DOCSLIB.ORG

Subject Index Volume 23 Number S2

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Subject Index Volume 23 Number S2 SUBJECT INDEX VOLUME 23 NUMBER S2 A B Cigarette smoking, S150 Circadian salivary cortisol levels, S105 Abnormal neuroendocrine, S97 B12 vitamin, S140 Circannual melatonin, S108 Abstinent male alcoholics, S156 Beclomethasone-induced vasoconstriction Circuitry pharmacotherapy, S73–S75 Academia, S10 (BIV), S121 Clinical diagnosis, S115 Academically-striving countries, S59 Bed nucleus of the stria terminals, S111 Clinical Global Impression Scale, S116 ACE gene, S130 Behavior problems, S100 Clinical trials, S43 ACE I/D polymorphism, S106 Behavioral effects of NK1, S23 Clobazam, S3 ACTH secretion, S29 Behavioral endocrine responses, S119 Clonidine administration, S132, S139 Acute adolescent mania, S124 Benign intracranial hypertension, S136 Clorniphene, S78 Acute major depressive disorder, S113 Benzodiazepine withdrawal syndrome, Clozapine, S54, S116, S123, S135 Acute schizophrenia, S122 S124 Cocaine, S17, S46, S133 Addiction, S17, S102 Benzodiazapines, S56 Cognition, S51, S79, S92–S94 Administrative arrangements, S9 Benzothiophenes, S79 Cognitive aging, S94 Adolescent, S82 Bilateral grand mal seizure, S91 Cognitive dysfunction, S128 Adrenal hyperplasia, S60 Biochemical markers, S110 Cognitive functioning, S8 Adrenal insufficiency, S48 Biogenic amine systems, S43 Cognitive therapeutic considerations, S99 Adrenalectomy treatment, S145 Biological Psychiatry, S35 Collaboration, S58 ␤-, ␣2-adrenergic receptors, S3 Biosynthesis, S70 Collegium International A2-adrenoceptor supersensibility, S139 Bipolar adolescents, S124 NeuroPsychopharmacologicum, S9 Adrenoceptor up-regulation, S138 Bipolar disorder, S3, S12, S64, S68, S75, S87, Comorbid psychiatric disorders of somatic Adverse early environment, S5 S107, S132 illness, S143 Affective disorders, S137 Blood glucose metabolism, S123 Consultation-liaison psychiatry, S100 Aggression, S136, S151 Body, S8 Convulsive therapy, S91 ␬ agonists, S145 Body-mind interplay, S40 Corticotropin releasing factor, S1, S4, S29, AIDS, S19, S49–S51, S113 Bone mineral density, S34 S60, S77, S149 Alcohol-exposed children, S148 Brain, S92–S94 Corticotropin-releasing hormone, S81 Alcohol ingestion in the afternoon, S117 Brain aging, S94 Corticotropin-releasing hormone system, Alcoholics, abstinent male, S156 Brain closure function, S152 S124 Algorithm-based treatment, S68 Brain damage, S86 Cortisol, S47 Allopregnanolone, S24, S40, S72 Brain development, S12, S70 CRF, S6 Allotetrahydrodeoxycorticosterone, S24 Brain fear circuits, S65 CRF cells, S111 Alzheimer’s disease, S8, S48, S52, S94, S128 Brain functions, S140 CRF neurocircuits, S63 Ampakines, S84 Brain plasticity, S36 CRF receptor antagonists, S5 Amphetamine receptor antagonists, S118 Brain redox systems, S52–S54 CRF1-selective antagonist, S119 Amphetamine, S17 Brain regional structures, S64 CRH hypothesis, S6 Amygdala, S77 Brasilian study, S114 CRH system, S76 ␤-Amyloid, S52 Bulimia nervosa, S104 CRH type-1 receptor antagonism, S119 Analgesic responses, S145 Business ethics, S16 Cultural formulation, S37 Androstadienone, S28 Cultural framework, S95 Angiotensin I-converting enzyme, S106 Cultural specificity, S45 Anorexia nervosa, S104 C Culture, S37 Anticonvulsant drugs, S3 Cyclic Amp response element binding Anticonvulsant theory, S89 C-6 glioma cells, S131 protein, S18 Antidepressant effect, S146 Calcium-calmodulin kinase type II, S18 Cytokines, S60 Antidepressant treatment, S26, S103 cAMP, S3 Antidepressant trials, S44 Carbamazepine, S3 Antidepressants, S23, S42–S44, S74, S95 Carbohydrate tolerance, S80 Antioxidants, S52, S53 Carbon monoxide, S30 D Antipsychotic drugs, S32, S55, S73 CCK-4 induced panic, S157 Antipsychotic therapy, S32–S35, S134 Cell biology, S35 D-allele, S106 Antipsychotic treatment, S144 Cell communication, S15 Daylength variation rate, S108 Anti-saccade performance, S151 Central nervous system, S12, S92 Dehydroepiandrosterone, S25, S56 Anxiety, S61, S65, S77, S86, S133 Cephalalgia, S132 Delayed-type hypersensitivity, S105 Anxiety disorders, S5, S6, S56, S64, S76, S104 Cerebral function, S67 Dementia, S126, S136 Anxiolytic metabolite, S26 Cerebralum®, S127/ Depressed men, S147 Anxiolytic-hypnotic drugs, S24 Cerebravascular disease, S127 Depression ideation, S139 Astrocytes, S131 Chang, S22 Depression, S26, S34, S35, S47, S57, S59–S61, Atenolol, S138 Channel blockers, S75 S62, S65, S76, S80–S83, S89, S101, S103, Attention deficits, S152 Channel openers, S75 S104, S121, S133, S138, S144, S153 Atypical antipsychotic drugs, S14 Chemosensory transduction, S27 Depression subtypes, S113 Atypical neuroleptics, S55 Child, S82 Depressive disorders, S44, S64, S95, S105, Autoimmune disorders, S30 Cholesterol, S24 S113, S115 Autonomic responses, S119 CHR, S49 Depressive patients, S130 AVP-neuropbysin, S50 Chronic depression, S113 Dexamethasone suppression test (DST), Axis stress responses, S2 Chronic fatigue syndrome (CFS), S76, S114 S110 NEUROPSYCHOPHARMACOLOGY 2000–VOL. 23, NO. S2 © 2000 Elsevier Science Inc. and American College of Neuropsychopharmacology 0893-133X/00/$–see front matter 655 Avenue of the Americas, New York, NY 10010 PII S0893-133X(00)00124-X NEUROPSYCHOPHARMACOLOGY 2000–VOL. 23, NO. S2 Subject Index S163 Dexamethasone treatment, S145 G 5-HT-1A receptor, S91 Deydroepiandrosterone, S40 Human sexuality, S94–S95 D-Fenfluramine challenge test, S89, S122 GABA mediated inhibition, S26 Hydrocortisone treatment, S124 DHEA, S46–S48, S127 GABAA receptor, S72 Hypercortisolism, S60 DHEA-S, S25, S127 GABAA receptors gene expression, S24 Hyperforin, S88 Diabetes, S106, S123 GABRA5 gene locus, S136 Hypericum perforatum, S88 Diencephalic stimulation theory, S90 Gaddum, S22 Hyperprolactinemia, S33 Differential gender effects, S32 Gender, S32–S35, S123 Hypogonadal men, S147 Discomfort index, S109 Gender differences in brain stems, S64–S66 Hypothalamic-pituitary-adrenal (HPA) Diurnal cortisol, S19 Gender specific, S28 axis, S2, S6, S14, S29, S30, S35, S50, S60, DNA technology, S8 Gene expression, S15, S70 S65, S76, S88, S146 Dopamine, S17, S35, S53, S93, S118 Gene-related peptide, S118 Hypothalamic-pituitary-gonadal (HPG) Dopamine hormones, S148 General medicine, S102 axis, S66 Dopamine neurotransmission, S137 General practitioners, S98–S99, S102 hypothalamic-pituitary-thyroid (HPT) axis, Dopamine receptor antagonists, S118 Genetic association study, S136 S67, S69 Dopamine receptor D3, S137 Genetic enhancement, S18 Hypothalamo-pituitary-adrenal (HPA) Dopamine receptors D2, S137 Genetic risk, S12 system, S80 Doxorubicin, S118 Genetics, S7 Hypothalamus, S57, S91 Drug development, S13 Genital herpes, S31 Hypothyroidism, S106 Drug metabolism, S32 Geomagnetic factors, S109 Drugs of abuse, S19 Geomagnetic field, S108 Dysthymic patients, S113 Geomagnetic index DST, S109 I Germany, S16 Globalization, S9, S20 I/D polymorphisms, S130 Glucocorticoid antagonists, S56 Idiographic fomulation, S95 E Glucocorticoid negative feedback, S65 IGF-1, S118 Immune function, S19 Early-onset schizophrenia, S126 Glucocorticoid receptor, S131 Glucocorticoid receptors antagonists, S59– Immune system, S18–S20, S101 Eating disorders, S25, S96, S104 Immunity, S31 Educational programs, S59 S61 Glucocorticoids, S49, S101 Impaired glucose tolerance, S123 EEG complexity changes, S125 Impulsivity, S134 EEG sleep, S82 Glucose tolerance, S123 Insomnia, S104 Efficacy, S42, S43 Glutamate, S93 Insurance, S16 Elderly men, S136 Glutamate mechanisms, S83–S87 Interferon-␣, S133 Elderly patients, S126 Glutamate synapse, S53 Intervention, S99 Electroconvulsive therapy (ECT), S69, S89– Glycemic peak delay, S123 Intracellular messengers, S3 S91, S127 Gonadal hormones, S109, S114 Intravenous drug use (IDU), S113 Electroconvulsive treatments, S62 Gonadal steroids, S96, S109 Gonadectomy, S114 Intravenous infusion of sodium lactate, S135 ELISPOT technique, S110 Ischemic brain damage, S86 Emotional functioning, S8 Gonadotropins, S28 Emotional stressor, S111 Government, S43 ␤-END, S117 Governmental agencies, S10 Endocrine dysfunction, S34 Grand mal seizure, S91 K Endocrine functions, S80–S83 Growth hormone, S82 Growth hormone-releasing hormone, S80, Ketamine, S86 Endocrine system, S59 Kraepelin, S123, S140 Endogenous pharmacology, S128 S81, S82 Environmental factors, S109 GSK-3B, S38 Episodic psychiatric disorders, S3 Gynecology and psychiatry, interface Estradiol, S56, S92 between, S96–S98 L Estrogen, S41, S66, S92–S94, S107 ␤ Lamotrigine, S3 Estrogen receptor , S92 H Latency, S146 Estrogen replacement therapy, S94 LC/NE system, S76 Estrogen supplementation, S153 Haloperidol, S54, S89, S150 Learning, S18 Estrogen therapy, S126 Haloperidol treatment, S123 Learning disabilities, S106 Estrogen-serotonin link, S98 Health care, S7 Learning/memory performance, S114 Ethanol, S72 Health care aspects, S15–S16 Leeman, S22 Ethics, S16 Health care policy, S7 Legislation, S21 Euthyroid psychiatric subjects, S142 Healthy smokers, S134 Levothyroxine, S68 Evolution, S12 Help-seeking Pathways, S95 Lithium, S39, S57, S62, S69 Experimental psychopathology, S35 Heterosexuals, S120 Lithium prophylaxis, S87 High melatonin excretors, S107, S138 Lithium response, S124 High risk subjects, S117 Lithium treatment, S156 F High-resolution imaging, S126 Long-term depression, S17 Hippocampal CA1 pyramidal cells, S92 Long-term potentiation (LTP), S17, S125 Federal Drug Administration, S44 Hippocampal circuitry, S92 Lordosis quotient, S112 Female depression, S130 Hippocampus, S17, S38, S90 Low melatonin depressives, S140 Female rat brain, S109 Hippocrates, S100 Low melatonin excretors, S107, S138 Female rats, S112 HIV, S18, S19
Load more

Recommended publications
  • Hyperforin Inhibits Cell Growth by Inducing Intrinsic and Extrinsic
    ANTICANCER RESEARCH 37 : 161-168 (2017) doi:10.21873/anticanres.11301 Hyperforin Inhibits Cell Growth by Inducing Intrinsic and Extrinsic Apoptotic Pathways in Hepatocellular Carcinoma Cells I-TSANG CHIANG 1,2,3* , WEI-TING CHEN 4* , CHIH-WEI TSENG 5, YEN-CHUNG CHEN 2,6 , YU-CHENG KUO 7, BI-JHIH CHEN 8, MAO-CHI WENG 9, HWAI-JENG LIN 10,11# and WEI-SHU WANG 2,12,13# Departments of 1Radiation Oncology, 6Pathology, and 13 Medicine, and 2Cancer Medical Care Center, National Yang-Ming University Hospital, Yilan, Taiwan, R.O.C.; 3Department of Radiological Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.; 4Department of Psychiatry, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.; 5Division of Gastroenterology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, Taiwan, R.O.C.; 7Radiation Oncology, Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.; 8Department of Laboratory Medicine, Changhua Christian Hospital, Changhua Christian Medical Foundation, Changhua, Taiwan, R.O.C.; 9Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan, R.O.C.; 10 Department of Internal Medicine, Division of Gastroenterology and Hepatology, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C.; 11 Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shuang-Ho Hospital, New Taipei, Taiwan, R.O.C.; 12 National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C. Abstract. The aim of the present study was to investigate the (c-FLIP), X-linked inhibitor of apoptosis protein (XIAP), antitumor effect and mechanism of action of hyperforin in myeloid cell leukemia 1(MCL1), and cyclin-D1] were hepatocellular carcinoma (HCC) SK-Hep1 cells in vitro.
    [Show full text]
  • Chronic Stress Makes People Sick. but How? and How Might We Prevent Those Ill Effects?
    Sussing Out TRESS SChronic stress makes people sick. But how? And how might we prevent those ill effects? By Hermann Englert oad rage, heart attacks, migraine headaches, stom- ach ulcers, irritable bowel syndrome, hair loss among women—stress is blamed for all those and many other ills. Nature provided our prehistoric ancestors with a tool to help them meet threats: a Rquick activation system that focused attention, quickened the heartbeat, dilated blood vessels and prepared muscles to fight or flee the bear stalking into their cave. But we, as modern people, are sub- jected to stress constantly from commuter traffic, deadlines, bills, angry bosses, irritable spouses, noise, as well as social pressure, physical sickness and mental challenges. Many organs in our bodies are consequently hit with a relentless barrage of alarm signals that can damage them and ruin our health. 56 SCIENTIFIC AMERICAN MIND COPYRIGHT 2003 SCIENTIFIC AMERICAN, INC. Daily pressures raise our stress level, but our ancient stress reactions—fight or flight—do not help us survive this kind of tension. www.sciam.com 57 COPYRIGHT 2003 SCIENTIFIC AMERICAN, INC. What exactly happens in our brains and bod- mone (CRH), a messenger compound that un- ies when we are under stress? Which organs are leashes the stress reaction. activated? When do the alarms begin to cause crit- CRH was discovered in 1981 by Wylie Vale ical problems? We are only now formulating a co- and his colleagues at the Salk Institute for Biolog- herent model of how ongoing stress hurts us, yet ical Studies in San Diego and since then has been in it we are finding possible clues to counteract- widely investigated.
    [Show full text]
  • WO 2013/142184 Al 26 September 2013 (26.09.2013) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2013/142184 Al 26 September 2013 (26.09.2013) P O P C T (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, A61K 33/16 (2006.01) A61K 31/7048 (2006.01) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, A61K 33/14 (2006.01) A61K 31/70 (2006.01) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, A61K 33/18 (2006.01) A61K 31/4196 (2006.01) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (21) International Application Number: RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, PCT/US20 13/030788 TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (22) International Filing Date: ZM, ZW. 13 March 2013 (13.03.2013) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (26) Publication Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (30) Priority Data: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 61/612,689 19 March 2012 (19.03.2012) US EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (71) Applicant: YALE UNIVERSITY [US/US]; Two Whitney TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Avenue, New Haven, CT 065 10 (US).
    [Show full text]
  • Love, Marriage, and Divorce: Newlyweds' Stress Hormones
    Journal of Consulting and Clinical Psychology Copyright 2003 by the American Psychological Association, Inc. 2003, Vol. 71, No. 1, 176–188 0022-006X/03/$12.00 DOI: 10.1037/0022-006X.71.1.176 Love, Marriage, and Divorce: Newlyweds’ Stress Hormones Foreshadow Relationship Changes Janice K. Kiecolt-Glaser Cynthia Bane Ohio State University College of Medicine and Ohio State Ohio State University Institute for Behavioral Medicine Research Ronald Glaser and William B. Malarkey Ohio State University College of Medicine and Ohio State Institute for Behavioral Medicine Research Neuroendocrine function, assessed in 90 couples during their first year of marriage (Time 1), was related to marital dissolution and satisfaction 10 years later. Compared to those who remained married, epinephrine levels of divorced couples were 34% higher during a Time 1 conflict discussion, 22% higher throughout the day, and both epinephrine and norepinephrine were 16% higher at night. Among couples who were still married, Time 1 conflict ACTH levels were twice as high among women whose marriages were troubled 10 years later than among women whose marriages were untroubled. Couples whose marriages were troubled at follow-up produced 34% more norepinephrine during conflict, 24% more norepinephrine during the daytime, and 17% more during nighttime hours at Time 1 than the untroubled. Broadly stated, social learning models suggest that disordered Bradbury’s (1999b) “two factor” hypothesis suggests that aggres- communication promotes poor marital outcomes (Bradbury & sion and aggressive tendencies appear to be a key risk factor for Carney, 1993). Although communication measures have been early divorces, whereas marital communication contributes to the linked to marital discord and divorce across a number of studies, variability in satisfaction in intact marriages.
    [Show full text]
  • St. John's Wort 2018
    ONLINE SERIES MONOGRAPHS The Scientific Foundation for Herbal Medicinal Products Hyperici herba St. John's Wort 2018 www.escop.com The Scientific Foundation for Herbal Medicinal Products HYPERICI HERBA St. John's Wort 2018 ESCOP Monographs were first published in loose-leaf form progressively from 1996 to 1999 as Fascicules 1-6, each of 10 monographs © ESCOP 1996, 1997, 1999 Second Edition, completely revised and expanded © ESCOP 2003 Second Edition, Supplement 2009 © ESCOP 2009 ONLINE SERIES ISBN 978-1-901964-61-5 Hyperici herba - St. John's Wort © ESCOP 2018 Published by the European Scientific Cooperative on Phytotherapy (ESCOP) Notaries House, Chapel Street, Exeter EX1 1EZ, United Kingdom www.escop.com All rights reserved Except for the purposes of private study, research, criticism or review no part of this text may be reproduced, stored in a retrieval system or transmitted, in any form or by any means, without the written permission of the publisher. Important Note: Medical knowledge is ever-changing. As new research and clinical experience broaden our knowledge, changes in treatment may be required. In their efforts to provide information on the efficacy and safety of herbal drugs and herbal preparations, presented as a substantial overview together with summaries of relevant data, the authors of the material herein have consulted comprehensive sources believed to be reliable. However, in view of the possibility of human error by the authors or publisher of the work herein, or changes in medical knowledge, neither the authors nor the publisher, nor any other party involved in the preparation of this work, warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for results obtained by the use of such information.
    [Show full text]
  • Synaptic Action of Anandamide and Related Substances in Mammalian Brain
    SYNAPTIC ACTION OF ANANDAMIDE AND RELATED SUBSTANCES IN MAMMALIAN BRAIN by Chengyong Liao M.Sc., Sichuan University, 1991 B.Sc., Sichuan University, 1984 THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY Inthe Department of Biological Sciences © Chengyong Liao 2007 SIMON FRASER UNIVERSITY 2007 All rights reserved. This work may not be reproduced in whole or in part, by photocopy or other means, without permission ofthe author. APPROVAL Name: Chengyong Liao Degree: Doctor of Philosophy Title of Thesis: Synaptic Actions of Anandamide and Related Substances in Mammalian Brain Examining Committee: Chair: Dr. Z. Punja Professor ofDepartment ofBiological Sciences, SFU. Dr. R. A. Nicholson Senior Supervisor Associate Professor ofDepartment ofBiological Sciences, SFU. Dr. C. J. Kennedy, Supervisor Associate Professor of Department ofBiological Sciences, SFU Dr. F. C. P. Law, Supervisor Professor ofDepartment ofBiological Sciences, SFU Dr. M. A. Silverman Public Examiner Associate Professor ofDepartment ofBiological Sciences, SFU Dr. J. Church External Examiner Professor ofDepartment ofCellular and Physiological Sciences, UBC Date Defended/Approved: 11 SIMON FRASER UNIVERSITY LIBRARY Declaration of Partial Copyright Licence The author, whose copyright is declared on the title page of this work, has granted to Simon Fraser University the right to lend this thesis, project or extended essay to users of the Simon Fraser University Library, and to make partial or single copies only for such users or
    [Show full text]
  • Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types
    (19) TZZ ¥Z_T (11) EP 2 380 595 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 26.10.2011 Bulletin 2011/43 A61K 47/48 (2006.01) C12N 15/11 (2006.01) A61P 25/00 (2006.01) A61K 49/00 (2006.01) (2006.01) (21) Application number: 10382087.4 A61K 51/00 (22) Date of filing: 19.04.2010 (84) Designated Contracting States: • Alvarado Urbina, Gabriel AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Nepean Ontario K2G 4Z1 (CA) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL • Bortolozzi Biassoni, Analia Alejandra PT RO SE SI SK SM TR E-08036, Barcelona (ES) Designated Extension States: • Artigas Perez, Francesc AL BA ME RS E-08036, Barcelona (ES) • Vila Bover, Miquel (71) Applicant: Nlife Therapeutics S.L. 15006 La Coruna (ES) E-08035, Barcelona (ES) (72) Inventors: (74) Representative: ABG Patentes, S.L. • Montefeltro, Andrés Pablo Avenida de Burgos 16D E-08014, Barcelon (ES) Edificio Euromor 28036 Madrid (ES) (54) Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types (57) The invention provides a conjugate comprising nucleuc acid toi cell of interests and thus, for the treat- (i) a nucleic acid which is complementary to a target nu- ment of diseases which require a down-regulation of the cleic acid sequence and which expression prevents or protein encoded by the target nucleic acid as well as for reduces expression of the target nucleic acid and (ii) a the delivery of contrast agents to the cells for diagnostic selectivity agent which is capable of binding with high purposes.
    [Show full text]
  • Note: the Letters 'F' and 'T' Following the Locators Refers to Figures and Tables
    Index Note: The letters ‘f’ and ‘t’ following the locators refers to figures and tables cited in the text. A Acyl-lipid desaturas, 455 AA, see Arachidonic acid (AA) Adenophostin A, 71, 72t aa, see Amino acid (aa) Adenosine 5-diphosphoribose, 65, 789 AACOCF3, see Arachidonyl trifluoromethyl Adlea, 651 ketone (AACOCF3) ADP, 4t, 10, 155, 597, 598f, 599, 602, 669, α1A-adrenoceptor antagonist prazosin, 711t, 814–815, 890 553 ADPKD, see Autosomal dominant polycystic aa 723–928 fragment, 19 kidney disease (ADPKD) aa 839–873 fragment, 17, 19 ADPKD-causing mutations Aβ, see Amyloid β-peptide (Aβ) PKD1 ABC protein, see ATP-binding cassette protein L4224P, 17 (ABC transporter) R4227X, 17 Abeele, F. V., 715 TRPP2 Abbott Laboratories, 645 E837X, 17 ACA, see N-(p-amylcinnamoyl)anthranilic R742X, 17 acid (ACA) R807X, 17 Acetaldehyde, 68t, 69 R872X, 17 Acetic acid-induced nociceptive response, ADPR, see ADP-ribose (ADPR) 50 ADP-ribose (ADPR), 99, 112–113, 113f, Acetylcholine-secreting sympathetic neuron, 380–382, 464, 534–536, 535f, 179 537f, 538, 711t, 712–713, Acetylsalicylic acid, 49t, 55 717, 770, 784, 789, 816–820, Acrolein, 67t, 69, 867, 971–972 885 Acrosome reaction, 125, 130, 301, 325, β-Adrenergic agonists, 740 578, 881–882, 885, 888–889, α2 Adrenoreceptor, 49t, 55, 188 891–895 Adult polycystic kidney disease (ADPKD), Actinopterigy, 223 1023 Activation gate, 485–486 Aframomum daniellii (aframodial), 46t, 52 Leu681, amino acid residue, 485–486 Aframomum melegueta (Melegueta pepper), Tyr671, ion pathway, 486 45t, 51, 70 Acute myeloid leukaemia and myelodysplastic Agelenopsis aperta (American funnel web syndrome (AML/MDS), 949 spider), 48t, 54 Acylated phloroglucinol hyperforin, 71 Agonist-dependent vasorelaxation, 378 Acylation, 96 Ahern, G.
    [Show full text]
  • Assessment Report on Hypericum Perforatum L., Herba
    European Medicines Agency Evaluation of Medicines for Human Use London, 12 November 2009 Doc. Ref.: EMA/HMPC/101303/2008 COMMITTEE ON HERBAL MEDICINAL PRODUCTS (HMPC) ASSESSMENT REPORT ON HYPERICUM PERFORATUM L., HERBA 7 Westferry Circus, Canary Wharf, London, E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 75 23 70 51 E-mail: [email protected] http://www.emea.europa.eu © European Medicines Agency, 2009. Reproduction is authorised provided the source is acknowledged TABLE OF CONTENTS I. REGULATORY STATUS OVERVIEW...................................................................................4 II. ASSESSMENT REPORT............................................................................................................5 II.1 INTRODUCTION..........................................................................................................................6 II.1.1 Description of the herbal substance(s), herbal preparation(s) or combinations thereof 6 II.1.1.1 Herbal substance:........................................................................................................ 6 II.1.1.2 Herbal preparation(s): ................................................................................................ 7 II.1.1.3 Combinations of herbal substance(s) and/or herbal preparation(s)........................... 9 Not applicable. ................................................................................................................................9 II.1.1.4 Vitamin(s) ...................................................................................................................
    [Show full text]
  • The Relationship Between Oral Contraceptive Use and Sensitivity to Olfactory Stimuli
    YHBEH-03499; No. of pages: 6; 4C: Hormones and Behavior xxx (2013) xxx–xxx Contents lists available at SciVerse ScienceDirect Hormones and Behavior journal homepage: www.elsevier.com/locate/yhbeh The relationship between oral contraceptive use and sensitivity to olfactory stimuli Kaytlin J. Renfro ⁎, Heather Hoffmann Psychology Department, Knox College, 2 East South Street, Galesburg, IL 61401-4999, USA article info abstract Article history: The present study examined differences in olfactory sensitivity between 16 naturally cycling (NC) women Received 2 March 2012 and 17 women taking monophasic oral contraceptives (OCs) to six odors: lemon, peppermint, rose, musk, Revised 20 November 2012 androstenone and androsterone. Thresholds were assessed twice for both groups of women (during the Accepted 2 January 2013 periovulatory and luteal phases of their cycles) via a forced-choice discrimination task. NC women in the Available online xxxx periovulatory phase were significantly more sensitive to androstenone, androsterone, and musk than women taking OCs. These findings give support to odor-specific hormonal modulation of olfaction. Further, Keywords: Oral contraceptives due to the social and possibly sexual nature of these odors, future work should address whether there is a re- Olfaction lationship between decreased sensitivity to these odors and reported behavioral side effects among women Odor taking OCs. Ovarian steroids © 2013 Elsevier Inc. All rights reserved. Threshold Introduction problems, such as stroke (Seibert et al., 2003). Women taking OCs have also reported many behavioral side effects, such as emotional la- There are a number of physiological, perceptual, and behavioral bility and decreased sexual desire (Battaglia et al., 2012; Caruso et al., changes that have been reported to co-occur with ovulation in 2004; Sanders et al., 2001; Warner Chilcott, 2009, but see Alexander women; these changes have largely been attributed to the hormonal et al., 1990).
    [Show full text]
  • The Boar Testis: the Most Versatile Steroid Producing Organ Known
    The boar testis: the most versatile steroid producing organ known Raeside', H.L. Christie', R.L. Renaud' and P.A. Sinclair" 'Department of Biomedical Sciences and 2Department of Animal and Poultry Science, University of Guelph, Guelph, ON Canada N IG 2WI A review of the remarkable production of steroids by the testes of the boar is presented, with the principal aims of highlighting the achievements of the Leydig cells and, at the same time, pointing to the considerable deficiencies in our understanding of its biological relevance. The onset of gonadal steroidogenesis at an early stage of sex differentiation and the pattern of pre- and postnatal secretion of steroids are outlined. This is followed by a list of steroids identified in extracts of the boar testis, with emphasis on those that can reasonably be assumed to be secretory products of the Leydig cells. For example, the high concentrations of 16- unsaturated C19and sulphoconjugated compounds are noted. Next, an impressive list of steroids found in venous blood from the boar testis is given; among them are the 16-unsaturated steroids, the oestrogens and dehydroepiandrosterone, all mainly in the form of sulphates. However, the list also includes some less likely members, such as 11-0H and 19- OH androgens as well as Sce-reduced steroids. Lastly, the high concentrations of steroids reported in testicular lymph, especially sulphates, are mentioned. Although roles for testosterone are uncontested, and even for the pheromone-like Co steroids, there is little that can be said with assurance about the other compounds listed. Some speculations are made on their possible contributions to the reproductive physiology of the boar.
    [Show full text]
  • Poverty Raises Levels of the Stress Hormone Cortisol: Evidence from Weather Shocks in Kenya*
    Poverty Raises Levels of the Stress Hormone Cortisol: Evidence from Weather Shocks in Kenya* Johannes Haushofer, Joost de Laat, Matthieu Chemin October 21, 2012 Abstract Does poverty lead to stress? Despite numerous studies showing correlations between socioeconomic status and levels of the stress hormone cortisol, it remains unknown whether this relationship is causal. We used random weather shocks in Kenya to address this question. Our identication strategy exploits the fact that rainfall is an important input for farmers, but not for non-farmers such as urban artisans. We obtained salivary cortisol samples from poor rural farmers in Kianyaga district, Kenya, and informal metal workers in Nairobi, Kenya, together with GPS coordinates for household location and high-resolution infrared satellite imagery meausring rainfall. Since rainfall is a main input into agricultural production in the region, the absence of rain constitutes a random negative income shock for farmers, but not for non-farmers. We nd that low levels of rain increase cortisol levels with a temporal lag of 10-20 days; crucially, this eect is larger in farmers than in non-farmers. Both rain and cortisol levels are correlated with self-reported worries about life. Together, these ndings suggest that negative events lead to increases in worries and the stress hormone cortisol in poor people. JEL Codes: C93, D03, D87, O12 Keywords: weather shocks, rainfall, cortisol, stress, worries *We thank Ernst Fehr, David Laibson, Esther Duo, Abhijit Banerjee, and the members of the Harvard Program in History, Politics, and Economics for valuable feedback; Ellen Moscoe, Averie Baird, and Robin Audy for excellent research assistance; and Tavneet Suri for providing the rainfall data.
    [Show full text]