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2021 Revision 3 Our Commitment to the Customer We at ScyTek Laboratories, Inc. have committed ourselves to producing only the highest quality products for the laboratory market. Since the company was founded in 1991, ScyTek has continued to grow at a rapid rate as a result of our commitment to continuous improvement of each and every product line. In addition, aggressive pricing through vigilant cost containment and continuous improvements in efficiency combined with our commitment to quality have helped to foster strong customer bonds. While the majority of our business consists of producing custom reagents for the resale/OEM market, we still insist on providing only the highest quality service for those customers that use the product in their own laboratories. Being a primary manufacturer allows ScyTek to continually identify areas that can be improved through the implementation of Kaizen and other manufacturing management techniques. Being a primary manufacturer also allows the customer to have maximum flexibility in the products specifications making ScyTek an ideal manufacturing partner. ScyTek has the ability to produce and vial products in various environmental conditions up to Class 1000. For our OEM customers, we have the capability of producing most any liquid or dry blend for the laboratory and can customize packaging to meet nearly any requirement. Whether the product is an off- the-shelf item, or one made specifically to meet the customer’s needs, we are committed to delivering the product when expected and matching the anticipated specifications. As the President of ScyTek Laboratories, Inc., I encourage you to contact me directly with any questions or comments regarding the performance of our company or our products. -
Maccarrone-G.Pdf
Journal of Chromatography B, 1047 (2017) 131–140 Contents lists available at ScienceDirect Journal of Chromatography B jou rnal homepage: www.elsevier.com/locate/chromb MALDI imaging mass spectrometry analysis—A new approach for protein mapping in multiple sclerosis brain lesions a,b,1 a,1 c Giuseppina Maccarrone , Sandra Nischwitz , Sören-Oliver Deininger , a d,e d Joachim Hornung , Fatima Barbara König , Christine Stadelmann , b,1 a,f,∗,1 Christoph W. Turck , Frank Weber a Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany b Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Germany c Bruker Daltonik GmbH, Fahrenheitstr. 4, 28359 Bremen, Germany d Institute of Neuropathology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany e Institut für Pathologie, Klinikum Kassel, Mönchebergstr. 41-43, 34125 Kassel, Germany f Medical Park Bad Camberg, Obertorstr. 100-102, 65520 Bad Camberg, Germany a r t i c l e i n f o a b s t r a c t Article history: Multiple sclerosis is a disease of the central nervous system characterized by recurrent inflammatory Received 21 February 2016 demyelinating lesions in the early disease stage. Lesion formation and mechanisms leading to lesion Accepted 1 July 2016 remyelination are not fully understood. Matrix Assisted Laser Desorption Ionisation Mass Spectrom- Available online 1 July 2016 etry imaging (MALDI–IMS) is a technology which analyses proteins and peptides in tissue, preserves their spatial localization, and generates molecular maps within the tissue section. In a pilot study we Keywords: employed MALDI imaging mass spectrometry to profile and identify peptides and proteins expressed in MALDI imaging mass spectrometry normal-appearing white matter, grey matter and multiple sclerosis brain lesions with different extents LC–ESI–MS/MS of remyelination. -
(12) United States Patent (10) Patent No.: US 7,993,927 B2 Frangioni (45) Date of Patent: Aug
US007993 927B2 (12) United States Patent (10) Patent No.: US 7,993,927 B2 Frangioni (45) Date of Patent: Aug. 9, 2011 (54) HISTOLOGY METHODS FOREIGN PATENT DOCUMENTS WO WO96, 17628 6, 1996 (75) Inventor: John V. Frangioni, Wayland, MA (US) WO WO98,22146 5, 1998 WO WO98,48838 11, 1998 (73) Assignee: Beth Israel Deaconess Medical Center, WO WO 98.48846 11, 1998 Inc., Boston, MA (US) WO WO O2/O98885 12/2002 OTHER PUBLICATIONS (*) Notice: Subject to any disclaimer, the term of this Parungo et al., “Intraoperative identification of esophageal sentinel patent is extended or adjusted under 35 1ymph nodes with near-infrared fluorescence imaging'.--- - - - - J. Thorac. U.S.C. 154(b) by 1070 days. Cardiovasc. Surg., Apr. 2005; 129: 84.* Kim et al., “Near-infrared fluorescent type II quantum dots for sen (21) Appl. No.: 11/824,915 tinellymph node mapping”. Nature Biotechnology 22,93-97 (Jan. 1, 2004).* (22) Filed: Jul. 3, 2007 gatesBrinkley, with "A Dyes, Brief Haptens, Survey ofand Methods Cross-Linking for Preparing Reagents'. Protein Perspec Conju O O tives in Bioconjugate Chemistry, pp. 59-70, C. Meares (Ed.), ACS (65) Prior Publication Data Publication, Washington, D.C. (1993). US 2008/OO7356.6 A1 Mar 27, 2008 Frangioni, J.V., “In vivo near-infrared fluorescence imaging. Curr. • 1- s Opin. Chem. Biol. 7:626-634 (2003). O O Hilger et al., “Near-infrared fluorescence imaging of HER-2 protein Related U.S. Application Data over-expression in tumour cells'. Eur, Radiol., 14:1124-1129 (2004). Li et al., “Tumor Localization Using Fluorescence of Indocyanine (60) Provisional application No. -
Snomed Ct Dicom Subset of January 2017 Release of Snomed Ct International Edition
SNOMED CT DICOM SUBSET OF JANUARY 2017 RELEASE OF SNOMED CT INTERNATIONAL EDITION EXHIBIT A: SNOMED CT DICOM SUBSET VERSION 1. -
Luxol Fast Blue Protocol Ihc World
Luxol Fast Blue Protocol Ihc World RedfordIs Len shadowed absterging when distractedly Zacharias if singling euhemerizing Clyde loudensdespotically? or burgeons. Fractional Barnard pre-empt very distressfully while Bartlet remains spick and undespairing. HE staining of PFA fixed, frozen postmortem human brain tissue. Gmri trichrome stain Luxol fast red stain Methyl blue Movat's stain. Members have heavy walls in tap water. Product Description IHC World control slides are prepared using top quality tissues that ever been processed embedded and sectioned following standard. Ministerial action group on time would have likewise banded together. White glass, with ground edges. SVF offers advantages of direct with rapid isolation procedure to a xenobiotic-free environment. A fast music-resolution single-point 3D MPF mapping protocol was. MS is an autoimmune disease that causes demyelination of the neurons in the central nervous system. The world by two high on request is better tissue is made at sakura finetek usa, but we can easily. The presence of a tumor and its distance from the surgical margin is an essential element of tumor assessment. For Researchers Icahn School wilderness Medicine. Alternatively, the devise may be embedded separately, in specific ways, such equation the valves may be viewed optimally, or embedded with the apex first, poll that sections will play both ventricles for evaluation of thickness etc. Please support our research. Made of acetal polymer. The agreement tended to be better for FNACs than fluid specimens. These cassettes are used luxol fast blue, all protocols were approved. HT 09 Nerve Flashcards Quizlet. CNS by matrine in experimental autoimmune encephalomyelitis. -
Are Routine Methods Good Enough to Stain Senile Plaques and Neurofibrillary Tangles in Different Brain Regions of Demented Patie
Psychiatria Danubina, 2011; Vol. 23, No. 4, pp 334-339 Original paper © Medicinska naklada - Zagreb, Croatia ARE ROUTINE METHODS GOOD ENOUGH TO STAIN SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN DIFFERENT BRAIN REGIONS OF DEMENTED PATIENTS? Paraskevi Mavrogiorgou1,3, Hermann-Josef Gertz2, Ron Ferszt3, Rainer Wolf1, Karl-Jürgen Bär1 & Georg Juckel1,3 1Department of Psychiatry, Ruhr University, Bochum, Germany 2Department of Psychiatry, University Leipzig, Germany 3Department of Psychiatry, Charité – University Medicine Berlin, Campus Mitte, Berlin, Germany received: 10.8.2010; revised: 11.9.2011; accepted: 24.10.2011 SUMMARY Introduction: Numerous clinical cases have been reported showing the clinical picture of dementia but not meeting the neuropathological criteria for Alzheimer’s dementia (AD). Different methods used to stain senile plaques (SPs) and neurofibrillary tangles (NFTs) might account for this discrepancy. Subjects and methods: Here, brains of 11 patients with dementia were examined. Cryosections and paraffin sections from 6 different brain regions (frontal medial, temporal medial and occipital gyrus, hippocampus, superior parietal lobe and cerebellum) of all cases were stained with Bielschowsky, Campbell, Gallyas and Congo red stains each. Results: The study shows that the Bielschowsky silver stain is insufficient for detecting SPs and NFTs, whereas two other methods proved to be more accurate. SPs were found in similar frequency in all brain regions examined (exception: cerebellum). The highest amount was shown with Campbell silver stain in paraffin sections. In Congo red only 25 percent of these SPs were stained, which is probably due to a great number of them not containing any amyloid. NFTs were found almost exclusively in the hippocampus. -
We're on Your Team. 1-800-442-3573 Today the World Looks Different Than It Did a Year Ago
NEW! INTERACTIVE DIGITAL EDITION We're on your team. 1-800-442-3573 Today the world looks different than it did a year ago. And that makes having a reliable partner for laboratory supplies even more important. We're navigating a new world together— manufacturing more products than ever to create a stable supply chain, expanding our capacity with a new distribution center and manufacturing capabilities, and launching new product categories to ensure you have what you need to take care of patients. We're on your team. ISO 13485 certified 5,000 products to meet manufacturer your laboratory needs Quality Management Systems ensure Including a full line of advanced reliable products you can count on diagnostics products and equipment 2 1-800-442-3573 WASHINGTON Mt. Vernon, WA 98273 MARYLAND Columbia, MD 21046 zoom zoom by noon TEXAS McKinney, TX 75069 Order by 12PM CST for same-day shipping. Simple, fast ordering. Call Online We make it easy to access what you need, 1-800-442-3573 ext. 2 statlab.com starting by shipping your order the same day it's received. Place your order early in the day to ensure same-day shipping from our three distribution centers. • Emergency or next-day air delivery options (non-hazardous only) Fax Email • No-questions-asked quality guarantee 972-436-1369 [email protected] Dedicated technical support and Not a current customer? product development teams No problem. Call 1-800-442-3573, ext. 5 Call 1-800-442-3573, ext. 2 to order— in 5 Email [email protected] minutes you'll have an account number Visit StatLab.com and be set to order online in the future. -
Quantitative and Histomorphological Studies on Age-Correlated Changes in Canine and Porcine Hypophysis Lakshminarayana Das Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1971 Quantitative and histomorphological studies on age-correlated changes in canine and porcine hypophysis Lakshminarayana Das Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Animal Structures Commons, and the Veterinary Anatomy Commons Recommended Citation Das, Lakshminarayana, "Quantitative and histomorphological studies on age-correlated changes in canine and porcine hypophysis" (1971). Retrospective Theses and Dissertations. 4873. https://lib.dr.iastate.edu/rtd/4873 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. 71-26,847 DAS, Lakshminarayana, 1936- QUANTITATIVE AND HISTOMORPHOLOGICAL STUDIES ON AGE-CORRELATED CHANGES IN CANINE AND PORCINE HYPOPHYSIS (VOLUMES I AND II). Iowa State University, Ph.D., 1971 Anatomy• University Microfilms, A XEROX Company, Ann Arbor. Michigan Quantitative and histomorphological studies on age-correlated changes in canine and porcine hypophysis py Lakshminarayana Das Volume 1 of 2 A Dissertation Submitted to the Graduate Faculty in Partial Fulfillment of The Requirements for the Degree of DOCTOR OP PHILOSOPHY Major Subject: -
Gram Stain Kit (Gram Fuchsin Counterstain)
Simplicity for Science Stain Kits 1 Contact Us About Us +44 (0) 161 366 5123 Atom Scientific is a specialised manufacturer of diagnostic reagents [email protected] with over 50 years in delivering exceptional quality to the life science industry throughout the world +44 (0) 1704 33 7167 ISO15189 compliant products simply delivering consistency History Quality Facilities www.atomscientific.com and reliability to Life Sciences Established in 2009, Atom Our Quality Management In 2014, the company Scientific is a specialist Systems are Certificated to opened our current single Orders manufacturer of diagnostic ISO9001:2008 site facility in Manchester, stains and reagents for Life enabling Atom Scientific Orders can be placed On-Line, by Email or by Fax Science Laboratories Our QA/Compliance Team to significantly increase ensure our products are fully operational capacity, whilst As the business has grown auditable from raw material ensuring compliance to all [email protected] it has organically grown its to finished product current and future legislation. product range to incorporate We specialise in finished All orders must include Delivery and a comprehensive range Our Life Science Testing product pack sizes from Invoice Address and product of chemicals to suit our Laboratory is operated by 10ml/10gm to 25L/25Kg and information as follows: customer’s needs experienced Life Scientists, have manufacturing capacity ensuring our products • Product Code for batches from 500ml • Product Name Our Primary Aims are to are compliant -
The Mechanical Importance of Myelination in the Central Nervous System ⁎ Johannes Weickenmeiera, Rijk De Rooija, Silvia Buddayb, Timothy C
Journal of the Mechanical Behavior of Biomedical Materials xxx (xxxx) xxx–xxx Contents lists available at ScienceDirect Journal of the Mechanical Behavior of Biomedical Materials journal homepage: www.elsevier.com/locate/jmbbm The mechanical importance of myelination in the central nervous system ⁎ Johannes Weickenmeiera, Rijk de Rooija, Silvia Buddayb, Timothy C. Ovaertc, Ellen Kuhld, a Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA b Chair of Applied Mechanics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany c Department of Aerospace and Mechanical Engineering, The University of Notre Dame, Notre Dame, IN 46556, USA d Departments of Mechanical Engineering and Bioengineering, Stanford University, Stanford, CA 94305, USA ARTICLE INFO ABSTRACT Keywords: Neurons in the central nervous system are surrounded and cross-linked by myelin, a fatty white substance that Brain wraps around axons to create an electrically insulating layer. The electrical function of myelin is widely Stiffness recognized; yet, its mechanical importance remains underestimated. Here we combined nanoindentation testing Indentation and histological staining to correlate brain stiffness to the degree of myelination in immature, pre-natal brains White matter and mature, post-natal brains. We found that both gray and white matter tissue stiffened significantly Myelin (p ≪ 0.001) upon maturation: the gray matter stiffness doubled from 0.31 ± 0.20 kPa pre-natally to Myelination 0.68 ± 0.20 kPa post-natally; the white matter stiffness tripled from 0.45 ± 0.18 kPa pre-natally to 1.33 ± 0.64 kPa post-natally. At the same time, the white matter myelin content increased significantly (p ≪ 0.001) from 58 ± 2% to 74 ± 9%. -
1. Aldehyde Fuchsin - Can Be Used to Stain Pancreatic Islet Beta Cell Granules 2
1. Aldehyde Fuchsin - can be used to stain pancreatic islet beta cell granules 2. Alician Blue - a Mucin stain (a category of histology stains, listed below) - can stain mucins and mucosubstances blue (due to the copper in the stain) 3. Alizarin Red S - can be used to identify calcium in tissue sections - used on the Dupont ACA analyzer to measure serum calcium photometrically 4. Alkaline Phosphatase - can be used to stain endothelial cells 5. Azan Stain - can be used to differentiate osteoid from mineralised bone 6. Bielschowsky Stain - can be used to show reticular fibres - used for showing neurofibrillary tangles and senile plaques - uses the chemical element silver (Ag) 7. Cajal Stain - can be used on nervous tissue. 8. Congo Red - used to stain amyloid fibres (to appear orange/red). 9. Cresyl Violet - will stain both neurons and glia - bonds with acidic parts of cells such as ribosomes, nuclei and nucleoli 10. Eosin - commonly used for general histology staining when paired with haematoxylin - see Hematoxylin and Eosin (H&E) 11. Fontana-Masson - uses the chemical element silver (Ag) - stains argentaffin granules and melanin black - while also staining nuclei pink/red and cytoplasm light pink - a specific example of a Melanin Stain (general category of histology stains) 12. Giemsa Stain - a Romanowski (also written "Romanowsky") type stain - used for peripheral blood smears, i.e. a thin layer of blood smeared on a microscope slide and used for bone marrow. - used to study parasites and malaria 13. Golgi Stain - can be used to stain neurons 14. Gomori Trichrome - trichrome histology stains are formed from a mixture of three dyes - Gomori's trichrome stains connective tissue and collagen (green or blue), muscle, keratin and cytoplasm (red) and nuclei (grey/blue/black) 15. -
The Use of GMDN Codes for IVD Medical Devices in Australia
The use of GMDN codes for IVD medical devices in Australia September 2010 Therapeutic Goods Administration About the Therapeutic Goods Administration (TGA) · The TGA is a division of the Australian Government Department of Health and Ageing, and is responsible for regulating medicines and medical devices. · TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. · The work of the TGA is based on applying scientific and clinical expertise to decision-making, to ensure that the benefits to consumers outweigh any risks associated with the use of medicines and medical devices. · The TGA relies on the public, healthcare professionals and industry to report problems with medicines or medical devices. TGA investigates reports received by it to determine any necessary regulatory action. · To report a problem with a medicine or medical device, please see the information on the TGA website. Copyright © Commonwealth of Australia 2010 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be reproduced by any process without prior written permission from the Commonwealth. Requests and inquiries concerning reproduction and rights should be addressed to the Commonwealth Copyright Administration, Attorney General’s Department, National Circuit, Barton ACT 2600 or posted at http://www.ag.gov.au/cca The use of GMDN codes for IVD medical devices in Australia, Page i September 2010 Therapeutic Goods Administration The use of GMDN codes for IVD medical devices in Australia This section Global Medical Device Nomenclature (GMDN) ...............................................