Course Description Subject: Biology Course: 1º Semester: 1º Degree (S) Physiotherapy Modality: Attendance Is Required Academic Year 2021/2022 Faculty of Medicine

COURSE DESCRIPTION SUBJECT: BIOLOGY COURSE: 1º SEMESTER: 1º DEGREE (S) PHYSIOTHERAPY MODALITY: ATTENDANCE IS REQUIRED ACADEMIC YEAR 2021/2022 FACULTY OF MEDICINE

Course Description / Academic year 2021-2022

1. COURSE/SUBJECT IDENTIFICATION

1.- COURSE/SUBJECT:

Name: Biology

Code: 19330

Year (s) course is taught: 1 Semester (s) when the course is taught: 1

Type: Basic ECTS of the course: 6 Hours ECTS: 30

Language: English Modality: Attendance is required

Degree (s) in which the course is taught: Physiotherapy

School which the course is taught: Medicine

2.- ORGANIZATION OF THE COURSE:

Department: Medical Basic Sciences

Area of knowledge: Biochemistry, molecular and cellular biology, histology

2. LECTURERS OF THE COURSE/SUBJECT

1.-LECTURERS:

Responsible of the Course CONTACT Name: Beatriz Oltra García Phone (ext): 91 372 47 00 (15068) Email: [email protected] Office: 212 MED building Teaching and Research profile Associate doctor professor Research Lines Prostatic intraepithelial neoplasm

Lecturer(s) CONTACT

Course Description / Academic year 2021-2022

Name: Encarnación Amusquivar Arias Phone (ext): 91 372 47 00 (15269) Email: [email protected] Office: 216 C building

2.- TUTORIALS:

For any queries students can contact lecturers by e-mail, phone or visiting their office during the teacher’s tutorial times published on the students’ Virtual Campus.

3. COURSE DESCRIPTION

Structure and ultrastructure of the eukaryotic cell. Structure and ultrastructure of the different cell types of the human body. Molecular, organellar, cellular and tissular biocomponents of the organs and body systems. Bioenergetic systems operation and development of the metabolic processes in the body. Biological and biochemical basis of metabolic pathways in the body. Morphological characteristics and functional bases of the different cell types and cell communication. Macroscopic and microscopic biological components of the organs and systems of the human body. Correlation between cell and tissue types and the functional characteristics of the organs and systems of human beings. Relationship of cell physiology and biochemistry of organs and body systems. General and fundamental basis of pathological processes in the body related to research and professional activity of Physiotherapist. Genes, heredity and genetic variability. Gene expression Fundamentals of popu- lation genetics.

4. COMPETENCIES

1.- COMPETENCIES

Code Basic and General Competencies

CG1 Know and understand the morphology, physiology, pathology and behavior of people, both healthy and sick, in the natural and social environment.

That students have demonstrated to possess and understand knowledge in an area of CB1 study that starts from the base of general secondary education, and is usually found at a level that, although supported by advanced textbooks, also includes some aspects that imply knowledge from the forefront of your field of study.

Course Description / Academic year 2021-2022

CB2 That students know how to apply their knowledge to their work or vocation in a professional way and possess the competencies that are usually demonstrated through the elaboration and defense of arguments and the resolution of problems within their area of study.

CB3 That students have the ability to gather and interpret relevant data (usually within their area of study) to make judgments that include reflection on relevant issues of a social, scientific or ethical nature.

CB4 That students can transmit information, ideas, problems and solutions to both specialized and non-specialized audiences.

CB5 That students have developed those learning skills necessary to undertake further stud- ies with a high degree of autonomy.

Code Specific Competencies

CE7 Identify anatomical structures as a knowledge base to establish dynamic relations with the functional organization.

2.- LEARNING OUTCOMES:

Code Learning outcomes

List the major macromolecules that make up human cells. Explain the structure and characteristics of the different macromolecules and associate each of them with the functions they perform in the cell. Describe the structure of a human cell. Explain the function of each cell organelle. Associate the function of each cell organelle with its structure. Ex- plain the structure of each one of the tissues that make up the human body. Explain the function of each of the tissues that make up the human body. Associate the structure with the function performed by each of the tissues that make up the human body.

5. LEARNING ACTIVITIES

1.- DISTRIBUTION OF STUDENTS` ASSIGNMENT:

Total hours of the course 180

Code Name On-campus hours

Course Description / Academic year 2021-2022

AF1 Theoretical classes 44

AF3 Practical classes 18

AF5 Externships 4

TOTAL Presence Hours 66

Code Name Not on-campus hours

AF9 Independent study 114

2.- DESCRIPTION OF LEARNING ACTIVITIES:

Activity Definition The teacher will explain the themes of the program and the integration of Theoretical clas- them, according to the program of the subject, with the active participa- ses tion of students. Teaching support materials will be employed (documents handed out in class and digitized will be disseminated through the virtual campus). The practical classes will be developed in the laboratory for six days in sessions of 3 hours per day, divided into two blocks of 3 days each. Practical clas- -Once the student is assigned into a practice group, any changes will not ses be permitted except for just cause. Students are organized into working groups to carry out the practical classes proposed on the program of the subject, under the supervision of the responsible teacher of the practical part. Besides, the student has to analyze and discuss the results, translating them individually in a laboratory notebook, which will be delivered only to the corresponding teacher, at the date and place indicated. Externships Students take assessment test under the professor´s supervision

Course Description / Academic year 2021-2022

6. ASSESMENT OF LEARNING

1.- CLASS ATTENDANCE:

 Attendance checks will be carried out and students with more than a 75% of attendance will be considered as it is said on “Assesment System and Criteria”.

 100% attendance at practical classes is required to pass the subject. The student that miss a practical class, will have to take that class in another group presenting previously an official proof and filling the “recovery of attendance to practice” document signed by the teacher or teachers of that practical class.

 Not being contemplated the realization of practical classes between the Ordinary C. and the Extraordinary C., the non realization of these classes during the programmed months entails failing both calls.

2.- ASSESMENT SYSTEM AND CRITERIA:

ORDINARY EXAMINATION (continuous assessment) Code Name Percentage

Partial exams 60

Final exam 15

Practices 10

Activities along the course 10

Attendance and participation in class 5

MAKE UP EXAM/EXTRAORDINARY EXAMINATION

Code Name Percentage

Extraordinary exam 90

Practices 10

3.- DESCRIPTION OF ASSESSMENT CRITERIA:

Course Description / Academic year 2021-2022

Assessment Definition criteria Partial exams During the course two partial exams will be held on the dates indicated by the teacher and will comprise the part of the program also indicated by the teacher. Each partial exam will mean 30% of the final grade of continuous assessment and obtaining a minimum score of 5 in each exam will be compulsory to pass the course. Final exam At the end of the course will be held a final exam that will comprise the part of the program indicated by the teacher. Students must obtain in this exam a minimum score of 5 to pass the subject. Besides, students who have not passed the partial exams may take them along with the final exam and also must obtain a minimum score of 5 in each part of the course. Practices Practices will be held in two blocks of three days each and 3 hours per day. It is compulsory 100% attendance at practical classes and to pass the evaluation system of each block to pass the course. Each block represents 50% of the grade of practices. Activities Throughout the course the professor will propose some activities to perform along the in class. course Extraordinary Students who do not pass the subject by the system of continuous assess- exam ment must take the extraordinary final exam, which includes the entire program of the subject. The student must obtain a minimum score of 5 to pass the subject.

7. COURSE PROGRAMME

Course Description / Academic year 2021-2022

THEORETICAL:

1. CELL BIOLOGY The cell: plasmatic membrane, cytoskeleton, cytoplasmic organelles and nucleus. Cell cycle, death and renewal.

2. EPITHELIAL TISSUE Features and classification of epithelia. Lining and glandular epithelia.

3. CONNECTIVE TISSUE Features and classification of connective tissue. Adipose tissue.

4. CARTILAGINOUS TISSUE Features and classification of cartilaginous tissue. Hyaline, elastic and fibrous cartilage.

5. BONE TISSUE AND SKELETAL SYSTEM Features and classification of bone tissue. Ossification and bone growth. Classification, shape, structure and function of bones. Joints and synovial membranes.

6. MUSCLE TISSUE AND SYSTEM Features and varieties of muscle tissue. Smooth, striated skeletal and cardiac striated muscle. Muscle contraction. Regeneration of muscle tissue.

7. CONTROL SYSTEMS Nervous tissue and system: neuron function and structure, glia and nervous fibers. Nervous system organization. Endocrine system: organization and function.

8. TRANSPORT, DEFENSE AND COMMUNICATION SYSTEMS Blood. Immune system. Cardiovascular system. Integumentary system.

9. BREATH, DIGESTION AND EXCRETION SYSTEMS Respiratory system. Digestive system. Urinary system.

10. REPRODUCTION SYSTEM Male reproduction system. Female reproduction system.

11. BIOCHEMISTRY INTRODUCTION. Definition and importance of biochemistry in Physiotherapy. Chemical composition of living beings. The internal environment. Homeostasis and steady state.

12. WATER AND ELECTROLYTES. Role of water in biological processes. Structure and properties of water. Compartments of body fluids and their constituents.

13. AMINOACIDS AND PROTEINS. Characteristics, structure and general classification of aminoacids and proteins. Characteristics of the peptide bond. Structural protein levels.

14. RELATIONSHIP OF PROTEIN STRUCTURE AND FUNCTION. Globular proteins: actin, hemoglobin and myoglobin Fibrous proteins: collagen, keratin, myosin and actin fibers.

1.- COURSE PROGRAMME:

Course Description / Academic year 2021-2022

15. ENZYMOLOGY General structure and importance of enzymes in the development of biological reactions. Influence of temperature and pH on enzymatic reactions. Water soluble vitamins as coenzymes. Regulation of enzyme activity.

16. GENERAL METABOLISM. Biological transformations of energy. Anabolic and catabolic reactions. Energy-rich com- pounds: role of ATP. Endergonic and exergonic reactions, coupled reactions.

17. ENERGY GENERATION IN THE BODY. Concept and functional role of biological oxidation. The respiratory chain and ATP synthesis. Role of the citric acid cycle in energy generation.

18. METABOLISM OF CARBOHYDRATES. Characteristics, structure and classification of carbohydrates. Digestion and absorption of carbohydrates. Cell synthesis and degradation of glucose. The Cori cycle. Cycle glucose-alanine Synthesis and degradation of glycogen.

19. LIPID METABOLISM. Characteristics, structure and classification of lipids. Digestion and absorption of lipids. Transport of lipids in the blood. Accumulation and mobilization of lipids. Obtaining energy from lipids. Role of carnitine in fatty acid metabolism.

20. PROTEIN AND AMINOACID METABOLISM. Digestion and absorption of proteins. Final ending of the carbon skeleton and the amino group of aminoacids. Urea cycle.

21. NUCLEIC ACID AND PROTEIN SYNTHESIS DNA and RNA: structure and properties. Replication. Transcription. Translation.

22. METABOLIC NUTRITION IN EXERCISE AND ADJUSTMENTS. Metabolism at rest and during exercise. Major energy and structural substrates and metabolic pathways used. Metabolic differences in aerobic and anaerobic situation. Effects of physical training on the muscles. Role and energy intake of each nutrient. Phosphocreatine and other nutritional supplements to supply energy.

PRACTICAL WORK PROGRAMME:

PART I. HISTOLOGY LABORATORY: 1. Use of the microscope. 2. Observation of histological samples: lining and glandular epithelium, connective tissue, cartilaginous, bone, muscle and nervous tissues. 3. Blood and oral mucosa staining

PART II. BIOCHEMISTRY LABORATORY: 1. Preparation of a buffer solution and evaluation of its buffering capacity. 2. Determination of plasma muscle metabolism related metabolites. 3. Determination of enzyme activity of creatine kinase.

Course Description / Academic year 2021-2022

8. RECOMMENDED READING

1.- ESSENTIAL BIBLIOGRAPHY:

 Harvey, R, Ferrier, D. Lippincott´s Illustrated Reviews: Biochemistry. Ed. Wolters Kluwer Health, 5th edition, 2011  Newsholme, E.A., Leech, T.R. “Functional Biochemistry in Health and Disease”. Ed. Wiley- Blackwell, 2010.  Cooper, G.M. The Cell. 2th ed. Sinauer Associates, 2000.  Gartner, L.P. y HIATT, J.L. Textbook of histology. 3th ed. Elsevier, 2006.

2.- ADDITIONAL BIBLIOGRAPHY:

 Alberts, B. et al. Molecular Biology of the cell. 5th ed. Garland Science, 2008.  Bloom & Fawcett. A textbook of histology. 12th revised ed. CRC Press, 1998.  Junqueira, L.C y Carneiro, J. Basic histology: text & atlas. 11th ed. McGraw-Hill Medical, 2005.  Kierszenbaum, Abraham L. Histology and Cell Biology. An introduction to pathology. 3th ed. Mosby, 2011.  Lodish, H et al. Molecular Cell Biology. 6th ed. W.H. Freeman 2007.  Ross, M.H.,et al. Histology: A text and atlas. Lippincott Raven, 2010.  Stevens y Lowe. Human Histology. 3th ed. Mosby, 2004.  Wheater’s. Functional Histology. 5th ed. Churchill Livingstone. 2006.  Voet, D., Voet, J.G “Principles of Biochemistry”. 3rd edition. Wiley International Edition. USA, 2007.  Guyton. Hall. “Textbook of Medical Physiology” Ed.Saunders Elsevier, 12ª Edición. 2010.  Baynes J., Dominiczak, M. “Medical Biochemistry”, Ed. Elsevier Mosby, 3rd edition, 2009.  Devlin, T.M. “Textbook of biochemistry with clinical correlations”. 7 ED. Wiley and Sons, 2010. Wiley-Liss. USA.

4.- WEB RESOURCES :

Course Description / Academic year 2021-2022

 http://wzar.unizar.es/acad/histologia/paginas/Atlas_inicio.htm  https://mmegias.webs.uvigo.es  http://www.ujaen.es/investiga/atlas/  https://www.batamedica.com/histologia/  http://www.bu.edu/histology/m/t_electr.html  http://www.udel.edu/Biology/Wags/histopage/histopage.htm  Students’ Portal with several documents in order to complement the seminar and lectures contents. Exercises proposed to the students.  http://biomodel.uah.es/c_enlaces/inicio.htm: links to several web pages concerning Biochem- istry and Molecular Biology topics  http://www.biorom.uma.es/indices/index.html  http://www.whfreeman.com/lehninger/  http://www.ceu.es/pages/biblio.htm : bases de datos EBSCO

9. ATTITUDE IN THE CLASSROOM

1.- REGULATIONS

Any irregular act of academic integrity (no reference to cited sources, plagiarism of work or inappropriate use of prohibited information during examinations) or signing the attendance sheet for fellow students not present in class will result in the student not being eligible for continuous assessment and possibly being penalized according to the Univer- sity regulations. The use of the documentation provided by the teacher through the students portal (presentations, questions, exercises, seminars, laboratory notebooks, etc.), is restricted to the preparation of the subject. The teacher reserves the right to make use of the measures contained in the current legislation on intellectual property in cases where an unauthorized use and/or disclosure of said material is detected.

10. EXCEPTIONAL MEASURES

Should an exceptional situation occur which prevents continuing with face-to-face teaching under the conditions previously established to this end, the University will take ap- propriate decisions and adopt the necessary measures to guarantee the acquisition of skills and attainment of learning outcomes as established in this Course Unit Guide. This will be done in accordance with the teaching coordination mechanisms included in the Internal Quality Assurance System of each degree.

Course Description / Academic year 2021-2022