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GRAS Notice 789 for Erythritol
GRAS Notice (GRN) No. 789 https://www.fda.gov/food/generally-recognized-safe-gras/gras-notice-inventory. Toi• Strategies ~~~~G~~[)) JUN 7 20'8 Innovative solutions Sound science OFFICE OF FOOD ADDITIVE SAFE1Y June 5, 2018 Dr. Dennis Keefe Director, Division of Biotechnology and GRAS Notice Review Office of Food Additive Safety (HFS-200) Center for Food Safety and Applied Nutrition Food and Drug Administration 5100 Paint Branch Parkway College Park, MD 20740-3835 Subject: GRAS Notification - Erythritol Dear Dr. Keefe: On behalf of Cargill, Incorporated, ToxStrategies, Inc. (its agent) is submitting, for FDA review, a copy of the GRAS notification as required. The enclosed document provides notice of a claim that the food ingredient, erythritol, described in the enclosed notification is exempt from the premarket approval requirement of the Federal Food, Drug, and Cosmetic Act because it has been determined to be generally recognized as safe (GRAS), based on scientific procedures, for addition to food. If you have any questions or require additional information, please do not hesitate to contact me at 630-352-0303, or [email protected]. Sincerely, (b) (6) Donald F. Schmitt, M.P.H. Senior Managing Scientist ToxStrategies, Inc., 931 W. 75th St. , Suite 137, PMB 263, Naperville, IL 60565 1 Office (630) 352-0303 • www.toxstrategies.com GRAS Determination of Erythritol for Use in Human Food JUNES,2018 Innovative solutions s ,..,.,',--.r-.r--.r--. OFFICE OF FOOD ADDITIVE SAFE1Y GRAS Determination of Erythritol for Use in Human Food SUBMITTED BY: Cargill, Incorporated 15407 McGinty Road West Wayzata, MN 55391 SUBMITTED TO: U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition Office of Food Additive Safety HFS-200 5100 Paint Branch Parkway College Park MD 20740-3835 CONTACT FOR TECHNICAL OR OTIIER INFORMATION Donald F. -
Determining the Effect of Small Doses of Fructose and Its Epimers on Glycemic Control
Determining the Effect of Small Doses of Fructose and its Epimers on Glycemic Control by Jarvis Clyde Noronha A thesis submitted in conformity with the requirements for the degree of Master of Science Department of Nutritional Sciences University of Toronto © Copyright by Jarvis Clyde Noronha 2017 ii Determining the Effect of Small Doses of Fructose and its Epimers on Glycemic Control Jarvis Clyde Noronha Master of Science Department of Nutritional Sciences University of Toronto 2017 Abstract Given that sugars have emerged as the dominant nutrient of concern in diabetes, there is a need for the development of alternative sweeteners. To assess the role of small doses (5g, 10g) of fructose and allulose on postprandial glucose metabolism, we conducted an acute randomized controlled trial in individuals with type 2 diabetes. We found that small doses of allulose, but not fructose, modestly reduced the postprandial glycemic response to a 75g oral glucose load. To assess whether low-dose (< 50-g/day) fructose and all its epimers (allulose, tagatose and sorbose) lead to sustainable improvements in long-term glycemic control, we conducted a systematic review and meta-analysis of controlled feeding trials. The available evidence suggested that fructose and tagatose led to significant reductions in HbA1c and fasting glucose. Our findings highlight the need for long-term randomized controlled trials to confirm the viability of fructose and its epimers as alternative sweeteners. iii Table of Contents Contents Abstract ........................................................................................................................... -
Low Molecular Weight Organic Composition of Ethanol Stillage from Sugarcane Molasses, Citrus Waste, and Sweet Whey Michael K
Chemical and Biological Engineering Publications Chemical and Biological Engineering 2-1994 Low Molecular Weight Organic Composition of Ethanol Stillage from Sugarcane Molasses, Citrus Waste, and Sweet Whey Michael K. Dowd Iowa State University Steven L. Johansen Iowa State University Laura Cantarella Iowa State University See next page for additional authors Follow this and additional works at: http://lib.dr.iastate.edu/cbe_pubs Part of the Biochemical and Biomolecular Engineering Commons, and the Biological Engineering Commons The ompc lete bibliographic information for this item can be found at http://lib.dr.iastate.edu/ cbe_pubs/12. For information on how to cite this item, please visit http://lib.dr.iastate.edu/ howtocite.html. This Article is brought to you for free and open access by the Chemical and Biological Engineering at Iowa State University Digital Repository. It has been accepted for inclusion in Chemical and Biological Engineering Publications by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. Low Molecular Weight Organic Composition of Ethanol Stillage from Sugarcane Molasses, Citrus Waste, and Sweet Whey Abstract Filtered stillage from the distillation of ethanol made by yeast fermentation of sugarcane molasses, citrus waste, and sweet whey was analyzed by gas chromatography/mass spectroscopy and by high-performance liquid chromatography. Nearly all of the major peaks representing low molecular weight organic components were identified. The am jor components in cane stillage were, in decreasing order of concentration, lactic acid, glycerol, ethanol, and acetic acid. In citrus stillage they were lactic acid, glycerol, myo-inositol, acetic acid, chiro-inositol, and proline. -
A/Prof Ken Sikaris Melbourne Pathology Bsc(Hons), MBBS, FRCPA, FAACB, Ffsc
AACB July Webinar The Clinical Biochemistry of SUGAR A/Prof Ken Sikaris Melbourne Pathology BSc(Hons), MBBS, FRCPA, FAACB, FFSc A/Prof Ken Sikaris 9th July 2014 Prof. Robert H Lustig, San Francisco A/Prof Ken Sikaris 9th July 2014 Lustig R.H. “Obesity and the toxic environment”, Clin Biochem Rev. 2008 Nov; S120–S121 Lustig RH, Schmidt LA, Brindis CD, “The toxic truth about sugar.” Nature 2012;482:27-9 A/Prof Ken Sikaris 9th July 2014 I love sugar A/Prof Ken Sikaris 9th July 2014 Life loves ‘sugar’.... A/Prof Ken Sikaris 9th July 2014 Glucose – The Universal Fuel Archaea Bacteria / Eukaryotes Gluconeogenesis A/Prof Ken Sikaris 9th July 2014 A/Prof Ken Sikaris 9th July 2014 Humans and Glucose Glucose INSULIN A/Prof Ken Sikaris 9th July 2014 Carbohydrate ENERGY OXYGEN CARBON DIOXIDE CARBO ENERGY HYDRATE WATER Hydration A/Prof Ken Sikaris 9th July 2014 Seasonal Fruits A/Prof Ken Sikaris 9th July 2014 Plants and seed dispersal A/Prof Ken Sikaris 9th July 2014 A/Prof Ken Sikaris 9th July 2014 A/Prof Ken Sikaris 9th July 2014 A/Prof Ken Sikaris 9th July 2014 A/Prof Ken Sikaris 9th July 2014 Carbohydrates • Mono-saccharides – Glucose, Fructose, Galactose • Di-saccharides – Sucrose, Maltose, Lactose • Sucrase, Maltase, Lactase A/Prof Ken Sikaris 9th July 2014 Sweetness A/Prof Ken Sikaris 9th July 2014 Carbohydrates • Mono-saccharides – Glucose, Fructose, Galactose • Di-saccharides – Sucrose, Maltose, Lactose • Sucrase, Maltase, Lactase • Polysaccharides – Starches, Fibre A/Prof Ken Sikaris 9th July 2014 Plants • Make Carbohydrate • But glucose -
New Yeasts Capable of Assimilating Methanol*
J. Gen. Appl. Microbiol., 18, 295-305 (1972) NEW YEASTS CAPABLE OF ASSIMILATING METHANOL* TOSHIKAZU OKI, KAGEAKI KOUNO, ATSUO KITAI, ANDASAICHIRO OZAKI Central Research Laboratories of Sanraku- Ocean Co., Ltd., Fujisawa, Japan (Received May 10, 1972) Twenty strains of methanol strongly assimilating yeasts were isolated from rotten tomato and a flower of azalea through investigations on the single- cell protein production and on the microbial utilization of Cl compound. Taxonomic studies indicated that these yeasts were limited to certain species of Candida and Torulopsis, including two new species; C. methanolica OKi et KouNo sp. nov. and T. methanolovescens OKi et KouNo sp. nov. One hundred and ninety-one strains of yeasts obtained from type culture collections did not exhibit methanol assimilability at all. The possibility of producing a single-cell protein from methanol by micro- organisms was suggested by the extensive studies concerning methane- or methanol-assimilating bacteria, Pseudomonas sp. PRL-W4 (1), Pseudomonas methanica (2, 3, 4), Methanomonas methanooxidans (5, 6), Pseudomonas AM 1(7 ), Pseudomonas sp. M27 (8), and Vibrio extorquens (9). Moreover, it is of considerable interest that OGATA et al. first reported the assimila- tion of methanol by yeast, Kloeckera sp. No. 2201 (10, 11, 12). More recently, ASTHANA et al. (13) isolated one species of yeast capable of uti- lizing methanol as a primary carbon source and identified it tentatively as Torulopsis glabrata. However, its taxonomical characteristics have not been reported yet. In the course of investigations on yeast production and microbial utiliza- tion of Ci compounds, two new species of yeasts assimilating methanol as a carbon and energy source were isolated from natural sources. -
Benzyl-L-Threitol
A Publication of Reliable Methods for the Preparation of Organic Compounds Working with Hazardous Chemicals The procedures in Organic Syntheses are intended for use only by persons with proper training in experimental organic chemistry. All hazardous materials should be handled using the standard procedures for work with chemicals described in references such as "Prudent Practices in the Laboratory" (The National Academies Press, Washington, D.C., 2011; the full text can be accessed free of charge at http://www.nap.edu/catalog.php?record_id=12654). All chemical waste should be disposed of in accordance with local regulations. For general guidelines for the management of chemical waste, see Chapter 8 of Prudent Practices. In some articles in Organic Syntheses, chemical-specific hazards are highlighted in red “Caution Notes” within a procedure. It is important to recognize that the absence of a caution note does not imply that no significant hazards are associated with the chemicals involved in that procedure. Prior to performing a reaction, a thorough risk assessment should be carried out that includes a review of the potential hazards associated with each chemical and experimental operation on the scale that is planned for the procedure. Guidelines for carrying out a risk assessment and for analyzing the hazards associated with chemicals can be found in Chapter 4 of Prudent Practices. The procedures described in Organic Syntheses are provided as published and are conducted at one's own risk. Organic Syntheses, Inc., its Editors, and its Board of Directors do not warrant or guarantee the safety of individuals using these procedures and hereby disclaim any liability for any injuries or damages claimed to have resulted from or related in any way to the procedures herein. -
A Scientific Look at the Impact of Sugar Allison C. Sylvetsky, Phd Assistant Professor Department of Exercise and Nutr
A Scientific Look at the Impact of Sugar Maia C. Kats, Of Counsel, Kaplan Fox & Kilsheimer LLP Allison C. Sylvetsky, Assistant Professor, Milken Institute School of Public Health, The George Washington University Kurt D. Weaver, Partner, Womble Bond Dickinson (US) LLP Moderated by Suzie L. Trigg, Partner, Haynes & Boone LLP and Chair, Food Adverting, Labeling, and Litigation Conference A Scientific Look at the Impact of Sugar Allison C. Sylvetsky, PhD Assistant Professor Department of Exercise and Nutrition Sciences The Milken Institute School of Public Health [email protected] September 26th, 2019 1 Presentation outline • Sugar consumption • What is sugar? • What happens to sugar in the body? • How does sugar impact health? 2 Sugar consumption • Sugar contributes significantly to energy intake in the United States • Sugar is believed to play an important role in obesity, diabetes, and cardiovascular disease • Current levels of consumption have increased compared to prior generations 3 Sugar consumption • Sugars have always been present in the human diet • Sugars are now present in a wide range of foods and beverages and sugars are often “hidden” • Sugars are added to foods for a variety of reasons, some unrelated to taste • For example: browning, preservation, texture 4 Recommendations for Added Sugar • World Health Organization (as per 2015 guidance) recommends that added sugar comprise less than 10% of total daily calories Example: 2,000 calorie diet → maximum of 200 calories from added sugar (50 g) 39 g 15 g 4 g 20 g 5 Recommendations for Added Sugar • The American Heart Association (as of 2010) recommended an upper limit of 6 teaspoons per day for women and 9 teaspoons per day for men. -
The Comparative Effect on Satiety and Subsequent Energy Intake of Ingesting Sucrose Or Isomaltulose Sweetened Trifle: a Randomized Crossover Trial
nutrients Article The Comparative Effect on Satiety and Subsequent Energy Intake of Ingesting Sucrose or Isomaltulose Sweetened Trifle: A Randomized Crossover Trial Fiona E. Kendall, Olivia Marchand, Jillian J. Haszard and Bernard J. Venn * Department of Human Nutrition, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; [email protected] (F.E.K.); [email protected] (O.M.); [email protected] (J.J.H.) * Correspondence: [email protected]; Tel.: +64-3-479-5068 Received: 25 September 2018; Accepted: 13 October 2018; Published: 15 October 2018 Abstract: The effect that blood glucose concentration has on feelings of satiety is unclear. Our aims were to assess satiety and subsequent energy intake following the ingestion of trifle sweetened with sucrose or isomaltulose whilst measuring plasma glucose concentration to confirm glycemic differences between trifles. Seventy-seven healthy adults participated in a double-blind crossover trial where trifle sweetened with sucrose or isomaltulose was consumed on separate days with a two-week washout. Blood was sampled at the baseline, 1 and 2 h postprandially, and satiety assessed using visual analogue scales (VAS). Weighed diet records were taken on test days. A statistically significant difference in blood glucose concentration between trifles was found at 60 min following consumption, with the isomaltulose trifle having a 0.69 mmol/L (95% confidence interval (CI): −1.07, −0.31) lower concentration when compared with the sucrose trifle. Mean satiety response by area-under-the-curve (AUC) was not significantly different between trifles. Mean (SD) appetite scores for the sucrose and isomaltulose trifles were 4493 (2393) and 4527 (2590) mm·min, respectively, with a between trifle difference of −9 (95% CI: −589, 572) mm·min. -
Calories Are Different DEPENDING on WHERE THEY COME FROM, THEY HAVE a DIFFERENT EFFECT
, ,, ,, LET S DEBUNK THIS MYTH: ALL CALORIES SHOULD BE TREATED EQUALLY This myth is a dangerous assumption Threatening our health COUNTING CALORIES HAS BEEN MISLEADING! a calorie IS A unit OF measurEMENT Conventionally used The system dates back It fails to accurately reveal to measure the amount of to the 1900s; it is useful what happens to energy from energy that foods produce but also inadequate foods once in our body WE BURN DIFFERENT AMOUNTS OF CALORIES TO DIGEST DIFFERENT FOOD FIBERS PROTEINS FATS You eat 160 calories in It takes twice as much energy All fats are 9 calories/gram. almonds, but only absorb to metabolize protein than it But omega-3 fats are 130 because some fiber takes to metabolize carbs heart-healthy, while trans calories pass through (more calories are fats will clog your arteries without metabolizing spent in processing it) and kill you then calories are different DEPENDING ON WHERE THEY COME FROM, THEY HAVE A DIFFERENT EFFECT High-risk diseases Type 2 diabetes , reached epidemic a DANGEROUS LEVELS, AND are metabolic diSEASE, linked to sugar IS NOW AN IMMINENT overconsumption RISK FOR CHILDREN Sugar is like alcohol for a child. The food industry targets customers Without limits, sugar can cause at early ages, with tactics like non-alcoholic fatty liver disease those used by the tobacco industry 20 years ago, type 2 diabetes Today, in the U.S. there are was so rarely found in children that 60,000 children with cases were reported in medical journals type 2 diabetes companies FILL our foods with tons of HIDDEN ADDED SUGAR 61 names like rice Soft drinks contain The average breakfast 74% of all food items syrup, barley malt and 37% of all added cereal likely exceeds the in U.S. -
FDA Finalizes Allulose Guidance and Requests Information on Other Sugars Metabolized Differently Than Traditional Sugars
FDA Finalizes Allulose Guidance and Requests Information on Other Sugars Metabolized Differently Than Traditional Sugars October 19, 2020 Food, Drug, and Device FDA has taken two notable actions regarding the sugars declaration in the Nutrition Facts Label (NFL) and Supplement Facts Label (SFL). On Friday, the agency released a final guidance regarding the declaration of allulose, confirming that this monosaccharide need not be included in the declaration of “Total Sugars” or “Added Sugars,” though it must be included in the “Total Carbohydrates” declaration in the NFL. Today, FDA published a Federal Register notice requesting information about and comments on the nutrition labeling of other sugars that are metabolized differently than traditional sugars. We briefly summarize both documents below to help inform stakeholder comments on the notice, which are due to FDA by December 18, 2020. Allulose Final Guidance Allulose, or D-psicose, is a monosaccharide that can be used as a substitute for traditional sugar in food and beverage products. For purposes of nutrition labeling, FDA has generally 1 defined nutrients based on their chemical structure.0F Accordingly, when FDA updated its NFL and SFL regulations in 2016, the agency reiterated the definition of “Total Sugars” as the sum of 2 all free monosaccharides and disaccharides (e.g. glucose, fructose, and sucrose).1F FDA also added to these regulations a definition of “Added Sugars” – sugars added during the processing 3 of food, or packaged as such – and required their declaration in the NFL and SFL.2F Although the agency recognized that there are sugars that are metabolized differently than traditional sugars, FDA did not make a determination at that time as to whether allulose should be excluded from “Total Carbohydrate,” “Total Sugars,” or “Added Sugars” Declarations. -
Effects of D-Allulose on Glucose Tolerance and Insulin Response to A
Clinical care/Education/Nutrition Open access Original research BMJ Open Diab Res Care: first published as 10.1136/bmjdrc-2020-001939 on 26 February 2021. Downloaded from Effects of D- allulose on glucose tolerance and insulin response to a standard oral sucrose load: results of a prospective, randomized, crossover study Francesco Franchi ,1 Dmitry M Yaranov,1 Fabiana Rollini,1 Andrea Rivas,1 Jose Rivas Rios,1 Latonya Been,1 Yuma Tani,2 Masaaki Tokuda,3 Tetsuo Iida,2 Noriko Hayashi,2 Dominick J Angiolillo,1 Arshag D Mooradian1 To cite: Franchi F, Yaranov DM, ABSTRACT Rollini F, et al. Effects of D- Introduction Current dietary guidelines recommend Significance of this study allulose on glucose tolerance limiting sugar intake for the prevention of diabetes and insulin response to a mellitus (DM). Reduction in sugar intake may require sugar What is already known about this subject? standard oral sucrose load: substitutes. Among these, D- allulose is a non- calorie rare ► D- allulose is defined one of the rare sugars, results of a prospective, which has been shown in animal and clinical randomized, crossover study. monosaccharide with 70% sweetness of sucrose, which has shown anti- DM effects in Asian populations. However, studies, conducted mostly in Asian populations, BMJ Open Diab Res Care to have postprandial plasma glucose suppres- 2021;9:e001939. doi:10.1136/ there is limited data on the effects of D- allulose in other sive effects with antiobesity and antidiabetic bmjdrc-2020-001939 populations, including Westerners. Research design and methods This was a prospective, effects. copyright. randomized, double- blind, placebo- controlled, crossover What are the new findings? ► Supplemental material is study conducted in 30 subjects without DM. -
United States Patent Office
- 2,926,180 United States Patent Office Patented Feb. 23, 1960 2 cycloalkyl, etc. These substituents R and R' may also be substituted with various groupings such as carboxyl 2,926,180 groups, sulfo groups, halogen atoms, etc. Examples of CONDENSATION OF AROMATIC KETONES WITH compounds which are included within the scope of this CARBOHYDRATES AND RELATED MATER ALS 5 general formula are acetophenone, propiophenone, benzo Carl B. Linn, Riverside, Ill., assignor, by mesne assign phenone, acetomesitylene, phenylglyoxal, benzylaceto ments, to Universal Oil Products Company, Des phenone, dypnone, dibenzoylmethane, benzopinacolone, Plaines, Ill., a corporation of Delaware dimethylaminobenzophenone, acetonaphthalene, benzoyl No Drawing. Application June 18, 1957 naphthalene, acetonaphthacene, benzoylnaphthacene, ben 10 zil, benzilacetophenone, ortho-hydroxyacetophenone, para Serial No. 666,489 hydroxyacetophenone, ortho - hydroxy-para - methoxy 5 Claims. (C. 260-345.9) acetophenone, para-hydroxy-meta-methoxyacetophenone, zingerone, etc. This application is a continuation-in-part of my co Carbohydrates which are condensed with aromatic pending application Serial No. 401,068, filed December 5 ketones to form a compound selected from the group 29, 1953, now Patent No. 2,798,079. consisting of an acylaryl-desoxy-alditol and an acylaryl This invention relates to a process for interacting aro desoxy-ketitol include simple sugars, their desoxy- and matic ketones with carbohydrates and materials closely omega-carboxy derivatives, compound sugars or oligo related to carbohydrates. The process relates more par saccharides, and polysaccharides. ticularly to the condensation of simple sugars, their 20 Simple sugars include dioses, trioses, tetroses, pentoses, desoxy- and their omega-carboxy derivatives, compound hexoses, heptoses, octoses, nonoses, and decoses. Com sugars or oligosaccharides, and polysaccharides with aro pound sugars include disaccharides, trisaccharides, and matic ketones in the presence of a hydrogen fluoride tetrasaccharides.