Mented, Negative-Strand RNA Virus
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
2020 Taxonomic Update for Phylum Negarnaviricota (Riboviria: Orthornavirae), Including the Large Orders Bunyavirales and Mononegavirales
Archives of Virology https://doi.org/10.1007/s00705-020-04731-2 VIROLOGY DIVISION NEWS 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales Jens H. Kuhn1 · Scott Adkins2 · Daniela Alioto3 · Sergey V. Alkhovsky4 · Gaya K. Amarasinghe5 · Simon J. Anthony6,7 · Tatjana Avšič‑Županc8 · María A. Ayllón9,10 · Justin Bahl11 · Anne Balkema‑Buschmann12 · Matthew J. Ballinger13 · Tomáš Bartonička14 · Christopher Basler15 · Sina Bavari16 · Martin Beer17 · Dennis A. Bente18 · Éric Bergeron19 · Brian H. Bird20 · Carol Blair21 · Kim R. Blasdell22 · Steven B. Bradfute23 · Rachel Breyta24 · Thomas Briese25 · Paul A. Brown26 · Ursula J. Buchholz27 · Michael J. Buchmeier28 · Alexander Bukreyev18,29 · Felicity Burt30 · Nihal Buzkan31 · Charles H. Calisher32 · Mengji Cao33,34 · Inmaculada Casas35 · John Chamberlain36 · Kartik Chandran37 · Rémi N. Charrel38 · Biao Chen39 · Michela Chiumenti40 · Il‑Ryong Choi41 · J. Christopher S. Clegg42 · Ian Crozier43 · John V. da Graça44 · Elena Dal Bó45 · Alberto M. R. Dávila46 · Juan Carlos de la Torre47 · Xavier de Lamballerie38 · Rik L. de Swart48 · Patrick L. Di Bello49 · Nicholas Di Paola50 · Francesco Di Serio40 · Ralf G. Dietzgen51 · Michele Digiaro52 · Valerian V. Dolja53 · Olga Dolnik54 · Michael A. Drebot55 · Jan Felix Drexler56 · Ralf Dürrwald57 · Lucie Dufkova58 · William G. Dundon59 · W. Paul Duprex60 · John M. Dye50 · Andrew J. Easton61 · Hideki Ebihara62 · Toufc Elbeaino63 · Koray Ergünay64 · Jorlan Fernandes195 · Anthony R. Fooks65 · Pierre B. H. Formenty66 · Leonie F. Forth17 · Ron A. M. Fouchier48 · Juliana Freitas‑Astúa67 · Selma Gago‑Zachert68,69 · George Fú Gāo70 · María Laura García71 · Adolfo García‑Sastre72 · Aura R. Garrison50 · Aiah Gbakima73 · Tracey Goldstein74 · Jean‑Paul J. Gonzalez75,76 · Anthony Grifths77 · Martin H. Groschup12 · Stephan Günther78 · Alexandro Guterres195 · Roy A. -
Borna Disease Virus Infection in Animals and Humans
Synopses Borna Disease Virus Infection in Animals and Humans Jürgen A. Richt,* Isolde Pfeuffer,* Matthias Christ,* Knut Frese,† Karl Bechter,‡ and Sibylle Herzog* *Institut für Virologie, Giessen, Germany; †Institut für Veterinär-Pathologie, Giessen, Germany; and ‡Universität Ulm, Günzburg, Germany The geographic distribution and host range of Borna disease (BD), a fatal neuro- logic disease of horses and sheep, are larger than previously thought. The etiologic agent, Borna disease virus (BDV), has been identified as an enveloped nonsegmented negative-strand RNA virus with unique properties of replication. Data indicate a high degree of genetic stability of BDV in its natural host, the horse. Studies in the Lewis rat have shown that BDV replication does not directly influence vital functions; rather, the disease is caused by a virus-induced T-cell–mediated immune reaction. Because antibodies reactive with BDV have been found in the sera of patients with neuro- psychiatric disorders, this review examines the possible link between BDV and such disorders. Seroepidemiologic and cerebrospinal fluid investigations of psychiatric patients suggest a causal role of BDV infection in human psychiatric disorders. In diagnostically unselected psychiatric patients, the distribution of psychiatric disorders was found to be similar in BDV seropositive and seronegative patients. In addition, BDV-seropositive neurologic patients became ill with lymphocytic meningoencephali- tis. In contrast to others, we found no evidence is reported for BDV RNA, BDV antigens, or infectious BDV in peripheral blood cells of psychiatric patients. Borna disease (BD), first described more predilection for the gray matter of the cerebral than 200 years ago in southern Germany as a hemispheres and the brain stem (8,19). -
Borna Disease Virus
APPENDIX 2 Borna Disease Virus At-Risk Populations: • Unknown Disease Agent: Vector and Reservoir Involved: • Borna disease virus (BDV) • Sporadic enzootic disease of horses and sheep Disease Agent Characteristics: although host range is wide; however, mode of trans- • Family: Bornaviridae; Genus: Bornavirus mission and reservoir is unknown. • Virion morphology and size: Enveloped, helical • Neonatal rats experimentally infected with BDV nucleocapsid symmetry, spherical, 90-100 nm or develop viral persistence, so rodents are a theoretical larger in diameter reservoir and vector, although naturally infected • Nucleic acid: Linear, nonsegmented, negative-sense, rodents have not been found. single-stranded RNA, 8.9 kb in size • Physicochemical properties: Cell-free virion infectiv- Blood Phase: ity is inactivated by heating at 56°C for 0.5-3 hours but • Unknown, but transcripts and proteins detected more stable in tissues or in the presence of serum; in PBMC from patients with acute or chronic under in vitro conditions, virions are relatively stable psychiatric disease; cross-contamination not ruled when stored at 37°C, with minimal loss of infectivity out after 24 hours in the presence of serum; stable after drying and for at least 3 months at 4°C; tolerant of Survival/Persistence in Blood Products: alkaline pH but inactivated below pH 4; virions are • Unknown sensitive to treatment with organic solvents and detergents, and infectivity is reduced after exposure Transmission by Blood Transfusion: to ultraviolet light and irradiation. • Never -
Borna Disease Virus, a Negative-Strand RNA Virus
Proc. Natl. Acad. Sci. USA Vol. 89, pp. 11486-11489, December 1992 Neurobiology Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells (central nervous system infection/behavioral disorders) THOMAS BRIESE*t, JUAN CARLOS DE LA TORREt, ANN LEWIS§, HANNS LUDWIG*, AND W. IAN LIPKIN§¶ *Institute of Virology, Free University of Berlin, Nordufer 20, D 1000 Berlin 65, Federal Republic of Germany; tDepartment of Neuropharmacology, Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037; and IDepartments of Anatomy and Neurobiology, Neurology, and Microbiology and Molecular Genetics, University of California, Irvine, CA 92717 Communicated by D. Carleton Gajdusek, September 1, 1992 (receivedfor review April 22, 1992) ABSTRACT Borna disease virus, an uncas ied Infec- 100,000 x g for 1 hr at 200C, resuspended in 20 mM Tris HCl, tious agent, causes immune-mediated neurologic disease in a pH 7.4/125 mM MgCl2 (Tris-Mg,2 buffer), and treated with wide variety of animal hosts and may be involved in patho- DNase (Boehringer Mannheim) at 50 Ag/ml and RNase genesis of selected neuropsychiatric diseases in man. 1nitial (Boehringer Mannheim) at 50 ,ug/ml for 1 hr at 3TC. Virus reports suggested that Borna disease virus is a singlesranded particles were pelleted at 100,000 x g for 1 hr at 40C and RNA virus. We describe here a method for isolatin of viral resuspended in Tris-Mg,25 buffer for virus titration or nucleic particles that has allowed definitive identification ofthe genome acid extraction. as containg a negative-polarity RNA. Further, we show that Extraction of RNAs from Virus Partickles. -
Bornaviridae
1 Bornaviridae Taxonomy Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Born aviridae Derivation of name Borna refers to the city of Borna in Saxony, Germany, where many horses died in 1885 during an epidemic of a neurological disease, designated as Borna disease (BD), caused by the infectious agent presently known as Borna disease virus (BDV). Genus Bornavirus Type species Borna disease virus Virion properties Morphology Electron microscopy studies of negatively stained infectious particles of an isolate of Borna disease virus (BDV) have shown that virions have a spherical morphology with a diameter of 90±10 nm containing an internal electron-dense core (50–60 nm). Physicochemical and physical properties Virion Molecular weight not known. Virus infectivity is rapidly lost by heat treatment at 56 °C. Virions are relatively stable at 37 °C, and only minimal infectivity loss is observed after 24 hrs incubation at 37 °C in the presence of serum. Virions are inactivated below pH 5.0, as well as by treatment with organic solvents, detergents, and exposure to UV radiation. Infectivity is completely and rapidly destroyed by chlorine-containing disinfectants or formaldehyde treatment. Nucleic acid The genome consists of a single molecule of a linear, negative sense ssRNA about 8.9 kb in size and Mr of about 3×106). The RNA genome is not polyadenylated. Extracistronic sequences are found at the 3′ (leader) and 5′ (trailer) ends of the BDV genome. The ends of the BDV genome RNA exhibit partial Prepared By : Dr. Vandana Gupta 2 inverted complementarity. Full-length plus-strand (antigenomic) RNAs are present in infected cells and in viral ribonucleoproteins. -
Genomic Organization of Borna Disease Virus
Proc. Natl. Acad. Sci. USA Vol. 91, pp. 4362-4366, May 1994 Neurobiology Genomic organization of Borna disease virus (central nervous system Infection/behavioral disorders/negative-strand RNA viruses) THOMAS BRIESE*t, ANETTE SCHNEEMANN*, ANN J. LEWIS*, YOO-SUN PARK*, SARA KIM*, HANNS LUDWIGt, AND W. IAN LIPKIN**§¶ Departments of *Neurology, *Anatomy and Neurobiology, and Microbiology and Molecular Genetics, University of California, Irvine, CA 92717; and tInstitute of Virology, Freie Universitit Berlin, Nordufer 20, D 13353 Berlin, Germany Communicated by Hilary Koprowski, January 27, 1994 ABSTRACT Borna disease virus is a neurotropic negative- RNA. The 5'-terminal sequence from each library was used strand RNA virus that infects a wide range ofvertebrate hosts, to design an oligonucleotide primer for construction of the causing disturbances in movement and behavior. We have next library. cloned and sequenced the 8910-nucleotide viral genome by DNA Sequencing and Sequence Analysis. Plasmid DNA was using RNA from Borna disease virus particles. The viral sequenced on both strands by the dideoxynucleotide chain- genome has complementary 3' and 5' termini and contains termination method (13) using a modified bacteriophage T7 antisense information for five open reading frames. Homology DNA polymerase (Sequenase version 2.0; United States to Filoviridae, Paramyxoviridae, and Rhabdoviridae is found Biochemical). Five to 10 independent clones from each in both cistronic and extracistronic regions. Northern analysis library were sequenced with overlap so that each region of indicates that the virus transcribes mono- and polycistronic the genomic RNA was covered by at least 2 clones. Four RNAs and uses terminatlon/polyadenylylation signals remi- libraries were analyzed, yielding =8.9 kb of continuous niscent ofthose observed in other negative-strand RNA viruses. -
Viral Equine Encephalitis, a Growing Threat
Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe? Sylvie Lecollinet, Stéphane Pronost, Muriel Coulpier, Cécile Beck, Gaëlle Gonzalez, Agnès Leblond, Pierre Tritz To cite this version: Sylvie Lecollinet, Stéphane Pronost, Muriel Coulpier, Cécile Beck, Gaëlle Gonzalez, et al.. Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?. Viruses, MDPI, 2019, 12 (1), pp.23. 10.3390/v12010023. hal-02425366 HAL Id: hal-02425366 https://hal-normandie-univ.archives-ouvertes.fr/hal-02425366 Submitted on 23 Apr 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License viruses Review Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe? Sylvie Lecollinet 1,2,* , Stéphane Pronost 2,3,4, Muriel Coulpier 1,Cécile Beck 1,2 , Gaelle Gonzalez 1, Agnès Leblond 5 and Pierre Tritz 2,6,7 1 UMR (Unité Mixte de Recherche) 1161 Virologie, Anses (the French Agency for Food, Environmental and Occupational Health and Safety), INRAE -
Infections of Horses and Shrews with Bornaviruses in Upper Austria: a Novel Endemic Area of Borna Disease
OPEN Emerging Microbes & Infections (2017) 6, e52; doi:10.1038/emi.2017.36 www.nature.com/emi ORIGINAL ARTICLE Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease Herbert Weissenböck1,*, Zoltán Bagó2,*, Jolanta Kolodziejek3,*, Barbara Hager4, Günter Palmetzhofer5, Ralf Dürrwald3 and Norbert Nowotny3,6 Borna disease, a lethal infection with Borna disease virus-1 (BoDV-1), was diagnosed in four horses from Upper Austria in 2015 and 2016. All cases occurred in winter (two cases in February 2015 and two cases in December 2016), and the maximal distance of the affected stables was 17 km. To demonstrate whether the causative agent was also harbored by its reservoir host, the bicolored white-toothed shrew (Crocidura leucodon), 28 shrews from this geographic area were collected in 2015 and investigated for the presence of BoDV-1. The shrew species were identified according to taxonomic clues and molecular barcodes. Affected horses and all shrews were investigated using histology, immunohistochemistry (IHC) and reverse transcription PCR. The horses exhibited severe nonpurulent encephalitis. Large amounts of BoDV-1 antigen were identified in their CNS. Among the 28 shrews, nine were identified as C. leucodon and 13 as Sorex araneus (Common shrew; Eurasian shrew). Six C. leucodon (66.7%) and one S. araneus (7.7%) had BoDV-1 infections. In accordance with previous findings, the IHC of C. leucodon exhibited a high amount of viral antigen in many neural and extraneural tissues. By contrast, the single positive S. araneus had an exclusively neural staining pattern. Of all positive samples, whole-genome BoDV-1 sequences were generated. -
Disease Virus-Infected Rats Neutralizing Antibodies in Borna
DOWNLOADED FROM Neutralizing antibodies in Borna disease virus-infected rats CG Hatalski, S Kliche, L Stitz, et al. 1995. Neutralizing antibodies in Borna disease jvi.ASM.ORG - virus-infected rats. J. Virol. 69(2):741-747. Updated information and services can be found at: http://jvi.asm.org at COLUMBIA UNIVERSITY July 22, 2010 These include: CONTENT ALERTS Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more>> Information about commercial reprint orders: http://journals.asm.org/misc/reprints.dtl To subscribe to an ASM journal go to: http://journals.asm.org/subscriptions/ DOWNLOADED FROM JOURNAL OF VIROLOGY, Feb. 1995, p. 741–747 Vol. 69, No. 2 0022-538X/95/$04.0010 Copyright q 1995, American Society for Microbiology Neutralizing Antibodies in Borna Disease Virus-Infected Rats 1,2 1 3 1 CAROLYN G. HATALSKI, STEFANIE KLICHE, LOTHAR STITZ, AND W. IAN LIPKIN * Laboratory for Neurovirology, Department of Neurology,1 and Department of Anatomy and Neurobiology,2 University of California, Irvine, California 92717, and Institut fu¨r Virologie, jvi.ASM.ORG - Justus-Liebig-Universita¨t, D-35392 Giessen, Germany3 Received 8 August 1994/Accepted 2 November 1994 Borna disease is a neurologic syndrome caused by infection with a nonsegmented, negative-strand RNA virus, Borna disease virus. Infected animals have antibodies to two soluble viral proteins, p40 and p23, and a at COLUMBIA UNIVERSITY July 22, 2010 membrane-associated viral glycoprotein, gp18. We examined the time course for the development of neutral- ization activity and the expression of antibodies to individual viral proteins in sera of infected rats. -
Avian Bornavirus Infection in Waterfowl
Avian Bornavirus Infection in Waterfowl by Pauline G. Delnatte A Thesis presented to The University of Guelph In partial fulfilment of requirements for the degree of Doctor of Veterinary Science in Pathobiology Guelph, Ontario, Canada ©Pauline G. Delnatte, August, 2013 ii ABSTRACT AVIAN BORNAVIRUS INFECTION IN WATERFOWL Pauline G. Delnatte Advisor: University of Guelph, 2013 Dr. Dale A. Smith Avian bornavirus (ABV) is a newly recognized cause of neurological disease and mortality in free-ranging geese and swans in Ontario. To determine the correlation between clinical signs, pathological lesions and presence of ABV in tissues of wild waterfowl, 955 pathology cases from Canada geese (Branta canadensis), trumpeter swans (Cygnus buccinator) and mute swans (Cygnus olor) were reviewed, and 51 cases selected based on the presence of pathology or clinical history suggestive of ABV infection. The presence of virus in brains, assessed by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) was highly correlated with the presence of non-suppurative inflammation in the central, peripheral and autonomic nervous systems. Partial sequencing of the ABV-nucleocapsid gene from infected geese indicated a unique waterfowl genotype. To estimate the prevalence of ABV infection in southern Ontario, cloacal swabs and blood samples were collected from 624 asymptomatic free-ranging waterfowl and evaluated using RT-PCR and an enzyme-linked immunosorbent assay, respectively. Thirteen percent of Canada geese caught on the Toronto Zoo site shed ABV in urofeces iii compared to none of the geese sampled at three other locations. The prevalences of ABV shedding in mute swans, trumpeter swans and mallard ducks (Anas platyrhynchos) were 9.3%, 0% and 0%, respectively. -
New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections
cells Review New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections Olga Dolnik , Gesche K. Gerresheim and Nadine Biedenkopf * Institute for Virology, Philipps-University Marburg, 35043 Marburg, Germany; [email protected] (O.D.); [email protected] (G.K.G.) * Correspondence: [email protected]; +49-(0)-64212825307 Abstract: Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient viral replication. The induction of those membrane-less viral compartments leads inevitably to structural remodeling of the cellular architecture. Recent studies suggested that viral IBs have properties of biomolecular condensates (or liquid organelles), as have previously been shown for other membrane- less cellular compartments like stress granules or P-bodies. Biomolecular condensates are highly dynamic structures formed by liquid-liquid phase separation (LLPS). Key drivers for LLPS in cells are multivalent protein:protein and protein:RNA interactions leading to specialized areas in the cell that recruit molecules with similar properties, while other non-similar molecules are excluded. These typical features of cellular biomolecular condensates are also a common characteristic in the biogenesis of viral inclusion bodies. Viral IBs are predominantly induced by the expression of the viral nucleoprotein (N, NP) and phosphoprotein (P); both are characterized by a special protein architecture containing multiple disordered regions and RNA-binding domains that contribute to Citation: Dolnik, O.; Gerresheim, different protein functions. P keeps N soluble after expression to allow a concerted binding of N to G.K.; Biedenkopf, N. -
RNA Viruses: Hijacking the Dynamic Nucleolus
REVIEWS RNA viruses: hijacking the dynamic nucleolus Julian A. Hiscox Abstract | The nucleolus is a dynamic subnuclear structure with roles in ribosome subunit biogenesis, mediation of cell-stress responses and regulation of cell growth. The proteome and structure of the nucleolus are constantly changing in response to metabolic conditions. RNA viruses interact with the nucleolus to usurp host-cell functions and recruit nucleolar proteins to facilitate virus replication. Investigating the interactions between RNA viruses and the nucleolus will facilitate the design of novel anti-viral therapies, such as recombinant vaccines and therapeutic molecular interventions, and also contribute to a more detailed understanding of the cell biology of the nucleolus. Positive-strand RNA virus Viruses are obligate intracellular parasites and this char- which in turn are surrounded by a granular component 1 A virus with a single-stranded acteristic is exemplified by RNA viruses . The genomes (FIG. 1). The composition and structure of the nucleolus RNA genome that can function of RNA viruses are usually smaller than the genomes of varies between different biological kingdoms. In mam- as an mRNA without further DNA viruses, and RNA viruses are therefore more malian cells the nucleolus is present during interphase transcription. reliant on subverting host-cell proteins, and cellular but disintegrates and reforms in mitosis4. In yeast the Negative-strand RNA virus structures and functions to facilitate virus replication. nucleolus is present throughout the cell cycle and is A virus with a single-stranded One structure that is targeted by RNA viruses is the proximal to the nuclear envelope. Plant-cell nucleoli RNA genome that is nucleolus, a dynamic subnuclear structure.