Common Name: ANTIMONY TRIOXIDE

CAS Number: 1309-64-4 RTK Substance number: 0149 DOT Number: UN 1549 Date: February 1998 Revision: June 2004 ------

HAZARD SUMMARY * Antimony Trioxide can affect you when breathed in. * Exposure to hazardous substances should be routinely * Antimony Trioxide should be handled as a evaluated. This may include collecting personal and area CARCINOGEN--WITH EXTREME CAUTION. air samples. You can obtain copies of sampling results * Contact can irritate and may burn the eyes and skin and from your employer. You have a legal right to this cause an itchy skin rash. information under OSHA 1910.1020. * Exposure to Antimony Trioxide can irritate the nose, * If you think you are experiencing any work-related health mouth, throat and lungs causing cough, wheezing and/or problems, see a doctor trained to recognize occupational shortness of breath. diseases. Take this Fact Sheet with you. * Antimony Trioxide can cause headaches, poor appetite, nausea, vomiting, dry throat, and loss of sleep. WORKPLACE EXPOSURE LIMITS * Prolonged or repeated contact can cause ulcers or sores in The following exposure limits are for Antimony and the nose. compounds (measured as Antimony): * Repeated exposure can affect the lungs and cause an abnormal chest x-ray to develop. OSHA: The legal airborne permissible exposure limit 3 * Antimony Trioxide may damage the kidneys, liver and (PEL) is 0.5 mg/m averaged over an 8-hour heart. workshift.

IDENTIFICATION NIOSH: The recommended airborne exposure limit is 0.5 mg/m3 averaged over a 10-hour workshift. Antimony Trioxide is a white, odorless crystalline (sand-like) powder. It is used as a flame-proofing agent, in pigments and ACGIH: The recommended airborne exposure limit is ceramics, to stain iron and copper, and to decolorize glass. 3 0.5 mg/m averaged over an 8-hour workshift.

REASON FOR CITATION * Antimony Trioxide may be a CARCINOGEN in humans. * Antimony Trioxide is on the Hazardous Substance List There may be no safe level of exposure to a carcinogen, so because it is regulated by OSHA and cited by ACGIH, all contact should be reduced to the lowest possible level. DOT, NIOSH, DEP, IARC, IRIS and EPA. * This chemical is on the Special Health Hazard Substance WAYS OF REDUCING EXPOSURE List because it is a CARCINOGEN. * Enclose operations and use local exhaust ventilation at the * Definitions are provided on page 5. site of chemical release. If local exhaust ventilation or

enclosure is not used, respirators should be worn. HOW TO DETERMINE IF YOU ARE BEING * Wear protective work clothing. EXPOSED * Wash thoroughly immediately after exposure to Antimony The New Jersey Right to Know Act requires most employers Trioxide and at the end of the workshift. to label chemicals in the workplace and requires public * Post hazard and warning information in the work area. In employers to provide their employees with information and addition, as part of an ongoing education and training training concerning chemical hazards and controls. The effort, communicate all information on the health and federal OSHA Hazard Communication Standard, 1910.1200, safety hazards of Antimony Trioxide to potentially requires private employers to provide similar training and exposed workers. information to their employees.

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This Fact Sheet is a summary source of information of all If symptoms develop or overexposure is suspected, the potential and most severe health hazards that may result from following are recommended: exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the * Chest x-ray and lung function tests. potential effects described below. * EKG. ------* Liver and kidney function tests. - Any evaluation should include a careful history of past and HEALTH HAZARD INFORMATION present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling Acute Health Effects exposure. The following acute (short-term) health effects may occur immediately or shortly after exposure to Antimony Trioxide: Request copies of your medical testing. You have a legal right to this information under OSHA 1910.1020. * Contact can irritate and may burn the eyes and skin and cause an itchy skin rash. Mixed Exposures * Exposure to Antimony Trioxide can irritate the nose, * Because smoking can cause heart disease, as well as lung mouth, throat and lungs causing cough, wheezing and/or cancer, emphysema, and other respiratory problems, it may shortness of breath. A metallic taste may occur. worsen respiratory conditions caused by chemical exposure. * Antimony Trioxide can cause headaches, poor appetite, Even if you have smoked for a long time, stopping now will nausea, vomiting, dry throat, and loss of sleep. reduce your risk of developing health problems. * Because more than light alcohol consumption can cause Chronic Health Effects liver damage, drinking alcohol can increase the liver The following chronic (long-term) health effects can occur at damage caused by Antimony Trioxide. some time after exposure to Antimony Trioxide and can last for months or years: WORKPLACE CONTROLS AND PRACTICES

Cancer Hazard Unless a less toxic chemical can be substituted for a hazardous * Antimony Trioxide may be a CARCINOGEN in humans substance, ENGINEERING CONTROLS are the most since it has been shown to cause lung cancer in animals. effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at Reproductive Hazard the site of chemical release. Isolating operations can also * There is some evidence that Antimony Trioxide may reduce exposure. Using respirators or protective equipment is damage the developing fetus and cause miscarriages. less effective than the controls mentioned above, but is * It may damage the male reproductive system and decrease sometimes necessary. the sperm count in animals. In evaluating the controls present in your workplace, consider: Other Long-Term Effects (1) how hazardous the substance is, (2) how much of the * Prolonged or repeated contact can cause ulcers or sores in substance is released into the workplace and (3) whether the nose. harmful skin or eye contact could occur. Special controls * Repeated exposure can affect the lungs and cause an should be in place for highly toxic chemicals or when abnormal chest x-ray to develop. significant skin, eye, or breathing exposures are possible. * Antimony Trioxide may damage the kidneys, liver and heart. In addition, the following control is recommended:

MEDICAL * Where possible, automatically transfer Antimony Trioxide from drums or other storage containers to process containers. Medical Testing For those with frequent or potentially high exposure (half the Good WORK PRACTICES can help to reduce hazardous PEL or greater), the following are recommended before exposures. The following work practices are recommended: beginning work and at regular times after that: * Workers whose clothing has been contaminated by * Urine test for Antimony. Antimony Trioxide should change into clean clothing promptly. * Do not take contaminated work clothes home. Family members could be exposed. ANTIMONY TRIOXIDE page 3 of 6

* Contaminated work clothes should be laundered by * NIOSH has established new testing and certification individuals who have been informed of the hazards of requirements for negative pressure, air purifying, particulate exposure to Antimony Trioxide. filter and filtering facepiece respirators. The filter * Eye wash fountains should be provided in the immediate classifications of dust/mist/fume, paint spray or pesticide work area for emergency use. prefilters, and filters for radon daughters, have been * If there is the possibility of skin exposure, emergency replaced with the N, R, and P series. Each series has three shower facilities should be provided. levels of filtering efficiency: 95%, 99%, and 99.9%. * On skin contact with Antimony Trioxide, immediately Check with your safety equipment supplier or your wash or shower to remove the chemical. At the end of the respirator manufacturer to determine which respirator is workshift, wash any areas of the body that may have appropriate for your facility. contacted Antimony Trioxide, whether or not known skin * If while wearing a filter or cartridge respirator you can contact has occurred. smell, taste, or otherwise detect Antimony Trioxide, or if * Do not eat, smoke, or drink where Antimony Trioxide is while wearing particulate filters abnormal resistance to handled, processed, or stored, since the chemical can be breathing is experienced, or eye irritation occurs while swallowed. Wash hands carefully before eating, drinking, wearing a full facepiece respirator, leave the area smoking, or using the toilet. immediately. Check to make sure the respirator-to-face seal * Use a vacuum or a wet method to reduce dust during clean- is still good. If it is, replace the filter or cartridge. If the up. DO NOT DRY SWEEP. seal is no longer good, you may need a new respirator. * Be sure to consider all potential exposures in your PERSONAL PROTECTIVE EQUIPMENT workplace. You may need a combination of filters, prefilters or cartridges to protect against different forms of a WORKPLACE CONTROLS ARE BETTER THAN chemical (such as vapor and mist) or against a mixture of PERSONAL PROTECTIVE EQUIPMENT. However, for chemicals. some jobs (such as outside work, confined space entry, jobs * Where the potential for high exposure exists, use a done only once in a while, or jobs done while workplace MSHA/NIOSH approved supplied-air respirator with a full controls are being installed), personal protective equipment facepiece operated in a pressure-demand or other positive- may be appropriate. pressure mode. For increased protection use in combination with an auxiliary self-contained breathing apparatus OSHA 1910.132 requires employers to determine the operated in a pressure-demand or other positive-pressure appropriate personal protective equipment for each hazard and mode. to train employees on how and when to use protective * Exposure to 50 mg/m3 (as Antimony) is immediately equipment. dangerous to life and health. If the possibility of exposure above 50 mg/m3 (as Antimony) exists, use a NIOSH The following recommendations are only guidelines and may approved self-contained breathing apparatus with a full not apply to every situation. facepiece operated in a pressure-demand or other positive- pressure mode equipped with an emergency escape air Clothing cylinder. * Avoid skin contact with Antimony Trioxide. Wear protective gloves and clothing. Safety equipment QUESTIONS AND ANSWERS suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your Q: If I have acute health effects, will I later get chronic operation. health effects? * All protective clothing (suits, gloves, footwear, headgear) A: Not always. Most chronic (long-term) effects result from should be clean, available each day, and put on before repeated exposures to a chemical. work.

Eye Protection Q: Can I get long-term effects without ever having short- term effects? * Wear eye protection with side shields or goggles. A: Yes, because long-term effects can occur from repeated * Wear a face shield along with goggles when working with exposures to a chemical at levels not high enough to make corrosive, highly irritating or toxic substances. you immediately sick. * Contact lenses should not be worn when working with this

substance. Q: What are my chances of getting sick when I have been

Respiratory Protection exposed to chemicals? A: The likelihood of becoming sick from chemicals is IMPROPER USE OF RESPIRATORS IS DANGEROUS. increased as the amount of exposure increases. This is Such equipment should only be used if the employer has a determined by the length of time and the amount of written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and material to which someone is exposed. medical exams, as described in OSHA 1910.134.

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Q: When are higher exposures more likely? ------A: Conditions which increase risk of exposure include dust The following information is available from: releasing operations (grinding, mixing, blasting, dumping, etc.), other physical and mechanical processes (heating, New Jersey Department of Health and Senior Services pouring, spraying, spills and evaporation from large Occupational Health Service surface areas such as open containers), and "confined PO Box 360 space" exposures (working inside vats, reactors, boilers, Trenton, NJ 08625-0360 small rooms, etc.). (609) 984-1863 (609) 984-7407 (fax) Q: Is the risk of getting sick higher for workers than for community residents? Web address: http://www.state.nj.us/health/eoh/odisweb/ A: Yes. Exposures in the community, except possibly in cases of fires or spills, are usually much lower than those Industrial Hygiene Information found in the workplace. However, people in the Industrial hygienists are available to answer your questions community may be exposed to contaminated water as well regarding the control of chemical exposures using exhaust as to chemicals in the air over long periods. This may be ventilation, special work practices, good housekeeping, good a problem for children or people who are already ill. hygiene practices, and personal protective equipment including respirators. In addition, they can help to interpret the results of

industrial hygiene survey data. Q: Don't all chemicals cause cancer?

A: No. Most chemicals tested by scientists are not cancer- causing. Medical Evaluation If you think you are becoming sick because of exposure to Q: Should I be concerned if a chemical causes cancer in chemicals at your workplace, you may call personnel at the animals? Department of Health and Senior Services, Occupational A: Yes. Most scientists agree that a chemical that causes Health Service, who can help you find the information you cancer in animals should be treated as a suspected human need. carcinogen unless proven otherwise. Public Presentations Q: But don't they test animals using much higher levels of a Presentations and educational programs on occupational health chemical than people usually are exposed to? or the Right to Know Act can be organized for labor unions, A: Yes. That's so effects can be seen more clearly using trade associations and other groups. fewer animals. But high doses alone don't cause cancer unless it's a cancer agent. In fact, a chemical that causes Right to Know Information Resources cancer in animals at high doses could cause cancer in The Right to Know Infoline (609) 984-2202 can answer humans exposed to low doses. questions about the identity and potential health effects of chemicals, list of educational materials in occupational health, Q: Can men as well as women be affected by chemicals that references used to prepare the Fact Sheets, preparation of the cause reproductive system damage? Right to Know Survey, education and training programs, A: Yes. Some chemicals reduce potency or fertility in both labeling requirements, and general information regarding the men and women. Some damage sperm and eggs, possibly Right to Know Act. Violations of the law should be reported to leading to birth defects. (609) 984-2202. ------Q: Who is at the greatest risk from reproductive hazards? A: Pregnant women are at greatest risk from chemicals that harm the developing fetus. However, chemicals may affect the ability to have children, so both men and women of childbearing age are at high risk. ANTIMONY TRIOXIDE page 5 of 6

DEFINITIONS

ACGIH is the American Conference of Governmental NAERG is the North American Emergency Response Industrial Hygienists. It recommends upper limits (called Guidebook. It was jointly developed by Transport Canada, the TLVs) for exposure to workplace chemicals. United States Department of Transportation and the Secretariat of Communications and Transportation of Mexico. It is a A carcinogen is a substance that causes cancer. guide for first responders to quickly identify the specific or generic hazards of material involved in a transportation The CAS number is assigned by the Chemical Abstracts incident, and to protect themselves and the general public Service to identify a specific chemical. during the initial response phase of the incident.

CFR is the Code of Federal Regulations, which consists of the NFPA is the National Fire Protection Association. It classifies regulations of the United States government. substances according to their fire and explosion hazard.

A combustible substance is a solid, liquid or gas that will burn. NIOSH is the National Institute for Occupational Safety and Health. It tests equipment, evaluates and approves respirators, A corrosive substance is a gas, liquid or solid that causes conducts studies of workplace hazards, and proposes standards irreversible damage to human tissue or containers. to OSHA.

DEP is the New Jersey Department of Environmental NTP is the National Toxicology Program which tests Protection. chemicals and reviews evidence for cancer.

DOT is the Department of Transportation, the federal agency OSHA is the Occupational Safety and Health Administration, that regulates the transportation of chemicals. which adopts and enforces health and safety standards.

EPA is the Environmental Protection Agency, the federal PEL is the Permissible Exposure Limit which is enforceable by agency responsible for regulating environmental hazards. the Occupational Safety and Health Administration.

A fetus is an unborn human or animal. PIH is a DOT designation for chemicals which are Poison Inhalation Hazards. A flammable substance is a solid, liquid, vapor or gas that will ignite easily and burn rapidly. ppm means parts of a substance per million parts of air. It is a measure of concentration by volume in air. The flash point is the temperature at which a liquid or solid gives off vapor that can form a flammable mixture with air. A reactive substance is a solid, liquid or gas that releases energy under certain conditions. IARC is the International Agency for Research on Cancer, a scientific group that classifies chemicals according to their STEL is a Short Term Exposure Limit which is usually a 15- cancer-causing potential. minute exposure that should not be exceeded at any time during a work day. IRIS is the Integrated Risk Information System database of the federal EPA. A teratogen is a substance that causes birth defects by damaging the fetus. A miscible substance is a liquid or gas that will evenly dissolve in another. TLV is the Threshold Limit Value, the workplace exposure limit recommended by ACGIH. mg/m3 means milligrams of a chemical in a cubic meter of air. It is a measure of concentration (weight/volume). The vapor pressure is a measure of how readily a liquid or a solid mixes with air at its surface. A higher vapor pressure A mutagen is a substance that causes mutations. A mutation is indicates a higher concentration of the substance in air and a change in the genetic material in a body cell. Mutations can therefore increases the likelihood of breathing it in. lead to birth defects, miscarriages, or cancer.

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Common Name: ANTIMONY TRIOXIDE HANDLING AND STORAGE DOT Number: UN 1549 NAERG Code: 157 * Prior to working with Antimony Trioxide you should be CAS Number: 1309-64-4 trained on its proper handling and storage. * Antimony Trioxide, if reduced with HYDROGEN or if used near STRONG ACIDS (such as HYDROCHLORIC, Hazard rating NJDHSS NFPA SULFURIC and NITRIC), may form deadly Stibine gas. FLAMMABILITY 0 - * Antimony Trioxide is not compatible with STRONG REACTIVITY 0 - BASES (such as SODIUM HYDROXIDE and POISONOUS GASES ARE PRODUCED IN FIRE POTASSIUM HYDROXIDE) and REDUCING AGENTS (such as RHUBIDIUM, SODIUM and POTASSIUM). Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; * Antimony Trioxide must be stored to avoid contact with 3=serious; 4=severe BROMINE TRIFLUORIDE, CHLORINATED RUBBER, and PERCHLORIC ACID. FIRE HAZARDS FIRST AID * Extinguish fire using an agent suitable for type of surrounding fire. Antimony Trioxide itself does not burn. For POISON INFORMATION call 1-800-222-1222 * POISONOUS GASES ARE PRODUCED IN FIRE, including Antimony fumes. Eye Contact * If employees are expected to fight fires, they must be * Immediately flush with large amounts of water for at least trained and equipped as stated in OSHA 1910.156. 15 minutes, occasionally lifting upper and lower lids.

SPILLS AND EMERGENCIES Skin Contact * Remove contaminated clothing. Wash contaminated skin If Antimony Trioxide is spilled, take the following steps: with soap and water.

* Evacuate persons not wearing protective equipment from Breathing area of spill until clean-up is complete. * Remove the person from exposure. * Collect powdered material in the most convenient and safe * Begin rescue breathing (using universal precautions) if manner and deposit in sealed containers. breathing has stopped and CPR if heart action has stopped. * Ventilate and wash area after clean-up is complete. * Transfer promptly to a medical facility. * It may be necessary to contain and dispose of Antimony Trioxide as a HAZARDOUS WASTE. Contact your state PHYSICAL DATA Department of Environmental Protection (DEP) or your regional office of the federal Environmental Protection Water Solubility: Very slightly soluble Agency (EPA) for specific recommendations. * If employees are required to clean-up spills, they must be OTHER COMMONLY USED NAMES properly trained and equipped. OSHA 1910.120(q) may be applicable. Chemical Name: Antimony Oxide (Sb2O3) ======Other Names: FOR LARGE SPILLS AND FIRES immediately call your fire Antimonious Oxide; Antimony White; Antimony Peroxide; department. You can request emergency information from the Antimony Sesquioxide following: ------CHEMTREC: (800) 424-9300 NJDEP HOTLINE: 1-877-WARN-DEP Not intended to be copied and sold for commercial ======purposes. ------NEW JERSEY DEPARTMENT OF HEALTH AND SENIOR SERVICES Right to Know Program PO Box 368, Trenton, NJ 08625-0368 (609) 984-2202 ------