic properties of Syzygium samarangense var. parviflorum leaf extract in in vitro , in vivo and in silico models Rahni HOSSAIN 1, Md. A. RAHMAN 2*, Md. K. J. RAFI 2, Tanvir A. SIDDIQUE 2, Abdullah A. NOMAN 1, Arwa MAKKI 3, Walla ALELWANI 3, Dina HAJJAR 3, Jitbanjong TANGPONG 4 1International Islamic University, Department of Pharmacy, Chittagong, Kumira, Chittagong-4318, Bangladesh;
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[email protected] Abstract This research investigated pharmacological properties mainly the anti-inflammatory, anthelmintic, thrombolytic and anxiolytic potential of methanol extract of Syzygium samarangense (MESS) var. parviflorum . Anti-inflammatory action by bovine serum albumin, egg albumin denaturation and membrane stabilization, anthelmintic by live parasites, thrombolytic by clot lysis and anxiolytic by elevated plus maze (EPM) and light and dark box (LDB) tests were measured. The four targeted pharmacological properties were further justified using the most prevalent compounds, isolated from this plant, to be undergone for their pharmacokinetic property’s analyses, sitemap analyses and lignad-receptor interactions by computational models through SwissADME and Schrödinger, 2018 softwares against PDB 6COX, 6D6T, 1JFF receptors.