CHCHD2 Antibody Cat. No.: 19-066

CHCHD2 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

IMMUNOGEN: A synthetic Peptide of human CHCHD2

TESTED APPLICATIONS: Flow, IHC, WB

WB: ,1:200 - 1:500

APPLICATIONS: IHC: ,1:50 - 1:100

Flow: ,1:20 - 1:50

POSITIVE CONTROL: 1) A-549

2) MCF7

PREDICTED MOLECULAR Observed: 17kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

September 30, 2021 1 https://www.prosci-inc.com/chchd2-antibody-19-066.html ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, pH7.3.

STORAGE CONDITIONS: Store at 4˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: CHCHD2

Coiled-coil-helix-coiled-coil-helix domain-containing 2, mitochondrial, Aging- ALTERNATE NAMES: associated 10 protein, HCV NS2 trans-regulated protein, NS2TP, CHCHD2, C7orf17

GENE ID: 51142

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The protein encoded by this gene belongs to a class of eukaryotic CX(9)C characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport BACKGROUND: chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated . In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. of this gene are found on multiple . Alternative splicing results in multiple transcript variants.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 30, 2021 2 https://www.prosci-inc.com/chchd2-antibody-19-066.html