Sensfeel™ Increases Man’S Power of Physical Attraction

Total Page：16

File Type：pdf, Size：1020Kb

sensfeel™ Increases man’s power of physical attraction sensfeel™ is an active designed to enhance man’s appeal, by increasing the synthesis of his own pheromones What are pheromones? How does sensfeelTM work? Pheromones are natural, odourless and sensfeelTM modulates the pheromones production consciously undetectable substances, which by the synergistic action of its components: trigger a deep sexual response in the brain of Forskolin those who come into contact with them. Diterpene obtained from makandi root (Coleus The pheromone related to human sexual forskohlii). attraction is androstadienone. Increases the expression of the enzyme The production and secretion of pheromones 3ß-HSD to produce more androstadienone. are natural processes regulated by hormones and stimuli from nervous system, which arrive Theaflavins to cells of apocrine glands and sebocytes of Polyphenols obtained from black tea leaves sebaceous glands. (Camellia sinensis). Reduce 5α-reductase activity to decrease androstadienone metabolization and cause its accumulation. 3ß-HSD 5α-reductase 3α-HSD Androstadienol Androstadienone Androstenone Androstenol FORSKOLIN +=THEAFLAVINS Activation Inhibition sensfeel™ sensfeel™ is a natural green alternative to enhance the production of a male pheromone called androstadienone, with the aim of increasing the power of attraction SENSORIAL In vitro efficacy Development of an innovative cellular model Boosting effect of androstadienone production The creation of a suitable cellular model able The complementary actions of forskolin and to produce pheromones was necessary to theaflavins lead to a boosting synergistic effect. evaluate sensfeel™ in vitro efficacy. sensfeel™ doubles the production of Progenitor keratinocytes, which can androstadienone (105%) at a concentration of differentiate to sebocytes under certain 1.2%. conditions, were selected. SYNERGISTIC EFFECT Originated sebocytes were identified, 205% 250 characterized and they showed their ability to 200 141% produce pheromones, especially 100% 111% 150 androstadienone. 100 50 0 ACTIVE FK TF FK/TF C3 INCREASE VS. CONTROL CONTROL (FORSKOLIN) (THEAFLAVINS) (sensfeel™ 1.2%) The amount of pheromone increases in parallel to the concentration of sensfeel™, SEBOCYTES (7 DAYS) SEBOCYTES reaching three times the control result at the maximum dosage (5%). DOSE EFFECT 269% 300 223% 205% 250 200 137% 150 100% 100 50 0 SEBOCYTES (15 DAYS) SEBOCYTES INCREASE VS. CONTROL ACTIVE FK/TF C1 FK/TF C3 FK/TF C4 FK/TF C5 CONTROL (sensfeel™ (sensfeel™ (sensfeel™ (sensfeel™ 0.25%) 1.2%) 2.5%) 5%) Representative images obtained by immunofluorescence. They show HPEK cells differentiated to keratinocytes and sebocytes at 7 and 15 days. The red dye represents polar lipids (phospholipids), the green With sensfeel™, feel the power dye non-polar or neutral lipids (triglycerides and waxes), and of attraction the blue dye nucleus..

Copy Link

Recommended publications

The Relationship Between Oral Contraceptive Use and Sensitivity to Olfactory Stimuli
YHBEH-03499; No. of pages: 6; 4C: Hormones and Behavior xxx (2013) xxx–xxx Contents lists available at SciVerse ScienceDirect Hormones and Behavior journal homepage: www.elsevier.com/locate/yhbeh The relationship between oral contraceptive use and sensitivity to olfactory stimuli Kaytlin J. Renfro ⁎, Heather Hoffmann Psychology Department, Knox College, 2 East South Street, Galesburg, IL 61401-4999, USA article info abstract Article history: The present study examined differences in olfactory sensitivity between 16 naturally cycling (NC) women Received 2 March 2012 and 17 women taking monophasic oral contraceptives (OCs) to six odors: lemon, peppermint, rose, musk, Revised 20 November 2012 androstenone and androsterone. Thresholds were assessed twice for both groups of women (during the Accepted 2 January 2013 periovulatory and luteal phases of their cycles) via a forced-choice discrimination task. NC women in the Available online xxxx periovulatory phase were significantly more sensitive to androstenone, androsterone, and musk than women taking OCs. These findings give support to odor-specific hormonal modulation of olfaction. Further, Keywords: Oral contraceptives due to the social and possibly sexual nature of these odors, future work should address whether there is a re- Olfaction lationship between decreased sensitivity to these odors and reported behavioral side effects among women Odor taking OCs. Ovarian steroids © 2013 Elsevier Inc. All rights reserved. Threshold Introduction problems, such as stroke (Seibert et al., 2003). Women taking OCs have also reported many behavioral side effects, such as emotional la- There are a number of physiological, perceptual, and behavioral bility and decreased sexual desire (Battaglia et al., 2012; Caruso et al., changes that have been reported to co-occur with ovulation in 2004; Sanders et al., 2001; Warner Chilcott, 2009, but see Alexander women; these changes have largely been attributed to the hormonal et al., 1990).
[Show full text]
The Boar Testis: the Most Versatile Steroid Producing Organ Known
The boar testis: the most versatile steroid producing organ known Raeside', H.L. Christie', R.L. Renaud' and P.A. Sinclair" 'Department of Biomedical Sciences and 2Department of Animal and Poultry Science, University of Guelph, Guelph, ON Canada N IG 2WI A review of the remarkable production of steroids by the testes of the boar is presented, with the principal aims of highlighting the achievements of the Leydig cells and, at the same time, pointing to the considerable deficiencies in our understanding of its biological relevance. The onset of gonadal steroidogenesis at an early stage of sex differentiation and the pattern of pre- and postnatal secretion of steroids are outlined. This is followed by a list of steroids identified in extracts of the boar testis, with emphasis on those that can reasonably be assumed to be secretory products of the Leydig cells. For example, the high concentrations of 16- unsaturated C19and sulphoconjugated compounds are noted. Next, an impressive list of steroids found in venous blood from the boar testis is given; among them are the 16-unsaturated steroids, the oestrogens and dehydroepiandrosterone, all mainly in the form of sulphates. However, the list also includes some less likely members, such as 11-0H and 19- OH androgens as well as Sce-reduced steroids. Lastly, the high concentrations of steroids reported in testicular lymph, especially sulphates, are mentioned. Although roles for testosterone are uncontested, and even for the pheromone-like Co steroids, there is little that can be said with assurance about the other compounds listed. Some speculations are made on their possible contributions to the reproductive physiology of the boar.
[Show full text]
Chemosensory Communication of Gender Through Two Human Steroids in a Sexually Dimorphic Manner
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Current Biology 24, 1091–1095, May 19, 2014 ª2014 Elsevier Ltd All rights reserved http://dx.doi.org/10.1016/j.cub.2014.03.035 Report Chemosensory Communication of Gender through Two Human Steroids in a Sexually Dimorphic Manner Wen Zhou,1,* Xiaoying Yang,1 Kepu Chen,1 Peng Cai,1 and, in particular, the gender-specific physiological effects of Sheng He,2,3 and Yi Jiang1,2 two human steroids: androstadienone and estratetraenol. 1Key Laboratory of Mental Health, Institute of Psychology, Androstadienone is the most prominent androstene present Chinese Academy of Sciences, Beijing 100101, China in male semen, in axillary hair, and on axillary skin surface 2State Key Laboratory of Brain and Cognitive Sciences, [12]. It heightens sympathetic arousal [13], alters levels of Beijing 100101, China cortisol [14], and promotes positive mood state [15, 16]in 3Department of Psychology, University of Minnesota, female as opposed to male recipients, probably in a context- Minneapolis, Minnesota 55455, USA dependent manner [17, 18]. Estratetraenol, first identified in female urine [19], has been likewise reported to affect men’s autonomic responses [18] and mood [20] under certain con- Summary texts, albeit with controversies [13, 17]. These effects are further accompanied by distinct hypothalamic response pat- Recent studies have suggested the existence of human sex terns to the two steroids: androstadienone is found to activate pheromones, with particular interest in two human steroids: the hypothalamus in heterosexual females and homosexual androstadienone (androsta-4,16,-dien-3-one) and estrate- males, but not in heterosexual males or homosexual females, traenol (estra-1,3,5(10),16-tetraen-3-ol).
[Show full text]
Full Text (PDF)
The Journal of Neuroscience, April 4, 2018 • 38(14):3377–3387 • 3377 Viewpoints Excreted Steroids in Vertebrate Social Communication Wayne I. Doyle and XJulian P. Meeks University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111 Steroids play vital roles in animal physiology across species, and the production of specific steroids is associated with particular internal biological functions. The internal functions of steroids are, in most cases, quite clear. However, an important feature of many steroids (their chemical stability) allows these molecules to play secondary, external roles as chemical messengers after their excretion via urine, feces, or other shed substances. The presence of steroids in animal excretions has long been appreciated, but their capacity to serve as chemosignals has not received as much attention. In theory, the blend of steroids excreted by an animal contains a readout of its own biological state. Initial mechanistic evidence for external steroid chemosensation arose from studies of many species of fish. In sea lampreys and ray-finned fishes, bile salts were identified as potent olfactory cues and later found to serve as pheromones. Recently, we and others have discovered that neurons in amphibian and mammalian olfactory systems are also highly sensitive to excreted glucocor- ticoids, sex steroids, and bile acids, and some of these molecules have been confirmed as mammalian pheromones. Steroid chemosen- sation in olfactory systems, unlike steroid detection in most tissues, is performed by plasma membrane receptors, but the details remain largely unclear. In this review, we present a broad view of steroid detection by vertebrate olfactory systems, focusing on recent research in fishes, amphibians, and mammals.
[Show full text]
Subject Index Volume 23 Number S2
SUBJECT INDEX VOLUME 23 NUMBER S2 A B Cigarette smoking, S150 Circadian salivary cortisol levels, S105 Abnormal neuroendocrine, S97 B12 vitamin, S140 Circannual melatonin, S108 Abstinent male alcoholics, S156 Beclomethasone-induced vasoconstriction Circuitry pharmacotherapy, S73–S75 Academia, S10 (BIV), S121 Clinical diagnosis, S115 Academically-striving countries, S59 Bed nucleus of the stria terminals, S111 Clinical Global Impression Scale, S116 ACE gene, S130 Behavior problems, S100 Clinical trials, S43 ACE I/D polymorphism, S106 Behavioral effects of NK1, S23 Clobazam, S3 ACTH secretion, S29 Behavioral endocrine responses, S119 Clonidine administration, S132, S139 Acute adolescent mania, S124 Benign intracranial hypertension, S136 Clorniphene, S78 Acute major depressive disorder, S113 Benzodiazepine withdrawal syndrome, Clozapine, S54, S116, S123, S135 Acute schizophrenia, S122 S124 Cocaine, S17, S46, S133 Addiction, S17, S102 Benzodiazapines, S56 Cognition, S51, S79, S92–S94 Administrative arrangements, S9 Benzothiophenes, S79 Cognitive aging, S94 Adolescent, S82 Bilateral grand mal seizure, S91 Cognitive dysfunction, S128 Adrenal hyperplasia, S60 Biochemical markers, S110 Cognitive functioning, S8 Adrenal insufficiency, S48 Biogenic amine systems, S43 Cognitive therapeutic considerations, S99 Adrenalectomy treatment, S145 Biological Psychiatry, S35 Collaboration, S58 ␤-, ␣2-adrenergic receptors, S3 Biosynthesis, S70 Collegium International A2-adrenoceptor supersensibility, S139 Bipolar adolescents, S124 NeuroPsychopharmacologicum,
[Show full text]
The Metabolism of Androstenone and Other Steroid Hormone Conjugates in Relation to Boar Taint
The Metabolism of Androstenone and Other Steroid Hormone Conjugates in Relation to Boar Taint by Heidi M. Laderoute A Thesis presented to The University of Guelph In partial fulfillment of requirements for the degree of Master of Science in Animal and Poultry Science with Toxicology Guelph, Ontario, Canada © Heidi M. Laderoute, April, 2015 ABSTRACT THE METABOLISM OF ANDROSTENONE AND OTHER STEROID HORMONE CONJUGATES IN RELATION TO BOAR TAINT Heidi M. Laderoute Advisor: University of Guelph, 2015 Dr. E.J. Squires Increased public interest in the welfare of pigs reared for pork production has led to an increased effort in finding new approaches for controlling the unpleasant odour and flavour from heated pork products known as boar taint. Therefore, this study investigated the metabolism of androstenone and the enzymes involved in its sulfoconjugation in order to further understand the pathways and genes involved in the development of this meat quality defect. Leydig cells that were incubated with androstenone produced 3-keto- sulfoxy-androstenone, providing direct evidence, for the first time, that sulfoconjugation of this steroid does occur in the boar. In addition, human embryonic kidney cells that were overexpressed with porcine sulfotransferase (SULT) enzymes showed that SULT2A1, but not SULT2B1, was responsible for sulfoconjugating androstenone. These findings emphasize the importance of conjugation in steroid metabolism and its relevance to boar taint is discussed. ACKNOWLEDGEMENTS I would like to gratefully and sincerely thank my advisor, Dr. E. James Squires, for providing me with the opportunity to be a graduate student and for introducing me to the world of boar taint. This project would not have been possible without your guidance, encouragement, and patience over the last few years.
[Show full text]
Substance: Nexus Pheromones Based on The
Health Santé Canada Canada STATUS DECISION OF CONTROLLED AND NON-CONTROLLED SUBSTANCE(S) Substance: Nexus Pheromones Based on the current information available to the Office of Controlled Substances, it appears that the above substance is: Controlled T Not Controlled 9 under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s): • The product contains androsterone and epiandrosterone which are included under item 23 of Schedule IV to the CDSA. Prepared by: Date: June 6, 2011 Zack Li Verified by: Date: Mark Kozlowski Approved by: Date: DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES This status was requested by: Michael Kim, RAPB 2 Drug Status Report Drug: Nexus Pheromones Drug Name Status: Nexus Pheromones is the product name. The product is a perfume which has been claimed to increase attraction between men and women1, and contains the following ingredients: Androstenone alpha- and beta-androstenol Androstadienone Androstanone Androsterone Epiandrosterone Canadian status: The status of androstenone ((5alpha)-androst-16-en-3-one), alpha- and beta-androstenol (5alpha- and 5beta-androst-16-en-3alpha-ol), androstadienone (androsta-4,16-dien-3-one) and androstanone (5alpha-androstan-17-one) were reviewed previously and were not found to be controlled under item 23 of Schedule IV to the CDSA, on the basis that they have not been reported in the scientific literature to display any anabolic activity, nor derived from an anabolic steroid. In contrast, previous reviews of androsterone (androstan-3alpha-ol-17-one) and epiandrosterone ((3beta,5alpha)-3-hydroxyandrostan-17-one) found these substances to be metabolites of dehydroepiandrosterone, which is currently listed as item 23(36) “Prasterone (3b- hydroxyandrsot-5-en-17-one)” in Schedule IV to the CDSA.
[Show full text]
Dynamic Functional Evolution of an Odorant Receptor for Sex-Steroid-Derived Odors in Primates
Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates Hanyi Zhuanga,b,1, Ming-Shan Chiena, and Hiroaki Matsunamia,c,1 Departments of aMolecular Genetics and Microbiology and cNeurobiology, Duke University Medical Center, Durham, NC 27710; and bDepartment of Pathophysiology, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China Edited by Masatoshi Nei, Pennsylvania State University, University Park, PA, and approved October 20, 2009 (received for review August 27, 2008) Odorant receptors are among the fastest evolving genes in ani- responded to these chemicals and appeared to be more sensitive mals. However, little is known about the functional changes of than the human S84N variant (9). individual odorant receptors during evolution. We have recently Positive Darwinian selection (positive selection) is a phenom- demonstrated a link between the in vitro function of a human enon whereby natural selection favors changes. As olfaction is odorant receptor, OR7D4, and in vivo olfactory perception of 2 essential for detecting food sources, avoiding toxic compounds steroidal ligands—androstenone and androstadienone—chemi- or predators, and evaluating mates, positive selection on an OR cals that are shown to affect physiological responses in humans. In gene, if any, can be important in modulating species-specific this study, we analyzed the in vitro function of OR7D4 in primate behaviors by changing sequences of the ORs, thereby modifying evolution. Orthologs of OR7D4 were cloned from different primate odor specificity and sensitivity. It is, however, possible that species. Ancestral reconstruction allowed us to reconstitute addi- olfaction is of diminishing importance to primates and therefore tional putative OR7D4 orthologs in hypothetical ancestral species.
[Show full text]
Gad Compounds Assessed
Name CAS # ((5-Amino-2-carboxyphenyl)thio)gold sodium salt 17010-23-0 (2-Hydroxypropyl)-γ-cyclodextrin 128446-34-4 (4-hydroxy-4-isobutylpiperidin-1-yl)(1H-imidazol-1-yl)methanone (5aR, 9aR)-octahydrobenzo[e][1,3,2]dioxathiepine 3,3- (LMPC) 1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine 20559-16-4 (Trimethylsilyl)acetic acid 2345-38-2 (Z) 7-Hexadecenal 56797-40-1 (Z)-2-chloro-4-(diethylamino)but-2-en-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate (Z)-3-chloro-4-(diethylamino)but-2-en-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate (Z,Z,Z) 8,11,14-Eicosatrienoic acid 1783-84-2 1-(2-butoxyethoxy)-ethanol 5446-78-5 1,1,1,3,5,5,7,7,7-Nonamethyl-3-(trimethylsiloxy) tetrasiloxane 38146-99-5 1,10-decanedithiol 1191-67-9 1,1'-bicyclohexyl-4,4'-diol 20601-38-1 1,1-bis(p-ethoxyphenyl)-2,2-dimethylpropane 27955-87-9 1,1-carbonyldiimidazole (CDI) 530-62-1 1,1-cyclohexanedithiol 3855-24-1 1,2,3,4-Tetrahydronaphthalene 119-6-2 1,2,3-trichloro-2-methylpropane 1871-58-5 1,2,3-triethylbenzene 42205-08-3 1,2,4-benzenetriol 533-73-3 1,2,4-triethylbenzene 877-44-1 1,2-cyclohexanediamine 694-83-7 1,2-cyclohexanedicarboxylic acid 1687-30-5 1,2-cyclohexanediol 931-17-9 1,2-dichlorobenzene 95-50-1 1,2-Ethanediamine 107-15-3 1,2-ethanedithiol 540-63-6 1,2-propanediol, monobutyl ether 29387-86-8 1,3,5-Tributyl-2,4,6-trioxo-hexahydro-striazine 846-74-2 1,3,5-triethylbenzene 102-25-0 1,3,5-Trioxane 110-88-3 1,3:2,4-Bis(3,4-dimethylbenzylidene)sorbitol 135861-56-2 1,3-Bis(diallylamino)-2-propanol 4831-46-3 1,3-butanediol 107-88-0 1,3-cycloheptadiene 4054-38-0 1,3-cyclohexanedicarboxylic
[Show full text]
Human Chemosignals Modulate Emotional Perception of Biological Motion in a Sex-Specific Manner T ⁎ Yuting Yea,B, Yuan Zhuanga,B, Monique A.M
Psychoneuroendocrinology 100 (2019) 246–253 Contents lists available at ScienceDirect Psychoneuroendocrinology journal homepage: www.elsevier.com/locate/psyneuen Human chemosignals modulate emotional perception of biological motion in a sex-specific manner T ⁎ Yuting Yea,b, Yuan Zhuanga,b, Monique A.M. Smeetsc,d, Wen Zhoua,b, a State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China b Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China c Unilever R&D, Vlaardingen, 3133 AT, The Netherlands d Department of Social, Health & Organizational Psychology, Utrecht University, Utrecht, 3584 CS, The Netherlands ARTICLE INFO ABSTRACT Keywords: Androsta-4,16,-dien-3-one and estra-1,3,5(10),16-tetraen-3-ol have previously been shown to communicate Androstadienone opposite sex information that is differently effective to the two sex groups. The current study critically examines Estratetraenol if the two human steroids could facilitate interactions with potential mates rather than competitors by acting on Biological motion the recipients’ emotional perception in a sex-appropriate manner. Using dynamic point-light displays that Valance portray the gaits of walkers whose emotional states are digitally morphed along the valence and the arousal axes, Arousal we show that smelling androstadienone subconsciously biases heterosexual women, but not men, towards perceiving the male,
[Show full text]
Androstadienone, a Putative Chemosignal of Dominance, Increases Gaze Avoidance Among Men with High Social Anxiety T ⁎ A
Psychoneuroendocrinology 102 (2019) 9–15 Contents lists available at ScienceDirect Psychoneuroendocrinology journal homepage: www.elsevier.com/locate/psyneuen Androstadienone, a putative chemosignal of dominance, increases gaze avoidance among men with high social anxiety T ⁎ A. Bannera, , S. Gabaya,b, S. Shamay-Tsoorya a Department of Psychology, University of Haifa, Abba Khoushy Ave 199, Haifa, Israel b The Institute of Information Processing and Decision Making, University of Haifa, Abba Khoushy Ave 199, Haifa, Israel ARTICLE INFO ABSTRACT Keywords: Socially anxious individuals show increased sensitivity toward social threat signals, including cues of dom- Androstadienone inance. This sensitivity may account for the hypervigilance and gaze avoidance commonly reported in in- Social chemosignals dividuals with social anxiety. This study examines visual scanning behavior in response to androstadienone Dominance (androsta-4,16,-dien-3-one), a putative chemosignal of dominance. We tested whether exposure to androsta- Submissiveness dienone would increase hypervigilance and gaze avoidance among individuals with high social anxiety. In a Gaze avoidance double-blind, placebo-controlled, within-subject design, 26 participants with high social anxiety and 26 with low Social anxiety social anxiety were exposed to androstadienone and a control solution on two separate days. On each day, an eye-tracker recorded their spontaneous scanning behavior while they viewed facial images of men depicting dominant and neutral poses. The results indicate that among participants with high social anxiety, androsta- dienone increased gaze avoidance by reducing the percentage of ﬁxations made to the eye-region and the total amount of time spent gazing at the eye-region of the faces. Participants with low social anxiety did not show this eﬀect.
[Show full text]
Androstadienone's Influence on the Perception
Psychoneuroendocrinology 66 (2016) 166–175 Contents lists available at ScienceDirect Psychoneuroendocrinology journal homepage: www.elsevier.com/locate/psyneuen Androstadienone’s influence on the perception of facial and vocal attractiveness is not sex specific a,b,∗ a,b a,b a,b Camille Ferdenzi , Sylvain Delplanque , Reni Atanassova , David Sander a Swiss Center for Affective Sciences, Campus Biotech, University of Geneva, Geneva, Switzerland b Laboratory for the Study of Emotion Elicitation and Expression (E3 Lab), Department of Psychology, FPSE, University of Geneva, Geneva, Switzerland a r t i c l e i n f o a b s t r a c t Article history: The androgen steroid androstadienone, an odorous compound emitted from the human axillary region, Received 25 June 2015 has recurrently been considered as a candidate compound involved in human chemical communication Received in revised form 15 January 2016 and mate choice. Although perception of androstadienone has been shown to influence several affective Accepted 15 January 2016 (mood), attentional, physiological and neural parameters, studies investigating its impact on human attractiveness remain unpersuasive because of incomplete designs (e.g., only female participants) and Keywords: contradictory results. The aim of this study was to investigate how androstadienone may influence others’ Human chemosignals attractiveness. Specifically, we used a complete design (male and female raters, male and female faces and Olfaction Attractiveness voices) to determine whether androstadienone influences the perception of social stimuli in a sex-specific manner, which would favor pheromonal-like properties of the compound, or in a more general manner, Sex differences Menstrual cycle which would suggest that the compound has broader influences on human psychological responses.
[Show full text]