Combiphar Haldin’s Cosmetic Ingredient Products Feminine Hygiene Ingredients

Study Properties Strong Weak

Anti-bacterial & Anti- inflammatory Manjakani Astringent

Anti-bacterial & Licorice Whitening

Kacip Fatimah Astringent

Guazuma Anti-bacterial

Pale Anti-bacterial Manjakani – Introduction

• Common Name: Manjakani (Indonesia) ; galls, Downy oak, nut (English) • Botanical Name: • Folklore Use – Restore the elasticity of the uterine wall and to reduce excessive vaginal discharge. – A powerful astringent and a natural antiseptic for women. • Properties for Skin: – Antibacterial & Astringent • Applications: – Intimacy Lotion / Gel – Feminine Wash – Feminine Hygiene Pads Clinical Studies on Manjakani

• The Department of Biomedical Sciences in National University of Malaysia, have found that the within Manjakani has demonstrated antifungal activity to certain type of fungal species, especially the Candida glabrata fungi species. • Dayang Basri et. Al., in their study has found that the extracts of manjakani displayed antimicrobial activity on the bacterial species such as Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis, and concluded that the galls of Quercus infectoria are potentially good source of antimicrobial agents. • Kaur G et. Al., through their studies suggest that extract of galls of Q. infectoria exerts in vivo antiinflammatory activity after oral or topical administration and also has the ability to prevent the production of some inflammatory mediators. Feminine Products Example Applications

Feminine Wash with Feminine Hygiene Intimacy Lotion / Gel Manjakani Extract Pads with Manjakani with Manjakani Extract Extract Kacip Fatimah – Introduction

• Common Name: Kacip fatimah; Rumput Fatimah, Selusuh fatimah • Botanical Name: Labisia pumila • Folklore Use – used traditionally by native Malays in post-partum recovery • Properties for Skin: – Labisa Pumila extracts at nano-size penetrate vaginal cell’s membrane and stimulate the proliferation of vaginal tissues, leading to the tightening effect from the increased vaginal cell mass • Applications: – Feminine Wash – Intimate Lotion Clinical Studies on Kacip Fatimah

• Ayida Al-Wahabi et. Al., Results of study have concluded the possible role for Labisia pumila var alata or Kacip Fatimah in modulating postmenopausal adiposity through the initiation of the lipolysis process in adipose tissue.

• Kacip Fatimah was Identified by Dr Wan Nazaimoon Wan Mahmud, head of the Cardiovascular, Diabetic & Nutrition Research Center at the Institute for Medical Research, Malaysia as the most powerful source of phytoestrogens; it exhibits the pharmacokinetics of Selective Estrogen Receptors Modulators in clinical studies Feminine Products Example Applications

Feminine Hygiene Intimate Lotion with Feminine Wash with Pads with Kacip Kacip Fatimah Extract Kacip Fatimah Extract Fatimah Extract Pale Catechu – Introduction

• Common Name: Pale Catechue, , Cat’s Claw • Botanical Name: gambir • Folklore Use – reduce the appearance of fine lines, wrinkles and sun damage. – relief of pain, itching and burning associated with hemorrhoids. • Properties for Skin: Externally, gambir is powerfully astringent. It restrains excessive discharges, overcomes relaxation and congestion, and checks local hemorrhages. • Applications: – Feminine Soap and Wash Pale Catechu Mechanism

• Due to it’s combination of phytotoxicity and antimicrobial activity of catechin that exist within Cat’s Claw plant, it could be a useful natural herbicide and antimicrobial.

• It was also found that the catechin within Pale Catechue plant has anticandidal activity, which is causing blockage of the hyphal formation, has the synergism combined with Amp B against disseminated candidiasis. Feminine Products Example Applications

Feminine Soap with Pale Catechu Extract Jati Belanda – Introduction

• Common Name: Jati Belanda / Bastard Cedar / Mutamba • Botanical Name: Guazuma ulmifolia • Folklore Use – Treat baldness, leprosy, dematosis and other skin conditions. • Properties for Skin: – As an external skin remedy for wounds, rashes, skin parasites, dermatitis, fungal infections and leprosy – For viral and bacterial infections (including syphilis & gonorrhea) Licorice – Introduction

• Common Name: Licorice or Liquorice • Botanical Name: Glycyrrhiza glabra • Folklore Use: – Whitening • Properties for Skin: – Whitening Astringent & Anti-Inflammatory • Mechanism – Glabridin was identified as a powerful skin whitening ingredient, – Glabrene as an anti-oxidant as strong as natural Vitamin E, and – Licochalcone as highly effective anti-acne ingredient which controls sebum production and wipes away bacteria. Licochalcone is also a mild sunscreen effective against the UVA & UVB rays of the sun. Feminine Products Example Applications

Intimate Hygiene Gel with Licorice Extract Anti-Acne Ingredients

Study Plant Properties Strong Weak

Anti-bacterial, Sourlime Antiseptic & Astringent Remove Dead Skin Cucumber Cells & Anti- Inflammatory Antioxidant & Anti- White Tea Inflammatory Sour Lime – Introduction

• Common Name: Sour Lime / Key Lime / Jeruk Nipis • Botanical Name: Citrus aurantifolia • Folklore Use – wound healing because it aids in stabilizing collagen. When applied topically, vitamin C can reduce fine lines and wrinkles and may lessen the severity of sunburns. Furthermore amino acids in sour lime useful for healthy skin renewal and well known to be soothing to the skin too. • Properties for Skin: help clear oily skin, acne, antiseptic and anti-bacterial • Applications: – Toner / Facial Cleanser (for Oily Skin) – Anti-acne Gel How Sour Lime works as an Anti-Acne agent

• Acne medicines may contain ingredients that remove the top layer of dead skin (such as salicylic acid, hydroxy acid, benzoyl peroxide, and sulfur) and ingredients that have antibacterial action. Some ingredients reduce sebum production; others reduce inflammation.

• Sour lime contains Citric acid, Tartaric acid, Glycolic acid, Lactic acid, and Malic acid, which are part of Alpha hydroxy acid (AHA). These acids help to reduce oil skin, pore cleansing, smooth the skin, enhance the effects of other skin rejuvenation treatments, keep problem skin under control, attract moisture to the skin, even texture and complexion of skin, clear the skin, and reverse some of the effects of UV damage. Sour Lime – Product Application Examples

Anti-Aging Stimulating Treatment Masque for Anti-Acne Gel Facial Cleanser Oily Skin Cucumber – Introduction

• Common Name: Cucumber / Timun • Folklore Use – Refresh and Smooth Dry Skin. – Treat hemorrhoids, rash, abscesses and other skin eruptions, inflammation, – It works wonderfully to smooth the skin and erase skin spots, freckles and wrinkles, thus rejuvenating the skin. • Properties for Skin: A mild astringent, aids in removing dead skin cells, alleviates inflammations and irritants. • Applications: – Toner / Facial Cleanser for Dry Skin – Peel off Mask – Sunscreen Cream Cucumber - Overview

• The flesh of cucumbers is primarily composed of water but also contains ascorbic acid (vitamin C) and caffeic acid, both of which help soothe skin irritations and reduce swelling. Cucumbers‘ hard skin is rich in fiber and contains a variety of beneficial minerals including silica, potassium and magnesium. • The silica in cucumber is an essential component of healthy connective tissue, which includes muscles, tendons, ligaments, cartilage, and bone. Cucumber juice is often recommended as a source of silica to improve the complexion and health of the skin, plus cucumber's high water content makes it naturally hydrating—a must for glowing skin. Cucumbers are also used topically for various types of skin problems, including swelling under the eyes and sunburn. Two compounds in cucumbers, ascorbic acid and caffeic acid, prevent water retention, which may explain why cucumbers applied topically are often helpful for swollen eyes, burns and dermatitis Cucumber - Overview

• Gives skin a cool soothing feeling to the skin. A mild astringent, aids in removing dead skin cells, alleviates inflammations and irritants. Cleopatra was said to have used cucumber juice to preserve her skin.

• Cucumber juice is an excellent treatment for skin rash, inflammation, etc., when applied as a lotion or used to wash the affected zone. Furthermore, it works wonderfully to smooth the skin and erase skin spots, freckles and wrinkles, thus rejuvenating the skin. Cucumber – Product Application Examples

Cleansing Lotion Facial Toner Peel off Mask Sunscreen Cream for Dry Skin White Tea – Introduction

• Common Name: Teh Putih • Folklore Use – Refresh and Smooth Dry Skin. – Treat hemorrhoids, rash, abscesses and other skin eruptions, inflammation, – It works wonderfully to smooth the skin and erase skin spots, freckles and wrinkles, thus rejuvenating the skin. • Properties for Skin: • Applications: – Moisturizer – Cleansing Gel White Tea Topical Benefits

• Antioxidants; White Tea helps prevents skin damaging DNA and accelerating aging. White Tea also protects the skin and helps to reverse some of the damage • Antibacterial White tea reinforces the immune system protection against all sorts of skin diseases. Clinical Studies on White Tea

• Cleveland (2003), had proven that ingredients in White Tea are effective in boosting the immune function of skin cells and protecting them against the damaging effects of sun. • Elma Baron & Seth Stevens (2003), found the application of White Tea extract protected critical elements of the skin immune system. Oxidative stress of the skin caused a breakdown in cellular strength and function. • Kevin Cooper (2003), his research strongly claimed that younger skin tended to be able to resist the oxidative stress associated with exposure to destructive rays of sunlight. The White Tea extract appeared to build the skin's resistance against stresses that cause the skin to age. • The Skin Study Center at UHC and CWRU (Cleveland, 2003) studied that White Tea extract maintained protective effects against its ingredient despite on exposure of direct sunburn, whilst green tea loses a portion of its active ingredients under same treatment. This study is the first of its kind involving White Tea. White Tea – Product Application Examples

Moisturizer Cleansing Foam Gel Toner for Acne Prevention Our Ingredients, Your Products, Shared Success… A Total Natural Result