Prognostic Significance of the Null Genotype of Glutathione S
Leukemia (2002) 16, 203–208 2002 Nature Publishing Group All rights reserved 0887-6924/02 $25.00 www.nature.com/leu Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy T Naoe1, Y Tagawa1, H Kiyoi1, Y Kodera2, S Miyawaki3, N Asou4, K Kuriyama5, S Kusumoto6, C Shimazaki7, K Saito8, H Akiyama9, T Motoji10, M Nishimura11, K Shinagawa12, R Ueda13, H Saito14 and R Ohno15 1Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan; 2Department of Medicine, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan; 3Department of Medicine, Saiseikai Maebashi Hospital, Maebashi, Japan; 4Second Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Nagasaki, Japan; 5Department of Hematology, Atomic Disease Institute Nagasaki University School of Medicine, Nagasaki, Japan; 6First Department of Internal Medicine, Saitama Medical School, Saitama, Japan; 7Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan; 8Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan; 9Hematology Division, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; 10Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan; 11Second Department of Internal Medicine, Chiba University School of Medicine, Chiba, Japan; 12Department of Medicine, Okayama University Medical School, Okayama, Japan; 13Second Department of Internal Medicine, Nagoya City University School of Medicine, Nagoya, Japan; 14Nagoya National Hospital, Nagoya, Japan; and 15Aichi Cancer Center, Nagoya, Japan We investigated the prognostic significance of genetic myeloperoxidase (MPO), the products of which are associated polymorphism in glutathione-S transferase mu 1 (GSTM1), glut- with drug metabolism as well as with detoxication, in de novo athione-S transferase theta 1 (GSTT1), NAD(P)H:quinone oxido- reductase (NQO1) and myeloperoxidase (MPO), the products acute myeloid leukemia (AML).
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