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EFEK PEMBERIAN EKSTRAK DAUN GANDARUSA (Justicia Gendarussa Burm F

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EFEK PEMBERIAN EKSTRAK DAUN GANDARUSA (Justicia Gendarussa Burm F EFEK PEMBERIAN EKSTRAK DAUN GANDARUSA (Justicia gendarussa Burm F. )TERHADAP KADAR HORMON ESTRADIOL ENDOGEN DAN PERUBAHAN GAMBARAN HISTOLOGI FOLIKEL ANTRAL OVARIUM PADA MENCIT BETINA TESIS Untuk memenuhi persyaratan mencapai derajat Sarjana S-2 Magister Ilmu Biomedik Ni’mah Hidayatul Laili 15 501 0060 PROGRAM STUDI MAGISTER BIOMEDIK FAKULTAS KEDOKTERAN UNIVERSITAS ISLAM SULTAN AGUNG SEMARANG 2018 TESIS EFEK PEMBERIAN EKSTRAK DAUN GANDARUSA (JusticiagendarussaBurmF.)TERHADAP KADAR HORMON ESTRADIOL ENDOGEN DAN PERUBAHAN GAMBARAN HISTOLOGI FOLIKEL ANTRAL OVARIUM PADA MENCIT BETINA Disusun oleh Ni’mah Hidayatul Laili MBK. 15 501 0060 telah dipertahankan di depan Tim Penguji pada tanggal 23 Oktober 2017 dan dinyatakan telah memenuhi syarat untuk diterima Menyetujui, Pembimbing Pembimbing I Pembimbing II Prof. Dr.dr.H. Taufiq R.Nasihun,M.Kes,Sp.AndDr.Ir.Hj.Titiek Sumarawati,M.Kes NIK. 220186022 NIK.2230198045 Mengetahui, Ketua Program Studi Magister Ilmu Biomedik Fakultas Kedokteran Universitas Islam Sultan Agung Prof. Dr.dr.H. Taufiq R. Nasihun,M.Kes, Sp.And NIK. 220186022 PERNYATAAN Dalam ini saya menyatakan bahwa tesis ini adalah hasil pekerjaan saya sendiri dan di dalamnya terdapat karya yang pernah diajukan untuk memperoleh gelar kesarjanaan di suatu perguruan tinggi dan lembaga pendidikan lainnya. Pengetahuan yang diperolehdarihasilpenerbitanmaupun yang belum / tidakditerbitkan, sumbernyadijelaskan di dalamtulisandandaftarpustaka. Semarang, Oktober 2017 ( Ni’mahHidayatulLaili ) RIWAYAT HIDUP A. Identitas Nama : Ni’mah HidayatulLaili Tempat / tanggalLahir : Karanganyar, 11 Januari 1992 Agama : Islam JenisKelamin : Perempuan B. RiwayatPendidikan : 1. SDN Potronayan 01 : Lulus tahun 2004 2. SMP AL – MUAYYAD Surakarta : Lulus tahun 2007 3. SMA AL-MUAYYAD Surakarta : Lulus tahun 2010 4. D III KebidananEstuUtomoBoyolali : Lulus tahun 2013 5. D IV StikesKaryaHusada Semarang : Lulus tahun 2014 6. Magister IlmuBiomedik FK UNISSULA ( 2015 – sekarang ) C. RiwayatPekerjaan : Klinik AN-NUR, Surakarta D. RiwayatKeluarga : 1. Nama Orang Tua Ayah :H. MaryonoS.Pd Ibu : Hj. SriyatiM.Pd 2. NamaSuami : Arif WahibNuryanta Amd.Rad 3. NamaAnak : Arsyfa HibatillahWahib KATA PENGANTAR Segala puji dan syukur kepada ALLAH SWT atas segala rahmat, anugerah dan pertolongannya sehingga penulis dapat menyelesaikan penyusunan Tesis dengan judul “EfekPemberian Ekstrak Daun Gandarusa (Justicia gendarussa, Burm f.)terhadap Kadar Hormon Estradiol Endogen dan Perubahan Gambaran Histologi Folikel Antral Ovarium pada Mencit Betina”. Tesis ini disusun sebagai salah satu persyaratan untuk memperoleh gelar Magister Ilmu Biomedikdari Program Studi Magister Biomedik Fakultas Kedokteran Universitas Islam Sultan Agung Semarang. Tesis ini dapat diselesaikan atas bimbingan, arahan dan bantuan dari berbagai pihak, oleh karena itu pada kesempatan ini penulis mengucapkan terimakasih dengan ketulusan serta rasa hormat kepada: 1. DR. dr.Setyo Trisandi, SH, Sp.F selaku DekanUniversitas Islam Sultan Agung Semarang. 2. Prof. DR. dr. H. Taufiq R. Nasihun, M.Kes, Sp.And selaku Ketua Program Magister Ilmu Biomedis Fakultas Kedokteran Unissula, Pembimbing I 3. Dr. Ir. Hj. TitiekSumarawati, M.Kes selaku pembimbing II 4. Dr. Drs. H. Israhnanto Isradji, Msi selaku Penguji I 5. Dr. dr. Hj. Chodidjah,M.Kes.PA selaku Penguji II 6. Dr. Hj. Atina Hussaana, Msi.Apt selaku penguji III Akhirnya penulis menyampaikan terima kasih yang besar kepada keluarga tercinta : Ayahanda dan Ibunda tercinta H.Maryono S.Pd dan Hj.Sriyati M.Pd, kakak dan adik-adik tersayang aunty kembar Afifah Azizah,omIrfan, Mukhlis, Iza dan Aunty Mutiara, mamah Fatiemah El-loekman, Ulfi, Linda atas doa dan cinta kasih,dukungan dan toleransi yang sangat luar biasa. Terimakasih juga untuk Suami Arif Wahib Nuryanta, Amd.Rad dan putriku terkasih Arsyfa Hibatillah Wahib atas dukungan dan pengorbanannya menemani penulis selama menyelesaikan pendidikan. SemogaALLAH SWTsenantiasamelimpahkanrahmat-Nyakepadakita semua. Akhir kata, penulismenyadaribahwadalampenyusunanTesisinimasihjauh dari sempurna, sebab di dunia ini tidak ada yang sempurna,kecuali Allah SWT semata. Karenaitu, penulis mengharapkan saran dan kritik demi perbaikan di masa yang akan datang. Semarang,Oktober2017 Ni’mah HidayatulLaili DAFTAR ISI Halaman HALAMAN JUDUL .......................................................................................... i HALAMAN PERSETUJUAN ............................................................................ ii PERNYATAAN.........................................................................................iii RIWAYAT HIDUP.....................................................................................iv KATA PENGANTAR ....................................................................................... v DAFTAR ISI ......................................................................................................vii DAFTAR TABEL ..............................................................................................ix DAFTAR GAMBAR .........................................................................................x DAFTAR SINGKATAN ...................................................................................xi DAFTAR LAMPIRAN .......................................................................................xii ABSTRAK ..........................................................................................................xiii BAB I PENDAHULUAN ............................................................................. 1 1.1. LatarBelakang ........................................................................... 1 1.2. RumusanMasalah ...................................................................... 4 1.3. TujuanPenelitian ....................................................................... 4 1.4. OriginalitasPenelitian ................................................................ 5 1.5. ManfaatPenelitian ..................................................................... 7 BAB II TINJAUAN PUSTAKA .................................................................... 8 2.1. Hormon Estrogen ...................................................................... 8 2.1.1. Hormon Estrogen ......................................................... 8 2.1.2. Efek Estrogen Sebagai TSH .......................................... 9 2.1.3. Menopause ...................................................................10 2.1.4. Tahap – tahap Menopause ............................................12 2.2. Histologi Ovarium .....................................................................13 2.3. Daun Gandarusa ........................................................................25 2.4. HubunganantaraDaunGandarusadenganMeningkatnyaHormo n Estrogen danHistologiOvarium .............................................. 33 BAB III KERANGKA TEORI, KERANGKAN KONSEP DAN HIPOTESIS 36 3.1. KerangkaTeori........................................................................... 36 3.2. KerangkaKonsep ....................................................................... 38 3.3. HipotesisPenelitian .................................................................... 39 BAB IV METODE PENELITIAN .................................................................. 40 4.1. JenisdanDesainPenelitian .......................................................... 40 4.2. PopulasidanSampelPenelitian ................................................... 41 4.3. VariabelPenelitian ..................................................................... 41 4.4. DefinisiOperasionaldanSkalaPengukuran ................................. 42 4.5. Bahan/Materipenelitian ............................................................. 43 4.6. Cara PenelitiandanAlurKerjaPenelitian .................................... 44 4.7. TeknikPengumpulan Data ........................................................ 49 4.8. Analisis Data ............................................................................ 49 4.9. JadwalPelaksanaannyaPenelitian .............................................. 50 BAB V. HASIL DAN PEMBAHASAN ............................................................ 51 5.1. Hasil ............................................................................................ 51 5.2. Pembahasan ................................................................................ 57 BAB VI. KESIMPULAN DAN SARAN ...........................................................63 6.1. Kesimpulan ..................................................................................63 6.2. Saran ........................................................................................... 63 DAFTAR PUSTAKA ........................................................................................ 64 LAMPIRAN ................................................................................................... 67 DAFTAR TABEL Tabel 1.1 OriginalitasPenelitian .......................................................................5 Tabel 5.1 Data Hasil Perlakuan ........................................................................50 Tabel 5.2 Uji Post-Hoct Variabel Hormon Estradiol Endogen........................ 55 Tabel 5.3 Uji Post-HoctVariabel Histologi Folikel Antral Ovarium kiri...... ...55 Tabel 5.4 Uji Post-Hoct Variabel Histologi Folikel Antral Ovarium kanan... 55 Tabel 5.5 Data KorelasiHormon Estradiol Endogen denganOvariumKiri.......56 Tabel 5.6 Data KorelasiHormon Estradiol Endogen denganOvariumkanan.56 DAFTAR GAMBAR Gambar 2.1 Ovarium ......................................................................................
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