Deconstruction, Theoretical Biology, and the Creative Universe As We H
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Epigenetics Landscape (Fig
© 2015. Published by The Company of Biologists Ltd | The Journal of Experimental Biology (2015) 218, 816-818 doi:10.1242/jeb.120071 CLASSICS Conrad Waddington and ‘decisions’ that could be represented as exploited plasticity that is already ‘valleys’ and ‘forks’ in a developmental present in the population. That strongly the origin of epigenetics landscape (Fig. 1). He knew from his suggests that all the alleles (gene developmental studies that embryo fruit variants) necessary for the inheritance of flies could be persuaded to show different the characteristic were already present in thorax and wing structures, simply by the population, but not initially in any changing the environmental temperature or particular individuals in the correct by a chemical stimulus. In his landscape combination. The experiment simply diagram, this could be represented as a brings them together. This is a small manipulation in slope that would lead modification of the pattern of the genome to one channel in the landscape being in response to the environmental change, favoured over another, so that the adult but not in a way that requires any new could show a different phenotype starting mutations. I came to this conclusion from the same genotype. before reading Waddington’s (1957) Epigenetics book, The Strategy of the Genes. But it is Denis Noble discusses Conrad The next step in his experiment was to in fact one of Waddington’s own ideas! Waddington’s classic paper, ‘The genetic select for and breed from the animals that He writes ‘There is no … reason which ’ assimilation of the bithorax phenotype , displayed the new characteristic. -
THE PAST of a DELUSION by Warren Sturgis Mcculloch
Winter-Edition 2007 THE PAST OF A DELUSION by Warren Sturgis McCulloch Englisch Deutsch Editorial Editorial By Joachim Paul, editor of von Joachim Paul, Hrsg.: www.vordenker.de www.vordenker.de To make Warren McCulloch's essay Den aus dem Jahr 1953 stammenden Aufsatz "THE PAST OF A DELUSION" from the "THE PAST OF A DELUSION" von Warren year 1953 now available in a German McCulloch als Arbeitstext auch in deutscher translation is in need to be explained. Sprache zugänglich zu machen, bedarf einer erläuternden Anmerkung. Undoubtedly Warren Sturgis McCulloch Warren Sturgis McCulloch ist unbestritten is one of the leading scientists of the einer der wichtigsten Wissenschaftler des 20. 20th century. His influence ranges from Jahrhunderts. Sein Einfluß reicht von den the early days of the Macy-Conferences frühen Tagen der Macy-Konferenzen über das over MIT and Biological Computer Lab in MIT und das Biological Computer Lab in Urbana, Illinois to the foundation of the Urbana, Illinois, bis hin zur Gründung des renowned "Santa Fe Institute for renommierten "Santa Fe Institute for Sciences Sciences of Complexity", where one of of Complexity", zu dessen bekannteren Mitar- the more prominent collaborators was beitern der Mediziner, Biochemiker und Biophy- the physician, biochemist and biophysi- siker Stuart Kauffman gehörte, zeitweilig ein cist Stuart Kauffman, a temporary Schüler McCullochs. 1927 bis 1934, bevor disciple of McCulloch. Before McCulloch McCulloch, einer der Väter von Kybernetik und returned to the academic world and Neuroinformatik, -
Daniel C. Dennett
KINDS OF MINDS Toward an Understanding of Consciousness DANIEL C. DENNETT A Member of the Perseus Books Group -iii- The Science Masters Series is a global publishing venture consisting of original science books written by leading scientists and published by a worldwide team of twenty-six publishers assembled by John Brockman. The series was conceived by Anthony Cheetham of Orion Publishers and John Brockman of Brockman Inc., a New York literary agency, and developed in coordination with BasicBooks. The Science Masters name and marks are owned by and licensed to the publisher by Brockman Inc. Copyright © 1996 by Daniel Dennett. Published by BasicBooks A Member of the Perseus Books Group All rights reserved. Printed in the United States of America. No part of this book may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embodied in critical articles and reviews. For information address Basic Books, 10 East 53rd Street, New York, NY 10022-5299. Designed by Joan Greenfield ISBN 0-465-07351-4 (pbk.) 99 00 01 ❖/RRD 10 9 8 7 6 5 -iv- CONTENTS Preface vii 1 What Kinds of Minds Are There? 1 Knowing Your Own Mind 1 We Mind-Havers, We Minders 3 Words and Minds 8 The Problem of Incommunicative Minds 12 2 Intentionality: The Intentional Systems Approach 19 Simple Beginnings: The Birth of Agency 19 Adopting the Intentional Stance 27 The Misguided Goal of Propositional Precision 41 Original and Derived Intentionality 50 3 The Body and Its Minds 57 From Sensitivity to Sentience? 57 The -
Service History July 2012 AGM - September 2018 AGM
Service History July 2012 AGM - September 2018 AGM The information in this Service History is true and complete to the best of The Society’s knowledge. If you are aware of any errors please let the Governance and Risk Manager know by email: [email protected] Service History Index DATES PAGE # 5 July 2012 – 24 July 2013 Page 1 24 July 2013 – 1 July 2014 Page 14 1 July 2014 – 7 July 2015 Page 28 7 July 2015 – 31 July 2016 Page 42 31 July 2016 – 12 July 2017 Page 60 12 July 2017 – 16 September 2018 Page 82 Service History: July 2012 AGM – Sept 2018 AGM Introduction Up until 2006 the service history of The Society’s members was captured in Grey Books. It was also documented between 1990-2013 in The Society’s old database iMIS, which will be migrated to the CRM member directory adopted in 2016. This document collates missing service history data from July 2012 to September 2018. Grey Books were relaunched as ‘Grey Records’ in 2019 beginning with the period from the September AGM 2018 up until July AGM 2019. There will now be a Grey Record published every year reflecting the previous year’s service history. The Grey Record will now showcase service history from Member Forum to Member Forum (typically held in the Winter). 5 July 2012 – 24 July 2013 Honorary Officers (and Trustees) POSITION NAME President Jonathan Ashmore Deputy President Richard Vaughan-Jones Honorary Treasurer Rod Dimaline Education & Outreach Committee Chair Blair Grubb Meetings Committee Chair David Wyllie Policy Committee Chair Mary Morrell Membership & Grants Committee -
Can Systems Medicine Integrate Scientific and Humanistic
View metadata, citation and similar papers at core.ac.uk brought to you by CORE bs_bs_banner provided by NORA - Norwegian Open Research Archives Journal of Evaluation in Clinical Practice ISSN 1365-2753 Getting personal: can systems medicine integrate scientific and humanistic conceptions of the patient? Henrik Vogt MD,1 Elling Ulvestad MD Dr Med,3,4 Thor Eirik Eriksen Cand Polit5,6 and Linn Getz MD PhD2 1PhD Candidate, 2Professor, General Practice Research Unit, Department of Public Health and General Practice, Norwegian University of Science and Technology (NTNU), Trondheim, Norway 3Professor, Department of Microbiology, The Gade Institute, Haukeland University Hospital, Bergen, Norway 4Professor, Department of Clinical Science, University of Bergen, Bergen, Norway 5PhD Candidate, Department of Work and Environmental Medicine, Hospital of North Norway, Tromsø, Norway 6Senior Advisor, Faculty of Humanities, Social Sciences and Education, Department of Philosophy, UiT – The Arctic University of Norway, Tromsø, Norway Keywords Abstract agency, biopsychosocial medicine, downward causation, emergence, Rationale, aims and objectives The practicing doctor, and most obviously the primary experience, free will, general practice, care clinician who encounters the full complexity of patients, faces several fundamental but generalism, holism, humanistic medicine, intrinsically related theoretical and practical challenges – strongly actualized by so-called intentionality, medically unexplained medically unexplained symptoms (MUS) and multi-morbidity. Systems medicine, which is symptoms, mind-body problem, the emerging application of systems biology to medicine and a merger of molecular multi-morbidity, narrative medicine, biomedicine, systems theory and mathematical modelling, has recently been proposed as a ontology, patient-centred medicine, primary care-centered strategy for medicine that promises to meet these challenges. -
Obituary Notice
Obituary Notice Susan Noble 1940-2015 Susan Noble, who died on October 4th 2015 at the funding for graduate work and provided space in age of 75, had worked for many years in the Oxford a corner of her own lab. Here Susan worked with cardiac group led by her husband, Denis. others (Hilary Brown, Anne Clark and Wayne Giles) investigating the membrane currents in strips of Susan’s parents were both schoolteachers (of frog atrial muscle voltage clamped using the double mathematics) and she was the eldest of their three sucrose gap technique. Of particular interest was children. Although always keenly interested in the the induced pacemaking that resulted from applying arts, the theatre and literature, she specialized in steady depolarizing currents to atrial muscle. This science at school. In 1959 she was accepted at type of pacemaking was shown to depend on the Somerville College, Oxford, to read for a degree in decay of outward potassium currents, though in Physiology. After two years of the course, however, multicellular preparations things are complicated by she became ill and had to withdraw from Oxford. slow current changes caused by the accumulation of potassium ions in extracellular spaces. On recovery, she completed her undergraduate studies at University College London. Shortly In 1972, Susan was awarded her D.Phil. for a thesis after she graduated, she and Denis Noble were entitled ‘Membrane currents in frog atrial muscle’. married and in 1965, when Denis was appointed She went on to study potassium ion accumulation to a University Lectureship in Physiology and in detail (Noble, S.J. -
The Cybernetic Brain
THE CYBERNETIC BRAIN THE CYBERNETIC BRAIN SKETCHES OF ANOTHER FUTURE Andrew Pickering THE UNIVERSITY OF CHICAGO PRESS CHICAGO AND LONDON ANDREW PICKERING IS PROFESSOR OF SOCIOLOGY AND PHILOSOPHY AT THE UNIVERSITY OF EXETER. HIS BOOKS INCLUDE CONSTRUCTING QUARKS: A SO- CIOLOGICAL HISTORY OF PARTICLE PHYSICS, THE MANGLE OF PRACTICE: TIME, AGENCY, AND SCIENCE, AND SCIENCE AS PRACTICE AND CULTURE, A L L PUBLISHED BY THE UNIVERSITY OF CHICAGO PRESS, AND THE MANGLE IN PRAC- TICE: SCIENCE, SOCIETY, AND BECOMING (COEDITED WITH KEITH GUZIK). THE UNIVERSITY OF CHICAGO PRESS, CHICAGO 60637 THE UNIVERSITY OF CHICAGO PRESS, LTD., LONDON © 2010 BY THE UNIVERSITY OF CHICAGO ALL RIGHTS RESERVED. PUBLISHED 2010 PRINTED IN THE UNITED STATES OF AMERICA 19 18 17 16 15 14 13 12 11 10 1 2 3 4 5 ISBN-13: 978-0-226-66789-8 (CLOTH) ISBN-10: 0-226-66789-8 (CLOTH) Library of Congress Cataloging-in-Publication Data Pickering, Andrew. The cybernetic brain : sketches of another future / Andrew Pickering. p. cm. Includes bibliographical references and index. ISBN-13: 978-0-226-66789-8 (cloth : alk. paper) ISBN-10: 0-226-66789-8 (cloth : alk. paper) 1. Cybernetics. 2. Cybernetics—History. 3. Brain. 4. Self-organizing systems. I. Title. Q310.P53 2010 003’.5—dc22 2009023367 a THE PAPER USED IN THIS PUBLICATION MEETS THE MINIMUM REQUIREMENTS OF THE AMERICAN NATIONAL STANDARD FOR INFORMATION SCIENCES—PERMA- NENCE OF PAPER FOR PRINTED LIBRARY MATERIALS, ANSI Z39.48-1992. DEDICATION For Jane F. CONTENTS Acknowledgments / ix 1. The Adaptive Brain / 1 2. Ontological Theater / 17 PART 1: PSYCHIATRY TO CYBERNETICS 3. -
42 LS08 Abstracts
42 LS08 Abstracts IP0 plasticity, whereas a breakdown in trafficking appears to be Public Lecture: Reinventing the Sacred: Science, a contributory factor to a number of neurodegenerative dis- Faith and Complexity eases associated with memory loss including Alzheimer’s. I propose to discuss three topics. Several alternative the- ories and experimental work bear on the origin of molecu- Paul C. Bressloff lar reproduction (here we at least think we know what we University of Utah are talking about). Second, we discuss agency, the capac- Department of Mathematics ity of organisms to act on their own behalf, hence doing bressloff@math.utah.edu (here molecular reproduction causes value to enter the bio- sphere). Third, I discuss the evolution of the biosphere by Darwinian preadaptations, which, I believe, is partially IP2 beyond natural law. On the first topic I will discuss the Magnetic Resonance Elastography classical view that life must be based on template repli- cated DNA, RNA or their cousins, the RNA world, the Many disease processes such as cancer cause profound membrane-cell first world, my own work on the emergence changes in the mechanical properties of tissues, yet none of collectively autocatalytic sets of organic molecules and of the conventional medical imaging techniques such as polymers, experimental evidence for collectively autocat- CT, MRI, and ultrasound are capable of delineating this alytic sets of DNA and peptide sequences, and our own and property. Magnetic Resonance Elastography (MRE) is an other workers’ evidence that random peptides fold, at least emerging diagnostic imaging technology that uses a special to molten globules, hence may well have catalytic activity. -
Editor Denis Noble Publishing Editor Tim Holt
RSFS_4_5_Cover_RSFS_4_5_Cover 13/08/14 7:03 PM Page 2 GUIDANCE FOR AUTHORS Selection criteria Articles Editor The criteria for selection for both theme issues and their constituent Articles are contributions containing original scientific research. articles are scientific excellence, originality and interest across the Denis Noble physical sciences / life sciences interface. The Editor is responsible Reports Publishing Editor for all editorial decisions, in part based on the reports received from Reports are short, letter-style contributions which are published the referees. Many more good proposals and articles are submitted rapidly. Preliminary and more speculative work of high quality is Tim Holt to us than we have space to print; we give preference to those that strongly encouraged. are of broad interest and of high scientific quality. Reviews Editorial Board Reviews are articles of the highest quality and aim to be of interest Publishing format to communities working at the physical sciences / life sciences Along with all Royal Society journals, we are committed to archiving Denis Noble – Physiology, Anatomy and Genetics, University of Oxford interface. Reviews cover the latest developments in an area of cross- and providing perpetual access. The journal also offers the facility for disciplinary research. They put such research into a broader context including Electronic Supplementary Material to papers free of charge. Fraser A. Armstrong – Department of Chemistry, University of Oxford and are written in a style that makes them accessible to readers in a Sheng He – Institute of Biophysics, Chinese Academy of Sciences wide range of disciplines. Complete literature surveys are not Conditions of publication Clemens Kaminski – Chemical Engineering and Biotechnology, University of Cambridge encouraged. -
Against Biopoetics
Louisiana State University LSU Digital Commons LSU Doctoral Dissertations Graduate School 2004 Against biopoetics: on the use and misuse of the concept of evolution in contemporary literary theory Bradley Bankston Louisiana State University and Agricultural and Mechanical College Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_dissertations Part of the English Language and Literature Commons Recommended Citation Bankston, Bradley, "Against biopoetics: on the use and misuse of the concept of evolution in contemporary literary theory" (2004). LSU Doctoral Dissertations. 1703. https://digitalcommons.lsu.edu/gradschool_dissertations/1703 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Doctoral Dissertations by an authorized graduate school editor of LSU Digital Commons. For more information, please [email protected]. AGAINST BIOPOETICS: ON THE USE AND MISUSE OF THE CONCEPT OF EVOLUTION IN CONTEMPORARY LITERARY THEORY A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Department of English By Bradley Bankston B.A., New College, 1990 M.A., Louisiana State University, 1999 May 2004 Table of Contents Abstract................................................iii Introduction..............................................1 Part I: Evolutionary Psychology -
A Review of Stuart Kauffman's a World Beyond Physics and Its Parallel
Available online at https://jps.library.utoronto.ca/index.php/nexj Visit our blog at newexplorations.net Vol 1 № 1 (Spring 2020) A Review of Stuart Kauffman’s A World Beyond Physics and Its Parallel with McLuhan’s Reversal of Cause and Effect. Robert K. Logan University of Toronto ABSTRACT A review of Stuart Kauffman’s A World Beyond Physics is made and its parallels with McLuhan’s reversal of cause and effect is made. KEYWORDS: McLuhan; physics; enablement; general systems; extensions of man; media; technology; tool Robert K. Logan [email protected] 2 New Explorations: Studies in Culture & Communication In A World Beyond Physics, Stuart Kauffman (2019, 10) critiques the “physics-based view of the world” and the notion that physics can ultimately explain all phenomena of the universe including biology and cognition. He wrote, Brilliant physicist Steven Weinberg voiced the physicist thoughts: (1) the explanatory arrow always points downwards from social systems to people to organs to cells, to biochemistry to chemistry and finally physics; (2) the more we know of the universe, he wrote, the more meaningless it appears (ibid.). Kauffman (2019, 12-13) states that Weinberg is categorically wrong and points out, “One thing missing in the world according to physics is the crucial idea of agency… Given agency, meaning exists in the universe.” He then asks "How did the universe get from matter to mattering? In the meaningless, numb universe of Weinberg, where does mattering come from?” Mattering, in Kauffman’s play on words, is simply meaning or information and information is about the informing of a living agent that is able to propagate its organization. -
Exploring the Science of Complexity: Ideas and Implications for Development and Humanitarian Efforts
Overseas Development Institute Exploring the science of complexity: Ideas and implications for development and humanitarian efforts Ben Ramalingam and Harry Jones with Toussaint Reba and John Young Foreword by Robert Chambers Working Paper 285 Results of ODI research presented in preliminary form for discussion and critical comment Working Paper 285 Exploring the science of complexity Ideas and implications for development and humanitarian efforts Second Edition Ben Ramalingam and Harry Jones with Toussainte Reba and John Young Foreword by Robert Chambers October 2008 Overseas Development Institute 111 Westminster Bridge Road London SE7 1JD ISBN 978 0 85003 864 4 © Overseas Development Institute 2008 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior written permission of the publishers. ii Contents Foreword by Robert Chambers vii Executive summary viii Introduction viii Key concepts of complexity science viii Conclusions viii 1. Introduction 1 1.1 Aims and overview of the paper 1 1.2 Background: The RAPID programme and the focus on change 2 2. Putting complexity sciences into context 4 2.1 Origins 4 2.2 Applications in the social, political and economic realms 5 3. Concepts used in complexity sciences and their implications for development and humanitarian policy and practice 8 3.1 Unpacking complexity science: Key concepts and implications for international aid 8 3.2