PRODUCT INFORMATION 2-Fluoromethamphetamine (hydrochloride) Item No. 11420

CAS Registry No.: 1780004-19-4 Formal Name: 2-fluoro-N-α-dimethyl- benzeneethanamine, F H

monohydrochloride N Synonym: 2-FMA MF: C10H14FN • HCl FW: 203.7 Purity: ≥98% • HCl Stability: ≥2 years at -20°C Supplied as: A crystalline solid

Laboratory Procedures

For long term storage, we suggest that 2-fluoromethamphetamine (2-FMA) (hydrochloride) be stored as supplied at -20°C. It should be stable for at least two years. 2-FMA (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the 2-FMA (hydrochloride) in the solvent of choice. 2-FMA (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of 2-FMA (hydrochloride) in ethanol is approximately 30 mg/ml and approximately 20 mg/ml in DMSO and DMF. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of 2-FMA (hydrochloride) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of 2-FMA (hydrochloride) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

Description

2-FMA is a drug related to and 2-fluoroamphetamine.1 Through little is known of the pharmacological properties of fluoro methoxy substituted , 2-FMA has been identified as a component of designer drugs sold as “legal high” replacements for restricted substances.1,2 The hydrochloride formulation of this compound is intended for use as a standard for the forensic analysis of samples that may contain 2-FMA.

References

1. Rösner, P., Quednow, B., Girreser, U., et al. Isomeric fluoro-methoxy-phenylalkylamines: A new series of controlled-substance analogues (designer drugs). Forensic Sci. Int. 148, 143-156 (2005). 2. Camilleri, A., Johnston, M.R., Brennan, M., et al. Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, a-phthalimidopropiophenone and N-ethylcathinone. Forensic Sci. Int. 197, 59-66 (2010).

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