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Benzylpenicillin / Dihydrostreptomycin Sul- Phate / Nafcillin Formulation

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Benzylpenicillin / Dihydrostreptomycin Sul- Phate / Nafcillin Formulation SAFETY DATA SHEET Benzylpenicillin / Dihydrostreptomycin Sul- phate / Nafcillin Formulation Version Revision Date: SDS Number: Date of last issue: 30.10.2020 2.0 09.04.2021 7213846-00002 Date of first issue: 30.10.2020 SECTION 1. PRODUCT AND COMPANY IDENTIFICATION Product name : Benzylpenicillin / Dihydrostreptomycin Sulphate / Nafcillin For- mulation Manufacturer or supplier's details Company : MSD Address : Rua Coronel Bento Soares, 530 Cruzeiro - Sao Paulo - Brazil CEP 12730-340 Telephone : 908-740-4000 Emergency telephone : 1-908-423-6000 E-mail address : [email protected] Recommended use of the chemical and restrictions on use Recommended use : Veterinary product SECTION 2. HAZARDS IDENTIFICATION GHS Classification in accordance with ABNT NBR 14725 Standard Respiratory sensitization : Category 1 Skin sensitization : Category 1 Specific target organ toxicity - : Category 2 (ear, Kidney, inner ear) repeated exposure (Oral) Aspiration hazard : Category 1 Short-term (acute) aquatic : Category 2 hazard Long-term (chronic) aquatic : Category 4 hazard GHS label elements in accordance with ABNT NBR 14725 Standard Hazard pictograms : Signal Word : Danger Hazard Statements : H304 May be fatal if swallowed and enters airways. H317 May cause an allergic skin reaction. H334 May cause allergy or asthma symptoms or breathing 1 / 18 SAFETY DATA SHEET Benzylpenicillin / Dihydrostreptomycin Sul- phate / Nafcillin Formulation Version Revision Date: SDS Number: Date of last issue: 30.10.2020 2.0 09.04.2021 7213846-00002 Date of first issue: 30.10.2020 difficulties if inhaled. H373 May cause damage to organs (ear, Kidney, inner ear) through prolonged or repeated exposure if swallowed. H401 Toxic to aquatic life. H413 May cause long lasting harmful effects to aquatic life. Precautionary Statements : Prevention: P273 Avoid release to the environment. P280 Wear protective gloves. Response: P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P331 Do NOT induce vomiting. P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/ doctor. Other hazards which do not result in classification None known. SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS Substance / Mixture : Mixture Components Chemical name CAS-No. Classification Concentration (% w/w) Paraffin oil 8012-95-1 Aspiration hazard, >= 70 - < 90 Category 1 Long-term (chronic) aquatic hazard, Category 4 Benzylpenicillin 61-33-6 Respiratory sensitiza- >= 10 - < 20 tion, Sub-category 1A Skin sensitization, Sub-category 1B Short-term (acute) aquatic hazard, Category 1 Long-term (chronic) aquatic hazard, Category 3 Sodium [2S-(2α,5α,6β)]-6-[[(2- 985-16-0 >= 1 - < 5 ethoxy-1- naphthyl)carbonyl]amino]-3,3- dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-2- carboxylate Dihydrostreptomycin sulphate 5490-27-7 Specific target organ >= 1 - < 5 2 / 18 SAFETY DATA SHEET Benzylpenicillin / Dihydrostreptomycin Sul- phate / Nafcillin Formulation Version Revision Date: SDS Number: Date of last issue: 30.10.2020 2.0 09.04.2021 7213846-00002 Date of first issue: 30.10.2020 toxicity - repeated exposure (Oral) (ear, Kidney, inner ear), Category 1 Fatty acids, C14-26, alumi- 97404-28-9 >= 1 - < 5 num salts SECTION 4. FIRST AID MEASURES General advice : In the case of accident or if you feel unwell, seek medical advice immediately. When symptoms persist or in all cases of doubt seek medical advice. If inhaled : If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. In case of skin contact : In case of contact, immediately flush skin with soap and plenty of water. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse. In case of eye contact : Flush eyes with water as a precaution. Get medical attention if irritation develops and persists. If swallowed : If swallowed, DO NOT induce vomiting. If vomiting occurs have person lean forward. Call a physician or poison control center immediately. Never give anything by mouth to an unconscious person. Most important symptoms : May be fatal if swallowed and enters airways. and effects, both acute and May cause an allergic skin reaction. delayed May cause allergy or asthma symptoms or breathing difficul- ties if inhaled. May cause damage to organs through prolonged or repeated exposure if swallowed. Excessive exposure may aggravate preexisting asthma and other respiratory disorders (e.g. emphysema, bronchitis, reac- tive airways dysfunction syndrome). Protection of first-aiders : First Aid responders should pay attention to self-protection, and use the recommended personal protective equipment when the potential for exposure exists (see section 8). Notes to physician : Treat symptomatically and supportively. SECTION 5. FIRE-FIGHTING MEASURES Suitable extinguishing media : Water spray Alcohol-resistant foam Carbon dioxide (CO2) Dry chemical Unsuitable extinguishing : None known. media 3 / 18 SAFETY DATA SHEET Benzylpenicillin / Dihydrostreptomycin Sul- phate / Nafcillin Formulation Version Revision Date: SDS Number: Date of last issue: 30.10.2020 2.0 09.04.2021 7213846-00002 Date of first issue: 30.10.2020 Specific hazards during fire : Exposure to combustion products may be a hazard to health. fighting Hazardous combustion prod- : Carbon oxides ucts Metal oxides Specific extinguishing meth- : Use extinguishing measures that are appropriate to local cir- ods cumstances and the surrounding environment. Use water spray to cool unopened containers. Remove undamaged containers from fire area if it is safe to do so. Evacuate area. Special protective equipment : In the event of fire, wear self-contained breathing apparatus. for fire-fighters Use personal protective equipment. SECTION 6. ACCIDENTAL RELEASE MEASURES Personal precautions, protec- : Use personal protective equipment. tive equipment and emer- Follow safe handling advice (see section 7) and personal gency procedures protective equipment recommendations (see section 8). Environmental precautions : Avoid release to the environment. Prevent further leakage or spillage if safe to do so. Prevent spreading over a wide area (e.g., by containment or oil barriers). Retain and dispose of contaminated wash water. Local authorities should be advised if significant spillages cannot be contained. Methods and materials for : Soak up with inert absorbent material. containment and cleaning up For large spills, provide diking or other appropriate containment to keep material from spreading. If diked material can be pumped, store recovered material in appropriate container. Clean up remaining materials from spill with suitable absorbent. Local or national regulations may apply to releases and disposal of this material, as well as those materials and items employed in the cleanup of releases. You will need to determine which regulations are applicable. Sections 13 and 15 of this SDS provide information regarding certain local or national requirements. SECTION 7. HANDLING AND STORAGE Technical measures : See Engineering measures under EXPOSURE CONTROLS/PERSONAL PROTECTION section. Local/Total ventilation : Use only with adequate ventilation. Advice on safe handling : Do not get on skin or clothing. Do not breathe mist or vapors. Do not swallow. Avoid contact with eyes. Wash skin thoroughly after handling. Handle in accordance with good industrial hygiene and safety 4 / 18 SAFETY DATA SHEET Benzylpenicillin / Dihydrostreptomycin Sul- phate / Nafcillin Formulation Version Revision Date: SDS Number: Date of last issue: 30.10.2020 2.0 09.04.2021 7213846-00002 Date of first issue: 30.10.2020 practice, based on the results of the workplace exposure assessment Keep container tightly closed. Already sensitized individuals should consult their physician regarding working with respiratory irritants or sensitizers. Do not eat, drink or smoke when using this product. Take care to prevent spills, waste and minimize release to the environment. Hygiene measures : If exposure to chemical is likely during typical use, provide eye flushing systems and safety showers close to the working place. When using do not eat, drink or smoke. Contaminated work clothing should not be allowed out of the workplace. Wash contaminated clothing before re-use. The effective operation of a facility should include review of engineering controls, proper personal protective equipment, appropriate degowning and decontamination procedures, industrial hygiene monitoring, medical surveillance and the use of administrative controls. Conditions for safe storage : Keep in properly labeled containers. Store locked up. Keep tightly closed. Store in accordance with the particular national regulations. Materials to avoid : Do not store with the following product types: Strong oxidizing agents Organic peroxides Explosives Gases SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Ingredients with workplace control parameters Components CAS-No. Value type Control parame- Basis (Form of ters / Permissible exposure) concentration Paraffin oil 8012-95-1 TWA 5 mg/m³ ACGIH (Inhalable particulate matter) Benzylpenicillin 61-33-6 TWA 2000 µg/m3 (OEB Internal 1) Further information: RSEN, DSEN Wipe limit 100 µg/100 cm2 Internal Sodium [2S-(2α,5α,6β)]-6-[[(2- 985-16-0 TWA 0.7 mg/m3 (OEB Internal ethoxy-1- 2) naphthyl)carbonyl]amino]-3,3- dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-2- carboxylate Dihydrostreptomycin
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