Glyceollins Trigger Anti-Proliferative Effects Through Estradiol-Dependent
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Biologically Active Molecules from Soybeans
10 Biologically Active Molecules from Soybeans Michio Kurosu Department of Pharmaceutical Sciences, University of Tennessee Health Science Center USA 1. Introduction Soybeans (Glycine max [L.] Merr.) contain an impressive array of biologically active components. People have been eating soybeans for almost 5,000 years. Unlike most plant foods, soybeans are high in protein. Researchers are interested in both the nutritional value and the potential health benefits of soybeans. Research of the health effects of soyfoods and soybean constituents has been received significant attention to support the health improvements or health risks observed clinically or in vitro experiments. This research includes a wide range of areas, such as cancer, coronary heart disease (cardiovascular disease), osteoporosis, cognitive function (memory related), menopausal symptoms, renal function, and many others. This chapter provides up-to-date coverage on biologically active and related organic molecules isolated from soy and soy products. Their biological activities are briefly summarized. Molecules discussed in this chapter are as follows: isoflavones, phytic acid, soy lipids, soy phytoalexins, soyasaponins, lectins, hemagglutinin, soy toxins, and vitamins. 2. Health benefit of soy or soy products Soy products have been considered as great source of protein for many decades. Japanese, in particular, eat a soy-based diet. Japanese monks eat soy products as their main protein source. They are known to live longer and have lower rates of chronic diseases. Because soybeans contain practically no starch, soybeans are an important part of a diabetic diet. Soybeans are 1) rich in protein (vide supra), calcium, and vitamins, and 2) high in mono- saturated fatty acids. In addition, soybeans contain several biologically interesting phytochemicals as minor components, which scientists are interested in understanding their biological functions. -
Metabolomics and Transcriptomics Identify Multiple Downstream Targets of Paraburkholderia Phymatum Σ54 During Symbiosis with Phaseolus Vulgaris
Research Collection Journal Article Metabolomics and Transcriptomics Identify Multiple Downstream Targets of Paraburkholderia phymatum σ54 During Symbiosis with Phaseolus vulgaris Author(s): Lardi, Martina; Liu, Yilei; Giudice, Gaetano; Ahrens, Christian H.; Zamboni, Nicola; Pessi, Gabriella Publication Date: 2018-04 Permanent Link: https://doi.org/10.3929/ethz-b-000258158 Originally published in: International Journal of Molecular Sciences 19(4), http://doi.org/10.3390/ijms19041049 Rights / License: Creative Commons Attribution 4.0 International This page was generated automatically upon download from the ETH Zurich Research Collection. For more information please consult the Terms of use. ETH Library International Journal of Molecular Sciences Article Metabolomics and Transcriptomics Identify Multiple Downstream Targets of Paraburkholderia phymatum σ54 During Symbiosis with Phaseolus vulgaris Martina Lardi 1, Yilei Liu 1, Gaetano Giudice 1, Christian H. Ahrens 2, Nicola Zamboni 3 and Gabriella Pessi 1,* ID 1 Department of Plant and Microbial Biology, University of Zurich, CH-8057 Zurich, Switzerland; [email protected] (M.L.); [email protected] (Y.L.); [email protected] (G.G.) 2 Agroscope, Research Group Molecular Diagnostics, Genomics and Bioinformatics & Swiss Institute of Bioinformatics (SIB), CH-8820 Wädenswil, Switzerland; [email protected] 3 Institute of Molecular Systems Biology, ETH Zurich, CH-8093 Zurich, Switzerland; [email protected] * Correspondence: [email protected]; Tel.: +41-44-6352904 Received: 28 February 2018; Accepted: 28 March 2018; Published: 1 April 2018 Abstract: RpoN (or σ54) is the key sigma factor for the regulation of transcription of nitrogen fixation genes in diazotrophic bacteria, which include α- and β-rhizobia. -
The Pharmacologist 2 0 0 6 December
Vol. 48 Number 4 The Pharmacologist 2 0 0 6 December 2006 YEAR IN REVIEW The Presidential Torch is passed from James E. Experimental Biology 2006 in San Francisco Barrett to Elaine Sanders-Bush ASPET Members attend the 15th World Congress in China Young Scientists at EB 2006 ASPET Awards Winners at EB 2006 Inside this Issue: ASPET Election Online EB ’07 Program Grid Neuropharmacology Division Mixer at SFN 2006 New England Chapter Meeting Summary SEPS Meeting Summary and Abstracts MAPS Meeting Summary and Abstracts Call for Late-Breaking Abstracts for EB‘07 A Publication of the American Society for 121 Pharmacology and Experimental Therapeutics - ASPET Volume 48 Number 4, 2006 The Pharmacologist is published and distributed by the American Society for Pharmacology and Experimental Therapeutics. The Editor PHARMACOLOGIST Suzie Thompson EDITORIAL ADVISORY BOARD Bryan F. Cox, Ph.D. News Ronald N. Hines, Ph.D. Terrence J. Monks, Ph.D. 2006 Year in Review page 123 COUNCIL . President Contributors for 2006 . page 124 Elaine Sanders-Bush, Ph.D. Election 2007 . President-Elect page 126 Kenneth P. Minneman, Ph.D. EB 2007 Program Grid . page 130 Past President James E. Barrett, Ph.D. Features Secretary/Treasurer Lynn Wecker, Ph.D. Secretary/Treasurer-Elect Journals . Annette E. Fleckenstein, Ph.D. page 132 Past Secretary/Treasurer Public Affairs & Government Relations . page 134 Patricia K. Sonsalla, Ph.D. Division News Councilors Bryan F. Cox, Ph.D. Division for Neuropharmacology . page 136 Ronald N. Hines, Ph.D. Centennial Update . Terrence J. Monks, Ph.D. page 137 Chair, Board of Publications Trustees Members in the News . -
(12) United States Patent (10) Patent No.: US 8,829,205 B2 Jeon Et Al
USOO8829205B2 (12) United States Patent (10) Patent No.: US 8,829,205 B2 Jeon et al. (45) Date of Patent: Sep. 9, 2014 (54) METHOD FOR PREPARING COUMESTROL (58) Field of Classification Search AND COUMESTROL PREPARED BY SAME USPC ........................................... 549/279; 435/119 See application file for complete search history. (75) Inventors: Hee Young Jeon, Yongin-si (KR); Dae Bang Seo, Yongin-si (KR); Si Young (56) References Cited Cho, Seoul (KR); Sang Jun Lee, U.S. PATENT DOCUMENTS Seongnam-si (KR) 3,564,019 A * 2/1971 Holmlund et al. ............ 549,279 (73) Assignee: Amorepacific Corporation, Seoul (KR) 6,129,937 A 10/2000 Zurbriggen et al. (*) Notice: Subject to any disclaimer, the term of this FOREIGN PATENT DOCUMENTS patent is extended or adjusted under 35 EP 1357,807 B1 3, 2007 U.S.C. 154(b) by 226 days. JP 2008-120729. A 5/2008 KR 10-0360306 B1 11, 2002 (21) Appl. No.: 13/575,267 KR 10-0706279 B1 4/2007 KR 10-0778.938 B1 11, 2007 (22) PCT Filed: Jan. 31, 2011 WO WOO1f97769 A1 12/2001 OTHER PUBLICATIONS (86). PCT No.: PCT/KR2O11AOOO673 S. M. Boué et al., “Induction of the Soybean Phytoalexins S371 (c)(1), Coumestrol and Glyceollin by Aspergillus,” J. Agric. Food Chem. (2), (4) Date: Jul. 25, 2012 vol. 48, No. 6, pp. 2167-2172, 2000. X. Hao et a... "Analysis of Coumestrol Content in Soybean.” Journal (87) PCT Pub. No.: WO2011/093686 of Beijing University of Agriculture, vol. 23, No. 3, pp. 7-9, 2008. PCT Pub. Date: Aug. -
Phytoalexins: Current Progress and Future Prospects
Phytoalexins: Current Progress and Future Prospects Edited by Philippe Jeandet Printed Edition of the Special Issue Published in Molecules www.mdpi.com/journal/molecules Philippe Jeandet (Ed.) Phytoalexins: Current Progress and Future Prospects This book is a reprint of the special issue that appeared in the online open access journal Molecules (ISSN 1420-3049) in 2014 (available at: http://www.mdpi.com/journal/molecules/special_issues/phytoalexins-progress). Guest Editor Philippe Jeandet Laboratory of Stress, Defenses and Plant Reproduction U.R.V.V.C., UPRES EA 4707, Faculty of Sciences, University of Reims, PO Box. 1039, 51687 Reims cedex 02, France Editorial Office MDPI AG Klybeckstrasse 64 Basel, Switzerland Publisher Shu-Kun Lin Managing Editor Ran Dang 1. Edition 2015 MDPI • Basel • Beijing ISBN 978-3-03842-059-0 © 2015 by the authors; licensee MDPI, Basel, Switzerland. All articles in this volume are Open Access distributed under the Creative Commons Attribution 3.0 license (http://creativecommons.org/licenses/by/3.0/), which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. However, the dissemination and distribution of copies of this book as a whole is restricted to MDPI, Basel, Switzerland. III Table of Contents About the Editor ............................................................................................................... VII List of -
Nutraceuticals: Chemoradiation Sensitizers Oroma B
Research Article iMedPub Journals Herbal Medicine: Open Access 2017 http://www.imedpub.com ISSN 2472-0151 Vol. 3 No. 2: 5 DOI: 10.21767/2472-0151.100025 Nutraceuticals: Chemoradiation Sensitizers Oroma B and Adverse Effect Resolvers Obstetrics and Gynecology Locum Tenens, PO Box 59, Salinas, CA 93902- 0059, USA Abstract Corresponding author: Oroma Nwanodi B Background: Conventional cancer treatment is associated with resistant cancer development, treatment and quality of life limiting adverse effects, and patients’ inability to complete intended treatment plans. Conventional cancer treatment’s [email protected] adverse effects lead 36.1% of cancer patients to seek integrative cancer treatments, which can provide a 15 percentage-point improvement in their health status. Obstetrics and Gynecology Locum Tenens, Therefore, a review of the extent of nutraceuticals applicable to conventional PO Box 59, Salinas, CA 93902-0059, USA. chemoradiation sensitization and adverse effect amelioration, as well as, for chemoprevention is valuable. Tel: 3143042946 Methods: PubMed searches in September 2016 and January 2017, and hand searches in August 2016 and January 2017 were performed for English language, free full text articles published from 2012 onwards. Search terms were combinations of Citation: Nwanodi OB. Nutraceuticals: the key words: Homeopathy, nutraceuticals, phytochemicals, cancer, breast cancer, Chemoradiation Sensitizers and Adverse cervical cancer, endometrial cancer, ovarian cancer, prevention, and treatment. Effect Resolvers. Herb Med. 2017, 3:2. Adjuvant characteristics, adverse effects, and chemoradiation sensitization treatments were taken from these searches. Findings: Organosulphurs are immunologic chemosensitizers. Terpenes can inhibit or reverse drug resistance. Epigallocatechin modulates estrogen receptor expression. Polyunsaturated fatty acids are cancer cell membrane chemoradiation sensitizers. -
ABSTRACT Title of Document: BIOLOGICAL
ABSTRACT Title of Document: BIOLOGICAL EFFICACY, MECHANISMS OF ACTIONS OF SOY-DERIVED PHYTOALEXIN GLYCEOLLINS IN PREVENTION OF CHRONIC DISEASES Haiqiu Huang, Doctor of Philosophy, 2014 Directed By: Professor Liangli (Lucy) Yu Department of Nutrition and Food Science Cardiovascular disease (CVD) is the leading cause of deaths worldwide. Prostate cancer is the most prevalent cancer in U.S. male population. Diet-induced hypercholesterolemia and chronic inflammation promote the development of both CVD and prostate cancer. Glyceollins are a group of soy phytoalexins possessing a variety of biological activities. This research project focused on characterizing glyceollins’ bioactivities in alleviating cholesterol dysregulation, prevention of prostate cancer, and regulating gut microbiome. The first part of the project aimed to evaluate glyceollins’ cholesterol- lowering effect in-vivo. Male golden Syrian hamsters were fed high-fat diet with or without glyceollins supplementation for 28 days. Glyceollins supplementation led to a significant reduction of plasma VLDL, hepatic cholesterol esters and total lipid content. Consistent with changes in circulating cholesterol, glyceollins supplementation also altered expression of the genes related to cholesterol metabolism in the liver. The second part of the study aimed to evaluate glyceollins’ effect in reducing prostate cancer tumor growth in a xenograft model. An initial delayed appearance of tumor was observed in a PC-3 xenograft model. However, no difference in tumor sizes was observed in a LNCaP xenograft model. Extrapolation analysis of tumor measurements indicated that no difference in sizes was expected for both PC-3 and LNCaP tumors. Glyceollins had no effect on the androgen responsive pathway, its proliferation, cell cycle, or on angiogenesis genes in tumor and xenobiotic metabolism, cholesterol transport, and inflammatory cytokine genes in liver. -
Ten Commandments for a Good Scientist
Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds Ana María Sotoca Covaleda Wageningen 2010 Thesis committee Thesis supervisors Prof. dr. ir. Ivonne M.C.M. Rietjens Professor of Toxicology Wageningen University Prof. dr. Albertinka J. Murk Personal chair at the sub-department of Toxicology Wageningen University Thesis co-supervisor Dr. ir. Jacques J.M. Vervoort Associate professor at the Laboratory of Biochemistry Wageningen University Other members Prof. dr. Michael R. Muller, Wageningen University Prof. dr. ir. Huub F.J. Savelkoul, Wageningen University Prof. dr. Everardus J. van Zoelen, Radboud University Nijmegen Dr. ir. Toine F.H. Bovee, RIKILT, Wageningen This research was conducted under the auspices of the Graduate School VLAG Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds Ana María Sotoca Covaleda Thesis submitted in fulfillment of the requirements for the degree of doctor at Wageningen University by the authority of the Rector Magnificus Prof. dr. M.J. Kropff, in the presence of the Thesis Committee appointed by the Academic Board to be defended in public on Tuesday 14 September 2010 at 4 p.m. in the Aula Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds. Ana María Sotoca Covaleda Thesis Wageningen University, Wageningen, The Netherlands, 2010, With references, and with summary in Dutch. ISBN: 978-90-8585-707-5 “Caminante no hay camino, se hace camino al andar. Al andar se hace camino, y al volver la vista atrás se ve la senda que nunca se ha de volver a pisar” - Antonio Machado – A mi madre. -
Curcumin Alters Gene Expression-Associated DNA Damage, Cell Cycle, Cell Survival and Cell Migration and Invasion in NCI-H460 Human Lung Cancer Cells in Vitro
ONCOLOGY REPORTS 34: 1853-1874, 2015 Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro I-TSANG CHIANG1,2, WEI-SHU WANG3, HSIN-CHUNG LIU4, SU-TSO YANG5, NOU-YING TANG6 and JING-GUNG CHUNG4,7 1Department of Radiation Oncology, National Yang‑Ming University Hospital, Yilan 260; 2Department of Radiological Technology, Central Taiwan University of Science and Technology, Taichung 40601; 3Department of Internal Medicine, National Yang‑Ming University Hospital, Yilan 260; 4Department of Biological Science and Technology, China Medical University, Taichung 404; 5Department of Radiology, China Medical University Hospital, Taichung 404; 6Graduate Institute of Chinese Medicine, China Medical University, Taichung 404; 7Department of Biotechnology, Asia University, Taichung 404, Taiwan, R.O.C. Received March 31, 2015; Accepted June 26, 2015 DOI: 10.3892/or.2015.4159 Abstract. Lung cancer is the most common cause of cancer CARD6, ID1 and ID2 genes, associated with cell survival and mortality and new cases are on the increase worldwide. the BRMS1L, associated with cell migration and invasion. However, the treatment of lung cancer remains unsatisfactory. Additionally, 59 downregulated genes exhibited a >4-fold Curcumin has been shown to induce cell death in many human change, including the DDIT3 gene, associated with DNA cancer cells, including human lung cancer cells. However, the damage; while 97 genes had a >3- to 4-fold change including the effects of curcumin on genetic mechanisms associated with DDIT4 gene, associated with DNA damage; the CCPG1 gene, these actions remain unclear. Curcumin (2 µM) was added associated with cell cycle and 321 genes with a >2- to 3-fold to NCI-H460 human lung cancer cells and the cells were including the GADD45A and CGREF1 genes, associated with incubated for 24 h. -
Glyphosate Poisoning
Toxicol Rev 2004; 23 (3): 159-167 REVIEW ARTICLE 1176-2551/04/0003-0159/$31.00/0 © 2004 Adis Data Information BV. All rights reserved. Glyphosate Poisoning Sally M. Bradberry, Alex T. Proudfoot and J. Allister Vale National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham, UK Contents Abstract ...............................................................................................................159 1. Epidemiology .......................................................................................................160 2. Mode of Action .....................................................................................................161 3. Mechanisms of Toxicity ..............................................................................................161 3.1 Glyphosate ....................................................................................................161 3.1.1 Acute Toxicity ............................................................................................161 3.1.2 Chronic Toxicity ...........................................................................................161 3.2 Surfactants .....................................................................................................161 3.2.1 Polyoxyethyleneamine ....................................................................................162 3.2.2 Surfactants Derived from Plant Fats .........................................................................162 3.2.3 Other Surfactants -
Loss of MGA Repression Mediated by an Atypical Polycomb Complex
RESEARCH ARTICLE Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness Haritha Mathsyaraja1, Jonathen Catchpole1, Brian Freie1, Emily Eastwood2, Ekaterina Babaeva1, Michael Geuenich1, Pei Feng Cheng1, Jessica Ayers3, Ming Yu3, Nan Wu2, Sitapriya Moorthi2, Kumud R Poudel1, Amanda Koehne4, William Grady3,5, A McGarry Houghton2,3, Alice H Berger2, Yuzuru Shiio6, David MacPherson2*, Robert N Eisenman1* 1Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States; 2Human Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, United States; 3Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States; 4Comparative Pathology, Fred Hutchinson Cancer Research Center, Seattle, United States; 5Department of Medicine, University of Washington School of Medicine, Seattle, United States; 6Greehey Children’s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, United States Abstract MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive role, we inactivated Mga in two mouse models of non-small cell lung cancer using a CRISPR-based approach. MGA loss significantly accelerated tumor growth in both models and led to de-repression of non-canonical Polycomb ncPRC1.6 targets, including genes involved in metastasis and meiosis. Moreover, MGA deletion in human lung adenocarcinoma lines augmented invasive capabilities. We further show that MGA-MAX, E2F6, and L3MBTL2 co-occupy thousands of promoters and that MGA stabilizes these ncPRC1.6 subunits. Lastly, we report that MGA loss also induces a pro-growth effect in *For correspondence: human colon organoids. -
Appendix 1 – Protocol for Preventing Or Reversing Chronic Disease The
Appendix 1 – Protocol for Preventing or Reversing Chronic Disease The first author has developed a protocol over the past decade for preventing or reversing chronic disease based on the following systemic medical principle: “at the present time, removal of cause is a necessary, but not necessarily sufficient, condition for restorative treatment to be effective”[1]. The protocol methodology refines the age-old principles of both reducing harm in addition to providing treatment, and allows better identification of factors that contribute to the disease process (so that they may be eliminated if possible). These contributing factors are expansive and may include a combination of Lifestyle choices (diet, exercise, smoking), iatrogenic and biotoxin exposures, environmental/occupational exposures, and psychosocial stressors. This strategy exploits the existing literature to identify patterns of biologic response using biomarkers from various modalities of diagnostic testing to capture a much broader list of potential contributing factors. Existing inflammatory bowel diseases (IBD) Biomarker Identification to Remove Contributing Factors and Implement Treatment The initial protocol steps are diagnostic. The main output of these diagnostics will be identification of the biomarker levels and symptoms that reflect abnormalities, and the directions of change required to eliminate these abnormalities. In the present study, hundreds of general and specific biomarkers and symptoms were identified from the core IBD literature. The highest frequency (based on numbers of record appearances) biomarkers and symptoms were extracted, and are listed in Table 1 (highest frequency items first, reading down each column before proceeding to the next column). They are not necessarily consensus biomarkers. They are biomarkers whose values were altered by a treatment or contributing factor, and reported in the core IBD literature.