Through a Psychological Lens Darkly: Interpreting Current Reactions to the Pandemic
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The T-SPOT.TB Test Frequently Asked Questions
General tuberculosis information T-SPOT.TB Test description and Frequently asked performance questions T-SPOT.TB Test performance characteristics T-SPOT.TB advantages over tuberculin skin test T-SPOT.TB test results T-SPOT.TB methodology Screening control programs Contact investigations References References Table of contents General tuberculosis information Tuberculosis: Definition, infection and disease 1. What is the scale of the TB problem? 2. How is TB spread? 3. What is TB infection (Latent Tuberculosis Infection “LTBI” or “latent TB”)? 4. What is TB disease (“active TB”)? 5. Are certain groups of individuals at an increased risk of exposure to Mycobacterium tuberculosis? 6. Are certain individuals at an increased risk of progressing from latent TB infection to TB disease? 7. How important is treatment for TB disease? 8. Why is the treatment period for TB disease so long? 9. How important is treatment for TB infection (“LTBI” or “latent TB”)? TB detection 10. Is there a test for the detection of TB infection (“LTBI” or “latent TB”)? • Tuberculin Skin Test (TST) • Interferon-Gamma Release Assays (IGRA) 11. Is there a test for the detection of TB disease (“active TB”)? 12. What are the limitations of the TST? Bacille Calmette-Guérin (BCG) vaccination 13. What is the BCG vaccination? T-SPOT.TB test description and performance 14. What is the intended use of the T-SPOT.TB test? 15. Why does the T-SPOT.TB test measure interferon-gamma? 16. Does the T-SPOT.TB test differentiate between latent TB infection and TB disease? 17. What data is there to support the T-SPOT.TB test in clinical use? 18. -
History and Epidemiology of Global Smallpox Eradication Smallpox
History and Epidemiology of Global Smallpox Eradication Smallpox Three Egyptian Mummies 1570-1085 BC Ramses the Vth Died 1157 BC Early Written Description of Smallpox India 400 AD “Severe pain is felt in the large and small joints, with cough, shaking, listlessness and langour; the palate, lips, and tongue are dry with thirst and no appetite. The pustules are red, yellow, and white and they are accompanied by burning pain. The form soon ripens …the body has a blue color and seems studded with rice. The pustules become black and flat, are depressed in the centre, with much pain.” Smallpox and History • In the Elephant war in Mecca 568 AD, smallpox decimated the Ethiopian soldiers • Introduction of smallpox into the new world (Carribean 1507, Mexico 1520, Peru 1524, and Brazil 1555 ) facilitated Spanish conquest • Smallpox destroys Hottentots (1713) • In 1738, smallpox killed half the Cherokee Indian population • Smallpox disrupted colonial army in 1776 Smallpox Control Strategies • Smallpox hospitals (Japan 982 AD). • Variolation 10th Century. • Quarantine 1650s. • Home isolation of smallpox in Virginia 1667. • Inoculation and isolation (Haygarth 1793). • Jenner and widespread practice of vaccination throughout Europe and rest of the world. • Mass vaccination. • Surveillance containment. Variolation Inoculation with Smallpox Pus • Observations: – Pocked marked persons never affected with smallpox – Persons inoculated with smallpox pustular fluid or dried scabs usually had milder disease • Not ideal control strategy – Case fatality rate still 2% – Can transmit disease to others during illness The 1st Smallpox Vaccination Jenner 1796 Cowpox lesions on the hand of Sarah Nelmes (case XVI in Jenner’s Inquiry), from which material was taken for the vaccination of James Phipps below in 1796 History of Smallpox Vaccination 1805 Growth of virus on the flank of a calf in Italy. -
The Decline in Mortality in Philadelphia from 1870 to 1930: the Role of Municipal Services
The Decline in Mortality in Philadelphia from 1870 to 1930: The Role of Municipal Services HE CHRISTMAS SEASON of 1880 should have been a happy occasion for Charles and Caroline Kautz. Charles, a German T immigrant in his mid-forties, had operated a three-person bakery in the Moyamensing section of Philadelphia over a decade. Caroline, several years his junior and his wife of over fifteen years, had married him during her teens and soon assumed the responsibilities of parenthood. Though Pennsylvania born, Caroline also came from German stock and, with her husband, worshipped at a loc&l German Lutheran church. Caroline and Charles Kautz and their three sons and three daughters must have eagerly anticipated a joyous holiday cele- bration. But it was not their fate to enjoy this Christmas. In three and one-half weeks from late November to mid-December, smallpox took the lives of five of the six Kautz children. Six-year-old Clara died on November 20, followed by Albert (aged 2) two weeks later, then Edward (aged 4) on December 10, Charles (aged 8) on December 11, and Bertha (aged 10) on December 14. Only twelve-year-old Sophia survived. Burial in the Lutheran church cemetery followed each of the deaths in numbing succession. The tragedies that befell the Kautzes over a century ago illustrate in a concrete way part of the enormous gap separating the twentieth and the nineteenth centuries in America. Epidemic diseases, childhood death, and low adult life expectancies dominated life. Indeed, in the space of a decade, the Kautzes had witnessed smallpox epidemics in Philadelphia in 1871-72 and 1876 prior to the 1880-81 epidemic that devastated their family. -
History of Tuberculosis and Tuberculosis Control Program in Turkey
In Focus History of tuberculosis and tuberculosis control program in Turkey Indian) and 4 (X, Haarlem, LAM [Latin-American Mediterranean]). In Turkey, the latest evolved lineage 4 has been most dominant. Current evidence might suggest migratory movements over the past 35,000–89,000 years from Africa spread four main lineages into Eurasia, while the remaining two phylogenetically ‘ancient’ lineages Cengiz Cavu¸ so¸ glu stayed in Africa. These lineages were later spread to the Sub-Indian Ege University Faculty of Medicine Department of Medical Microbiology continent and from there into Europe, sub-Saharan Africa and Mycobacteriology Laboratory America, following a wave of reverse Homo sapiens migrations and Bornova, Izmir,_ Turkey Email: [email protected] conquests. Analysis of known mutation rates of the M. tuberculosis reveals that the differences among strains started to appear 250– 1000 years ago3–9. Tuberculosis (TB) is debatably the most infectious disease Tuberculosis was initially documented over 5000 years ago in with highest rate of causalities throughout human history. Ancient Egypt; characteristic Pott deformations of TB were detected The Ottoman Empire also had the profound effect of the in mummies, and even represented in Ancient Egyptian art. disease; however, following the establishment of the Repub- Recently, DNA of M. tuberculosis was amplified from mummy lic of Turkey in 1923 effective TB control programs were tissues providing confirmatory evidence. There are documents implemented at times jointly with the WHO. From 1949 dating back 3300 years in India, and 2300 years in China and onwards, significant reduction in disease incidence and archaeological evidence from the Andes also confirm the existence death rates in Turkey was recorded due to the significant of pre-Columbian tuberculosis. -
GLOBAL TUBERCULOSIS REPORT 2018 Global Tuberculosis Report 2018
global TUBERCULOSIS REPORT 2018 GLOBAL TUBERCULOSIS REPORT 2018 Global Tuberculosis Report 2018 ISBN 978-92-4-156564-6 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY- NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. Global tuberculosis report 2018. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris. Sales, rights and licensing. To purchase WHO publications, see http://apps.who.int/bookorders. To submit requests for commercial use and queries on rights and licensing, see http://www.who.int/about/licensing. -
White Plague, White City: Landscape and the Racialization of Tuberculosis in Washington, D.C
W&M ScholarWorks Undergraduate Honors Theses Theses, Dissertations, & Master Projects 4-2019 White Plague, White City: Landscape and the Racialization of Tuberculosis in Washington, D.C. from 1846 to 1960 Ivie Orobaton Follow this and additional works at: https://scholarworks.wm.edu/honorstheses Part of the African American Studies Commons, Social History Commons, and the United States History Commons Recommended Citation Orobaton, Ivie, "White Plague, White City: Landscape and the Racialization of Tuberculosis in Washington, D.C. from 1846 to 1960" (2019). Undergraduate Honors Theses. Paper 1378. https://scholarworks.wm.edu/honorstheses/1378 This Honors Thesis is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Undergraduate Honors Theses by an authorized administrator of W&M ScholarWorks. For more information, please contact [email protected]. 1 TABLE OF CONTENTS Page Introduction: Why Tuberculosis? Why Washington, D.C.?......................................................3-7 Chapter 1: The Landscape of Washington, D.C. and the Emergence of Tuberculosis in the City …………………………………………………………………………………………………8-21 Chapter 2: Practical Responses to the Tuberculosis Issue (1846-1910)…………………….22-37 Chapter 3: Ideological Debates Around the Practical Responses to Tuberculosis (1890-1930) …….………………………………………………………………………………………….38-56 Conclusion: The Passing of the Debate and the End of Tuberculosis in the City (1930-1960) ………………………………………….…………………………………………………….57-58 -
Modelling the Impact of a Smallpox Attack in India and Influence of Disease Control Measures
Open access Original research BMJ Open: first published as 10.1136/bmjopen-2020-038480 on 13 December 2020. Downloaded from Modelling the impact of a smallpox attack in India and influence of disease control measures Biswajit Mohanty,1 Valentina Costantino ,2 Jai Narain,1 Abrar Ahmad Chughtai,1 Arpita Das,2 C Raina MacIntyre 2 To cite: Mohanty B, ABSTRACT Strengths and limitations of this study Costantino V, Narain J, et al. Objectives To estimate the impact of a smallpox attack Modelling the impact of a in Mumbai, India, examine the impact of case isolation ► The model takes into account heterogeneity of age, smallpox attack in India and ring vaccination for epidemic containment and test and influence of disease disease transmission and immunological levels. the health system capacity under different scenarios with control measures. BMJ Open ► Age- specific rates of immunosuppressive condi- available interventions. 2020;10:e038480. doi:10.1136/ tions were estimated for Mumbai and included in Setting The research is based on Mumbai, India bmjopen-2020-038480 the model. population. ► This study does not include different route of trans- ► Prepublication history and Interventions We tested 50%, 70%, 90% of case mission than airborne. additional material for this paper isolation and contacts traced and vaccinated (ring is available online. To view these ► Other aspects that could influence transmission in- vaccination) in the susceptible, exposed, infected, files, please visit the journal clude seasonality, or vaccination effectiveness such recovered model and varied the start of intervention online (http:// dx. doi. org/ 10. as vaccine refusal were not included in the model. -
Smallpox: a Primer
Smallpox: A Primer Lieutenant Colonel Brenda J. McEleney, USAF US Air Force Counterproliferation Center 9 Future Warfare Series No. 9 CHAPTER 6 Smallpox: A Primer Brenda J. McEleney Smallpox, is a virus that plagued humanity for millennia. It was the first and only disease ever intentionally eradicated from the face of this planet, a scourge defeated in a remarkable, never-before-attempted campaign of generosity and cooperation by the nations of the world. Its eradication was a triumphant symbol of science and dogged persistence winning over nature. Moreover, its eradication was a gift of man to all mankind. Yet, is it possible that the same hand of man, that once rid the scourge of smallpox from the world, will be used to unleash this terror again on its unprotected citizens? This chapter, by providing a thorough review of the history, epidemiology, and current risks associated with this dreaded disease, addresses that question and its implications for the American public. Origins of Smallpox Smallpox has been described as one of the great scourges of mankind.1 Every corner of the world has felt its grip and known its devastation. Historians speculate that smallpox first appeared around 10,000 B.C. in the agricultural settlements in northeastern Africa. From there, it probably spread to India via Egyptian merchants. There is evidence smallpox is at least 3,000 years old. It was known in China as early as 1122 B.C. Its scars have been found on the mummy of Pharaoh Ramses V, who died in 1157 B.C., as well as on other mummies from the 18th and 20th Egyptian dynasties.2,3 141 Smallpox: A Primer The first known smallpox epidemic was recorded in 1350 B.C. -
The Tuberculosis Movement and Its Effect on Mortality
DISCUSSION PAPER SERIES IZA DP No. 10590 Was the First Public Health Campaign Successful? The Tuberculosis Movement and its Effect on Mortality D. Mark Anderson Kerwin Kofi Charles Claudio Las Heras Olivares Daniel I. Rees FEBRUARY 2017 DISCUSSION PAPER SERIES IZA DP No. 10590 Was the First Public Health Campaign Successful? The Tuberculosis Movement and its Effect on Mortality D. Mark Anderson Daniel I. Rees Montana State University and IZA University of Colorado Denver and IZA Kerwin Kofi Charles University of Chicago and NBER Claudio Las Heras Olivares Banco de Chile FEBRUARY 2017 Any opinions expressed in this paper are those of the author(s) and not those of IZA. Research published in this series may include views on policy, but IZA takes no institutional policy positions. The IZA research network is committed to the IZA Guiding Principles of Research Integrity. The IZA Institute of Labor Economics is an independent economic research institute that conducts research in labor economics and offers evidence-based policy advice on labor market issues. Supported by the Deutsche Post Foundation, IZA runs the world’s largest network of economists, whose research aims to provide answers to the global labor market challenges of our time. Our key objective is to build bridges between academic research, policymakers and society. IZA Discussion Papers often represent preliminary work and are circulated to encourage discussion. Citation of such a paper should account for its provisional character. A revised version may be available directly from the author. IZA – Institute of Labor Economics Schaumburg-Lippe-Straße 5–9 Phone: +49-228-3894-0 53113 Bonn, Germany Email: [email protected] www.iza.org IZA DP No. -
Module 1: Transmission and Pathogenesis of Tuberculosis
Module 1: Transmission and Pathogenesis of Tuberculosis Slide 1: (Title Slide.) Self-Study Modules on Tuberculosis, 1-5. Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, 2016. Slide 2: CDC Self-Study Modules on Tuberculosis, 1-5 • Module 1: Transmission and Pathogenesis of TB • Module 2: Epidemiology of TB • Module 3: Targeted Testing and the Diagnosis of Latent TB Infection and TB Disease • Module 4: Treatment of Latent TB Infection and TB Disease • Module 5: Infectiousness and Infection Control Slide 3: (Title Slide.) Self-Study Modules on Tuberculosis: Transmission and Pathogenesis of Tuberculosis Slide 4: Module 1: Objectives At completion of this module, learners will be able to 1. Describe the history of tuberculosis (TB). 2. Explain how TB is spread (transmission). 3. Define drug-resistant TB. 4. Explain the difference between latent TB infection (LTBI) and TB disease. 5. Explain how LTBI and TB disease develop (pathogenesis). 6. Describe the classification system for TB. Slide 5: Module 1: Overview • History of TB • TB Transmission • Drug-Resistant TB • TB Pathogenesis • Progression from LTBI to TB disease • Sites of TB disease • TB Classification System • Case Studies Slide 6: (Title Slide.) History of TB Slide 7: History of TB (1) • TB has affected humans for millennia • Historically known by a variety of names, including: o Consumption o Wasting disease o White plague • TB was a death sentence for many • [IMAGE: Red Cross Christmas Seal Campaign vintage image circa 1919. Image says “The Next to Go. Fight Tuberculosis.” Image credit: National Library of Medicine.] Slide 8: History of TB (2): Scientific Discoveries in 1800s • Until mid-1800s, many believed TB was hereditary • 1865 Jean Antoine-Villemin showed TB was contagious • 1882 Robert Koch discovered M. -
Global Epidemiology of Tuberculosis
271 Global Epidemiology of Tuberculosis Philippe Glaziou, MD1 Katherine Floyd, PhD1 Mario C. Raviglione, MD2 1 Global TB Programme, World Health Organization, Geneva, Switzerland Address for correspondence Philippe Glaziou, MD, Global TB 2 Global Health Programme, University of Milan, Italy Programme, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (e-mail: [email protected]). Semin Respir Crit Care Med 2018;39:271–285. Abstract Tuberculosis (TB) was the underlying cause of 1.3 million deaths among human immunodeficiency virus (HIV)-negative people in 2016, exceeding the global number of HIV/acquired immune deficiency syndrome (AIDS) deaths. In addition, TB was a contributing cause of 374,000 HIV deaths. Despite the success of chemotherapy over the past seven decades, TB is the top infectious killer globally. In 2016, 10.4 million new cases arose, a number that has remained stable since the beginning of the 21th Keywords century, frustrating public health experts tasked to design and implement interven- ► tuberculosis tions to reduce the burden of TB disease worldwide. Ambitious targets for reductions in ► epidemiology the epidemiological burden of TB have been set within the context of the Sustainable ► disease burden Development Goals (SDGs) and the End TB Strategy. Achieving these targets is the ► incidence focus of national and international efforts, and demonstrating whether or not they are ► mortality achieved is of major importance to guide future and sustainable investments. This ► risk factors article reviews epidemiological facts about TB, trends in the magnitude of the burden ► latent infection of TB and factors contributing to it, and the effectiveness of the public health response. -
Vaccines- a Brief and Relevant Social History
Curious Reactions: Vaccines- A Brief and Relevant Social History Larry Aguirre DMSc, PA-C, CAQ-PSY Adjunct Instructor of Health Disclosures and Disclaimers ▪ Employed by Mendocino College as an adjunct instructor, Redwood Quality Management Company, and contracted with Mendocino Community Health clinics, and Ukiah Juvenile Hall. ▪ Medical officer for the California Army National Guard. ▪ The views expressed in this presentation are those of the author and do not necessarily reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government, my employers, or Mendocino College. ▪ I do not receive funding form any vaccine or pharmaceutical companies. Smallpox Case Study ▪ The smallpox was always present, filling the churchyards with corpses, tormenting with constant fears all whom it had stricken, leaving on those whose lives it spared the hideous traces of its power, turning the babe into a changeling at which the mother shuddered, and making the eyes and cheeks of the bighearted maiden objects of horror to the lover. - T.B. Macaulay - The History of England from the Accession of James II, Vol IV. 1848 ▪ In the case of London, the Bills of Mortality indicate that smallpox was probably the single most lethal cause of death in the eighteenth century, accounting for 6–10% of all burials.[1] Smallpox ▪ Variola virus ▪ Double stranded DNA virus Size comparison phage Cheek cell Smallpox Clinical Manifestations[2] ▪ Enters the respiratory tract and into to mucus membranes and passing into the lymph nodes with a latent replication cycle of 4-14 days. ▪ Abrupt severe headache, backache, and fever, followed by sores in the mouth.