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Berlin 16 th World Congress International Cartilage Regeneration Germany & Joint Preservation Society April 12 – 15, 2022

ICRS 2022 Preliminary Programme & Call For Abstracts

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International Cartilage Regeneration & Joint Preservation Society www.cartilage.org INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration WELCOME BY THE PRESIDENT & Joint Preservation Society 3

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Dear Colleagues & Friends collaborationsREGENERATION & SOCIETY and celebrateREGENERATION our& SOCIETY society again together! It is with great pleas- ure that I invite you to Our scientific programme chairs, Magali

th INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION the 16 World Con- Cucchiarini& JOINT PRESERVATION and SOCIETY Stefan Nehrer& JOINT PRESERVATIONhave SOCIETY laid International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration gress of the ICRS. out a great scientific agenda and look This venue will be in forward to receiving your abstracts to The ICRS is the Main Forum for International Collaboration & Joint Preservation Society the beautiful city and finalise our programme. ChrisInternational Erggelet Cartilage Regeneration is & I NTERNATIONAL C ARTILAGE R EGENERATION in Cartilaginous Tissue Research & Joint Preservation capital of Germany, our local& JOINT PRESERVATION host SandOCIETY promises toJoint Preservationgive usSociety an Berlin. This has long enjoyable social programme. Recognizing that there is a continuum from cartilage injury to degenerative joint disease we bring been considered one of the most well together basic scientists, clinical researchers, physicians, other healthcare providers and members of known and populous (3.8 million) cities Please mark your calendars and plan to industry, engaged or interested in the field of articular biology, its genetic basis and regenerative medicine. We seek to improve our patients´ quality of life, decrease their disability and reduce the impact of of Europe. It is a world city of culture, join us April 12-15, 2022 in Berlin, Ger- degenerative joint disease on healthcare systems worldwide by preserving joints and maintaining func- politics, media and science. It is known many. tion.” The Society has currently 1300 active members from 65 countries. for its high tech firms, media, and research. Its convention venues are world I look forward to seeing you again. Stay The purpose of ICRS is charitable: The society envisages the scientific research and the exchange of renowned, lucky for us. healthy my colleagues and friends, knowledge among physicians, scientists, patients and researchers of the industry in the field of Cartila- ge Regeneration and Joint Preservation. To serve its purpose, the society organizes international con- gresses and events, publishes journals and provides a universal internet platform. After an unprecedented turn of events Best Wishes of global proportions in 2020, our Congress in April 2022 will allow us Tom Minas Join ICRS Now! Benefits for ICRS Members to renew our friendships, networking, ICRS President 2019 – 2022 • 4 Issues of the official ICRS Journal Cartilage, published by SAGE • Highly reduced registration fees for all ICRS educational events • Eligibility for ICRS Scholarships • Eligibility for ICRS Travelling Fellowships • Access to the “Member Only” section of the ICRS Website (incl. Membership Database and access to the Cartilage Knowledge Database, Electronic Posters, INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE Abstracts andJOINT selected PRESERVATIONSymposia presentations) REGENERATION SOCIETY REGENERATION• Free advertisingSOCIETY of your cartilage meeting/course in the ICRS Newsletter & The Annual Membership Fees are: and& online event calendar Ordinary Members: € 220.00 Junior Members: € 100.00 Corporate Members: € 3000.00 Our Mission Join ICRS online at www.cartilage.org Advancing Science & Education of the Prevention [email protected] & Treatment of Cartilage Disease Worldwide

Brandenburgertor – Foto: Wolfgang Scholvien International Cartilage Regeneration & Joint Preservation Society

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION w & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

International Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION & JOINT PRESERVATION S OCIETY Joint Preservation Society INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

WELCOME BY THE SCIENTIFIC WELCOME BY THE SCIENTIFIC

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration PROGRAMME COMMITTEE PROGRAMME COMMITTEE & Joint Preservation Society 5

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION The world is still in the After many years of increasing our knowl- updated, especially with respect to back to emony REGENERATIONhosted& SOCIETY by the ICRS Board,REGENERATION the& SOCIETY ICRS hand of the corona edge und insights into cartilage repair and sports and applied biomechanics. A lot of in- Awards Ceremony and the ICRS Welcome virus and we are all joint preservation, we have to go back on formation through our keynote speakers and Cocktail will offer the best opportunities to struggling to keep our- one hand to critically analyse and learn from distinguished faculty will be provided and meet with peers of the ICRS family and to

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION selves and the persons our successes and failures in regeneration interaction of all participants and industry is join our& JOINT effortsPRESERVATION SOCIETYto have an outstanding& JOINT PRESERVATION meetSOCIETY - International Cartilage Regeneration & Joint Preservation Society International Cartilagenext to us surviving Regenerationthis and repair and to rethink what happened. necessary to reach the goal of the meeting. ing. The ICRS Farewell Night will give you crisis. Even our health On the other hand, we have to rethink our Plenary sessions and abstract presentations a flavour of Berlin, a vibrant city with many & Joint Preservationsystems and econo -Societyimpact on the health system in light of dig- with the highlighted topics, morning work- opportunities, just check it out!International Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION mies down to basis of italisation, transdisciplinary approaches, shops on basic and advanced skills in clinic & JOINT PRESERVATION S OCIETY Joint Preservation Society our society are enor- and globalisation. The goal is to redefine and research, poster sessions and industry Magali Cucchiarini & Stefan Nehrer mously challenged. our processes and technology in the context exhibition, and lunch workshops will be the Co-Chairs of the Scientific Programme However, we also have of a more complex translational approach backbone of the meeting. The Opening Cer- Committee 2022 to look into the future and unite our efforts in research and clinic to and strongly move for- really move forward. But also, side-effects of ward in the world of those trends connected to Big Data and Arti- medical research and ficial Intelligence, as well as fake news and experimental science in cartilage repair social media, and new regulations like the WELCOME BY THE LOCAL COMMITTEE and joint preservation. The mission of the medical device regulations are challenges to ICRS to promote science and education in be addressed. Register data and long-term the treatment of musculoskeletal conditions outcomes can set the stage for the evaluation Berlin – The Beaten City economic power: Fantastic architecture, is a sustainable goal and will be thereafter of existing technologies. Obstacles for clini- museums, art – as well as graffiti, pot- – hopefully – we have mastered this virus di- cal use of those successful technologies have Center of the Ger- holes in the streets and remnants of a saster. The pandemic of musculoskeletal dis- to be discussed among clinical researchers, man empire in 1871, communist lifestyle. This is where the eases – like osteoarthritis – and the burden scientists, and industry to develop strategic stripped off all interna- “Berliner” kicks in – with the uncondi- of pain and immobility will still challenge our measurements for the implementation of tional influence after tioned will to survive, with street clev- daily work in research and clinics. We look these treatments for the best of our patients. Word War I, reinvent- erness and a good sense of humour forward to welcoming all of you healthy Reviews on results of clinical research and ing itself as a cultural, – explaining the obvious uniqueness of and strong in Berlin for the 16th ICRS World experimental science have to be discussed scientific, and social Berlin. INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONALCongress CARTILAGEfrom April 12-15, 2022. JOINTWe - toPRESERVATION translate this knowledge into an assess- hotspot in the 1920ies REGENERATION SOCIETY MagaliREGENERATION Cucchiarini and Stefan NehrerSOCIETY - are ment of new, upcoming technologies. Artifi- and hosting the Nazi dictatorship with the ICRS is striving as well to support a good & the Co-chairs of the Scientific& Programme cial Intelligence can help to get more insights dream to “make Germany great again”. life with beaten joints - save, support, and Committee and together with our Commit- into big data or digital imaging analysis. That turned out to be a terrible illusion – restore existing structures to maintain func- tee Members, we are now planning the Omics, epigenetics as well as cell signal- details of this dark chapter in the history tioning joints. Therefore, Berlin is the nat- scientific programme with the goal to focus ling, and extracellular vesicles are hot topics of the city are now known. Raided, virtu- ural choice for a ICRS World Congress! on current developments in our field and which play an important role to understand ally destroyed during world war II, and report, discuss and analyse those among healing and regenerative mechanisms. Re- split up by the winning nations. The Ber- Plan your trip, bring your family, and learn scientists and clinical researchers as well as search of joint homeostasis and aging will lin wall became a prominent landmark about the “survival in style” of beaten orthopaedic surgeons, healthcare providers bring new aspects of treatment modalities in of the cold war area. Economic growth structures. The team of ICRS and the city and – last but not least – industry, providing degenerative joint diseases. New surgical and political development were cut back of Berlin will be happy to provide guid- the economic background of all our efforts. techniques in various joints are technical according to the decisions made a the ance, insights, and memories you will nev- We propose the “R” within the ICRS as our demanding and need advice and training Potsdam Conference ending world war er forget! Hope to see you in Berlin! main topics: Repair, Regenerate, Restore, Replace, of how and when to use it. Standardised II until the reunification of Germany in Rehabilitate, Research, Review, Redefine, Rethink protocols in rehabilitation are the key for 1990. Since then, Berlin is struggling to On behalf of the Local Organizing Committee will be the bullet points of our meeting. patient-related outcomes and have to be gain international influence again and Christoph Erggelet, Congress Chair 2022

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration ORGANIZATION ICRS SOCIETY & Joint Preservation Society 7

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Local Organizing Committee Congress Organizing Office ICRS Executive Board 2020 – 2022 ICRS GeneralREGENERATION & SOCIETY Board 2020REGENERATION – 2022& SOCIETY Berruto Massimo, Milan, IT Congress Chair: Cartilage Executive Office GmbH President: Brittberg Matts, Kungsbacka, SE Erggelet Christoph, MD, Prof c/o Mr. Stephan Seiler Minas Tom, West Palm Beach, USA Bugbee Bill, La Jolla, USA

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION Alphaclinic, Zurich, CH Spitalstrasse 190 Cole& JOINTBrian, PRESERVATION Chicago, SOCIETY USA & JOINT PRESERVATION SOCIETY International Cartilage Regeneration & Joint Preservation Society International Cartilage RegenerationHouse 3 1st Vice President: Decker Rebekah, San Diego, USA Members of the Local Committee: CH-8623 Wetzikon ZH Kon Elizaveta, Milan, IT Erggelet Christoph, Zurich, CH & Joint• Angele Peter,Preservation Regensburg, DE SocietySwitzerland Gobbi Alberto, Milan, IT International Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION • Madry Henning, Homburg, DE Phone: +41 44 503 73 70 2nd Vice President: Grande& JOINT PRESERVATIONDaniel, S OCIETY Manhasset, JointUSA Preservation Society • Richter Wiltrud, Heidelberg, DE Email: [email protected] Daniel Grande, Manhasset, USA Kon Elizaveta, Milan, IT • Rössler Philip, Mayen, DE Krych Aaron, Rochester, USA • Salzmann Gian, Wiesbaden, DE Secretary General: John Lane, La Jolla, USA • Petersen Wolf, Berlin, DE Brian Cole, Chicago, USA Lattermann Christian, Boston, USA • Zinser Wolfgang, Dinslaken, DE Mandelbaum Bert, Santa Monica, USA Treasurer: Marlovits Stefan, Vienna, AT Lattermann Christian, Boston, USA McNicholas Mike, Liverpool, UK Scientific Programme Committee Congress Venue Minas Tom, West Palm Beach, USA Past President: Nehrer Stefan, Krems, AT Programme Chairs: Hotel InterContinental Berlin Gobbi Alberto, Milan, IT Sciaretta Fabio, Rome, IT • Cucchiarini Magali, PhD, Prof Budapester Straße 2, Sherman Seth, Redwood City, USA Saarland University Medical Center, 10787 Berlin, Germany Please note: This is a preliminary programme. The Homburg, DE www.intercontinental.com/berlin information in this programme is subject to change without prior notice. For updated information, please Phone: +49 30 26020 visit frequently our website: www.cartilage.org • Nehrer Stefan, MD, Prof Toll Free: 0800 186 10 06 Donau University Krems, Krems, AT E-Mail: [email protected]

Programme Committee Members: • Cucchiarini Magali, Homburg, DE INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL• Getgood CARTILAGE Alan, London, ON, CA JOINT PRESERVATION REGENERATION SOCIETY • REGENERATIONHa Chul Won, Seoul, ROK SOCIETY & • Hollander Anthony, Liverpool,& UK • Nehrer Stefan, Krems, AT • Niemeyer Philipp, Munich, DE • Vonk Lucienne, Teltow, DE

Berlin Cathedral

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration PROGRAMME OVERVIEW & Joint Preservation Society 9

Tuesday, April 12, 2022 Wednesday, April 13, 2022 Thursday, April 14, 2022 Friday, April 15, 2022 INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION REGENERATION & SOCIETY REGENERATION & SOCIETY

07:30–08:30 07:30–08:30 07:30–08:30 07:30–08:30 07:30–08:30 07:30–08:30 07:30–08:30 Industry Breakfast Symposia Next Gen Next Gen Next Gen Morning Morning Morning Workshop Workshop Workshop Workshop Workshop Workshop INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION Grant Get your Dream Meet the Ex- Meet& the JOINT EditorsPRESERVATION SOCIETYMeet the Expert Meet& JOINT PRESERVATION the In SOCIETY- International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration Writing Academic Job perts dustry

& Joint Preservation Society International Cartilage Regeneration 08:30–09:30 & 08:30–09:30 08:30–09:30 I NTERNATIONAL C ARTILAGE R EGENERATION & JOINT PRESERVATION S OCIETY Joint Preservation Society Plenary Session Plenary Session Plenary Session Digitalisation Biological Matrices Translation: Bridging the Gap Between Basic Knowl- edge & Clinical Applications 09:45–10:45 09:45–10:45 09:45–10:45 09:30–10:30 10:00–18:00 9:30–10:45 Special Sessions Special Sessions Special Sessions Plenary Session Registration Coffee Break / Poster Exhibition Blood- Clinical Applica- Prevention & Mini Battles Derived Products tion Progenitor Rehabilitation in Cells Sports 10:45–11:45 10:45–11:45 10:45–11:45 10:30–11:00 Special Sessions Special Sessions Special Sessions Coffee Break / Exhibition Early OA & Car- Development & Imaging & AI 10:45–11:15 tilage Repair Signalling Coffee Break / Exhibition

11:00–12:30 12:00–13:00 11:15–12:45 Free Paper Sessions Opening Session 12:00–13:00 Free Paper Sessions ICRS Meets Germany Industry Satellite Symposia 13:00–14:00 12:30–13:30 12:30–13:30 12:30–13:30 13:15 –14:15 Industry Symposia Special Sessions Special Sessions Special Sessions Plenary Session 13:00 –14:30 Biomaterials & Experimental and Rehabilitation Repair, Restore, Regenerate, Free Paper Sessions Bioprinting Natural Biologics Redefine, Rehabilitate 14:15–15:45 Free Paper Sessions INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION 13:30 14:30–15:30 14:30–15:30 14:30–15:30 14:45–15:45 14:45–15:45 14:45–15:45 16:00–17:00 16:00–17:00 16:00–17:00 End of Meeting SpecialREGENERATION Sessions Special Sessions Special SessionsSOCIETYSpecial Sessions Special Sessions Special Sessions REGENERATION SOCIETY & Special Sessions Special Sessions Special Sessions & Homeostasis, Arthroscopic Clinical Trials in Omics, Biomechanics Disease Mod- Systems Biology and Gait Anal- elling, Animal Cell Communi- Repair, Cell Therapy, Aging Approach to 2019 Cartilage ysis Models cation & Cell Restore, Body Defects Phenotypes Replace Responses 15:45–16:30 15:30 –16:15 Coffee Break / Exhibition Coffee Break / Exhibition / Poster Session 17:00 –17:30 Coffee Break / Exhibition 16:15 –17:0 0 16:30 –18:00 Opening Ceremony & Awards Session Free Paper Sessions 17:30–18:30 17:00–18:00 ICRS General Assembly (For Members Only) Honorary Lectures

19:30 –23:00 18:00 –19:30 19:30 –23:00 Farewell Party Welcome Cocktail in the Exhibition Area President’s Dinner (Upon Invitation Only)

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration SCIENTIFIC PROGRAMME SCIENTIFIC PROGRAMME & Joint Preservation Society 11

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Tuesday, April 12, 2022 Wednesday, April 13, 2022 REGENERATION & SOCIETY REGENERATION & SOCIETY

12:00–13:00 Opening Session 07:30–08:30 Industry Breakfast Symposia 1–3 ICRS Meets Germany 08:30–09:30 Plenary Session INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION International Cartilage Regeneration & Joint Preservation Society International Cartilage• Cartilage Repair Regeneration– The Clinical Perspective & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY • Cartilage Repair – The Register Perspective Digitalisation • Cartilage Repair – The Translational Perspective • Digitalisation – A Pandemic Process & Joint Preservation Society International Cartilage Regeneration & • Cartilage Repair – The Research Perspective I NTERNATIONAL C ARTILAGE R EGENERATION • Big Data in Imaging & JOINT PRESERVATION S OCIETY Joint Preservation Society • Digitalisation – Are there Unintended Effects? 13.15–14.15 Plenary Session • Fake News in Medicine Repair, Restore, Regenerate, Redefine, Rehabilitate • Repair is not Good Enough? • Restore Joints – A Complex Task? 09:30 - 10:45 Coffee Break / Exhibition / Poster Viewing • Regenerate – The Holy Grail? • Redefine the Goals Of Cartilage Repair – What is Next? 10:45 - 11:45 Special Sessions 4–6 14:30–15:30 Special Sessions 1-3 Early OA & Cartilage Repair Homeostasis, Aging • What is Early OA? And What Are We Doing? • Progenitor Cells & Aging • Conservative Treatment • Osteoarthritis & Aging • Surgical Treatment • Biomarkers • Early OA Scientific Perspective • Musculoskeletal Homeostasis Development & Signalling Arthroscopic Approach to Cartilage Defects • Morphogenesis • Knee • Epigenetics • Ankle • Inflammation & Immunity • Hip • Signalling in Cartilage Homeostasis

• Shoulder & Elbow Imaging & Artificial Intelligence INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Clinical Trials in 2020 • MRI News – MOCART 4.0 REGENERATION SOCIETY REGENERATION SOCIETY • AI in OA Diagnosis & • Long-Term& Results • Register Data • New Modalities in Joint Imaging • Where is the Evidence? • What do we See in Imaging? • Guidelines for Cartilage Repair 12.00–13.00 Industry Satellite Symposia 4–6

15.30–16.15 Coffee Break / Exhibition / Poster Viewing 13:00–14.30 Free Paper Sessions 1–3

16:15–17.00 Opening Ceremony & Awards Session • Knee • Foot & Ankle • Shoulder 17:00–18.00 Honorary Lectures • ICRS Vision Lecture • Keynote Lecture 18.00–19.30 Welcome Cocktail in the Exhibition Area

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration SCIENTIFIC PROGRAMME SCIENTIFIC PROGRAMME & Joint Preservation Society 13

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Wednesday, April 13, 2022 Thursday, April 14, 2022 REGENERATION & SOCIETY REGENERATION & SOCIETY

14:45–15:45 Special Sessions 6–9 07:30–08:30 Next Gen Workshops 1–3 • Grant Writing Omics, Systems Biology INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION • Get your Dream Academic Job & JOINT PRESERVATION SOCIETY • The Mitochondria in OA & JOINT PRESERVATION SOCIETY International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration • Meet the Experts • Proteomics • Genome Analysis & Joint Preservation Society 08:30–09:30 Plenary Session International Cartilage Regeneration & • Novel Epigenetic Markers I NTERNATIONAL C ARTILAGE R EGENERATION & JOINT PRESERVATION S OCIETY Joint Preservation Society Biological Matrices Biomechanics and Gait Analysis • Cells & Scaffolds • The BIO-Mechanic of Cartilage Repair • Biological Controlled Release • Biomechanics of Evolution • Immune Modulation & Scaffolds • Tissue Biomechanics • Clinical Application of Matrices • Micro Mechanobiology Disease Modelling, Animal Models 09:45–10:45 Special Sessions 9–12 • Large Animal Models Blood-Derived Products – Hype or Fake? • Progenitor Cells in Vivo • PRP is not PRP • Experimental OA Models • How does PRP/BMAC Work Experimentally? • Cartilage Disease Modelling • Stem Cells and/or PRP • Clinical Application Progenitor Cells 15:45–16:30 Coffee Break / Exhibition Innovative Gene Therapy • Gene Therapy 16.30–18:00 Free Paper Session 3–6 • Genome Editing • Animal Studies • Scaffold-Based Nucleic Acid Therapeutics • Clinical Trials • Biomaterial-Guided Clinical Gene Therapy • Allografts Prevention & Rehabilitation in Sports INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL19:30–23:00 CARTILAGE President’s DinnerJOINT (Upon PRESERVATION Invitation Only) • Sport Injuries – No Sports? REGENERATION SOCIETY REGENERATION SOCIETY • Prevention of OA – So we Need Surgery? & & • Back to Sports after Cartilage Injuries • OA & Sports

10:45–11:15 Coffee Break / Exhibition

11.15–12.45 Free Paper Sessions 6–9 • Biomaterials • Translational OA • Joint Preservation

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration SCIENTIFIC PROGRAMME SCIENTIFIC PROGRAMME & Joint Preservation Society 15

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Thursday, April 14, 2022 Friday, April 15, 2022 REGENERATION & SOCIETY REGENERATION & SOCIETY

13.00–14.00 Industry Symposia 7–9 07:30–08:30 Morning Workshops 4–6 • Meet the Editors 14.15–15.45 Free Paper Sessions 9–12 • Meet the Expert – Treatment Strategy for Cartilage Defects INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION International Cartilage Regeneration & Joint Preservation Society International Cartilage• Stem Cells Regeneration • Meet the Industry & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY • Imaging 08:30–09:30 Plenary Session • Rehabilitation & Joint Preservation Society Translation: Bridging the Gap Between Basic KnowledgeInternational Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION & JOINT PRESERVATION S OCIETY Joint Preservation Society 16:00–17:00 Special Sessions 12–15 & Clinical Applications • Translational Gene Therapy: Advances & Challenges Cell Communication & Cell Phenotypes • Clinical Therapy: Current Progress • Chondrocyte Phenotype • Clinical OA Treatment: Latest Developments • Mesenchymal Stromal Cells • Legal Aspects • The Microbiome 09:30–10:30 Plenary Session • EVs in Aging Mini Battlefield Repair, Restore, Replace • Do We Need Biological Augmentation? • Borders of Joint Preservation • Do We Still Need Osteotomy? • Surgical Cartilage Regeneration - Anything New? • Can We Prevent OA by Regenerative Medicine? • Allograft – Phoenix of Cartilage Treatment • Do We Really Need PRP? • Do We Still Need Microfracture? • Partial & Total Joint Repair – The Solution? Cell Therapy, Body Responses 10:30–11:00 Coffee Break / Exhibition • Cell Therapy for Cartilage Repair - Modelling • Cellular Responses to Implants 11:00–12:30 Free Paper Sessions 12–15 • Autophagy & Cellular Stress • Growth Factors • Osteoarthritis • Body Responses to Materials • Late Breaking Abstract 17:00–17:30 Coffee Break / Exhibition 12:30–13:30 Special Sessions 15–18 INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Biomaterials & Bioprinting REGENERATION SOCIETY 17:30–18:30REGENERATION ICRS General AssemblySOCIETY (For Members Only) • Biomaterials & Hydrogels & & • Tissue Engineering & Cells • Tissue Engineering & Growth factors • 3D Bioprinting Experimental and Natural Biologics 19:30–23:00 German Night–Farewell Party • Recent Advances & Opportunities for Cartilage Repair • Novel Biologics • Natural Materials • PRP & Tissue Engineering Rehabilitation • New Concepts of Cartilage Healing – What Can Help? • Continuous Passive Motion – What is the Science Behind it? • Loading Unloading – Where is the Evidence? • Physical Therapy in Joint Rehabilitation 13.30 End of Meeting

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY ICRS Member Testimonials

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration March 2020 & Joint Preservation Society 17 „Good „Cartilage is a scientific meetings - field of main interest in INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION excellent medical information REGENERATION & SOCIETY orthopaedic andREGENERATION one& SOCIETY of the most - conferences containing the latest sparkling for research, furthemore modern science - getting to know col- ICRS family means a lot for me and my leagues from different countries.“ „Be- practice. I invite all the young surgeon Adel Hossny Hegaze, INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETYand reserchers& JOINT of PRESERVATION the SOCIETYfield to parti- International Cartilage Regeneration Saudi Arabia longing to the ICRS International Cartilage Regeneration & Joint Preservation Society family has opened the doors cipate.“ Francesca Vannini, „At- of research and discovery of the Italy & Joint Preservation Society tending ICRS International Cartilage Regeneration best and most modern therapeutic & I NTERNATIONAL C ARTILAGE R EGENERATION meetings has been a & JOINT PRESERVATION S OCIETY Joint Preservation Society options to treat my patients with „I enjoy the ICRS game-changer for me as an joint injuries.“ since this is a highly motiva- ® orthopedic surgeon. As a result, I Ramon Saldana Mattar, ted and focused global group of NOVOCART 3D became an early adopter of Biolo- Dom. Republic scientists, clinicians and industry who gics. The scientific content pertaining come together for the common objecti- A New Frontier in Cartilage Repair to Biologics that is presented from „ICRS ve of better solutions for patients.“ researchers all over the globe is is a great society Daniel Lee, USA unsurpassed.“ with global reach and is Joanne Halbrecht, an it’s members and scope USA are an excellent blend of clini- „I would like to thank ICRS for its „For cal and basic science in translational medicine.“ brilliance and enormous contribution me, ICRS is a comple- to orthopedists around the world! Con- te scientific Society, including Tim Woodfield, New Zealand gratulations !!“ clinicians and researchers in diffe- José Leonardo Rocha de Faria, rent fields with a high level of content „ICRS is a very Brazil and friendly community.“ dynamic society mer- Ignacio Dallo, ging fundamental and clinical „Great socie- Argentina scientist, The ICRS is a meeting ty - excellent inter- and exchange place for scientists and action between scien- „ICRS bridges sci- health professionals seeking to improve tists and surgeons.“ entists and clinicans in the health of patients with cartilage da- Ken Zaslav, USA INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION cartilage repair, regenerati- mage. The multidisciplinary approach ve medine anf joint preservati- to the problem is unique and rich in REGENERATION SOCIETY „The REGENERATION & SOCIETY & on.Go cartilage, go ICRS!“ lessons.“ ICRS comprises Stefan Nehrer, Austria Yves Henrotin, Belgium an extraordinary scientific system where academic „ICRS „The and personal realities take content is the “go-to” only meeting where Biologic approaches to tissue repair and regeneration place and the sharing and the educational source for those I can be a Professor in one represent the future in healthcare worldwide. exchange of views with eminent looking to develop a career in session and a Student in the Aesculap Biologics is leading the way. experts is one of the leading cartilage surgery.“ next session and learn from my strenght aspects.“ Learn more at www.aesculapbiologics.com Kristofer Jones, USA FRIENDS.“ Stephen Abelow, USA/ Giovanna „ICRS Spain „The Desando,Italy colloborations of diffe- Aesculap Biologics, LLC | 866-229-3002 | www.aesculapusa.com it is a great „Peo- society that mixes ple in this society ring medical disciplines coming Aesculap Biologics, LLC - a B. Braun company science and friendli- are overall warm and together at ICRS conferences is truly ness.“ open to anyone. ICRS is very special. I have learned more at these Hernan Giuria, comfortable place.“ than many other conferences I at-

NOVOCART 3D is an investigational product and not approved for use in the U.S. or in Canada outside of the clinical study. Argentina Takehiko Matsushita, tend during the year.“ Japan Brice Blatz, USA

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

CALL FOR ABSTRACTS CALL FOR ABSTRACTS

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration AUTHORS INFORMATION AUTHORS INFORMATION & Joint Preservation Society 19

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Call for Abstracts online blind review with regard to sci- on the ICRS website. No abstract sub- ConfirmationREGENERATION & SOCIETY of AbstractsREGENERATION & SOCIETY entific content, educational value, and missions by letter, fax or E-Mail will be Scientific contributions will be confirmed The scientific programme committee is visual impression. Awards for the 6 best accepted and no extension of the submis- latest by November 30, 2021 by E-Mail to pleased to invite all authors wishing to electronic posters and best abstracts will sion deadline will be granted. ICRS will the submitting author. The submitting author

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION present a paper or a poster at the ICRS be given during the ICRS Opening & NOT edit abstracts for language issues, must &inform JOINT PRESERVATION the SOCIETY presenter and &all JOINT PRESERVATIONco-authors SOCIETY International Cartilage Regeneration & Joint Preservation Society International2022 World CartilageCongress to submit their Regenerationab- Awards Ceremony on Tuesday, April 12, typing, spelling, or grammatical mis- of the notification result. Presenting authors stracts until October 15, 2021 latest. No 2022 from 16.15 – 17.00. takes. There is no fee charged to submit of accepted abstracts will be requested to re- & Jointextension Preservationof this deadline will be possi -Society an abstract for ICRS 2022 and you may confirm their presentations andInternational they Cartilage are Regeneration ex- & I NTERNATIONAL C ARTILAGE R EGENERATION ble. The overall best rated Abstract and • Traditional Wall Posters submit as many abstracts as you wish. pected& JOINT to PRESERVATION register S OCIETY normally to Jointthe Preservation congress. Society Posters will be awarded by the Society. In addition to the electronic posters, which However, it is highly recommended that They must cover their own travel, lodging must be submitted on a mandatory basis, you do not leave your submissions until and registration fees. • Podium Presentations the authors are invited to produce a tradi- the very last day. Free papers related to all topics in joint tional poster for the poster walls as well. If Publication – Journal “Cartilage” preservation and cartilage regeneration your abstract is accepted as a poster, you Presentation Preference We encourage authors to additionally will be presented during 15 free paper will be requested to submit your electronic Submitted abstracts will be peer-reviewed submit furthermore manuscripts to our sessions. Speaking time is 6 minutes plus version to the ICRS online poster submis- and may be accepted for either an oral- peer reviewed journal “Cartilage” (Im- 3 minutes for discussion. The speaking sion system and you might bring with you or a poster presentation. Submitters may pact Factor 3.857) published by Sage time must strictly be observed by the a traditional wall poster for the poster ex- indicate their presentation preference ISSN 1947-6043, which publishes full- presenters. If an abstract is accepted hibit onsite by reserving your poster wall during the submission process, but the length original manuscripts on all types as an oral presentation, presenters must in advance through our Office. Scientific Programme Committee re- of cartilage including articular, nasal, au- speak in fluent English and be prepared serves the right to define the final presen- ricular, tracheal/bronchial, and interver- to answer questions from the audience Submission of Abstracts – tation type. No podium presentations will tebral disc fibrocartilage. Manuscripts and moderators. All session rooms are Guidelines be guaranteed to any author. on clinical and laboratory research equipped with networked computer pro- Scientific abstracts must be submitted in are welcome. Instructions to authors for jection. Presenters are requested to bring impeccable English within the following Financial Disclosure submissions are available at http://cart. their PowerPoint presentation (Windows structure: Purpose – Materials & Meth- Submitting authors must complete a Fi- sagepub.com 10 and Microsoft Office 2016) on a USB ods – Results – Conclusion and must be nancial Disclosure Statement on behalf of stick and to check-in at the Preview Cen- written according to the few abstract all authors. Disclosures will not be seen Awards & Honours ICRS 2022 INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONALter 3 hours CARTILAGE prior to their presentation.JOINT submissionPRESERVATION instructions to be found in the or taken into consideration for the ab- Awards for the best abstracts and post- REGENERATION SOCIETY DetailedREGENERATION information will be sent SOCIETYto the ICRS abstract online submission system. stract grading process nor for the deci- ers as well as for other achievements will & presenters on time. & Abstract length is limited to a maximum sion of acceptance of an abstract. be given during the ICRS Opening & of 300 words and may contain up to 2 Awards Ceremony on Tuesday, April 12, • Electronic Posters graphs, pictures, or tabs. For experimen- We request all submitters to cooperate in 2022 from 16.15 – 17.00 One of the main benefits of an electronic tal clinical studies and animal studies, a this by: • 1 x Overall Best Rated Abstract poster exhibit is the post-congress avail- copy of the approval received by the lo- 1. Declaring any potential conflict of interest • 6 x Best E- Posters ability of the posters for many years in cal ethical committee must be sent to our by any of the authors when submitting an 2 x Magna Cum Laude the ICRS member’s area. Our scientific Executive Office after successful submis- abstract. 2 x Cum Laude cartilage knowledge database is fully sion of your abstract. 2. Declaring any commercial role in the re- 2 x Certificate of Merit searchable by title, poster ID, authors, full lated research of any Co-author on the • 1 x ICRS Lifetime Award text, and image annotation. Information Abstract Submission Deadline first slides for podium presentations or on • 1 x Young Investigator’s Award on how to use the electronic poster sub- Abstracts may be submitted online the posters for poster presentations. (US$ 1000.00) mission system will be sent to the authors through October 15, 2021 at noon CEST • 1 x James Richardson Award of the accepted posters. An independent (Central European Summer Time) by jury will judge the electronic posters by accessing our online submission system

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

CALL FOR ABSTRACTS

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration AUTHORS INFORMATION GENERAL INFORMATION & Joint Preservation Society 21

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION CME Credits your presentation in the session rooms. It is Congress Organizer VenueREGENERATION Location& SOCIETY REGENERATION & SOCIETY The ICRS 2022 Congress intends to be mandatory that the data carriers are deliv- Cartilage Executive Office (CEO) GmbH The centrally located Hotel InterContinental accredited by the European Accredita- ered to the Speaker Ready Room at least Spitalstrasse 190 - House 3 Berlin is situated in the city west area next to tion Council for Continuing Medical Ed- 3 hours prior to your session. The network 8623 Wetzikon ZH, Switzerland the winding Landwehr Canal at the edge of

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION ucations – EACCME, an institution of the of our computers in the session rooms and Phone: +41 44 503 73 70 the Tiergarten& JOINT PRESERVATION park SOCIETY and close to& JOINT Berlin PRESERVATION SOCIETYZoo. International Cartilage Regeneration & Joint Preservation Society InternationalEuropean Union Cartilage of Medical Specialists Regeneration in the Speaker Ready Room are equipped Fax: +41 44 503 73 72 The Intercontinental is in a prime position – UEMS, recognised by AMA. Informa- and run with Microsoft Windows 10. If [email protected] to experience both the greener side of the & Jointtion on accreditation Preservation and the number of Societyyou use Macintosh, please convert your city as well as its bustle. AbundantInternational Cartilage shops, Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION awarded CME credits will be available Key Point presentation or your PowerPoint Congress Venue / Accommodation restaurants& JOINT PRESERVATION and S OCIETY cafés are clusteredJoint Preservation around Society beginning of 2022 on our website www. Presentation for MAC into PowerPoint for Hotel InterContinental Berlin the redeveloped Breitscheidplatz area, a cartilage.org. PC Windows format. Speaker’s presenta- Budapester Straße 2, 10787 Berlin, DE 10-minute walk away. tions should be delivered as a standard in www.intercontinental.com/berlin Speaker Service / AV Centre Microsoft Office format to avoid any tech- Phone: +49 30 2602-0 Please note that only digital material will nical problems with the presentation sys- Toll Free: 0800 186 10 06 be allowed for oral presentations. The tem. If you have videos included in your E-Mail: [email protected] material must be in English and must be PP presentation, make sure that they run provided typically on a USB memory stick in the most commonly used video formats. in a MS Office 2016 format to be placed If you have any doubt, please contact the Welcome to Berlin on the central server on-site. Presentations ICRS Office at least 15 days before the cannot include any promotional com- congress. It is the presenters’ responsibility The German capital Berlin with its 3.8 Mil- mercial messages. It will not be possible to make sure that videos run on our stan- lion habitants, is not just a city of world-fa- to use your own laptop or notebook for dardised congress IT / AV system. mous faces – it also shines at the highest level with its food and fashion. Urban gardening, green fashion, and vegan gas- tronomy are turning the former industrial city of Berlin into an increasingly green Important Dates & Deadlines metropolis. The German capital attracts Abstract Submission Deadline October 15, 2021 artists, creative minds, culture lovers, and INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONALAbstract CARTILAGE Notification Letters JOINT PRESERVATIONNovember 30, 2021 theatre fans from all over Germany and REGENERATION SOCIETY REGENERATIONEarly Bird Registration Fee SOCIETY December 10, 2021 around the world. The diverse cultural of- & Cancellation Registration& (Refund 75%) December 10, 2021 ferings and the colourful hustle and bus- Hotel Cancellation Deadline no charge February 28, 2022 tle of the city create an incredibly special Deadline Normal Registration Fee March 31, 2022 atmosphere. Opera performances, art Cancellation Registration (Refund 50%) March 31, 2022 exhibitions, theatre productions, concerts, Hotel Cancellation Deadline Charge of 1 Night March 31, 2022 and festivals are all everyday occurrences Hotel Cancellation Deadline Charge of Entire Reservation April 01, 2022 here. Numerous memorials commemorate Late/Onsite Registration Fee as from April 01, 2022 events over the course of the city’s turbu- Travel & Transportation lent history. With around 200 museums, 400 galleries, three opera houses, eight The new Willy Brandt Berlin Brandenburg major symphony orchestras, more than 90 Airport (BER) is currently being built in Berlin cinemas, about 150 theatres and stages, Schönefeld with its opening scheduled for as well as many other cultural institutions, October/November 2020 after 10 years the German capital offers an almost inex- of construction delay. In the future the entire haustible selection of options. air traffic of the region should be handled

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration GENERAL INFORMATION GENERAL INFORMATION & Joint Preservation Society 23

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION from the new airport and the older Berlin If you are using a foreign card at a bank ma- another 62 countries can travel to the TechnicalREGENERATION &IndustrySOCIETY ExhibitionREGENERATION & SOCIETY Tegel Airport is supposed to be closed. chine, your money will be disbursed in Euros. Schengen Zone as a tourist for periods A technical industry exhibition will take of up to 90 days without having to pro- place at the Intercontinental Berlin. It • By Train: Berlin Brandenburg Airport has Currency cess a visa. This information may change will be open every day throughout the

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION its own six-platform railway station with The currency in Germany is the Euro. 1 € without further notice. meeting& JOINT PRESERVATION and exhibitorsSOCIETY from& JOINTaround PRESERVATION SOCIETY the International Cartilage Regeneration & Joint Preservation Society Internationalthree platforms Cartilage located directly under Regeneration- ≈ 1.21 US$ (Date of publication, February world will present a wide range of or- neath the terminal. The Airport Express 2021) If you have any doubts about your current thopaedic & cartilage related products. & Jointalready Preservationconnects Schönefeld Airport Society VISA need to enter Germany, we highly Participants are encouragedInternational to Cartilage take Regeneration ad- & I NTERNATIONAL C ARTILAGE R EGENERATION with Berlin city centre. In future, these Electricity, Weights & Measures recommend checking with your German vantage& JOINT PRESERVATION of this S OCIETY unique opportunityJoint Preservation Societyto be trains will run every 15 minutes between • Electricity: 220 - 240 volts 50 HZ Embassy or Consulate in your country. updated with the most recent advances Berlin central station and BER. The jour- • Weights: Kilo/Gramm System You also might find useful information for and latest news from our industry part- ney time is around half an hour. • Measures: Metric System German visa requirements here: ners. Interested companies may contact https://www.auswaertiges-amt.de/en the ICRS Executive Office for further ex- • By Taxi: Taxis can be easily found out- Tipping hibit & sponsoring information. side your arrival terminal. Standard fares Service and VAT are always included in the Disclaimer apply to all Berlin taxi drivers. In addition prices all over Germany. Still, it is typical to ICRS and the congress organizer cannot Intermissions to distance-based fares, surcharges may “round up” the amount to some more-or-less accept any liability for the acts of any sup- During intermissions, coffee, tea, and re- apply. Estimated cost to the city center is round figure to basic service providers such pliers to this meeting nor of the safety of freshments will be served in the exhibition 50.00 EUR and estimated travel time is as Taxi Drivers, Waiters, Porters, etc. A rule any attendee while in transit to or from this area as a courtesy from the ICRS. 30-40 min. of thumb is to add 5-10%, generally ending event. Participants are requested to carry with a full Euro amount. proper travel and health insurance as the Services for Persons Time Zone ICRS cannot accept liability for any acci- with Disabilities Central European Summer Time: UTC/ Health Care dents or injuries that may occur. Please inform the ICRS office or indicate on GMT +2 Special vaccinations are not required for the accommodation online booking form entry into Germany, but an individual travel Updated Information any special requirements you may have to Language & health insurance is highly recommended Information in this programme (published allow us to best serve you. The Interconti- The official congress language is English. because health insurance plans often do not in February 2021) is subject to change nental Berlin has international-standard fa- No simultaneous translation will be provid- extend full coverage for medical services re- without prior notice. For updated informa- cilities for the physically challenged, includ- INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONALed. German CARTILAGE is the official language spokenJOINT ceivedPRESERVATION outside the country of residence. tion please visit frequently our congress ing access ramps, elevators, and toilets for REGENERATION SOCIETY in REGENERATIONGermany. SOCIETY website at www.cartilage.org people with special needs. & & Entry Formality / Visa Climate The European borderless region, known Cancellation of the Congress Security / Badges In Berlin, the climate is moderately conti- as “Schengen Area” consists actually of by the Organizer The safety of all congress attendees is of nental, characterised by cold winters and 26 European countries: Belgium, Czech Congress fees will be reimbursed if the utmost importance to our society. The ICRS warm summers. The month of April is usu- Republic, Denmark, Germany, Estonia, congress is cancelled for other reasons and the Intercontinental Berlin have taken ally the month with the least rainfall and Greece, Spain, France, Italy, Latvia, than war, warlike events, and acts of ter- security precautions to ensure the maximum therefore a great time to visit the city with Lithuania, Luxembourg, Hungary, Malta, rorism or sickness epidemics/pandemics. possible safety for all participants. Identity average temperature ranging between Netherlands, Austria, Poland, Portugal, In the latter circumstances only a propor- check controls may occur at any time by min 6°C (42.4°F) and max 16°C (59.9°F). Slovenia, Slovakia, Finland and Sweden, tion of the congress fee would be refund- the security staff. Congress badges are per- along with Iceland, Liechtenstein, Nor- able. We recommend however that par- sonalised, not transferable and guarantee Credit Cards / Cash Machines way and Switzerland. Visitors from the ticipants book themselves refundable or individual access to different section of the All major credit cards are widely accepted. Schengen Area can hold a valid ID card changeable airfares. event. For organisational and security rea- Bank cash machines (ATM) can be found to travel within this area. Other visitors sons, badges have to be worn all the time easily and debit cards are also widely used. must hold a valid passport. Citizens from at the congress venue.

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration CONGRESS REGISTRATION CONGRESS REGISTRATION & Joint Preservation Society 25

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Registration Fees • Access to the scientific poster exhibition Mobile Phones from theREGENERATION poster& SOCIETY area is strictly REGENERATIONprohibited.& SOCIETY • Welcome Reception & Coffee Breaks All attendees will be requested to turn off, Note that the majority of the presenta- Early Bird – Prior to Dec 10, 2021 • Free Internet Access (WLAN) or to switch to silent mode their mobile tions, posters and many officially record- Resident/Students* € 350.00* • Congress Bag and Final phones during all scientific sessions. ed sessions will become available online

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION Physiotherapists/Nurses* € 350.00* Pocket Programme after& theJOINT PRESERVATION congress SOCIETY at the ICRS& JOINT website PRESERVATION SOCIETY in International Cartilage Regeneration & Joint Preservation Society InternationalICRS – Members Cartilage € 450.00 Regeneration• Badge and Certificate of Attendance Recording/Pictures the members’ area, therefore there is no Non – Members € 590.00 • CME Credits (to be confirmed) Taking photos or video/ audio record- need to take pictures during the sessions & JointIndustry Representatives Preservation € 690.00 Society• Congress App ing during the scientific presentations or or from the poster exhibits.International Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION Accompanying Person € 100.00 & JOINT PRESERVATION S OCIETY Joint Preservation Society Cancellation of Congress Normal – Dec 10 – March 31, 2022 Registrations - Name Changes Resident/Students* € 400.00* Written notification is required for all con- ACCOMODATION Physiotherapists/Nurses* € 400.00* gress cancellations and name changes. ICRS – Members € 550.00 Notifications should be sent to the Carti- Non – Members € 650.00 lage Executive Office [email protected]. Important: The ICRS has made a major commitment to the Intercontinental Berlin in Industry Representatives € 750.00 In case of a congress cancellation due to re- order to secure a sufficient block of quality hotel rooms at competitive rates within Accompanying Person € 120.00 jection of an abstract or entry Visa, the full the venue. We kindly ask participants and industry partners to book their hotel amount of the paid registration fee will be rooms at the Intercontinental Berlin through the official reservation link on our web- Late/Onsite – From April 1, 2022 refunded, minus 50 Euros processing fee. site. There is no extra administrative charge for this service, and we guarantee excel- Resident/Students* € 450.00* lent discounted rates in this property. Hotel rooms will be allocated on a first-come, Physiotherapists/Nurses* € 450.00* Refunds for congress cancellations by the first-serve basis. If you wish to extend your stay, the same discounted hotel rates are ICRS – Members € 600.00 attendee are as follows: available up to three nights prior and three nights after the congress dates subject Non – Members € 700.00 • 75 % refund for cancellations until De- to room availability. Industry Representatives € 800.00 cember 10, 2021 Accompanying Person € 150.00 • 50 % refund for cancellations until March 31, 2022 Official Congress Hotel / Venue Reservations / Hotel Booking *Registrations to be accompanied by a certificate signed by the head of department or valid student • No refund thereafter Intercontinental Berlin, Hotel InterContinental Berlin or professional ID • Name changes will be charged with a Budapester Strasse 2, 10787 Berlin, DE Group Reservation Code: ICRS 2022 INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATIONfee of € 100.00 www.intercontinental.com/berlin Phone: +49 (0)30 2602 1287 REGENERATION SOCIETY JoinREGENERATION ICRS & Benefit from SOCIETY Toll Free: 0800 186 1006 & Reduced Fees & Complimentary Internet/WLAN Special Courtesy: As a special courtesy, the Email: [email protected] Non-member attendees who apply for As a special courtesy, ICRS will provide hotel offers to ICRS congress attendees, com- A direct hotel reservation link will be provided ICRS membership 2021 right before their free WLAN Hot Spot with basic speed to plimentary fitness club access and free basic on our website www.cartilage.org as from congress registration will immediately all attendees and exhibitors in the conven- WLAN internet access in the hotel rooms. May 2021. profit from our highly reduced mem- tion area. bers’ fee. ICRS Members who are not Hotel Room Rates: Individual Reservations in good-standing with their membership Smoking SGL € 154.00 / DBL €179.00 (Breakfast, For individuals, online reservations will be dues 2020 / 2021 will automatically be The ICRS World Congress is a non-smok- Services & VAT Taxes are included, 5% City accepted through www.cartilage.org. On- charged with the non-member fee. ing congress. Smoking is not permitted at Tax to be paid by the guest upon check out) line reservations should be submitted as ear- the Intercontinental Berlin and its Confer- Upgrades to higher room categories and ly as possible, latest until March 31, 2022. Included in your registration fee ence Centre except in designated smok- to the Club Level are available through the Rooms will be confirmed on a first come, • Access to all scientific sessions ing areas. booking system through an additional fee. first serve policy. Reservations thereafter are • Access to the technical only confirmed upon availability and the industry exhibition hotel may charge a significantly higher rate.

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration ACCOMODATION SOCIAL EVENT INFORMATION & Joint Preservation Society 27

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Group Reservations – Industry cellation fees will apply: For cancellations REGENERATION & SOCIETY REGENERATION & SOCIETY The Intercontinental Berlin Reservation until February 28, 2022: No Charge. ICRS supports compliance with international ethical standards and therefore empha- department is pleased to receive group For cancellations until March 31, 2022: sises that participants who would like to attend social events shall bear all related costs reservations (9 Rooms or more). Please Charge of 1 night. For cancellations after themselves.

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION contact the Event Sales Team Ms. Tamara April 1, 2022 and No-Shows: Charge of & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY International Cartilage Regeneration & Joint Preservation Society InternationalJanowitz by phoneCartilage +49 (0)30 2602 1145Regeneration the entire reservation period. or Email: [email protected] Tuesday, April 12, 2022 Thursday, April 14, 2022 Hotel Reservation Changes & Joint Preservation Society International Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION Credit Card Guarantee / Payment Hotel reservation changes must be direct- Opening Ceremony & Welcome Reception German& JOINT PRESERVATIONNight S OCIETY- Farewell PartyJoint Preservation Society A credit card guarantee for the entire res- ed to the Intercontinental Berlin. Room 19.00 – 20.30 19.30 PM – 23.00 PM ervation period is required to confirm and night reductions of existing reservations secure your hotel room reservation. Please are subject to the cancellation conditions note that your hotel invoice shall be settled as described above. directly to the hotel upon your checkout.

Hotel Room Cancellation Cancellations are to be addressed to the hotel directly in writing. The following can-

All participants, industry representatives and accompanying persons are invited to join the opening ceremony and the welcome cocktail at the Intercontinental Berlin. The Welcome Reception is offered to you by the ICRS on a complimentary basis. Af- ter the cocktail, participants have free time for their own leisure to discover Berlin and enjoy one of the many nice restaurants, bars INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & clubs in town. REGENERATION SOCIETY REGENERATION SOCIETY & & Great entertainment for everyone! Join us Wednesday, April 13, 2022 for a fun summer evening with traditional mouth-watering German food, beer & President’s Dinner drinks in a relaxed party atmosphere. Enjoy (upon invitation only) typical music and live show acts. 19.30 PM – 23.00 PM Price per Person: € 80.00 Free Evening for participants’ individual (partly sponsored by ICRS) programmes and for industry related (incl. dinner, drinks & entertainment) events. The hotel concierge is pleased to book a table for you at one of your favourite restaurants in town.

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration BERLIN ATTRACTIONS BERLIN ATTRACTIONS & Joint Preservation Society 29

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION Until the fall of the Berlin Wall on No- Ku’damm,REGENERATION on& SOCIETY the street knownREGENERATION to& SOCIETYlocals The city has so many attractions, it is hard to say how many exactly! Berlin’s Mitte vember 9, 1989, it signified the border as the Tauentzien (short for Tauentzien- district alone has a wealth of famous sights from Brandenburg Gate and the Reichstag between West and East, Capitalism and strasse). Parliament building to Berlin’s Cathedral Church and the TV Tower – just to mention a Communism, freedom, and confinement. few. You can also explore Berlin’s neighbourhoods, discovering little known places and INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION Charlottenburg Palace & JOINT PRESERVATION SOCIETY More dramatically, US and Soviet tanks & JOINT PRESERVATION SOCIETY International Cartilage Regeneration & Joint Preservation Society Internationalinsider tips! HereCartilage are a few of the most Regeneration popular attractions in the city – Berlin’s absolute had a close encounter here in October The magnificent Charlottenburg Palace is must-see sights! 1961 when J.F. Kennedy and Nikita located just out of the centre of the city. & Joint Preservation Society Khrushchev’s tanks faced each other in The beautiful palace hosts fineInternational collections Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION an acrimonious moment feared around of china& JOINT PRESERVATION and paintings S OCIETY and isJoint Preservationsituated Society in Reichstag the World as a possible lead up to the middle of a picturesque palace gar- When the decision was made to move World War III. den right next to the river Spree. If you the Federal Government to Berlin, it was do not fancy a walk in the park, you can time to reawaken the Reichstag building Gendarmenmarkt feed your mind instead in the Charlotten- from its long years of slumber on the Mau- The Gendarmenmarkt is one of the most burg museums located directly opposite. erstreifen, the military zone between the stunning squares in the city, located close two sides of the Wall. The building has to Friedrichstraße, Berlin’s exclusive shop- Museum Island since been completely modernised, and ping street in the central Mitte district. Berlin’s Museum Island is one of the UN- today’s visitors to the Reichstag can look Three of the most impressive examples of ESCO world heritage sites and home to out from the building’s glass dome to get architecture in the capital city are to be the city’s most important exhibition cen- a bird’s eye view of the hustle and bustle found here: the Concert House designed tres: the Altes Museum (Old Museum), the in the city. There are also a number of by Schinkel and the German and French Neues Museum (New Museum) the Bode government buildings in the vicinity of the Cathedrals (the Deutscher Dom and the Museum, the Pergamon Museum and the Reichstag, for example the Bundeskan- Französischer Dom). Old National Gallery. The collections in zleramt (Federal Chancellery) and the these buildings encompass over 6,000 Brandenburg Gate. Berlin Cathedral years of art and cultural history. The Berlin Cathedral (Berliner Dom) with Brandenburger Gate its magnificent dome is a remarkable The Berlin Wall Memorial Without a doubt, the Brandenburg Gate example the of late 19th century archi- The Berlin Wall Memorial is located be- INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONALis Berlin’s CARTILAGE signature attraction. BuiltJOINT in makingPRESERVATION it the tallest building in Berlin. tecture. Near the Cathedral are also tween the districts of Wedding and Mitte REGENERATION SOCIETY 1791,REGENERATION it was just one of many oldSOCIETY city Built in the 1960s, visitors to the tower the German Historical Museum and the on Bernauer Straße, consisting of the & gates around the city of Berlin& which, at can enjoy a unique 360° panorama of Museum’s Island. On the side of Berlin’s Memorial to the Victims of the Wall, a that time, was still a manageable size. the city. boulevard “Unter den Linden” stands the Documentation Centre, and the Chapel The decorative Pariser Platz was laid at Catholic St.Hedwigs-Cathedral. of Reconciliation. The surviving section of the foot of the gate and is now home to Checkpoint Charlie the wall and watchtower enable visitors many of the city’s important buildings, for Checkpoint Charlie was the best known Kurfürstendamm to get a real feel for the reality of the example, the Hotel Adlon with its wealth border crossing during the Cold War. Extending all the way from the ruins of border facilities. of history and the Akademie der Künste The sign, which became a symbol of the the Kaiser Wilhelm Memorial Church on (Academy of the Arts). division of Cold War Berlin and read like Breitscheidplatz to Berlin’s elegant Hal- Potsdamer Platz a dire warning to those about to venture ensee neighbourhood, the affectionately Once the bustling heart of the city before Berlin Television Tower beyond the Wall – “YOU ARE LEAVING termed Kurfürstendamm is the most ex- the Second World War, then a no man’s The Berlin Television Tower, which is THE AMERICAN SECTOR” – in English, pensive address in the capital city and land from 1945 until the fall of the wall, known to locals as the “Fernsehturm”, Russian, French and German - stood home to the most exclusive brands. Eu- the history of Potsdamer Platz has been and is instantly recognisable from the dis- here. It is today an iconic marker of ter- rope’s biggest department store KaDeWe eventful to say the least. It changed com- tance, stand outs of the skyline at 368 m, ritorial boundary and political division. is also situated on the extension of the pletely after the fall of the wall in 1989

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION & JOINT PRESERVATION SOCIETY & JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE JOINT PRESERVATION & JOINT PRESERVATION SOCIETY REGENERATION & SOCIETY

International Cartilage Regeneration & Joint Preservation Society International Cartilage Regeneration BERLIN ATTRACTIONS & Joint Preservation Society 31

INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONAL CARTILAGE JOINT PRESERVATION and is now dominated by the presence to massive pizzas. As an extra tip, we also REGENERATION & SOCIETY REGENERATION & SOCIETY of the Sony Center, skyscrapers, and recommend the restaurants and cafés on THOUGHT endless shops. What is more, Potsdam- Ludwigkirchplatz. The square around the er Platz is the main place to be for stars church of St. Ludwig seduces especially

INTERNATIONAL CARTILAGE REGENERATION INTERNATIONAL CARTILAGE REGENERATION and celebrities, and not only during film with its cosy atmosphere, Mediterranean & JOINT PRESERVATION SOCIETY International Cartilage Regeneration & JOINT PRESERVATION SOCIETY International Cartilage Regeneration & Joint Preservation Society festivals. food, and good wine. LEADER AND

& JointNightlife &Preservation Clubbing Society International Cartilage Regeneration & I NTERNATIONAL C ARTILAGE R EGENERATION (Close to the InterContinental) Note & JOINT PRESERVATION S OCIETY Joint Preservation Society Before the Wall fell in 1989, City West As the official Berlin visitor’s site, https:// around the Zoo was one of the most im- www.visitberlin.de/en is your perfect guide INNOVATOR portant nightlife areas in old West Berlin, to this exciting city and your Hotel Con- but it lost a bit of its charm in the years af- cierge will be pleased to assist you for tai- ter reunification as the city’s attention shift- lor-made bookings and reservations! ed eastwards. Since then, the district has revived itself and offers plenty of modern bars and lounges for a sophisticated evening. The Monkey Bar in the Bikini Berlin concept mall offers breath-taking views of the Zoo and Tiergarten Park. Numerous ho-

tel bars like the Lang Bar, one of the best FEMORAL CONDYLE mm DISTAL TIBIA cocktail bars in the city, and the House of ⊲ Proprietary processing 16 ⊲ Restores glenoid with IN Gin with its over 150 varieties of gin prom- methods shown to NOW AVAILABLE live cartilage and ise special and unforgettable evenings in maintain 80% cartilage strong bone viability1 City West. The nightlife around Savigny- FRESH OCA CORES ⊲ No size match required ⊲ Sized matched ⊲ platz in Charlottenburg, meanwhile, has Provide intact hyaline cartilage, ⊲ Eliminates morbidity per patient nothing to apologise for. Here, old-school viable chondrocytes, and of autograft latarjet subchondral bone Berliners have mingled with students, art- ⊲ Shortest wait times in the industry ⊲ INTERNATIONAL CARTILAGE JOINT PRESERVATION INTERNATIONALists, and visitors CARTILAGE since time immemorial.JOINT Das PRESERVATION Single step treatment with no patient size matching required Schwarze Café is open almost around the REGENERATION SOCIETY REGENERATION SOCIETY ⊲ & clock. A visit to Dicke Wirtin, &a true classic A great alternative for small focal lesions pub in West Berlin, will take you back in time to the Cold War era. And Diener is an artists’ café with an atmosphere you will find hard to resist. If you are really hungry, Our mission is to improve quality of life through head over to Restaurant 12 Apostel, home innovative solutions for allograft joint repair.

1. Data on file, JRF Ortho

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