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1-15-2009 Washington University Record, January 15, 2009

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Recommended Citation "Washington University Record, January 15, 2009" (2009). Washington University Record. Book 1164. http://digitalcommons.wustl.edu/record/1164

This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Washington University Record by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. Medical News: BJC Institute 'Masked Marvels': Innovative Washington People: Cobb seeks of Health at WUSTL on schedule show for 'young people' series to return critically ill patients to health 8

Washington University in St Louis Jan. 15, 2009 record.wustl.edu Estrogen can benefit women with metastatic breast cancer

BY GWEN ERICSON "By stabilizing or shrinking tumors in some wom- en with metastatic breast cancer, estrogen

3 2201 20361 4561 2 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS

University honors legacy of Martin Luther King Jr.

BY NEIL SCHOENHERR Caucasian person. The aim of the project is to generate a fifi Shattering Ceilings: different way of talking about WCelebrating Success in race, identity and other issues Pursuit of'The Dream'" is the that divide Americans. The theme of Washington Univer- booth will be available through sity's 22nd annual celebration the evening of Friday, Jan. 16, in honoring Martin Luther King the north lobby of the Danforth Jr. at 7 p.m. Monday, Jan. 19, in University Center. For more Graham Chapel. information, call 935-4620. Chancellor Mark S. Wrigh- • The School of Medicine ton will begin the program will present its annual Martin with a welcome and remarks. Luther King Jr. celebration Camille A. Nelson, visiting lecture at 4 p.m. Monday, professor of law, will present Jan. 19, in the Eric P. Newman "Pursuing the Dream: Revisit- Education Center. William ing Dr. King's Message in the Julius Wilson, Ph.D., the Age of Obama." Lewis P. and Linda L. Geyser The Rosa L. Parks Award for University Professor at Harvard Meritorious Service to the University, will present "Fram- Community also will be ing the Issue: Political Dis- presented. course and Race Relations in The program will include the Barack Obama Era." A musical performances from sociologist and leading scholar Afriky Lolo, a nationally ac- on urban poverty, Wilson is the claimed West African dance director of the Joblessness and company based in St. Louis; the Urban Poverty Research University City High School Program at Harvard's Malcolm Jazz Band; and WUSTL stu- Wiener Center for Social Policy. dent groups Black Anthology, For more information, call That's a Wrap Students and staff members gather in Umrath Hali Nov. 15 to wrap hundreds of Visions Gospel Choir, Sur 362-6854. gifts received during Washington University's annual Give Thanks Give Back campaign. WUSTL Awaaz South Asian a capella Additionally, the School of employees "adopted" 106 families during the 2008 holiday season, donating gifts, clothing, group and The Greenleafs Law and the Black Law Students household appliances and other items to more than 310 St. Louis-area residents struggling to female a cappella group. Association will host prominent overcome poverty. Give Thanks Give Back supports 100 Neediest Cases, a joint project of the A reception in the Danforth criminal defense attorney and St. Louis Post-Dispatch and the United Way. University Center will follow civil rights advocate Michael the program. For more infor- Pinard, J.D., as the 2009 mation, call 935-5965. Dr. Martin Luther King Jr. anonymous, unidentifiable and way to identify the changes they Other MLK events: Commemorative Speaker Jan. confidential, the Wellness can make that will help improve • The Human Race 22; and the Society of Black Risk Council will receive broad-based their health and lower their risk Machine, sponsored by the Student Social Workers at the Web site offers tips reports on health risks that for disease." Assembly Series, is a photo George Warren Brown School groups of employees face. WUSTL's Information booth that takes a person's of Social Work will host for staying healthy Colditz and a team of health Technology team has implement- picture and then shows what "Financial Freedom Seminar: - from Page 1 researchers will relay the data to ed security measures to ensure that person would look like as Achieving Economic the Wellness Council so the that personal information en- an Asian, Hispanic, Indian, Independence Through they're already doing well." University can better target its tered into the site is stored in a Middle Eastern, black or Education" Saturday, Jan. 17. Colditz said one of the key wellness initiatives. For example, secure environment accessible features of Your Health Snapshot if rates of exercise are low for the with a secure username and is its Wellness Lab, which gathers WUSTL community as a whole, password established by the a person's main health messages the Wellness Council can plan employee. The tool also can be New gift increases number of social into one place. activities to help boost physical used without creating a user- "The Wellness Lab shows activity. name and password; however, a change grants available to students what someone can change to "Some fairly simple changes user's information will not be improve his or her health, what to how we live can have a huge stored for future reference. BY NEIL SCHOENHERR Change Grant is funded by sup- he or she is already doing well impact on our health and well "This is a straightforward tool porters of the Gephardt Institute and what screening tests he or being," Colditz said. "More than that's simple to use," said Ann Up to $22,000 is now available to for Public Service and supports she should have regularly," he half of all cancer and three-quar- Prenatt, vice chancellor for hu- WUSTL students for the devel- international civic engagement or said. "It also has a library of past ters of diseases like cardiovascu- man resources. "It is our hope opment and implementation of service projects demonstrating results and the Health Tracker, lar disease and diabetes could be that members of the University innovative community projects the capacity for sustainable im- which has tools to help people prevented through healthier community will use the features during the summer in the form of pact on an identified community keep track of weight and number lifestyles. Your Health Snapshot of the Web site often to track social change grants through the issue. of steps walked each day." offers people a personalized, their progress toward health Community Service Office. All students, including gradu- From the data, which will be straightforward and powerful goals." A new gift from Max and ate and professional students, are Judith Stern will provide funding eligible to apply for a Gephardt for a second Stern Social Change grant. Grant this year. The first grant was The deadline for proposals for Recycle established in 2000 to provide all grants is Feb. 20, and students 58.6 million pounds of students with the means to pursue may submit proposals for multiple creative and meaningful activities grants if they meet eligibility waste recycled in 2008 geared toward finding solutions to requirements. - from Page 1 society's needs. Social change grants provide a Both Stern grants will provide unique opportunity for students $6,000 each, are open to all under- to receive funding to pursue an achieve a top 10 performance this graduate students and may be independent summer project in year but is focused on long-term used for domestic or international the spirit of social entrepreneur- success. projects. ship. Students can use the funding "While we have consistently Two other grants are available: to pay themselves a salary in lieu improved our performance in • The $5,000 Kaldi's Social of summer work, to defray living RecycleMania, we know that im- Change Grant was established in expenses or to cover travel and proving the University's overall 2005 to provide students with the project expenses. Individuals or recycling rate is a huge area of opportunity to develop sustain- teams can apply. opportunity," Malten said. able community projects in the For more information, call "Throughout the year, our solid- St. Louis region. All undergradu- Mary Zabriskie at 935-7199 waste recycling rate averages about ates are eligible. or visit communityservice.wustl. 7 percent to 9 percent. Last year . The $5,000 Gephardt Social edu/grants. during RecycleMania, it was above 17 percent. "One of our aspirational goals is Then-Gov. Matt Blunt (left) presents the Missouri Recycling to achieve 35 percent recycling rate Association's Excellence Award to Donna Hall, environmental The University also will pro- throughout the year," Malten said. compliance manager, and Bruce Backus, assistant vice chancellor gram the sirens to notify the "So, we have much more to accom- for environmental health and safety, at a Dec. 15 ceremony at the Sirens North Campus Security office, plish, and we'll need every member State Capitol building. WUSTL received the award in recognition for Review information West Campus Data Center, of our campus community to do for its excellent performance in the 2008 RecycleMania contest. , Medical his or her part to get there. To help WUSTL finished No. 1 among Missouri universities and colleges. at emergency.wustl.edu - from Page 1 School Protective Services with this effort, the University will Dispatch Center and South work to help educate and market RecycleMania administrators. Capita Classic). Schools with the Campus maintenance office in an recycling programs to students, Each week, standings are post- most paper, beverage containers, The sirens will be tested the emergency. faculty and staff throughout the ed online to help motivate cam- cardboard and food waste recycled first Monday of the month at The School of Medicine is year." puses to continue recycling. also are recognized. 11 a.m. investigating the possibility of In particular, WUSTL is moni- Awards are given to the schools Last year, 58.6 million pounds WUSTL is working to get adding indoor and outdoor toring the total pounds of paper, that recycle the greatest overall of waste were recycled through alerts from the sirens broadcast sirens as well. corrugated cardboard, bottles and amount of recyclables (Gorilla) RecycleMania. To track WUSTL's indoors into the Danforth For more information about cans it recycles on a weekly basis. and the greatest percentage of weekly standings in the Recycle- University Center and other the Emergency Notification The University's Office of their overall waste (Grand Mania competition, visit Danforth Campus buildings System, contact Mark Bagby, Sustainability monitors and sub- Champion) and greatest amount recyclemaniacs.org/results.aspx through public-address systems University disaster coordinator, mits WUSTLs information to of recyclables per person (Per or sustain.wustl.edu. and digital signage. at [email protected]. record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Jan. 15, 2009 3 School of Medicine Update Mann named director of Cardiovascular Division

BY GWEN ERICSON ment of Medicine. "He is a leading aca- After an initial faculty appointment at Mann specializes in the field of con- demic cardiologist with an outstanding the Medical University of South Carolina, gestive heart failure and has made numer- Douglas L. Mann, M.D., has been reputation. We are im- Mann moved to Baylor College of Medicine ous contributions to the understanding of named the Tobias and Hortense pressed With Doug's in 1991 as chief of cardiology at the Michael cardiac remodeling and cardiac dysfunc- Lewin Professor and director of the broad vision for the E. DeBakey VA Medical Center. He became tion. His research focuses on the molecular Cardiovascular Division in the Department division and his com- chief of the cardiology section at Baylor and cellular basis of heart failure, especially of Medicine. mitment to interdisci- College in 2005. He also is professor of on the role of inflammatory mediators in The appointment will be effective in plinary programs in medicine and of molecular physiology and the progression of heart failure. March 2009. He also will become cardiolo- heart and vascular biophysics and the director of the Winters In the position of division director, gist-in-chief at Barnes-Jewish Hospital and" disease. We are fortu- Center for Heart Failure Research. Mann succeeds Daniel P. Kelly, M.D., who director of the new Heart and Vascular nate to have been able "I am honored to be chosen as chief of became scientific director of the Burnham Institute at Barnes-Jewish Hospital and to recruit someone of cardiology at Washington University and Institute for Medical Research-Lake Nona Washington University. his stature." cardiologist-in-chief at Barnes-Jewish in Orlando, Fla., last year. Mann is currently the Don W. Chap- Mann earned a Mann Hospital," Mann said.' "The quality of the The newly formed Heart and Vascular man, M.D., Chair of Cardiology and medical degree from faculty and the trainees at the School of Institute at Barnes-Jewish Hospital and chief of the Section of Cardiology at Temple University School of Medicine in Medicine is simply outstanding, and the Washington University is committed to Baylor College of Medicine and Texas Philadelphia in 1979 and completed his health care at Barnes-Jewish Hospital is providing breakthrough technological and Heart Institute at St. Luke's Episcopal residency in internal medicine at Temple superb. I am looking forward to working research advances to improve patient care Hospital. University Hospital in 1982. He completed with the University and hospital to con- by integrating multiple services. "I am delighted that Doug Mann will fellowship training in cardiology at the tinue the rich tradition of excellence in Mann will lead the strategic initiatives become our next chief of cardiology," said University of California, San Diego, and a research, education and patient care that along with his colleagues in heart surgery Kenneth S. Polonsky M.D., the Adolphus research fellowship at Massachusetts has established them as leaders in and vascular surgery to expand services Busch Professor and head of the Depart- General Hospital in Boston. medicine." locally, regionally and nationally. Inder receives The future of medicine is set in steel award from Doris BJC Institute of Health is on schedule to open in December 2009 Duke Foundation The future of medicine is walkways. BY BETH MILLER taking shape at the heart of Floors 1 through 5 will Washington University Medi- be left as flexible shell Terrie E. Inder, M.D., Ph.D., has cal Center. space for Barnes-Jewish received a 2008 Distinguished Construction crews have Hospital to develop in the Clinical Scientist Award from the framed the BJC Institute of future. Floors 7 through Doris Duke Charitable Foundation. Health at Washington 10 will provide space for The $1.5 million award recognizes University in 8,210 tons of the Departments of outstanding leadership in clinical steel beams. They are on Obstetrics and Gyneco- research and allows leading physician- schedule with the 11-story, logy and Pathology and scientists to meld biomedical research 700,000-square-foot building, Immunology as well as and clinical applications that improve despite a year of record-setting five Interdisciplinary human health. Inder, a pediatrician rain. Research Centers. The and researcher at the School of The School of Medicine centers will be focused on Medicine and St. Louis Children's and Barnes-Jewish Hospital cancer genomics, diabetic Hospital, was one of six award plan to open the BJC Institute cardiovascular disease, recipients. of Health, located at the cor- neurodegeneration, wom- "Terrie Inder is an outstanding ner of Euclid Avenue and en's infectious disease clinical investigator who bridges the Children's Place, in December research and membrane gaps between basic neurobiology, 2009. The $235 million build- excitability disorders. translational medicine and health ing will be the hub for BioMed The building's layout outcomes for our smallest and most 21, the University's initiative will facilitate teamwork vulnerable patients," said Alan to speed scientific discovery and interaction. Shared L. Schwartz, Ph.D., and to rapidly apply break- conference rooms and M.D., the Harriet throughs to patient care. It breakout areas will en- B. Spoehrer Pro- also will house Barnes-Jewish courage brainstorming fessor and head of Hospital support operations, and dialogue. The labs are pediatrics. potentially dietary services, designed to be open, with Inder, associate clinical laboratories and no walls in between. They professor of pediat- pharmacies. also will have flexibility rics, of neurology Steel "topping out" is a key built in, including case- and of radiology, milestone. The building is only work and equipment that uses imaging stud- one year from opening and can be moved easily to ies on brains of Inder benefitting future patients The $235 million BJC Institute of Health at Washington University will accommodate technology premature, at-risk through the discoveries that be the hub for BioMed 21, the University's initiative to speed scientific and change. infants to help will be cultivated in five discovery and to rapidly apply breakthroughs to patient care. The BJC Institute of predict developmental outcomes, in Interdisciplinary Research Health is striving for particular the risk of severe cognitive Centers. the enhanced scientific collabo- Institute of Health represents hope Leadership in Energy and delays, psychomotor delays, cerebral "We are building the foun- ration is extraordinary." and opportunity for countless Environmental Design (LEED) palsy or hearing or visual impairments. dation that will aid us in accel- BJC HealthCare has sup- patients for generations to come." certification, awarded to build- Using sophisticated analysis of erating the promise of BioMed ported construction of the Interior work on the BJC ings that demonstrate environ- magnetic resonance imaging (MRI) 21," said Larry Shapiro, M.D., Institute with a $30 million gift Institute of Health should start by mental responsibility. A scenic scans, Inder can determine abnormali- executive vice chancellor for over five years. March. A spacious, two-story plaza will front the building, ties in the brains of preterm infants medical affairs and dean of the "The framework to support lobby with a glass entryway will continuing efforts to make born at 30 weeks gestation or less and School of Medicine. "The lifesaving research is complete," lead into the building. A staircase Euclid a relaxing area for the assist in guiding families as to the risk potential for new treatments said Steven Lipstein, BJC presi- with built-in seating space will Medical Center and the general for future disability. The outcomes of and cures that can result from dent and CEO. "The BJC connect the lobby with upper community. the MRI scans also can inform the physicians about the impact of treat- ment in the neonatal intensive care unit on brain development. Free blood glucose screenings offered Jan. 23 Inder also co-directs a large multi- disciplinary team that provides clinical BY BETH MILLER the disease. > Americans who have pre-diabetes. care, teaching and research to improve "We chose diabetes as the focus for this The fair also will have information the outcomes for infants born at risk Nearly 24 million children and adults in event because we wanted to address issues available on smoking and its effect on for disability. The team combines the United States, or nearly 8 percent of we know people struggle with and yet can diabetes as well as on smoking cessation multidisciplinary research initiatives in the population, have diabetes. While about manage with the right information and programs. pediatrics, neurology, radiology, ob- 18 million have been diagnosed with dia- resources," said Legail Chandler, director of "Smoking greatly increases the risk of stetrics and psychology based on stud- betes, the rest may be unaware that they human resources at the School of Medicine heart attacks for people with any type of ies at the bedside of newborn infants in have the disease. and a member of the Wellness Council. "It diabetes," said Walton Sumner II, M.D., the neonatal and pediatric intensive The School of Medicine is sponsoring is a serious problem that can be detected associate professor of medicine and a mem- care units at St. Louis Children's free blood sugar screenings and informa- with a simple test." ber of the Wellness Council. "Fortunately, it Hospital. All infants are followed into tion on diabetes Jan. 23 from 7 a.m.-5 p.m. There are several types of diabetes. Type is possible to avoid that extra risk by quit- childhood to monitor their progress. The Health Happening event, held in the 1 diabetes results from the body's failure ting smoking, and there are now many aids Inder earned a medical degree and McDonnell Pediatric Research Building to produce insulin. Up to 10 percent of to help people quit smoking." doctorate from the University of Otago atrium, is free to all School of Medicine Americans who are diagnosed with diabe- Visitors to the event will be able to try in Dunedin, New Zealand. She com- employees. The health fair's focus on diabe- tes have type 1 diabetes. out the new Your Health Snapshot Web site pleted a residency in pediatrics at tes includes free blood glucose screenings Type 2 diabetes results from insulin at six computer stations. Your Health Dunedin Hospital, a newborn medi- by senior nursing students and medical resistance, a condition in which the body Snapshot is an easy-to-use tool that offers cine fellowship at Christchurch assistants from the Goldfarb College of fails to properly use insulin. Most personalized assessments of a person's risk Hospital/Otago Medical School and a Nursing at Barnes-Jewish Hospital. No Americans who are diagnosed with diabe- for diabetes, cancer, heart disease, stroke residency in child neurology at Boston fasting is necessary prior to the screening. tes have type 2 diabetes. and osteoporosis. (See story on p. 1.) Children's Hospital/Harvard Medical In addition, Washington University Pre-diabetes occurs when a person's Participants who turn in their health School. She joined the faculty at the physicians and diabetes educators from the blood glucose levels are higher than nor- results form will also be entered into a School of Medicine in 2005. Washington University Diabetes Center mal but not high enough for a diagnosis of drawing for one of three $300 MasterCard will be available to answer questions about type 2 diabetes. There are 57 million money cards. 4 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS University Events Imaginative show launches 'ovations for young people' A high-kicking giant. A clumsy winding the reel?" half of each year on the road cowpoke. A grumpy, pipe- But the stars of the show are performing "Masked Marvels & smoking trout fishing beside Coopers exquisite masks, each of Wondertales," a show he has an imaginary stream. which can take up to 300 hours to continually developed for close Welcome to "Masked Marvels make. Working primarily with to three decades, in more than & Wondertales," the eye-popping scavenged materials, Cooper 8,000 performances. Credits one-man variety show by Michael begins by ripping paper bags or range from the Brooklyn Cooper, the virtuoso storyteller, old cloth into small pieces that are Academy of Music and the Hong mask-maker and mime. then dipped into glue and lami- Kong International Children's The special one-day-only show nated over a carefully crafted clay Festival to The Comedy Store in — which launches Edison sculpture. Los Angeles, the Dublin Theater Theatre's spring ovations for Once the layers dry, the clay is Festival and the Great Woods young people series — takes place dug out and removed, leaving just Center near Boston. at 11 a.m. Saturday, Jan. 17, in the the hollowed-out mask ready for The ovations for young people 560 Music Center. The perfor- final flourishes, which often in- series presents specially priced mance is a change from the origi- cludes some clever engineering. Saturday matinee shows for nally scheduled event Jan. 24. The fish mask, for example, can audiences of all ages. Following Combining the mythical and blow bubbles from its mouth, "Masked Marvels & Wonder- the autobiographical, Cooper while Coopers wind creature tales," the series will continue employs astonishingly detailed features spinning limbs mounted Feb. 28 with the Ahn Trio, three masks as well as impressive physi- on an old bicycle wheel. Julliard trained sisters who cal dexterity to tell original stories Born and raised in rural Maine breathe new life into the standard that highlight the presence of the — where he still resides — Cooper piano-trio repertoire. The series miraculous in everyday earned a bachelor s degree in will conclude March 28 with occurrences. peace studies from Goddard Diavolo, the high-flying Los Vignettes include "The Baby," College in Plainfield, Vt., where he Angeles dance company. inspired by the birth of Coopers also developed an interest in per- Tickets to "Masked Marvels first child; "The Horse," which formance. He spent six years & Wondertales" are $10. pays homage to his father, a vet- training with two of the greatest Subscriptions to all three ova- erinarian who courted Coopers mime teachers of the 20th century: tions for young people events are mother on horseback; and "Fish- Etienne Decroux of Paris, France, available at $6 each. or-Man," in which he asks the and Tony Montanaro of Paris, Tickets are available at the Michael Cooper as a pipe-smoking fish, one of the colorful charac- audience "How do you think a fish Maine. Edison Theatre Box Office and ters that make "Masked Marvels" lively and distinct. would feel... if he were the one Today, Cooper spends roughly through all MetroTix outlets.

'Poet of witness' Forche to speak for Writing Program Reading Series

Poet Carolyn Forche, the visiting Fannie Poets Award. Castagnola Award and also was the Lamont William Kulik, 1991). Hurst Professor of Creative Literature in The following year, Selection of the Academy of American She also edited the anthology "Against the Writing Program in Arts & Sciences, she traveled to Spain Poets. Forgetting: Twentieth-Century Poetry of will read from her work at 8 p.m. Jan. 22. to translate the work Her third book of poetry, "The Angel of Witness" (1993). The talk — part of The Writing Program of Salvadoran-exile History" (1994), won The Los Angeles Other honors and awards include fel- Reading Series — is free and open to the Claribel Alegria and Times Book Award. Her fourth collection, lowships from the Guggenheim public and takes place in Duncker Hall, later spent time in "Blue Hour" (2003), takes its title from the Foundation, the Lannan Foundation and Room 201, Hurst Lounge. El Salvador working as French phrase for predawn light. the National Endowment for the Arts. In A reception and book signing will im- a human rights Forches translation of Alegria's "Flowers 1992, she received the Charity Randall mediately follow. advocate. from the Volcano" was released in 1983. Citation from the International" Poetry Known as a "poet of witness," Forche Forche Forches second Other translations include Mahmoud Forum. is the author of four books of poetry. Her book, "The Country Darwish's "Unfortunately," "It Was Paradise: For more information, call 935-7130 or first collection, "Gathering The Tribes" Between Us" (1982), received the Poetry Selected Poems" (with Munir Akash, 2003) e-mail David Schuman at dschuman@ (1976), won the Yale Series of Younger Society of America's Alice Fay di and Robert Desnos' "Selected Poetry" (with wustl.edu.

On the Road to Freedom • Very Hungry Parasite •Shearing Melt

"University Events" lists a portion of the Issue: Political Discourse and Race McDonnell Medical Sciences Bldg., Rm. Dream.'" Graham Chapel. Reception follows activities taking place Jan. 15-28 at Relations in the Barack Obama Era." 426.362-6950. at Danforth University Center. 935-5965. Washington University. Visit the Web for William Julius Wilson, prof., Harvard U. How to submit expanded calendars for the Danforth Eric P. Newman Education Center. Campus (news-info, wustl.edu/calendars) 362-6854. 'University Events' Sunday, Jan. 25 and the School of Medicine (medschool. 3 p.m. Art History and Archaeology Lecture. wustl. edu/calendars. html). George E. Mylonas Memorial Lecture. "The Tuesday, Jan. 20 Submit "University Events" Uses of the Past on Periklean Acropolis." On Stage 4:30 p.m. Freedom From Smoking Class. items to Angela Hall of the Jeffrey M. Hurwit, U. of Ore. Brown Hall "On the Road to Freedom." Center for Record staff via: Aud. 423-3900. Friday, Jan. 16 Advanced Medicine, Barnard Health and Cancer Info. Center. To register: 362-7844. e-mail — recordcalendar 7:30 p.m. OVATIONS! Series. "To Kill a Lectures Monday, Jan. 26 Mockingbird." (Also 7:30 p.m. Jan. 17; ©wustl.edu Noon. Work, Families and Public Policy 2 p.m. Jan. 17 and 18.) Cost: $32, $28 for Thursday, Jan. 22 campus mail — Thursday, Jan. 15 Brown Bag Seminar Series. "Institutions, seniors, faculty and staff, $20 for students Noon. School of Law Dr. Martin Luther King Campus Box 1070 Social Norms and Bargaining Power: An and children. Edison Theatre. 935-6543. 4 p.m. Vision Science Seminar Series. Jr. Commemorative Speaker. "The Civil lax —935-4259 Analysis of Individual Leisure Time in "The Neurobiology of Social Scents: Rights Dimensions of Prisoner Reentry: Upon request, forms for Couple Households." Leslie Stratton, assoc. Saturday, Jan. 24 Of Mice, Molecules and Microscopes." The Impact on Individuals, Families, and submitting events will be e-mailed, prof, of economics, Va. Commonwealth U. Timothy Holy, asst. prof, of neurobiology. Communities." Michael Pinard, attorney Seigle Hall, Rm. 348. 935-4918. 11 a.m. ovations for young people series. Maternity Bldg., Rm. 725.362-3315. and civil rights advocate. Bryan Cave Moot mailed or faxed to departments to be "Masked Marvels & Wondertales." Cost: 4 p.m. Immunology Research Seminar Courtroom, Anheuser-Busch Hall. filled out and returned. $10. 560 Music Center. 935-6543. Series. "Epithelia Morphogenesis in 935-7567. Friday, Jan. 16 Deadline for submissions Development and Disease." Greg Longmore, 9:15 a.m. Pediatric Grand Rounds. "You 3:30 p.m. Whitney R. Harris World Law is noon the Thursday prior to prof, of medicine. Farrell Learning and Say 'Disaster,' I Say 'Mass Casualty' but Institute Seminar. "The Visible and publication date. Teaching Center, Connor Aud. 362-2763. Invisible World of International Claims We Can't Call the Whole Thing Off." Dee 5:30 p.m. Cardiac Bioelectricity and Hodge, assoc. prof, of pediatrics, U. of Tribunals." Seigle Hall, Rm. 109.935-7988. Sports Arrhythmia Center Seminar. "The Calif., Berkeley. Clopton Aud., 4 p.m. Vision Science Seminar Series. Electrophysiological Substrate of Heart 4950 Children's Place. 454-6006. "Tuning Retinal Function With Inhibition Failure and Cardiac Resynchrojiization Friday, Jan. 16 and Transporter Activity." Peter 11 a.m. Energy, Environmental and Very Hungry Parasite: Progress Against Therapy." Niraj Varma, cardiovascular 6 p.m. Swimming and diving. WU Chemical Engineering Seminar Series. Lukasiewicz, prof, of ophthalmology and Malaria in the 21st Century." Audrey Odom, medicine, Cleveland Clinic. Whitaker Hall, Invitational. Athletic Complex. 935-4705. "Improving Butanol Fermentations visual sciences. Maternity Bldg., Rm. 725. instructor of pediatrics. Clopton Aud., Rm. 218. 935-7887. Through Metabolic and Bioprocess 362-3315. 4950 Children's Place. 454-6006. 6 p.m. Women's Basketball vs. Case Western Reserve U. Athletic Complex. Engineering Perspectives." David 4:15 p.m. Earth & Planetary Sciences 11 a.m. Computer Science and Engineering Tuesday, Jan. 27 935-4705. Nielsen, postdoctoral fellow in chemical Colloquium. Stephen Zatman Memorial Colloquium. "Dynamic Ideal Point 4:30 p.m. Freedom From Smoking Class. engineering, MIT. Lopata Hall, Rm. 101. Colloquium. "Shearing Melt of the Earth: An 8 p.m. Men's Basketball vs. Case Western Estimation and Ideological Change on the "Wanting to Quit." Center for Advanced 935-5548. Experimentalist's Perspective on the Reserve U. Athletic Complex. 935-4705. U.S. Supreme Court." Andrew Martin, prof, Medicine, Barnard Health and Cancer Info. Influence of Deformation on Melt Extraction of law. Cupples II Hall, Rm. 217.935-6160. Center. To register: 362-7844. Saturday, Jan. 17 from the Mantle" David Kohlstedt, prof, of Saturday, Jan. 17 geology and geophysics, U. of Minn. Earth 11 a.m. Energy, Environmental and 8:30 a.m.-4 p.m. George Warren Brown & Planetary Sciences Bldg., Rm. 203. Chemical Engineering Seminar Series. 11 a.m. Swimming and diving. WU School of Social Work Martin Luther King 935-5610. "Perchlorate-Reducing Gene Targets for Invitational. Athletic Complex. 935-4705. Jr. Remembrance. "Financial Freedom Biological Treatment Applications." Mary Jo Seminar: Achieving Economic 8 p.m. The Writing Program Reading Kirisits, asst. prof, of civil, architectural and And More Sunday, Jan. 18 Independence Through Education." Brown Series. Carolyn Forche, visiting prof. environmental engineering, U. of Texas at Hall, Rm. 100. To register: 935-7262. Duncker Hall, Rm. 201, Hurst Lounge. Austin. Lopata Hall, Rm. 101.935-5548. Noon. Men's Basketball vs. Emory U. 935-7130. Athletic Complex. 935-4705. Noon. Cell Biology and Physiology Seminar. Monday, Jan. 19 Monday, Jan. 19 "Intracellular FGFs Novel Regulators of 7 p.m. University's Annual Martin Luther 2 p.m. Women's Basketball vs. Emory U. 4 p.m. School of Medicine Martin Luther Friday, Jan. 23 Membrane Excitability." Jeanne M. King Jr. Celebration. "Shattering Ceilings: Athletic Complex. 935-4705. King Celebration Lecture. "Framing the 9:15 a.m. Pediatric Grand Rounds. "The Nerbonne, prof, of developmental biology. Celebrating Success in Pursuit of The * record.wustI.edu WASHINGTON UNIVERSITY IN ST. LOUIS Jan. 15,2009 5

Law's 'Access to Justice' speaker series kicks off BY JESSICA MARTIN on immigration and international affairs and has earned a number Prominent criminal defense of journalism awards for her attorney and civil rights work. She was a part of the team advocate Michael Pinard, that won the New York Times the J.D., will address the pressing 1998 Pulitzer Prize for reporting problem of prisoner re-entry in on international affairs for its America to kick off the spring series profiling the corrosive lineup of Washington University effects of drug corruption in School of Law's 11th annual Mexico. Public Interest Law & Policy • Feb. 23. Goodwin Liu, J.D., Speakers Series Jan. 22. associate dean and professor of Pinard is the law school's 2009 law at the University of California, Dr. Martin Luther King Jr. Berkeley, will present "The Future Commemorative Speaker. of Civil Rights: Reflections and The spring series includes civil Renewal." His talk is co-spon- rights experts, an award-winning sored by the American journalist, a top intellectual prop- Constitution Society. erty law scholar and a leading Co-director of the Chief advocate for children. The law Justice Earl Warren Institute on school's Clinical Education Race, Ethnicity, and Diversity at Program sponsors the series. Berkeley, Liu is a frequent com- Titled "Access to Justice: The mentator on constitutional law Social Responsibility of Lawyers," and education policy for top the yearlong series brings to media outlets. Liu is a former law WUSTL prominent experts in clerk for U.S. Supreme Court Civil rights in St. LOUiS William "Bill" Clay Sr., Missouri's first black congressman, discusses such areas as racial justice, civil Justice Ruth Bader Ginsburg, his new book, "The Jefferson Bank Confrontation: The Struggle for Civil Rights in St. Louis," with rights, international human former special assistant to the area high-school students in Edison Theatre Jan. 9. The book recounts St. Louis' most successful rights, the economics of poverty, deputy secretary of education and civil rights movement, which began in August 1963 and for which Clay spent 105 days in jail but clinical legal education, public former senior program officer for which ultimately opened employment opportunities in banking and other industries.The talk was service and pro bono legal AmeriCorps. sponsored as part of a National Endowment for the Arts' Big Read program centering on Harper practice. • March 26. Pam Samuelson, Lee's "To Kill a Mockingbird," perhaps the most widely read book exploring race in the United States. For a complete calendar of events related to the Big Read or to obtain a reader's guide, Karen L. Tokarz, J.D, the J.D., the Richard M. Sherman visit bigread.wustl.edu or call 935-4407. Charles Nagel Professor of Public Distinguished Professor of Law, Interest Law & Public Service and Professor of Information director of the Dispute Resolution Management and Chancellor's Program, coordinates the series in Professor at the University of conjunction with Pauline Kim, California, Berkeley, will discuss J.D., associate dean for research "The Public Interest in Intellectual Sports and faculty development and Property Law." This lecture is professor of law. co-sponsored by the Center for All lectures will be held at Research on Innovation and noon in the Bryan Cave Moot Entrepreneurship. Men's basketball three-pointers in the win and held On Jan. 5, the Bears defeated Courtroom of Anheuser-Busch An internationally recognized a 35-30 advantage on the boards. Webster University, 78-46, with Hall unless otherwise noted. They intellectual property law scholar, improves to 11-1 The victory over Webster was the senior Halsey Ward leading the are free and open to the public. Samuelson is the co-director of The men's basketball team held Bears' 73rd in a row when holding way with 12 points on 4-of-7 For more information, contact the Berkeley Center for Law and the University of Chicago without an opponent under 60 points. shooting from three-point Jeanne Heil-Chapdelaine at Technology and the founder and a field goal for a stretch of 12:31 in WUSTL (11-1,1-0 UAA) range. 935-7567. adviser for the Samuelson Law, the second half en route to a 74-62 continues conference action at WUSTL (9-3,1-0 UAA) The schedule: Technology and Public Policy victory over the Maroons in both home at 8 p.m. Friday, Jan. 16, resumes play at home at 6 p.m. • Jan. 22. Pinard, professor of Clinic. She has written and com- team's University Athletic Asso- against Case Western Reserve Friday, Jan. 16, against Case law at the University of Maryland, mented extensively about the ciation (UAA) opener Jan. 10 in University in the WU Field Western Reserve University in will present "The Civil Rights challenges that new information Chicago. House. the WU Field House. Dimensions of Prisoner Reentry: technologies pose for public The Bears shot 57.4 percent the Impact on Individuals, policy and traditional legal from the field in the victory and Women's basketball Swimming and diving Families, and Communities." His regimes. outrebounded the Maroons, sweep Lindenwood talk is co-sponsored by the Black • March 27,9 a.m. Jane 31-26. WUSTL, which leads the win streak at five Law Students Association. M. Spinak, J.D., the Edward Ross NCAA Division III in assist-to- The No. 25 women's basketball The men's and women's swim Pinard is the director of the Aranow Clinical Professor of Law turnover ratio (1.6), had 22 assists team pushed its winning streak to teams returned from the semes- Reentry of Ex-Offender's Clinic at at Columbia University, will pres- in the victory. five consecutive games with a ter break to pick up wins over the University of Maryland Law ent "Reforming Family Court: Junior Cameron Smith and dramatic 54-50 win at No. 21 Lindenwood University at School, former staff attorney for Getting It Right Between Rhetoric freshman Dylan Richter had University of Chicago in both Millstone Pool Jan. 9. the Neighborhood Defender and Reality." This talk is spon- 13 points, while junior Aaron team's University Athletic The men defeated Linden- Service of Harlem and former sored by the Clinical Education Thompson added 11 points on Association (UAA) opener in wood, 137-81, while the wom- attorney for the Office of the Program in conjunction with the 3-of-3 shooting from beyond the Chicago Jan. 10. en's squad picked up a 130-88 Appellate Defender of New York annual Access to Equal Justice arc. Senior Sean Wallis added nine Sophomore Kelsey Robb sunk victory over the visiting Lions. City. His scholarship and practice Colloquium on Family Court points, four rebounds and a game- a pair of free throws to break a The meet was the first interests focus on the American Reform. high 11 assists in the victory. 50-50 tie with 9.9 seconds remain- competition for the Bears criminal justice system, criminal Spinak co-founded Columbia's The Bears, ranked No. 3 over- ing to lead WUSTL to the win. since both teams placed second defense lawyering, the reentry of Child Advocacy Clinic, which all, suffered their first loss of the Robb led all scorers with a career- at the Wheaton Invitational individuals with criminal records represents children living in foster season Dec. 20 to Elmhurst high 14 points and also pulled Dec. 6. and the collateral consequences of care in family-court proceedings. College, 82-75, in the champion- down seven rebounds. Against Lindenwood, the criminal convictions. She directs the newly created ship game of the Bluejay Classic in The Bears' stifling defense was WUSTL women took first in • Feb. 2. Julia Preston, journal- Multi-Disciplinary Center of Elmhurst, 111. It was the final game pivotal in picking up the confer- eight events, and the men's team ist with The New York Times, will Excellence in Child Advocacy at before a 15-day layoff for the ence win, as it did not yield a field claimed the top spot in seven discuss "Immigration: Enough the law school in collaboration holiday break. goal over the final 4:29 of the events. Enforcement? The Crackdown with a national child advocacy They bounced back Jan. 5 with game and held Chicago to just Freshman Karina Stridh and the Policy Options for the organization, First Star. a 68-55 win at Webster University. 33.3 percent shooting. posted an NCAA provisional New Administration." This lecture Spinak is a member of the New In that game, WUSTL shot 50.9 The victory was the 525th of time of 53.10 in winning the is co-sponsored by the Center for York State Permanent Judicial percent from the field while hold- head coach Nancy Fahey's career 100-yard freestyle, the only Bear Interdisciplinary Studies. Commission on Justice for ing Webster to just 41.4 percent and the first for WUSTL at to eclipse an NCAA standard at Preston is a recognized expert Children. shooting. The Bears sank eight Chicago since Feb. 25, 2006. the meet. 'Work, Families and Public Policy5 brown bag lunch series continues BY JESSICA MARTIN • Feb. 9. David Neumark, Ph.D., professor of economics Corp., will discuss "Economic Preparation for Retirement: at the University of California, Irvine, will discuss Then and Now." Faculty and graduate students from St. Louis-area univer- "Neighbors and Co-Workers: The Importance of Robert A. Pollak, Ph.D., the Robert E. Hernreich sities with an interest in labor, households, health care, Residential Labor Market Networks." Distinguished Professor of Economics in Arts & Sciences law and social welfare are being invited to take part in a • Feb. 23. Anne Winkler, Ph.D., professor of economics and at the , has been the lead orga- series of Monday brown bag luncheon seminars to be held and public policy administration at the University of nizer of the series for the past 12 years. Co-organizer is on campus biweekly through April 27. Missouri-St. Louis, will examine "The Diffusion of I.T. in Michael W Sherraden, Ph.D., the Benjamin E. Youngdahl In its 13th year, the "Work, Families and Public Policy" Higher Education: Publishing Productivity of Academic Professor of Social Development and director of the Center series features one-hour presentations on research interests Life Scientists." for Social Development in the George Warren Brown of faculty from local and national universities. The series is • March 16. Pamela Jakiela, Ph.D., assistant professor of School of Social Work. designed to promote interdisciplinary research. economics in Arts & Sciences, will speak about "Education The series is sponsored by the Olin Business School; Presentations will be from noon-1 p.m. in Seigle Hall, and Social Norms: Experimental Evidence." the George Warren Brown School of Social Work and Room 348, and will be followed by a half-hour discussion. • March 30. Martha Ertman, J.D., professor of law at the the Center for Social Development; the Center for The series began Jan. 12 with a lecture by Daniel University of Maryland, will present "They Ain't Whites, Interdisciplinary Studies in the School of Law; the Hamermesh, Ph.D., the Edward Everett Hale Centennial They're Mormons: An Illustrated History of Polygamy as Department of Economics in Arts & Sciences; the Center Professor in Economics at the University of Texas, on Race Treason." for Health Policy; and the College of Arts 8c Sciences. "Grazing and Making Fat: Determinants and Effects." • April 13. Raul Santaeulalia-Llopis, Ph.D., assistant The classroom is courtesy of the Department of The remaining presentations: professor of economics in Arts & Sciences, will examine Economics. • Jan. 26. Leslie Stratton, Ph.D., associate professor at "AIDS and Economic Development: The Role of For more information, contact Pollak at 935-4918 or at Virginia Commonwealth University, will speak on "Insti- Reproductive Health and Family Planning Policies." [email protected]; Sherraden at 935-6691 or at sherrad@ tutions, Social Norms and Bargaining Power: An Analysis • April 27. Michael Hurd, Ph.D., director of the Center wustl.edu or visit olin.wustl.edu/links and click on the of Individual Leisure Time in Couple Households." for the Study of Aging and senior economist at RAND "Academic Seminars" drop-down menu. 6 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS

WUSTL, area universities to host research summit

llliashington University, SIUE and SLU Feb. 2, will ■ ■ Southern Illinois focus on agency programs and University Edwardsville will feature Sally Rockey, (SIUE), Saint Louis University Ph.D., acting deputy director (SLU) and the University of for extramural research at the Missouri-St. Louis (UMSL) National Institutes of Health. will partner to host the WUSTL will host the sec- Midwest Regional Outreach, ond day of programming at Science and Scholarship the Danforth University Summit: Leadership in Inter- Center Feb. 3. Funding trends, disciplinarity, Networking proposal development, merit and Collaboration (LINC) review and project manage- Feb. 2-4. ment will be addressed during Conference topics include Day 2. Samuel L. Stanley Jr., updates on the latest funding M.D., vice chancellor for trends from federal agencies research, will moderate the and informative sessions for day's plenary session, titled academic investigators on "Successful Interdisciplinary research practices and oppor- Science." tunities. Attendees also can Highlighted federal guests explore ways to enhance the include Thomas N. Cooley, A long jOtimey home NASA astronaut and WUSTL alum Robert Behnken, Ph.D. (right), visits success of their individual chief financial officer and with his former professor, Salvatore P. Sutera, Ph.D. (left), interim dean of the School of Engi- and collaborative research director of the Office of neering & Applied Science and senior professor of biomedical engineering, and Philip V. Bayly, projects. Budget, Finance and Award Ph.D., the Lilyan and E. Lisle Hughes Professor in Engineering and chair of the Department of Management at the National Mechanical, Aerospace and Structural Engineering. Behnken took the first space flight of his The conference is the Science Foundation, and career in March 2008 aboard the space shuttle Endeavor, which launched the International Space second of a biennial event Station. He returned home to St. Louis to be grand marshal for the Thanksgiving Day Parade and intended to facilitate faculty Linda Blevins, Ph.D., physical made a point to stop by the Danforth Campus, getting a student-guided tour before settling in research opportunities and scientist at the Office of the with Sutera and Bayly. stimulate broad-based in- Deputy Director for Science creases in sponsored research, Programs at the Department scholarship and interdisci- of Energy. plinary collaborations and "This is a very special partnerships. opportunity to hear from our The event was originally most important partners in Financial seminar at Brown School held in January 2007 as the the research arena and to get Metropolitan St. Louis Grants their views on present and Conference: Research Days. future trends in this realm," will spotlight challenging economy "Collaborative and inter- Stanley said. "It is not often that we can and fast facts about borrowing, Home Ownership; Smart disciplinary research creates BY JESSICA MARTIN bring such high-ranking lead- asset building and financial Borrowing; Investing Your both opportunities for fund- ing as well as management ers at the federal level to the To honor the life and work of planning. Money; and Asset Building. In challenges," said Cindy Kiel, Midwest, and I encourage our Martin Luther King Jr., the "That holds true for anyone, addition, two youth workshops assistant vice chancellor for faculty to take full advantage Society of Black Student Social whether you're retired, contem- are being offered in Financial research services and execu- of this chance," Stanley said. Workers (SBSSW) at the George plating starting a family or going Planning and College Planning. tive director of the Research Day 3 will be hosted by Warren Brown School of Social off to college," Bassett said. The seminar will begin with a Office. "In recognition of the both UMSL and SLU Feb. 4 Work will host the third annual Tesheba Wadley, second-year keynote address by Eric Dicker- importance of fostering cross- and will feature discussions on "Financial Freedom Seminar: graduate student in social work son, founder and president of Eric cutting research and to pro- technology transfer and the Achieving Economic Indepen- and SBSSW co-chair, said that the Dickerson Associates. Dickerson's vide tools to faculty to create relationship between industry dence Through Education," from Financial Freedom Seminar is an company works with organiza- more competitive proposals and academe. 8:30 a.m.-4 p.m. Saturday, Jan. 17, important event to the Brown tions and academic institutions to in an increasingly competitive The three days of program- in Brown Hall, Room 100. School as well as the St. Louis provide personal finance manage- environment, the College of ming have comprehensive The seminar, free and open community. ment training. The training pro- objectives: to the public, is designed for "Through the seminar, the gram is education-based and is Arts & Sciences, the College of Engineering and the Office • One is supporting junior St. Louis community youth and Brown School has an opportunity not affiliated with or supported by of the Vice Chancellor for faculty members by offering adults interested in building to reach out to African-Ameri- any investment or financial Research are co-sponsoring exposure to large collaborative wealth, repairing and maintaining cans and other community mem- organizations. this biennial conference. activities and interdisciplinary good credit, purchasing a home bers to let them know their needs Last year's Financial Freedom "In addition to timely thinking and to problem- or starting and expanding a are known and we want to work Seminar was attended by nearly trends and proposal develop- solving models outside their business. with thern to address those 200 members of the St. Louis ment information from po- fields of expertise. "Financial planning is key needs." Wadley said. "In turn, community. • Another is encouraging during today's economy," said St. Louisans have the chance to For more information and tential sponsors, this will be sponsored collaborations and Jessica Bassett, first-year graduate explore the campus and interact to register, visit gwbweb.wustl. an exciting opportunity to network with colleagues from scholarship by prompting student in social work and SBSSW with the University community in edu/Events/Pages/Financial dialogue with colleagues who member. "With tough economic a meaningful way." FreedomSeminar.aspx, e-mail other disciplines and begin have experienced successful times such as these, it is vital for Seminar participants will be [email protected] the important process of interdisciplinary partnerships. every individual, not just African- able to choose two workshops or call 935-3466. finding where the intersec- • The third is shaping re- Americans, to plan and prepare from the following areas: Credit Breakfast and lunch will be tions of science, art and search agenda through invita- for the future by getting the hard Education and Debt Freedom; provided. scholarship can create novel and innovative answers to the tions to federal agency repre- research questions of our sentatives and key faculty members to discuss the direc- mors in about 30 percent of the uptake, called a PET flare, were time. Please bring your exper- tion of future and current participants. But the high-dose the same patients who benefited tise and questions to make research. Estrogen regimen had significant side from estrogen therapy. this a fulfilling and memo- Registration is free for effects such as nausea, vomiting, It's too early to know why rable event," Kiel said. Accepted as treatment faculty from St. Louis-area vaginal bleeding, fluid retention estrogen has a negative effect on LINC wilTbe structured decades ago institutions. or calcium imbalances. In con- metastatic breast cancer tumors. around speakers, panelists For more information, visit - from Page 1 trast, the low-dose regimen had But Ellis has found one clue — es- and breakout sessions. research.wustl.edu/LINC. few side effects and was well trogen reduces the amount of a Day 1, jointly hosted by were postmenopausal with an tolerated. tumor-promoting hormone called average age of 59. The researchers found that if insulin-like growth factor-1 Coming into the study, all the study participants eventually (IGF1). participants were taking aro- experienced disease progression "I think that in order for breast matase inhibitors to slow or stop on estrogen, they could go back cancer cells to survive in the the growth of their tumors. But to an aromatase inhibitor that absence of estrogen (when pa- their tumors had stopped re- they were previously resistant to tients are on aromatase inhibi- Volume 33, Number 18 sponding to the treatment and and see a benefit — their tumors tors), the cells have to learn to had begun to grow again. Half of were once again inhibited by alter their cellular programs to Founded in 1905 • Washington University in St. Louis community news the patients got a high dose of estrogen deprivation. utilize alternative growth signals Associate Vice Chancellor Steven J. Givens Record (USPS 600-430; ISSN 1043-0520), estrogen (30 milligrams a day) That effect sometimes wore off like IGF1," Ellis said. Executive Editor Susan Killenberg McGinn Published for the faculty, staff and friends and half got a low dose (6 milli- after several months, but then the "In theory, when you give Editor Leslie Gibson McCarthy of Washington University. Produced weekly grams a day). tumors might again be sensitive estrogen back, IGF1 decreases, Associate Editor Neil Schoenherr during the school year, except school Ellis points out that decades to estrogen therapy. In fact, some and cancer cells die as a conse- Assistant Editor Jessica Daues holidays, and monthly during June, July ago, high-dose synthetic estrogen patients have cycled back and quence. But surviving cancer cells Medical News Editor Beth Miller and August by the Office of Public Affairs, was an accepted breast cancer Calendar Coordinator Angela Mall Washington University, Campus Box 1070, forth between estrogen and an prefer to switch back to living on Print Production Carl Jacobs One Brookings Drive, St. Louis, M0 63130. therapy and was only abandoned aromatase inhibitor for several estrogen — to them it's like eating Online Production Tammy Ritterskamp Periodicals postage paid at St. Louis, MO. when the estrogen-blocker ta- years, thereby managing their out at McDonald's every day News & Comments moxifen came along in the 1970s metastatic disease. instead of foraging on roots and Where to send address changes (314) 935-5293 Postmaster and nonemployees: Record, and proved just as effective with The researchers also found berries. These cells eventually Campus Box 1070 fewer side effects. Washington University, Campus Box 1070, that PET (positron emission reappear as estrogen- dependent [email protected] One Brookings Drive, St. Louis, M0 63130. The high dose in the current tomography) scans could predict tumors and the cycle starts over," Medical News Employees: Office of Human Resources, study was based on the amount whose tumors would respond to Ellis said. (314)286-0119 Washington University, Campus Box 1184, given to breast cancer patients estrogen therapy. They measured Ellis plans to continue to fol- Campus Box 8508 One Brookings Drive, St. Louis, M0 63130. in many of those earlier tumor glucose uptake before [email protected] low metastatic breast cancer pa- Reprint permission regimens. starting the women on estrogen tients to quantify the response Calendar Submissions Articles may be reprinted with appropriate Both the high- and low-dose and 24 hours later. rate to retreatment with aromatase Fax:(314)935-4259 credit to Washington University in St. Louis Campus Box 1070 treatments led to stabilization The patients whose tumors inhibitors when estrogen therapy Record. or shrinkage of metastatic tu- showed an increased glucose stops working. [email protected] record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Jan. 15,2009 7 Notables

Introducing new Six professors named AAAS fellows

faculty members BY BETH MILLER The following are among the new faculty members Six Washington University at the University. Others will faculty members have been be introduced periodically named fellows of the in this space. American Association for the Advancement of Science Long Chen, Ph.D., joins (AAAS), the world's largest Olin Business School as general scientific society. associate professor of finance. The highest honor awarded Hildebolt Ory Pikaard Schaffer Weinstock Wilson He earned a bachelors degree by AAAS, the rank of fellow is from in his bestowed upon members by native China before earning a their peers in recognition of biology and physiology, was in the biogenesis and function- evolution of man and master's degree and doctorate scientifically or socially distin- elected to the Section on ing of producing siRNAs. metazoans. from the University of New guished efforts to advance sci- Medical Sciences for his contri- • Jean E. Schaffer, M.D., the • Richard K. Wilson, Ph.D., Brunswick and the University ence or its applications. butions to understanding basic Virginia Minnich Distinguished professor of genetics and of of Toronto, respectively. Of the WUSTL honorees, molecular mechanisms in regu- Professor of Medicine and molecular microbiology, was Before attending school in five are from the School of lation of cholesterol homeosta- professor of developmental elected to the Section on Canada, Chen worked for a Medicine and one is from Arts sis with a special focus on the biology, was elected to the Biological Sciences for his con- Chinese importer and ex- & Sciences. human Niemann-Pick type C Section on Medical Sciences for tributions to the fields of mo- porter of metals, and he spent They are: (NPC) disease, an Alzheimer's her contributions in increasing lecular biology and genomics, a year as a trader at the Shen • Charles F.Hildebolt, disease-like disorder that affects the understanding of fat me- particularly for the development Zhen Metal Exchange and Ph.D., professor of radiology, children. tabolism and diabetes. of methods and approaches for Yunnan Metal Exchange in was elected to the Section on • Craig S. Pikaard, Ph.D., • George M. Weinstock, large-scale genome analysis. China. He has taught at Anthropology for his contribu- professor of biology in Arts & Ph.D., professor of genetics, This year's fellows were Michigan State University tions to the scientific study of Sciences, was elected to the was elected to the Section on announced in the Dec. 19 issue and researches the areas of dental and skeletal evolution in Section on Biological Sciences Biological Sciences for his con- of the journal Science, pub- asset pricing and corporate early hominids and for the for his contributions to the tributions to microbial and lished by AAAS. financing decisions. training of health professionals understanding of plant gene infectious-disease genomics, The WUSTL fellows will be Frederick Eberhardt, and scholars. silencing, chromatin modifying large-scale DNA sequencing recognized next month at the Ph.D., joins the Department • Daniel S. Ory, M.D., pro- complexes and the role of two and bioinformatics analyses and organization's annual meeting in of Philosophy in Arts & fessor of medicine and of cell plant-specific RNA polymerases analyses of the genome and Chicago. Sciences as assistant professor with an affiliation in the Philosophy- Neuroscience- Psychology Program. Eberhardt earned a doctorate from Carnegie Mellon Obituaries University in 2007 and since has been a postdoctoral fellow in the Institute for Cognitive and Brain Sciences and the Department of Wolff, longtime University benefactor, 93 Philosophy at the University of California, Berkeley. His Edith L. Wolff, a longtime donor whole will explore in interdepart- Timothy J. Ley, M.D. She also began a more active research is on causal reason- to the School of Medicine, died mental collaboration. Its goals In 2003, she endowed the and public philanthropic career, ing, and he has published a Dec. 26, 2008, at Barnes-Jewish reflect those of BioMed 21, the Alan A. and Edith L. Wolff and she sought to set an example number of articles on prob- Hospital after a brief illness. She University's Distinguished Professorship in of public giving in the hope that lems in statistics, probability was 93. multidisci- Medicine, which is held by others might increase their chari- and the work of Hans Wolff and her late husband, plinary re- William A. Peck, M.D., former table giving within their means. Reichenbach. At Berkeley, Alan A. Wolff, directed funds to search initia- executive vice chancellor and dean She gave to numerous causes his research involved experi- multiple areas of medical research tive to rapidly of the School of Medicine and now and charities, with the largest ments investigating how at the School of Medicine for translate basic director of the Center for Health contributions being made to humans learn causal more than 30 years. Most recently, research find- Policy. She also established the Washington University, Barnes- relations. Edith Wolff committed $20 mil- ings into ad- Edith L. Wolff Scholarship-Loan Jewish Hospital Foundation, Katherine Henzler- lion in late 2007 to establish the vances in Fund, a non-interest-bearing fund St. Louis ARC and its Childgarden Wildman, Ph.D., joins the Alan A. and Edith L. Wolff medical for medical students. School, Life Skills Foundation, Department of Biochemistry treatment. Institute, which supports biomedi- Wolff Alan Wolff founded Wolff Miriam Foundation and Rainbow and Molecular Biophysics as cal research projects that lead to In addi- Construction Co., a real-estate Village Foundation. assistant professor. Henzler- the prevention, treatment and tion, Edith Wolff endowed two development, investment and Edith Wolff's charitable contri- Wildman earned a doctorate cure of disease. The institute will professorships. The Alan A. and management company, in the late butions have been previously in chemistry at the University identify opportunities and gaps in Edith L. Wolff Professorship in 1940s. During the '50s and '60s, recognized by numerous awards of Michigan in 2003. She was biomedical research that no single Medicine was established in 1999 the company built numerous shop- from the organizations she ben- a Ruth L. Kirchstein NRSA discipline can address alone but to support progress in under- ping centers in Missouri, Illinois efited, including an honorary postdoctoral fellow at that the scientific community as a standing cancer and is held by and Kansas. doctorate from the University in Brandeis University. Her Following Alan Wolff's death in recognition of her extraordinary laboratory studies the confor- 1989, Edith Wolff became presi- support of life-saving medical mational dynamics of pro- Gaines, former commencement director, 86 dent of the company, which flour- research. teins, using NMR to examine ished under her direction and now Funeral services were held different motional modes GenevieveL. "Jean" Gaines, Registrar, now called Student focuses on real-estate investment Dec. 30, 2008. Memorial contribu- during enzyme turnover. who served Washington Records, where she was pro- and on management and leasing of tions may be made to a charity of Henzler-Wildman is investi- University for more than 55 moted from secretary to ad- commercial buildings. one's choice. gating the dynamics of the years in roles ranging from a ministrative assistant to associ- bacterial multidrug trans- secretary to administrative ate registrar. In 1998, she joined porter EmrE in detergent assistant to associate registrar public affairs as director of micelles and artificial bilayers and lastly as director of com- commencement. Miller, assistant prof, of genetics, 64 to identify motions that are mencement, died Dec. 17, "Jean Gaines was the ulti- linked to the mechanism of 2008. She was 86. mate Washington University Raymond D. Miller, Ph.D., seminar program will not be the active transport. Gaines employee," said James research assistant professor in same without him. He always Scott Wildman, Ph.D., retired from Burmeister, executive director genetics, died Dec. 13, 2008. He asked important questions about joins the Department of the Univer- of University relations and was 64. genetics and about science in Biochemistry and Biophysics sity in 2002, commencement and com- Miller was employed at the general. He will be greatly as research assistant profes- having mencement chair from the late medical school from 1982 until missed." sor. Wildman earned a doc- served 1960s through the mid-1970s. his retirement in April 2008. In Services were held Dec. 18 at torate in medicinal chemistry under six "She always put the students 2005, he was a member of the Christ Church Cathedral. He is at the University of Michigan chancellors, first in a caring and concerned International HapMap Consor- survived by his wife, Patricia in 2001 and has spent the beginning way." tium, which published a high- Taillon-Miller; daughter Sara past seven years in the phar- with Nobel A funeral mass was held density haplotype map of the Miller; and sister Margaret Bath. maceutical industry. Gaines laureate Dec. 20 at The Church of the human genome, a sequel to the Memorial contributions may be Wildman is working on Arthur Little Flower in Richmond Human Genome Project and a made to Tower Grove Park computational approaches for Holly Compton and running Heights, Mo. significant step toward personal- Foundation or to the Christ drug discovery, modeling through, in order, Ethan A.H. Memorial contributions ized medicine. His SNP Research Church Cathedral. protein-ligand interactions Shepley, , Thomas may be made in her memory Facility was one of six genotyp- — Beth Miller and the structural implica- Eliot, William H. Danforth and to Washington University, ing centers that participated in tions of large protein families. current Chancellor Mark S. Campus Box 1202, Attn: Brian Phase I of the project. Wildman will also be collabo- Wrighton. She is believed to Lewis, One Brookings Drive, "Ray was a very valued col- rating with the high-through- hold the record for the longest St. Louis, Mo., 63130, or the league in our department and a put screening and medicinal continuous service at Archdiocese of St. Louis, longtime member of the genetics Carmody, 87 chemistry efforts focused on Washington University. Attn: Chief Financial Officer, community in many different data analysis, hit prosecution From 1946-1998, Gaines 4445 Lindell Blvd., aspects," said Susan Dutcher, Robert Carmody, adjunct senior and lead optimization. worked in the Office of the St. Louis, Mo., 63108. Ph.D., interim chair of the lecturer in marketing from 1982- Department of Genetics. "Our 87, died Dec. 22, 2008. He was 87. 8 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS Jan. 15,2009 8 Washington People

In France, J. PerrenCobb, M.D., would be called a "reanimateur" — a critical- care doctor who specializes in bringing patients back from the brink of death. Here in the States, however, he is an inten- sivist, a rather bland term that reveals little about the awe-inspir- ing nature of his work. "Reanimateur better defines what we do," Cobb says. "In the intensive care unit, we are re- animating those who would oth- erwise be dead. I like the word because it stresses that what we're doing is positive and focused on healing — the glass is half-full as opposed to half-empty approach." Cobb, professor of surgery and BY CAROLINE ARBANAS of anesthesiology, cares for pa- tients in the surgical intensive care unit (SICU) on the eighth floor of Barnes-Jewish Hospital. Patients typically arrive on venti- lators after major surgery, such as complicated operations to repair a ruptured blood vessel or close a gaping wound from a car crash or other traumatic incident. The vast majority of patients recover fully. But a significant J. Perren Cobb, M.D. (center), goes over a patient X-ray in the surgical intensive care unit with Jaime A. number, especially those with Cavallo, M.D. (left), a general surgery resident, and Robert Southard, M.D., a surgical intensive care unit severe injuries caused by burns or fellow. "Dr. Cobb has a superb bedside manner and brings out the best in everyone involved in the care major trauma, face long and of patients he is overseeing," says Walter A. Boyle III, M.D., professor of anesthesiology. "Perren's ability difficult recoveries plagued by to put staff at ease and listen to their views optimizes the chances for good outcomes for patients." On a national level, Cobb collaborator Jeanine P. Wiener- recently led the inaugural meeting Kronish, M.D., anesthetist-in-chief of the U.S. Critical Illness and at Massachusetts General Hospital.. Bringing patients back Injury Trials Group. The gathering "He brings these people together brought together for the first-time so that ideas are shared and impor- potentially fatal complications. ways to improve patients' odds for critical-care physicians, nurses tant work can be accomplished." Cobb heals the For these patients, an SICU stay is survival. and researchers to establish a In the SICU, Cobb is highly a touch-and-go struggle for life as cooperative research framework regarded as a passionate advocate critically ill in the Cobb and others deal with one Looking to genes and clinical protocols that evalu- for his patients and a calm pres- medical crisis after another to Cobb's search for answers explain- ate different approaches to caring ence in a high-stress environment. surgical ICU stabilize their conditions. ing why one critically ill patient for critically ill patients. "Dr. Cobb has a superb bedside "People with traumatic injuries dies while another with the same manner and brings out the best in that at one time would have been injury lives has led him to the Making a difference everyone involved in the care of fatal can be put on ventilators and roots of illness: genes. While genes Cobb was drawn to the field of patients he is overseeing," says kept alive in states that never are known to play a role in dis- surgery by his role model and Walter A. Boyle III, M.D., profes- existed before," Cobb says. "But eases such as cancer, diabetes and mentor Hiram C. Polk Jr., M.D., sor of anesthesiology and of sur- our ability to treat these patients heart disease, research by Cobb former chairman of the Depart- gery and director of the Anes- still mostly amounts to a holding and his colleagues shows that a ment of Surgery at the University thesiology Critical Care Division. measure — the ventilator buys us constellation of genes goes awry as of Louisville School of Medicine, "Perren's ability to put staff at ease time to try to resolve their under- the body responds to traumatic where Cobb earned a medical and listen to their views optimizes lying medical issues." injury. degree. Polk was a general surgeon the chances for good outcomes for Sometimes, despite all heroic In recent years, Cobb has been who had special expertise in trau- patients." measures, critically ill patients' a leader in evaluating whether ma surgery. Although 5 million people are progress suddenly stalls and their gene chips, which can rapidly "I came under his spell as a admitted to ICUs each year, and organs begin to fail as doctors track patterns of activity of thou- second-year medical student, and their care accounts for 15 percent stand by helplessly. sands of genes, can help explain on I wanted to be just like him," to 20 percent of inpatient hospital "The technology exists to fix a a molecular level how patients Cobbs says. "He was a champion costs, there are no national advo- hole in the blood vessel, to sew up respond to critical illness and for every patient, and when I cacy groups focused on ICU care the intestine or to cover burns injury. made rounds with him, I found as there are for cancer, heart dis- with skin grafts," Cobb says. "But This line of investigation may the care of the critically ill and ease and other specific conditions. there's a tight window of time for eventually help to identify mo- injured to be a very seductive field Likewise, no federal agency is patients in shock to get aggressive lecular markers to pinpoint the because it was so exciting." designated to fund critical care treatment. When patients cross earliest onset of organ failure or Cobb completed a general research. In raising awareness of that threshold, their organs start infection, for example, giving surgery residency at the University the need for more attention to his to fail, and there's absolutely noth- doctors an opportunity to inter- of California, San Francisco, fol- field, Cobb finds the French term ing we can do but stand there and vene before underlying conditions lowed by two critical-care fellow- for his specialty particularly useful. watch them die. That is what get out of hand. ships, one at the National Insti- "We are challenged by the fact keeps me up at night and moti- Cobb has teamed with scienr tutes of Health and the other at that the community we serve, vates me to find answers." tists throughout the country to use the University of Pittsburgh. patients and the public, has no Physicians currently have no gene chips to detect changes in He came to Washington idea what an intensivist is," he says. way to predict which critically ill gene expression triggered by trau- University in 1995, intending to "But a reanimateur — now that or injured patients will fall into ma. And in his own lab, he is using spend his career in the operating gets people's attention. They don't this downward spiral and do not the chips to detect pneumonia room as a trauma surgeon. walk away from that conversation." have treatments to prevent it. associated with ventilator use and "But over time, it became very Frustrated by this, Cobb stopped to distinguish sepsis, a fast-mov- clear to me that I was increasingly performing surgery several years ing blood infection that is the attracted to what was going on in J. Perren Cobb ago to instead focus on finding leading cause of organ failure, the ICU and the many questions we needed.to answer to improve from inflammation related to Hometown: Louisville, Ky. injury. Both pneumonia and sepsis patient outcomes," Cobb says. are major problems in the ICU. In 2001, Cobb joined other Education: B.A., Vanderbilt University; To develop the gene chip tech- researchers throughout the coun- M.D., University of Louisville School nology and evaluate its use in try as part of a massive study of of Medicine patients, Cobb has brought to- trauma, funded by the National Titles: Professor of surgery and of gether scientists from diverse Institute of General Medical anesthesiology and associate fields — genomics, surgery, anes- Sciences under a so-called "glue professor of genetics. Cobb also thesiology, engineering, bioinfor- grant" mechanism. The 10-year founded and now directs the Center matics, mathematics and immu- project is teasing apart the com- for Critical Illness and Health nology. plex set of events involved in the Engineering, which improves "That takes a special talent, not body's reaction to traumatic outcomes for the critically ill and only to bring different people injury. injured through innovative biomedical together, but to get buy-in for how That collaboration also was a research and hospital performance to move forward," says Timothy springboard to others to advance improvement. Eberlein, M.D., the Bixby Pro- the use of genomics to help track fessor and chairman of the De- the course of critical illness. Family: Wife, Cindy; daughter, partment of Surgery. "Perren Cobb "Perren is able to find the Shelby, 13; and sons Everett, 11, and is a world-class researcher and the people who are involved in state- Marshall, 5 nicest guy in the world. He has a of-the-art research, who work Hobbies: Attending children's school vision for what it takes to solve with cutting-edge technologies activities and sporting events and complex medical problems in the and in fields not connected to reading The Economist, The New York The Cobb family: (clockwise from top) J. Perren Cobb; wife, Cindy; real world. My only regret is that I medicine but that have a lot to Times and the St. Louis Post-Dispatch daughter, Shelby, 13; and sons Everett, 11, and Marshall, 5. can't clone him." offer to medicine," says