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Compuestos Con Actividad Antimicrobiana En Plantas Del Género Kalanchoe Como Tratamiento Promisorio Para Infecciones Producidas Por Bacterias

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Compuestos Con Actividad Antimicrobiana En Plantas Del Género Kalanchoe Como Tratamiento Promisorio Para Infecciones Producidas Por Bacterias Compuestos con actividad antimicrobiana en plantas del género Kalanchoe como tratamiento promisorio para infecciones producidas por bacterias Juan Antonio Gómez González Universidad Nacional Abierta y a Distancia Escuela de Ciencias Básicas, Tecnología e Ingeniería Programa de Química Bogotá, Colombia 2019 1 Compuestos con actividad antimicrobiana en plantas del género Kalanchoe como tratamiento promisorio para infecciones producidas por bacterias Juan Antonio Gómez González Trabajo de grado como requisito final para optar al título de QUÍMICO Directora: M.Sc Eliana Yissel Aguilera Ángel UNIVERSIDAD NACIONAL ABIERTA Y A DISTANCIA ESCUELA DE CIENCIAS BASICAS, TECNOLOGÍA E INGENIERIA PROGRAMA QUÍMICA BOGOTÁ 2019 2 DEDICATORIA A Dios, Por permitirme cumplir mis Metas, por brindarme salud y bienestar. A mis padres, Juan Gómez y Gloria González Por apoyarme incondicionalmente para Seguir adelante y concretar mis objetivos. A mis hermanas, Sindy Gómez y Dayana Gómez Por animarme día a día a culminar Mi investigación. A mi esposa, Alejandra cuervo Por estar conmigo y acompañarme en todo momento. A mi tía, Nancy González y demás familiares Por apoyarme siempre. A mis amigos Oscar Herrera, Juan Carlos Angulo, Ramón Ramírez, Roberto Visbal, José Pren, Felipe Cadena, por compartir los buenos y malos momentos. 3 AGRADECIMIENTOS A la profesora Eliana Aguilera por su orientación y gran colaboración en la elaboración de esta investigación, aportando información relevante para culminar este trabajo investigativo. 4 TABLA DE CONTENIDO Resumen ......................................................................................................................... 12 Abstract .......................................................................................................................... 14 Introducción ................................................................................................................... 16 Capitulo 1: Problema de investigacion .......................................................................... 17 Capitulo 2: Generalidades ............................................................................................. 20 Capitulo 3: Ensayos cualitatitivos de caracterizacion en las plantas del género Kalanchoe ....................................................................................................................... 43 Capitulo 4: Ensayos cuantitativos de caracterizacion en las plantas del género Kalanchoe ....................................................................................................................... 61 Capitulo 5. Evaluacion de la actividad antimicrobiana en las plantas del género kalanchoe .........................................................................................................................77 Conclusiones ................................................................................................................... 88 Recomendaciones ........................................................................................................... 92 Referencias bibliográficas .............................................................................................. 93 5 LISTA DE FIGURAS Capítulo 2 Figura 1. Brotes vegetativos de Kalanchoe daigremontiana ............................................. 23 Figura 2. Distribución mundial del género Kalanchoe ...................................................... 23 Figura 3. Ilustración de corrida una placa cromatográfica por TLC .................................. 34 Figura 4a. Ilustración de un espectrómetro de masa .......................................................... 36 Figura 4b. Cámara de ionización ...................................................................................... 36 Figura 5. Ilustración de un equipo de HPLC ..................................................................... 37 Figura 6. Ilustración de un equipo de CG ......................................................................... 38 Figura 7. Ilustración de un equipo de CG/MS ................................................................... 39 Figura 8. Staphylococcus Aureus teñida como gran negativo ............................................ 40 Figura 9. Fotografía 3d de E. coli .................................................................................. 42 Capítulo 3 Figura 10. Tamizaje fitoquímico de diversos extractos de hojas de K. crenata .................. 48 Figura 11. Tamizaje fitoquímico de diversos extractos de raíces DE K. crenata ............... 48 Figura 12. Resultado del extracto de Kalanchoe gastonis en acetato de etilo .................... 50 Figura 13. Resultado del extracto de Kalanchoe gastonis en acetato de etilo .................... 50 Figura 14. Resultado del extracto de Kalanchoe gastonis en hexánico .............................. 51 Figura 15. Resultado del extracto de Kalanchoe gastonis en hexánico .............................. 51 Figura 16. Resultado del extracto etanólico de Kalanchoe gastonis .................................. 52 6 Figura 17. Resultado del extracto etanólico de Kalanchoe gastonis .................................. 52 Figura 18. Resultado del extracto hexánico de Kalanchoe pinnata ................................... 53 Figura 19. Resultado del extracto hexánico de Kalanchoe pinnata ................................... 53 Figura 20. Resultado del extracto de Kalanchoe pinnata en acetato de etilo ..................... 54 Figura 21. Resultado del extracto de Kalanchoe pinnata en acetato de etilo ..................... 54 Figura 22. Resultado del extracto etanólico de Kalanchoe pinnata ................................... 55 Figura 23. Resultado del extracto etanólico de Kalanchoe pinnata ................................... 55 Figura 24. Resultado del extracto etanólico de Kalanchoe flammea .................................. 56 Figura 25. Resultado del extracto etanólico de Kalanchoe flammea .................................. 56 Figura 26. Resultado del extracto de Kalanchoe flammea en acetato de etilo .................... 57 Figura 27. Resultado del extracto de Kalanchoe flammea en acetato de etilo .................... 57 Figura 28. Resultado del extracto en hexánico de Kalanchoe flammea ............................. 58 Figura 29. Resultado del extracto en hexánico de Kalanchoe flammea ............................. 58 Figura 30. CCF análisis cualitativos de extracto de K. daigremontiana revelada con NP/PEG fase inversa ........................................................................................................ 60 Figura 31. CCF análisis cualitativos de extracto de K. daigremontiana revelada con NP/PEG fase normal ........................................................................................................ 60 Figura 32. CCF análisis cualitativos de extracto de K. daigremontiana revelada con KOM 61 Figura 33. CCF análisis cualitativos de extracto de K. daigremontiana revelada con KOM 61 Figura 34. CCF análisis cualitativos de extracto de K. daigremontiana revelada con KOM en columna abierta de fase normal ................................................................................... 62 7 Capítulo 4 Figura 35. M/S para el extracto de Kalanchoe pinnata en cloroformo .............................. 64 Figura 36. Lista de compuestos probable por M/S para el extracto de Kalanchoe pinnata en cloroformo ....................................................................................................................... 65 Figura 37. M/S del extracto de Kalanchoe brasiliensis ..................................................... 66 Figura 38. Identificación por M/S del extracto de Kalanchoe brasiliensis......................... 66 Figura 39. Cromatograma y resultado por HPLC para extracto en cloroformo para esteroides de raíces de Kalanchoe pinnata ....................................................................... 68 Figura 40. Cromatograma y resultado por HPLC para extracto en cloroformo para flavonoides de raíces de Kalanchoe pinnata ..................................................................... 69 Figura 41. Fase móvil para análisis por HPLC Para identificar los flavonoides en la planta Kalanchoe daigremontiana ............................................................................................ 70 Figura 42. Perfil cromatografico mediante HPLC para extracto metanólico de K. draigemontiana ................................................................................................................ 71 Figura 43. Perfil cromatografico mediante HPLC para glucósido de quercetina ................ 71 Figura 44. Fase móvil para separación de ácido fenólicos ................................................. 72 Figura 45. Fase móvil para separación de flavonoides ...................................................... 73 Figura 46. HPLC de fase reversa del extracto en metanol Kalanchoe pinnata ................... 73 Figura 47. HPLC de fase reversa del extracto en acetato de etilo de Kalanchoe pinnata ... 74 Figura 48. CG para el extracto de K. pinnata en cloroformo ............................................. 75 Figura 49. Lista de compuestos probable por CG para el extracto de Kalanchoe pinnata en cloroformo ....................................................................................................................... 76 Figura 50. CG-MS para el extracto de Kalanchoe floribunda ........................................... 77 Figura 51. CG-MS para el extracto de Kalanchoe floribunda ..........................................
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