DSC3 Antibody Cat. No.: 58-711

DSC3 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This DSC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 822-850 amino acids from the C-terminal region of human DSC3.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 100 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

September 27, 2021 1 https://www.prosci-inc.com/dsc3-antibody-58-711.html BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: DSC3

ALTERNATE NAMES: -3, family member 3, Desmocollin-4, HT-CP, DSC3, CDHF3, DSC4

ACCESSION NO.: Q14574

PROTEIN GI NO.: 116241342

GENE ID: 1825

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The protein encoded by this is a calcium-dependent that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the , are found primarily in epithelial cells where they BACKGROUND: constitute the adhesive of the cell-cell junction and are required for and desmosome formation. The desmosomal family members are arranged in two clusters on 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.

REFERENCES: 1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

2) Johnatty, S.E., et al. PLoS Genet.(7), E1001016 (2010) :

3) Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)

4) Ayub, M., et al. Am. J. Hum. Genet. 85(4):515-520(2009)

ANTIBODIES FOR RESEARCH USE ONLY.

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