DSC3 Antibody Cat. No.: 58-711
DSC3 Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human
This DSC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 822-850 amino acids from the C-terminal region of human DSC3.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR 100 kDa WEIGHT:
Properties
This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
PHYSICAL STATE: Liquid
September 27, 2021 1 https://www.prosci-inc.com/dsc3-antibody-58-711.html BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: DSC3
ALTERNATE NAMES: Desmocollin-3, Cadherin family member 3, Desmocollin-4, HT-CP, DSC3, CDHF3, DSC4
ACCESSION NO.: Q14574
PROTEIN GI NO.: 116241342
GENE ID: 1825
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they BACKGROUND: constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.
REFERENCES: 1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
2) Johnatty, S.E., et al. PLoS Genet.(7), E1001016 (2010) :
3) Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)
4) Ayub, M., et al. Am. J. Hum. Genet. 85(4):515-520(2009)
ANTIBODIES FOR RESEARCH USE ONLY.
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