bioRxiv preprint doi: https://doi.org/10.1101/2020.05.14.096990; this version posted May 16, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Loss of FSTL1-expressing adipocyte progenitors drives the age-related involution of brown adipose tissue Zan Huang1,2,3,12,*, Zengdi Zhang3,12, Ryan Heck3, Ping Hu4, Hezkiel Nanda5, Kaiqun Ren3,6, Zequn Sun7, Alessandro Bartolomucci3, Yan Gao8, Dongjun Chung9, Weiyun Zhu1,2, Steven Shen5,10, Hai-Bin Ruan3,11,*,# 1Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agriculture University, Nanjing, Jiangsu, China 2National Center for International Research on Animal Gut Nutrition, Nanjing Agriculture University, Nanjing, Jiangsu, China 3Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA 4Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China 5Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA 6College of Medicine, Hunan Normal University, Changsha, Hunan, China 7Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA 8Department of Human Anatomy, School of Basic Medical Sciences, Capital Medical University, Beijing, China 9Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210, USA 10Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA 11Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA 12These authors contributed equally. *Correspondence: H.-B. R. (
[email protected]) or Z.