CX3CL1 System in the Cross-Talk Between Chronic Lymphocytic Leukemia Cells and Tumor Microenvironment
Leukemia (2011) 25, 1268–1277 & 2011 Macmillan Publishers Limited All rights reserved 0887-6924/11 www.nature.com/leu ORIGINAL ARTICLE A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment E Ferretti1, M Bertolotto2, S Deaglio3, C Tripodo4, D Ribatti5, V Audrito3, F Blengio6, S Matis7, S Zupo8, D Rossi9, L Ottonello2, G Gaidano9, F Malavasi10, V Pistoia1,11 and A Corcione1,11 1Laboratory of Oncology, IRCCS G. Gaslini, Genova, Italy; 2Laboratory of Phagocyte Physiopathology and Inflammation, Department of Internal Medicine, University of Genova, Genova, Italy; 3Department of Genetics, Biology & Biochemistry, Human Genetics Foundation (HuGeF), University of Torino, Torino, Italy; 4Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo, Palermo, Italy; 5Department of Human Anatomy and Histology, University of Bari, Bari, Italy; 6Laboratory of Molecular Biology, Gaslini Institute, Genova, Italy; 7Medical Oncology C, National Cancer Research Institute, Genova, Italy; 8Laboratory of Diagnostics of Lymphoproliferative Disorders, National Cancer Research Institute, Genova, Italy; 9Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro, University of Eastern Piedmont, Novara, Italy and 10Department of Genetics, Biology & Biochemistry, Research Center for Experimental Medicine (CeRMS), University of Torino, Torino, Italy Several chemokines/chemokine receptors such as CCR7, Additional prognostic markers are surface CD38 and intra- CXCR4 and CXCR5 attract chronic lymphocytic leukemia cellular ZAP-70 whose expression in leukemic cells correlates (CLL) cells to specific microenvironments. Here we have with unfavorable clinical outcome.2,4,5 Finally, different chro- investigated whether the CX3CR1/CX3CL1 axis is involved in the interaction of CLL with their microenvironment.
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